B.A., Connecticut College, 2001; Ph.D., Yale University, 2006. Caltech, 2008-; Executive Officer Sarah Reisman was born and raised in Bar Harbor, Maine. She attended Connecticut College in New London, CT, where she developed a passion for organic synthesis working in the laboratory of Prof. Timo Ovaska, and graduated with honors in 2001. In the fall of that year, Sarah enrolled in graduate studies at Yale University and joined the research group of Prof. John Wood. She earned her Ph.D. in chemistry in 2006; her thesis detailed the total synthesis of the natural product welwitindolinone A isonitrile. For her postdoctoral work, Sarah pursued studies in the field of asymmetric catalysis as an NIH fellow, working with Prof. Eric Jacobsen at Harvard University.

The Reisman Laboratory conducts research in the field of natural product synthesis, with an emphasis on the development of new synthetic methods that facilitate the construction of complex molecules.

Reductive Samarium (electro)catalysis Enabled by SmIII-alkoxide protonolysis. Boyd E. A.†; Shin C.†; Charboneau D. J.; Peters J. C.; Reisman S. E Science, 2024, 385, 847–853 DOI: https://doi.org/10.1126/science.adp5777​ Enantioselective C(sp2)–C(sp3) Bond Construction by Ni Catalysis Chen L-M.; Reisman S. E Acc. Chem. Res., 2024 DOI: doi.org/10.1021/acs.accounts.3c00775​ Electrocatalytic Asymmetric Nozaki–Hiyama–Kishi Decarboxylative Coupling: Scope, Applications, and Mechanism Gao Y.; Jiang B.; Friede N. C.; Hunter A. C.; Boucher D. G.; Minteer S. D.; Sigman M. S.; Reisman S. E; Baran P. S. J. Am. Chem. Soc., 2024 DOI: doi.org/10.1021/jacs.3c13442​ Ni-Catalyzed Asymmetric Reductive Arylation of⍺-Substituted Imides. Chen L. M.; Shin C. K.;Delano T.; Reisman S. E. ChemRxiv ,2023 21 December 2023, Version 1 DOI: 10.26434/chemrxiv-2023-97hjq​ Dataset design for building models of chemical reactivity. Raghavan P.; Haas B. C.; Ruos M. E.; Schleinitz J.; Doyle A. G.; Reisman S. E.;Sigman M. S.; Coley C. W. ACS Cent. Sci. 2023 9, 12, 2196–2204 DOI: doi.org/10.1021/acscentsci.3c01163​ A Pyridine Dearomatization Approach for the Gram Scale Synthesis of ()-Sparteine. Lam, P. H.; Kerkovius, J. K.; Reisman, S. E. Org. Lett. 2023. DOI: doi.org/10.1021/acs.orglett.3c03242​ Isolation, biosynthesis, and chemical syntheses of the hasubanan and acutumine alkaloids: A historical perspective. Grünenfelder, D. C.; Reisman, S. E.; Navarro, R. Tetrahedron. 2023, 149, 133709. DOI: doi.org/10.1016/j.tet.2023.133709​ Development of a Nickel-Catalyzed N–N Coupling for the Synthesis of Hydrazides. Barbor, J. P.; Nair, V. N.; Sharp, K. R.; Lohrey, T. D.; Dibrell, S. E.; Shah, T. K.; Walsh, M. J.; Reisman, S. E.; Stoltz, B. M. J. Am. Chem. Soc. 2023, 145, 28, 15071. DOI: doi.org/10.1021/jacs.3c04834​ Mechanistic Investigation of Ni-Catalyzed Reductive Cross-Coupling of Alkenyl and Benzyl Electrophiles. Turro, R. F.; Wahlman, J. L. H.; Tong, Z. J.; Chen, X.; Yang, M.; Chen, E. P.; Hong, X.; Hadt, R. G.; Houk, K. N.; Yang, Y.; Reisman, S. E. J. Am. Chem. Soc. 2023, 145, 27, 14705. DOI: doi.org/10.1021/jacs.3c02649​ Electronic Structures of Nickel(II)-Bis(indanyloxazoline)-dihalide Catalysts: Understanding Ligand Field Contributions that Promote C(sp2)–C(sp3) Cross-Coupling. McNicholas, B. J.; Tong, J.; Bím, D.; Turro, R. F.; Kazmierczak, N. P.; Chalupský, J.; Reisman, S. E.; Hadt, R. G. Inorg. Chem. 2023. DOI: doi.org/10.1021/acs.inorgchem.3c02048​ Electrochemical Preparation of Sm(II) Reagent Facilitated by Weakly Coordinating Anions. Ware, S. D.; Zhang, W.; Charboneau, D. J.; Klein, C. K.; Reisman, S. E.; See, K. A. Chem. Eur. J. 2023, 29, e202301045. DOI: doi.org/10.1002/chem.202301045​ A convergent fragment coupling strategy to access quaternary stereogenic centers Kerkovius, J. K.; Wong, A. R.; Mak, V. W.; Reisman, S. E. Chem. Sci. 2023 DOI: doi.org/10.1039/D2SC07023E​ Enantioselective Synthesis of N-Benzylic Heterocycles by Ni/Photoredox Dual Catalysis Lacker, C. R.; Delano, T. J.; Chen, E. P.; Kong, J.; Belyk, K. M.; Piou, T.; Reisman, S. E. J. Am. Chem. Soc. 2022,144, 20190 DOI: doi.org/10.1021/jacs.2c07917​ A Pyridine Dearomatization Approach to the Matrine–Type Lupin Alkaloids. Kerkovius, J. K.; Stegner, A.; Turlik, A.; Lam, P.H.; Houk, K.N.; Reisman, S. E. J. Am. Chem. Soc. 2022, 144, 15938 DOI: doi.org/10.1021/jacs.2c06584​ Expanding the Chiral Monoterpene Pool: Enantioselective Diels–Alder Reactions of α–Acyloxy Enones. Mendoza, S. D.; Rombola, M.; Tao, Y.; Zuend, S. J.; Götz, R.; McLaughlin, M. J.; Reisman, S. E. Org. Lett. 2022, 24, 3802. DOI: doi.org/10.1021/acs.orglett.2c01343​ Synthesis of Noraugustamine and Development of an Oxidative Heck/Aza-Wacker Cascade Cyclization. Holman, K. R.; Stanko, A.M.; Richter, M.J.R.; Feng, S. S.; Gessesse, M. N.; Reisman, S. E. Org. Lett. 2022, 24, 3019. DOI: doi.org/10.1021/acs.orglett.2c00948​ Enantioselective Synthesis of (–)-C10-Hydroxyacutuminine. Grünenfelder, D. C.; Navarro, R.; Wang, H.; Fastuca, N. J.; Butler, J. R.; Reisman, S. E. Angew. Chem. Int. Ed. 2022, 62, e202117480. DOI: 10.1002/anie.202117480​ Plugging the Leak: Empowering Women in Organic Chemistry. Dibrell, S. E.; Holman, K. R.; Reisman, S. E. Angew. Chem. Int. Ed. 2022, 61, e202111765. DOI: 10.1002/anie.202111765 Cobalt-Electrocatalytic Hydrogen Atom Transfer for Functionalization of Unsaturated C–C Bonds. Gnaim, S.; Bauer, A.; Zhang, H.-J.; Chen, L.; Gannet, C.; Malapit, C. A.; Hill, D. E.; Vogt, D.; Tang, T.; Daley, R.; Hao, W.; Quertenmont, M.; Beck, W. D.; Kandahari, E.; Vantourout, J. C.; Echeverria, P.-G.; Abruna, H.; Blackmond, D. G.; Minteer, S.; Reisman, S. E.; Sigman, M. S.; Baran, P. S. Nature 2022, 605, 687 3D Computer Vision Models Predict DFT-Level HOMO-LUMO Gap Energies from Force-Field-Optimized Geometries. Maser, M. R.; Reisman, S. E. ChemRxiv Nickel-Catalyzed Reductive Alkylation of Heteroaryl Imines. Turro, R. F.; Brandstätter, M.; Reisman, S. E. Angew. Chem. Int. Ed. 2022 e202207597 DOI:10.1002/anie.202207597 Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism. Gao, Y.; Hill, D. E.; Hao, W.; McNicholas, B. J.; Vantourout, J. C.; Hadt, R. G.; Reisman, S. E.; Blackmond, D. G.; Baran, P. S. J. Am. Chem. Soc. 2021, 143, 9478. DOI: 10.1021/jacs.1c03007 Total Syntheses of the C19 Diterpenoid Alkaloids (–)-Talatisamine, (–)-Liljestrandisine, and (–)-Liljestrandinine by a Fragment Coupling Approach. Wong, A. R.; Fastuca, N. J.; Mak, V. W.; Kerkovius, J. K.; Stevenson, S. M.; Reisman, S. E. ACS Cent. Sci. 2021, 7, 1311. DOI: 10.1021/acscentsci.1c00540. Palladium-Catalyzed Cascade Cyclizations Involving C–C and C–X Bond Formation: Strategic Applications in Natural Product Synthesis. Holman, K. R.; Stanko, A. M.; Reisman, S. E. Chem. Soc. Rev. 2021, 50, 7891. DOI: ​10.1039/D0CS01385D Total Synthesis of Complex Natural Products: More Than a Race for Molecular Summits. Reisman, S. E.; Maimone, T. J. Acc. Chem. Res. 2021, 54, 1815. DOI: 10.1021/acs.accounts.1c00184 Synthesis of Complex Diterpenes: Strategies Guided by Oxidation Pattern Analysis. Dibrell, S. E.; Tao, Y.; Reisman, S. E. Acc. Chem. Res. 2021, 54, 1360. DOI: 10.1021/acs.accounts.0c00858 Total Synthesis of Ritterazine B. Nakayama, N.; Maser, M. R.; Okita, T.; Dubrovskiy, A. V.; Campbell, T. L.; Reisman, S. E. J. Am. Chem. Soc. 2021, 143, 4187. DOI: 10.1021/jacs.1c01372 Nickel-Catalyzed Asymmetric Reductive Cross-Coupling of a-Chloroesters with (Hetero)Aryl Iodides. DeLano, T. J.; Dibrell, S. E.; Lacker, C. R.; Pancoast, A. R.; Poremba, K. E.; Cleary, L. B.; Sigman, M. S.; Reisman, S. E. Chem. Sci. 2021, 12, 7758. DOI: 10.1039/D1SC00822F Multi-Label Classification Models for the Prediction of Cross-Coupling Reaction Conditions. Maser, M. R.; Cui, A. Y.; Ryou, S.; DeLano, T. J.; Yue, Y.; Reisman, S. E. J. Chem. Inf. Model. 2021, 61, 156. DOI: 10.1021/acs.jcim.0c01234 Asymmetric Michael Addition of Dimethyl Malonate to 2-Cyclopenten-1-one Catalyzed by a Heterobimetallic Complex.​ Fastuca, N. J.; Wong, A. R.; Mak, V. W.; Reisman, S. E. Org. Synth. 2020, 97, 327. DOI: 10.15227/orgsyn.097.0327 A Copper-Catalyzed Asymmetric Oxime Propargylation Enables the Synthesis of the Gliovirin Tetrahydro-1,2-oxazine Core. Cowper, N. G. W.; Hesse, M. J.; Chan, K. M.; Reisman, S. E. Chem. Sci. 2020, 11, 11897. DOI: 10.1039/D0SC04802J Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABAA Receptor. Blom, A. E. M.; Su, J. Y.; Repka, L. M.; Reisman, S. E.; Dougherty, D. A. ACS Med. Chem. Lett. 2020, 11, 2204. DOI: 10.1021/acsmedchemlett.0c00340 Synthesis of Chiral Bisoxazoline Ligands: (3aR,3a'R,8aS,8a'S)-2,2'-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole). Hofstra, J. L.; DeLano, T. J.; Reisman, S. E. Org. Synth. 2020, 97, 172. DOI: 10.15227/orgsyn.097.0172 Organic Chemistry: A Call to Action for Diversity and Inclusion. Reisman, S. E.; Sarpong, R.; Sigman, M. S.; Yoon, T. P. J. Org. Chem. 2020, 85, 10287. DOI: 10.1021/acs.joc.0c01607 Graph Neural Networks for the Prediction of Substrate-Specific Organic Reaction Conditions. Ryou, S.; Maser, M. R.; Cui, A. Y.; DeLano, T. J.; Yue, Y.; Reisman, S. E. arXiv: 2007.04275 [cs.LG]. Appeared in the ICML 2020 workshop on Graph Representation Learning and Beyond (GRLB). Slides from the presentation can be found here. Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions. Poremba, K. E.; Dibrell, S. E.; Reisman, S. E. ACS Catal. 2020, 10, 8237. DOI: 10.1021/acscatal.0c01842 Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks. Wittmann, B. J.; Knight, A. M.; Hofstra, J. L.; Reisman, S. E.; Kan, J.; Arnold, F. H. ACS Catal. 2020, 10, 7112. DOI: 10.1021/acscatal.0c01888 SeO2-mediated Oxidative Transposition of Pauson–Khand Products. Dibrell, S. E.; Maser, M.; Reisman, S. E. J. Am. Chem. Soc. 2020, 142, 6483. DOI: 10.1021/jacs.9b13818