Biophysics, chemical biology and computational biology. Current projects Lung surfactant - The structure of lung surfactant. Effects of exposure to environmental air pollutants such as ozone and ultrafine particles on lipid and protein composition, structure and organization. Lipid bilayer oxidation. Structural, organisational and chemical changes to lipid bilayers upon oxidation. Nucleic acids: structural changes, electronically excited states, oxidation, fluorescent probes.

Degradation and Rearrangement of a Lung Surfactant Lipid at the Air–Water Interface during Exposure to the Pollutant Gas Ozone, Katherine C. Thompson, Stephanie H. Jones, Adrian R. Rennie, Martin D. King, Andrew D. Ward, Brian R. Hughes, Claire O. M. Lucas, Richard A. Campbell, and Arwel V. Hughes, Langmuir, 29(14), 4594 – 4602, 2013. DOI: 10.1021/la304312y Reaction of a Phospholipid Monolayer with Gas-Phase Ozone at the Air−Water Interface: Measurement of Surface Excess and Surface Pressure in Real Time, Katherine C. Thompson, Adrian R. Rennie, Martin D. King, Samantha J. O. Hardman, Claire O. M. Lucas, Christian Pfrang, Brian R. Hughes, and Arwel V. Hughes, Langmuir, 26(22), 17295–­17303, 2010. DOI: 10.1021/la1022714 Evidence for a non-base stacking effect for the environment sensitive fluorescent base pyrrolocytosine ¾ comparison with 2-aminopurine, Samantha J. O. Hardman, Stanley W. Botchway and Katherine C. Thompson, Photochemistry and Photobiology, 84(6), 1473-1479, 2008. DOI: 10.1111/j.1751-1097.2008.00368.x The Structure of Cyanine 5 Terminally Attached to Double-Stranded DNA: Implications for FRET studies, David G. Norman, Asif Iqbal, Lihua Wang, Katherine C. Thompson, David M. J. Lilley, Biochemistry, 47(30), 7857-7862, 2008. DOI: 10.1021/bi800773f The Influence of Base Stacking and Hydrogen Bonding on the Fluorescence of 2-Aminopurine and Pyrrolocytosine in Nucleic Acids, Samantha J. O. Hardman and Katherine C. Thompson, Biochemistry, 45(30), 9145-9155, 2006. DOI: 10.1021/bi060479t