学习经历 2003.09–2007.07天津大学 药物科学与技术学院，本科 2007.09–2012.06天津大学 药物科学与技术学院，博士（硕博连读） 2008.08–2011.12Hepatitis B Foundation（美国） Institute for Hepatitis and Virus Research（现Baruch S. Blumberg Institute），Research Scholar 工作经历 2012.07–2015.12郑州大学 化学学院，讲师 2015.12–2021.07郑州大学 化学学院，副教授 2021.07–现 今郑州大学 化学学院，教授 获奖与荣誉 河南省教育厅学术技术带头人 河南省技术发明一等奖 河南省科学技术进步一等奖 郑州大学首批青年拔尖人才 郑州大学三育人先进个人 郑州大学优秀本科毕业论文（设计）指导教师

药物化学、有机化学

Lan Liang, Yonggang Meng, Xiaoyu Chang, Ertong Li, Yucen Huang, Liming Yan, Zhiyong Lou, Youmei Peng, Bo Zhu, Wenquan Yu,* Junbiao Chang.* "Discovery of a 2'-α-Fluoro-2'-β-C-(fluoromethyl) Purine Nucleotide Prodrug as a Potential Oral Anti-SARS-CoV-2 Agent." Journal of Medicinal Chemistry, 2025, 68 (2), 1994-2007. Manman Wang, Yanmin He, Junbiao Chang, Wenquan Yu.* "Iodine-Mediated Oxidative C=C Double-Bond Formation toward Fused Quinolinones and Quinolinium Salts." Advanced Synthesis & Catalysis, 2025, 367 (2), e202401156. Zongxiang Zhao, Huilin Qiu, Junbiao Chang,* Wenquan Yu.* "Synthesis of Spiroindolenines by Iodine-Mediated Dearomative Aza-Spirocyclization of Indoles." Advanced Synthesis & Catalysis, 2024, 366 (8), 1751-1755. Jiao Hou, Jian-Hua Wang, Wenquan Yu,* Junbiao Chang.* "Synthesis of 2'-Deoxy-2'-β-fluoro-4'-azido-5-fluorouridine as a Potential Anti-HIV Agent." Synlett, 2024, 35 (6), 703-705. Qing Lu, Yanmin He, Junbiao Chang,* Wenquan Yu.* "Synthesis of 2,2-Difunctionalized 2H-Azirines by I2-Mediated Annulation of Enamines." Organic & Biomolecular Chemistry, 2024, 22 (11), 2292-2299. Wenjun Ye, Hanyu Xiong, Manman Wang, Junbiao Chang,* Wenquan Yu.* "Iodine-Mediated δ-Amination of sp3 C–H Bonds." Journal of Organic Chemistry, 2024, 89 (5), 3481-3490. Jiao Hou, Youmei Peng, Bingjie Liu, Qianqian Zhang, Jian-Hua Wang, Wenquan Yu,* Junbiao Chang.* "4'-Ethynyl-2'-deoxy-2'-β-fluoro-2-fluoroadenosine: A Highly Potent and Orally Available Clinical Candidate for the Treatment of HIV-1 Infection." Journal of Medicinal Chemistry, 2023, 66 (16), 11282-11293. Manman Wang, Xiaofei Yi, Wenjun Ye, Qinhao Shi, Wenquan Yu,* Junbiao Chang.* "Iodine-Mediated α-C–H Amination of Carbonyl Compounds via Nitrogen-Directed Oxidative Umpolung." Journal of Organic Chemistry, 2023, 88 (13), 8751-8760. Manman Wang, Wenjun Ye, Nannan Sun, Wenquan Yu,* Junbiao Chang.* "Synthesis of Quinazolinone-Fused Tetrahydroisoquinolines and Related Polycyclic Scaffolds by Iodine-Mediated sp3 C–H Amination." Journal of Organic Chemistry, 2023, 88 (2), 1061-1074. Xiaofei Yi, Zongxiang Zhao, Manman Wang, Wenquan Yu,* Junbiao Chang.* "Synthesis of 1,2-Fused/Disubstituted Benzimidazoles and Benzimidazolium Salts by I2-Mediated sp3 C–H Amination." Organic Letters, 2022, 24 (47), 8703-8708. Yingchao Fang, Manman Wang, Wei Hao, Yinggao Meng, Wenquan Yu,* Junbiao Chang.* "Transition-Metal-Free N-Functionalization of Benzimidazoles and Related Azaheterocycles with α-Acyloxy Sulfides." Advanced Synthesis & Catalysis, 2022, 364 (17), 2922-2925. Qianqian Zhang, Youmei Peng, Jiao Hou, Yanhong Chen, Bingjie Liu, Pinghu Zhang, Wenquan Yu,* Junbiao Chang.* "An O-Benzyl Phosphonamidate Prodrug of Tenofovir for the Treatment of Hepatitis B Virus Infection." Journal of Medicinal Chemistry, 2022, 65 (13), 9493-9505. Wei Hao, Kailu Li, Chenyang Ye, Wenquan Yu,* Junbiao Chang.* "Iodine-Mediated C=C Double Bond Cleavage toward Pyrido[2,1-b]quinazolinones." Organic Letters, 2022, 24 (17), 3286-3290. Lanlan Wei, Manman Wang, Yifei Zhao, Yingchao Fang, Zongxiang Zhao, Biao Xia, Wenquan Yu,* Junbiao Chang.* "Synthesis of 1,4-Dihydropyridines and Related Heterocycles by Iodine-Mediated Annulation Reactions of N-Cyclopropyl Enamines." Organic Letters, 2021, 23 (24), 9625-9630. Zhengyan Huang, Qianqian Zhang, Xiaofei Yi, Zongxiang Zhao, Wenquan Yu,* Junbiao Chang.* "Synthesis of 2-Imino-1,3,4-Selenadiazoles via Tributylphosphine-Mediated Annulation of N-Aroyldiazenes with Isoselenocyanates." Advanced Synthesis & Catalysis, 2021, 363 (21), 4894-4898. Wenjun Chen, Yangxu Du, Manman Wang, Yingchao Fang, Wenquan Yu,* Junbiao Chang.* "Synthesis of Benzo[4,5]imidazo[1,2-a]quinoxalines by I2-Mediated sp3 C−H Amination." Organic Chemistry Frontiers, 2020, 7 (22), 3705-3708. Li Sun,# Youmei Peng,# Wenquan Yu,# (#co-first authors) Yan Zhang, Lan Liang, Chuanjun Song, Jiao Hou, Yan Qiao, Qingduan Wang, Jingyu Chen, Mengli Wu, Dongwei Zhang, Ertong Li, Zhifu Han, Qingxia Zhao, Xia Jin, Bailing Zhang, Zhiwei Huang, Jijie Chai,* Jian-Hua Wang,* Junbiao Chang.* "Mechanistic Insight into Antiretroviral Potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention." Journal of Medicinal Chemistry, 2020, 63 (15), 8554-8566. Zhengyan Huang, Qianqian Zhang, Qiongli Zhao, Wenquan Yu,* Junbiao Chang.* "Synthesis of 2-Imino-1,3,4-thiadiazoles from Hydrazides and Isothiocyanates via Sequential Oxidation and P(NMe2)3-Mediated Annulation Reactions." Organic Letters, 2020, 22 (11), 4378-4382. Shuangshuang Zhang, Qiongli Zhao, Yifei Zhao, Wenquan Yu,* Junbiao Chang.* "Synthesis of 2-Amino Substituted Oxazoles from α-Amino Ketones and Isothiocyanates via Sequential Addition and I2-Mediated Desulfurative Cyclization." Advanced Synthesis & Catalysis, 2020, 362 (10), 1993-1997. Benyao Fang, Jiao Hou, Jinyue Tian, Wenquan Yu,* Junbiao Chang.* "Synthesis of Phenanthridines by I2-Mediated sp3 C−H Amination." Organic & Biomolecular Chemistry, 2020, 18 (17), 3312-3323. Biao Xia, Wenjun Chen, Qiongli Zhao, Wenquan Yu,* Junbiao Chang.* "Synthesis of Functionalized Imidazolium Salts via Iodine-Mediated Annulations of Enamines." Organic Letters, 2019, 21 (8), 2583-2587. Linning Ren, Manman Wang, Benyao Fang, Wenquan Yu,* Junbiao Chang.* "Iodine-Mediated Oxidative N−N Coupling of Secondary Amines to Hydrazines." Organic & Biomolecular Chemistry, 2019, 17 (13), 3446-3450. Qiongli Zhao, Linning Ren, Jiao Hou, Wenquan Yu,* Junbiao Chang.* "Annulation Reactions of In-situ Generated N-(Het)aroyldiazenes with Isothiocyanates Leading to 2-Imino-1,3,4-oxadiazolines." Organic Letters, 2019, 21 (1), 210-213.