Medical Biotechnology Immunology

The phenomenon of tissue regeneration, and the definition of stromal organiser cells which drive spleen tissue development, is the focus of my research.

My investigation addresses the fundamental aspects of spleen organiser cell identity, lineage origin and developmental potential, and utilises murine transplant models to establish the minimal cell requirements for spleen neogenesis.

Murine spleen tissue regeneration from neonatal spleen capsule requires lymphotoxin priming of stromal cells Journal of Immunology (2014) Jonathan Tan and Takeshi Watanabe Artificial engineering of secondary lymphoid organs Advances in Immunology (2010) Jonathan Tan and Takeshi Watanabe