University of Louisville, B.S. 1964, M.S. 1965 Indiana University, Ph.D., 1968 Stanford University, Postdoc, 1968-1970

Organic

Antiviral Drug Design and Discovery through Synthesis

Due to copyright restrictions, we are unable to provide the manuscripts online. Please refer to the journal websites or email (schnest@auburn.edu) for an electronic reprint.

Yin, X.; Zhao, G.; Schneller, S.W. Carbocyclic Sinefungin. Tetrahedron Lett. 2007, 48, 4809-4811. doi:10.1016/j.tetlet.2007.05.079

Li, W.; Yin, X.; Schneller, S.W. 5'-Fluoro-5'-deoxyaristeromycin. Bioorg. Med. Chem. Lett. 2008, 18, 220-222. doi:10.1016/j.bmcl.2007.10.095

Zhou, J.; Yang, M.; Akdag, A.; Wang, H.; Schneller, S.W. Carbocyclic 4'-epi-Formycin. Tetrahedron 2008, 64, 433-438. doi:10.1016/j.tet.2007.10.054

Ye, W.; He, M.; Schneller, S.W. Synthesis of the 6'-Iso Analogs of Neplanocin and 5'-Homoneplanocin A. Tetrahedron Lett. 2009, 50, 7156-7158. doi:10.1016/j.tetlet.2009.10.016

Yin, X.q.; Li, W.-k.; Yang, M.; Schneller, S.W. A New Synthesis and an Antiviral Assessment of the 4'-Fluoro Derivative of 4'-Deoxy-5'-noraristeromycin. Bioorg. Med. Chem. 2009, 17, 3126-3129. doi:10.1016/j.bmc.2009.03.004

Gowen, B.B.; Wong, M.H.; Larson, D.; Ye, W.; Jung, K.-H.; Sefing, E.J.; Skirpstunas, R.; Smee, D.F.; Morrey, J.D.; Schneller, S.W. Development of a New Tacaribe Arenavirus Infection Model and Its Use to Explore Antiviral Activity of a Novel Aristeromycin Analog. PLoS One 2010, 5, e12760. doi:10.1371/journal.pone.0012760.

Daffis, Stephane; Szretter, Kristy J.; Schriewer, Jill; Li, Jianqing; Youn, Soonjeon; Errett, John; Lin, Tsai-Yu; Schneller, Stewart; Zust, Roland; Dong, Hongping; Thiel, Volker; Sen, Ganes C.; Fensterl, Volker; Klimstra, William B.; Pierson, Theodore C.; Buller, R. Mark; Gale Jr, Michael; Shi, Pei-Yong; Diamond, Michael S. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 2010, 468(7322), 452-456. doi:10.1038/nature09489.

Liu, C.; Chen, Q.; Schneller, S.W. (+)-Neplanocin F, 2'-Fluoroneplanocin, and a 6'-isoneplanocin via a common versatile cyclopentenol precursor. Tetrahedron Lett. 2011, 52, 4931-4933. doi.10.1016/j.tetlet.2011.07.059

Li, W.; Ye, W.; Schneller, S.W. 6'-Oxa analogs of S-adenosylhomocysteine, Tetrahedron, 2012, 68, 65-71. doi.10.1016/j.tet.2011.10.063

Zhang, Y.; Ye, W.; Wang, H.; Schneller, S.W. Carbocyclic 4-deazaformycins. Synthesis, 2012, 44, 723-730. doi.10.1055/s-0031-1289688

Chen, C.; Ye, W.; Liu, C.; Schneller, S.W. 2’-Fluoro-3-deazaaristeromycin. Tetrahedron, 2012, 68, 3908-3914. doi:10.1016/j.tet.2012.03.023.

Liu, C.; Chen, Qi.; Schneller. S.W. 3-Bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin: Synthesis and antiviral activity. Bioorg. Med. Chem Letters 2012, 22, 5182-5184. http://dx.doi.org/10.1016/j.bmcl.2012.06.075

Gu, L.; Musiienko, V.; Bai, Z.; Qin, A.; Schneller, S.W.; Li, Q. Novel virostatic agents against bluetongue virus. PLOS One 2012, 7 (8), e43341. http://dx.doi.org/10.1371/journal.pone.0043341.

Chen, C.; Ye, W.; Schneller, S.W. A convenient synthesis of the L-like enantiomer of 4'-methyl-3-deazaaristeromycin, Heterocycles 2012, 86, 697-704 (invited paper for issue honoring Professor Ei-ichi Negishi, 2010 Nobel Laureate in chemistry for his research in palladium catalyzed cross couplings in organic synthesis; shared with Richard Heck and Akira Suzuki). http://dx.doi.org/10.3987/COM-12-S(N)20

Liu, C.; Chen, Q.; Yang, M.; Schneller, S.W. C-3 Halo and 3-methyl substituted 5’-nor-3-deazaaristeromycins: Synthesis and antiviral properties. Bioorg. Med. Chem. 2013, 21, 359-364. http://dx.doi.org/10.1016/j.bmc.2012.09.051

Yang, M; Wei, Y; Schneller, S.W. 6’-Methyl-5’-homoaristeromycin: A structural variation of the anti-orthopox virus candidate 5’-homoaristeromycin. Bioorg. Med. Chem. 2013, 21, 4374-4377. http://dx.doi.org/10.1016/j.bmc.2013.04.070

Sefing, E.J.; Wong, M.; Larson, D.P.; Hurst, B.L.; Van Wettere, A.J.; Schneller, S.W.; Gowen, B.B. Vascular leak ensues a vigorous proinflammatory cytokine response to Tacaribe arenavirus infection in AG129 mice. Virol. J. 2013, 10, 221-233. http://dx.doi.org/10.1186/1743-422x-10-221

Gu, L., Schneller, S. W., Li, Q. Assays for the Identification of Novel Antivirals against Bluetongue Virus. J. Vis. Exp. (80), e50820, doi:10.3791/50820 (2013). http://www.jove.com/video/50820/assays-for-identification-novel-antivirals-against-bluetongue

Chen, Q.; Liu, C.; Shulyak, T.S.; Schneller, S.W. The metathesis reaction for side chain construction in carbocyclic sinefungin analogue synthesis. Tetrahedron accepted in 2013 but has just appeared 2014, 70, 892-900. http://dx.doi.org/10.1016/j.tet.2013.12.030