B.S. in Chemistry, Denison University, 1973 M.S. in Organic Chemistry, University of Chicago, 1975 Ph.D., University of Chicago, 1979 Postdoctoral Fellow, Columbia University, 1979 – 1983

Synthetic Organic Chemistry

The Snyder Group focuses on both organic synthesis and the discovery of new synthetic methodology that allow for the synthesis of natural product type chemotypes that occupy new chemical space. These efforts explore novel applications of inverse electron demand Diels-Alder reactions, homo Diels-Alder reactions, and other chemistries in organic synthesis. They are also exploring the use of abundant natural products as scaffolds in the synthesis of small molecule libraries. The goal of this work is the discovery of completely novel compounds that have significant biological activities against disease targets, such as those illustrated in the Figure.  Our library synthesis work coordinates with the Boston University Center for Molecular Discovery (BU-CMD).

Strosberg, A. D.; Kota, S.; Takahashi, V. Snyder, J. K. "Core as a Novel Viral Target for Hepatitis C Drugs." Viruses 2010, 2, 1734-1751. Jones, A. L.; Snyder J. K. "Synthesis of Unique Scaffolds via Diels-Alder Cycloadditions of Tetrasubstituted Cyclohexadienes". Org. Lett. 2010, 12, 1592-1595. Jones, A. L.; Liu, X.; Snyder, J. K. "Enantioselective Syntheses of Candenatenins B and C Using a Chiral Anthracene Auxiliary". Tetrahedron Lett. 2010, 51, 1091-1094. Kota, S.; Scampavia, L.; Spicer, T.; Beeler, A. B.; Takahashi, V.; Snyder, J. K.; Porco, J. A., Jr.; Hodder, P.; Strosberg, A. D. "A Time-Resolved Fluorescence-Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization." ASSAY Drug Dev. Tech. 2010, 8, 96-105. Wei, W.; Cai, C.; Kota, S.; Takahasi, V.; Ni, F.; Strosberg, A. D.; Snyder, J. K. "New Small Molecule Inhibitors of Hepatitus C Virus". Bioorg. Med. Chem. Lett. 2009, 19, 6926-6930. Jones, A. L.; Snyder, J. K. "Intramolecular Rhodium-Catalyzed [2+2+2] Cyclizations of Diynes with Enones". J. Org. Chem. 2009, 74, 2907-2910. Liu, X.; Snyder, J. K. "Anthracene Cycloadducts as Highly Selective Chiral Auxiliaries". J. Org. Chem. 2008, 73, 2935-2938.

Zhou, Y.; Porco, J. A., Jr.; Snyder, J. K. "Synthesis of 5,6,7,8-Tetrahydro-1,6-napthyridines and Related Heterocycles by Cobalt-Catalyzed [2+2+2] Cyclizations". Org. Lett. 2007, 9(3), 393-396.