1987年毕业于四川大学化学系，1992年于华西医科大学药学院获硕士学位，1997年于中国科学院化学研究所获博士学位。1997-2000年在香港理工大学应用生物及化学科技系作博士后研究，2001-2003年在美国亚利桑纳大学 (University of Arizona)化学系作访问学者，2003年回国工作。现为中山大学药物化学研究室教授，博士生导师，中山大学“百人计划”引进人才，2006年入选教育部新世纪优秀人才，2011年入选“千百十工程”省级培养人才计划。研究领域为不对称合成反应、药物合成新反应、手性药物的合成工艺、新型抗菌药物的设计、合成和筛选。先后主持国家自然科学基金项目、广州市科技攻关项目、珠海市科技攻关项目、广东省教育厅工程技术研究中心、中山大学启动基金项目、教育部优秀人才项目。至今已在J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; Org. Lett.; J. Org. Chem; Chem.Commun.; Adv. Synth. Catal.; Org.Biomol.Chem.;Tetrahedron; Tetrahedron Lett.; Tetrahdron:Asymmetry.等国内外核心专业期刊上发表研究论文110余篇，获得国内外专利11项。

1. 手性技术与不对称合成反应 2. 新型抗菌药物 3. 药物的绿色合成工艺

Dong-yu Zhu, Yuan Chen, Xue-jing Zhang* and Ming Yan*，Regioselective conjugate addition of isoxazol-5-ones to ethenesulfonyl fluoride,Org. Biomol. Chem.2022,20,4714-4718. Peng Zhang, Jia Zeng, Ping Pan, Xue-jing Zhang, and Ming Yan*, Palladium-Catalyzed Migratory Insertion of Carbenes and C-C Cleavage of Cycloalkanecarboxamides,Org.Lett.2022,24,536-541. Lei Chen, Xiao-can Su, Rui-jun Peng, Xue-jing Zhang and Ming Yan*, Rh(III)-Catalyzed ortho C-H functionalization of aromatic amides with bis(phenylsulfonyl)diazomethane and α-diazosulfones,Org. Biomol. Chem.2022,20,3268-3272. Jie Chen, Yue Zhang, Dong-yu Zhu, Xue-jing Zhang* and Ming Yan*, Construction of Chiral Quaternary Carbon Stereocenters by Asymmetric Michael Addition of 4-Amido-5-hydroxylpyrazoles to Ethylene Sulfonyl Fluoride,Asian J.Org.Chem.2022,e202200063. Jing-xuan Zhou, Dong-yu Zhu, Jie Chen, Xue-jing Zhang,* Ming Yan,* and Albert S. C. Chan, Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications, Tetrahedron Lett.2021,65,152792. Jie Chen, Dong-yu Zhu, Xue-jing Zhang,* and Ming Yan,* Highly Enantioselective Addition of N‑2,2,2-Trifluoroethylisatin Ketimines to Ethylene Sulfonyl Fluoride, J. Org. Chem. 2021,86,3041−3048. Dong-yu Zhu, Xue-jing Zhang,* and Ming Yan,* Enantioselective Addition of Azlactones to Ethylene Sulfonyl Fluoride via Dual Catalysis, Org. Lett. 2021,23,4228−4232. Bao-qin Huang, Yuan Chen, Xue-jing Zhang, and Ming Yan*, Cross-Dehydrogenative Coupling of Tetrahydroisoquinolines and 2-Fluoro-1,3-benzodithiole 1,1,3,3-tetraoxide: A New Synthetic Approach to α-Monofluoromethyl Tertiary Amines, Eur. J. Org. Chem. 2021,3015-3022 Ping Pan, Lei Chen, Xue-jing Zhang, and Ming Yan*, Diverse functionalization of aryl halides mediated by bis(phenylsulfonyl)methane, Tetrahedron 2021,96, 132371. Lei Chen, Rui Jun Peng, Xue-jing Zhang, Ming Yan*, and Albert S. C. Chan, Aromatic C-H Methylation and Other Functionalizations via the Rh(III)-Catalyzed Migratory Insertion of Bis(phenylsulfonyl)carbene and Subsequent Transformations.J. Org. Chem.2021,86,10177-10189. Hua-ju Liang,Ya-juan Cheng,Lu-xia Wang,Bao-qin Huang,Niu-niu Zhang,Jie Liang,and Ming Yan*, Exploration of (3‐benzyl‐5-hydroxyphenyl) carbamates as new antibacterial agents against Gram‐positive bacteria, Arch. Pharm. Chem. Life Sci. 2020,353, e1900294. Zhen-Yu Chen,Bi-Zhen Lin,Lei Chen,Yong Zou,Ming Yan* and Xue-Jing Zhang*, Perfluorobutyl Iodide Mediated [1,2] and [2,3] Stevens Rearrangement for the Synthesis of Indolin-3-Ones, Adv. Synth. Catal. 2020,362,4368-437 Jie Chen, Bao-qin Huang, Zeng-qing Wang, Xue-jing Zhang, and Ming Yan*, Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3‑Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams, Org. Lett. 2019,21,9742-9746. Zhen-Yu Chen, Hua-Ju Liang, Ri-Xing Chen, Lei Chen, Xiang-Zheng Tang, Ming Yan* and Xue-Jing Zhang*, Cross-Dehygrogenative C-O Coupling of Oximes with Acetonitrile, Ketones and Esters, Adv. Synth. Catal. 2019,361,3324-3330. Ya-Juan Cheng, Zhi-Yong Liu, Hua-Ju Liang, Cui-Ting Fang, Niu-Niu Zhang, Tian-Yu Zhang,* and Ming Yan*, Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as New Antitubercular Agents with Potent In Vitro and In Vivo Efficacy, Molecules 2019,24,2021. Niu-niu Zhang, Bai-jiao An, Yan Zhou, Xing-shu Li* and Ming Yan *, Synthesis, Evaluation, and Mechanism Study of New Tepotinib Derivatives as Antiproliferative Agents, Molecules 2019,24,1173. Niu-niu Zhang, Yun-xiang Tang, Lu Qian, Ya-min Gao, Zhi-yong Liu, Zhi-liang Zou, Tian-yu Zhang*, Ming Yan*, Design, synthesis, and antitubercular activity of 3-amidophenols with 5-heteroatomic substitutions, Arch Pharm Chem Life Sci. 2019,352,e180027 Xiang-Zheng Tang, Jie Liang, Xue-Jing Zhang, Raymond Wai-Yin Sun, Ming Yan*, Albert S. C. Chan, Synthesis of multisubstituted arylsulfones via a one-pot, three-component [3 + 3] benzannulation reaction, Org. Biomol. Chem. 2019,17, 4753-4760. Lei Chen, Jie Liang, Zhen-yu Chen, Jie Chen, Ming Yan*, Xue-jing Zhang*, A Convenient Synthesis of Sulfones via Light Promoted Coupling of Sodium Sulfinates and Aryl Halides, Adv. Synth. Catal. 2019,361,956-960. Shenquan Guo, Niuniu Zhang, Xiangzheng Tang, Zhifeng Mao, Xuejing Zhang, Ming Yan,* Yining Xuan*, Cyclopropanation of active methylene compounds withβ-alkoxycarbonyl vinylsulfonium salts, Chin. Chem. Lett. 2019,30,406-408. Lang Tong, Zhi-feng Mao, Xiang-zheng Tang, Xue-jing Zhang*, Ming Yan*, Cycloaddition of hydrazones and 1, 2-diarylalkynes promoted by t-BuOK/DMF: A convenient synthesis of tetraarylpyrazoles, Chin. Chem. Lett. 2019,30,395-397. Xiang-zheng Tang, Jing-xuan zhou, Hua-ju Liang, Xue-jing Zhang, Ming Yan*, Albert S. C. Chan,A practical synthesis of functionalized isoindolinones via [3 + 3] benzannulation of 1,3-bissulfonylpropenes and 4-arylmethylene-2,3-dioxopyrrolidines, Tetrahedron Lett. 2019,60, 147-149. Jie Liang, Yun-xiang Tang, Xiang-zheng Tang, Hua-jv Liang, Yamin Gao, Cuiting Fang, Tian-yu Zhang*, Ming Yan*, Discovery of meta-amido bromophenols as new antitubercular agents, Chem. Pharm. Bull. 2019,67,372-381. Zi-cong Chen, Lang Tong, Zhi-bo Du, Zhi-feng Mao,* Xue-jing Zhang, Yong Zou and Ming Yan*，Annulation of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts: synthesis of dihydrofuran derivatives, Org. Biomol. Chem.2018,16,2634-2638. Xiang-zheng Tang, Lang Tong, Hua-ju Liang, Jie Liang, Yong Zou, Xue-jing Zhang,* Ming Yan * and Albert S. C. Chan, Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy, Org. Biomol. Chem.2018,16,3560-3563. Niu-niu Zhang, Zhi-yong Liu, Jie Liang, Yun-xiang Tang, Lu Qian, Ya-min Gao, Tian-yu Zhang * and Ming Yan *, Design, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents, Med. Chem. Commun. 2018,9,1293-1304.