Biochemistry

Our lab studies single molecule biophysics using scaning probe methods. The idea is to measure and manipulate individual molecules. The premise is that single molecules are simple enough to (eventually) be modeled accurately with computer simulations, yet, in a real environment, complex enough to reflect the variations that are important to their function. Projects include (a) A study of gene transcription using single molecule models of a gene promoter, (b) studies of conduction in single molecules aimed at laying the groundwork for molecular electronics and (c) development of new sngle molecule measurement techniques.

"Electronic Decay Constant of Carotenoid Polyenes from Single-Molecule Measurements," J. He, F. Chen, J. Li, O.F. Sankey, Y. Terazono, C. Herrero, D. Gust, T.A. Moore, A.L. Moore and S.M. Lindsay, J. Am. Chem. Soc.; (Communication) 127 (5) 1384-1385 (2005) "A Molecular Switch Based on Potential-Induced Changes of Oxidation State," F. Chen, J. He, C. Nuckolls, T. Roberts, J.E. Klare and S. Lindsay, Nano Letters 5 503-506 (2005) "Switching of a photochromic molecule on gold electrodes: single-molecule measurements," J. He, F. Chen, P.A. Liddell, J. Andreasson, S.D. Straight, D. Gust, T.A. Moore, A.L. Moore, J. Li, O.F. Sankey and S.M. Lindsay, Nanotechnology 16 695- 702 (2005) "Single-Molecule Electronic Measurements with Metal Electrodes," S.M. Lindsay, J. Chem. Ed 82 727-733 (2005) "Localization of Single Avidin-Biotin Interactions Using Simultaneous Topography and Molecular Recognition Imaging," A. Ebner , F. Kienberger , G. Kada , C.M. Stroh, M. Geretschlager, A.S.M. Kamruzzahan, L. Wildling , W.T. Johnson , B. Ashcroft , J. Nelson , S.M. Lindsay , H.J. Gruber and P. Hinterdorfer, Chem. Phys. Chem 6 897-900 (2005) "A Bond Fluctuation Mechanism for Stochastic Switching in Wired Molecules," G.K. Ramachandran, T.J. Hopson, A.R. Rawlett, L.A. Nagahara, A. Primak and S.M. Lindsay, Science 300 1413-1415 (2003) "Charge Transfer on the Nanoscale: Current Status," D.M. Adams, L. Brus, C.E.D. Chidsey, S. Creager, C. Creutz, C.R. Kagan, P.V. Kamat, M. Lieberman, S. Lindsay, R.A. Marcus, R.M. Metzger, M.E. Michel-Beyerle, J.R. Miller, M.D. Newton, D.R. Rolison, O. Sankey, K.S. Schanze, J. Yardley and X. Zhu, J. Phys. Chem. B. 107 6668-6697 (2003) "Comparison of electronic transport measurments on organic molecules," A. Salomon, D. Cahen, S. Lindsay, J. Tomfohr, V.B. Engelkes and C.D. Frisbie, Advanced Materials 15 1881-1890 (2003) "Nuclesomal Arrays can be Salt Reconstituted onto a Single Copy MMTV Promotor DNA Template: Their Properties Differ in Several Ways from those of Comparable 5s Concatemeric Arrays," R. Bash, H. Wang, J.G. Yodh, G.L. Hager, S.M. Lindsay and D. Lohr, Biochemistry 42 4681 (2003)

"The Electron Transport Properties of a Carotene Molecule in a Metal- (Single-Molecule)- Metal Junction," G.K. Ramachandran, J.K. Tomfohr, O.F. Sankey, J. Li, X. Zarate, A. Primak, Y. Terazano, T.A. Moore, A.L. Moore, D. Gust, L.A. Nagahara and S.M. Lindsay, J. Phys. Chem. B 107 6162-6169 (2003)