男，1986年生，中共党员，博士，中国科学院青年创新促进会会员，副研究员，硕士生导师。 2014年12月，毕业于中国科学院水生生物研究所，获得博士学位 2015年3月至2018年12月，于中国科学院水生生物研究所任助理研究员 2019.01-至今，于中国科学院水生生物研究所任副研究员

鱼类遗传学与分子育种。目前主要从事鲤科模式鱼类-斑马鱼和鲤科养殖鱼类-鲤的性腺发育和性别分化的机制研究。通过在斑马鱼中阻断性类固醇激素的合成(敲除cyp17a1)，构建了雄激素和雌激素缺乏的模型和“全雄性”纯合子群体，发现了鱼类中存在垂体Fshβ在精巢发育/精子发生中的补偿机制、雌激素对卵巢发育的可塑机制和雄激素对第二性征的维持机制。同时，将阻断性类固醇激素合成的策略在鲤中进行水产应用，获得了性染色体型为XX且精子发育正常的“伪雄鲤”，尝试通过“全雌鲤”品系的种质创制，最终实现增产。另外，还发现胰岛素受体 a促进糖转换成脂肪的过程，而胰岛素受体b通过激活生长激素信号通路，进而促进脂肪的利用和蛋白质的合成等

1. Zhai G, Gu Q, He J, Lou Q, Chen X, Jin X, Bi E, Yin Z. 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development. Molecular and Cellular Biology 34(7), 1310-1321.

2. Zhai G, Shu T, Xia Y, Lu Y, Shang G, Jin X, He J, Nie P, Yin Z. 2018 Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish. Endocrinology (2018) 159(10):3549-62.

3. Zhai G, Song J, Shu T, Yan J, Jin X, He J, Yin Z. 2017. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics 44 (6): 307-317.

4. Yang B1, Zhai G1, Gong Y1, Su J, Peng X, Shang G, Han D, Jin J, Liu H, Du Z, Yin Z., Xie S. 2018. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American Journal of Physiology - Endocrinology and metabolism 315, E38-E51.

5. Zhai G1, Shu T1, Xia Y, Jin X, He J, Yin Z. 2017. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A. Science Bulletin 62 (3):197-203.

6. Yang B1, Zhai G1, Gong Y, Su J, Han D, Yin Z, Xie S. 2017. Depletion of insulin receptors leads to β-cell hyperplasia in zebrafish. Science Bulletin 62 (7):486-492.

7. Gong Y1, Zhai G1, Su J, Yang B, Jin J, Liu H, Yin Z, Xie S, Han D. 2018. Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish. General and Comparative Endocrinology 269:33-45.

8. Shu T, Shu Y, Gao Y, Jin X, He J, Zhai G#, Yin Z#. 2018. Depletion of tissue-specific ion transporters causes differential expression of PRL targets in response to increased levels of endogenous PRL. Frontiers in Endocrinology 9, 683.

9. Peng X, Shang G, Wang W, Chen X, Lou Q, Zhai G, Li D, Du Z, Ye Y, Jin X, He J, Zhang Y, Yin Z. 2017. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1alpha,25(OH)2D3. Cell Reports 19, 1444-1455.

10. Li D, Lou Q, Zhai G, Peng X, Cheng X, Dai X, Zhuo Z, Shang G, Jin X, Chen X, Han D, He J, Yin Z. 2014. Hyperplasia and cellularity changes in IGF-1-overexpressing skeletal muscle of crucian carp. Endocrinology 155 (6):2199-2212.

11. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, Lou Q, Yin Z. 2016. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Frontiers in Endocrinology 7, 88.

12. Yang J, Li Z, Gan X, Zhai G, Gao J, Xiong C, Qiu X, Wang X, Yin Z, Zheng, F. 2016. Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. International Journal of Molecular Sciences 17 (11): 1746.

13. Dai X, Shu Y, Lou Q, Tian Q, Zhai G, Song J, Lu S, Yu H, He J, Yin Z. 2017. Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish. International Journal of Molecular Sciences 18 (6), 1127.

14. Shi C, Lu Y, Zhai G, Huang J, Shang G, Lou Q, Li D, Jin X, He J, Du Z, Gui J, Yin Z. 2019. Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of Molecular Cell Biology In Press.

15. Shang G, Peng X, Ji C, Zhai G, Ruan Y, Lou Q, Jin X, He J, Wang H, Yin Z. 2019. Star and LH are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish. Biology of Reproduction 101(4):760-770.

16. Luo J, Zhang X, He S, Lou Q, Zhai G, Shi C, Yin Z, Zheng F, 2020. Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology 28, 101355.

17. Shu T, Zhai G, Pradhan A, Olsson PE, Yin Z, 2020. Zebrafish cyp17a1 Knockout Reveals that Androgen-Mediated Signaling is Important for Male Brain Sex Differentiation. General and Comparative Endocrinology In press.