I maintain a small research interest in protein bioinformatics, initially in collaboration with Professor David Moss and now as a member of Dr Adrian Shepherd’s research group, and through supervising MSc students. My current research interests involve predicting the function and mechanism of immune system proteins and modelling the structures of G-protein coupled receptors.

Shepherd AJ, Skelton S, Sansom CE, Gomez K, Moss DS & Hart DP (2014). A large-scale computational study of inhibitor risk in non-severe haemophilia A. Brit J Haematol, in press. Shublaq N, Sansom C & Coveney PV (2013). Patient-specific modelling in drug design, development and selection including its role in clinical decision-making. Chem Biol Drug Des 81(1): 5-12. Halling-Brown M, Pappalardo F, Rapin N, Zhang P, Alemani D, Emerson A, Castiglione F, Duroux P, Pennisi M, Miotto O, Churchill D, Rossi E, Moss DS, Sansom CE, Bernaschi M, Lefranc MP, Brunak S, Lund O, Motta S, Lollini PL, Murgo A, Palladini A, Basford KE, Brusic V & Shepherd AJ (2010). ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale. Philos Trans A Math Phys Eng Sci. 368(1920): 2799-815. Halling-Brown M, Shaban R, Frampton D, Sansom CE, Davies M, Flower D, Duffield M, Titball RW, Brusic V & Moss DS (2009). Proteins accessible to immune surveillance show significant T-cell epitope depletion: Implications for vaccine design. Mol Immunol. 46(13): 2699-705. Halling-Brown MD, Moss DS, Sansom CE, Shepherd AJ (2009). A computational Grid framework for immunological applications. Philos Trans A Math Phys Eng Sci. 367(1898): 2705-16.