简历

研究员，1972年出生，国家杰出青年基金获得者；中国科学院昆明动物研究所研究员，博士生导师

主要学历

1991.9-1995.7西南师范大学，生物学，学士

1995.9-2001.7中科院昆明动物研究所，动物学，博士

主要科研工作经历

2001.8-2002.3，中国科学院昆明动物研究所，助理研究员

2002.4-2004.6，利物浦大学，博士后

2004.7-今，中国科学院昆明动物研究所，副所长，研究员

到目前以第一或者通讯作者身份共发表SCI论文200余篇，如NatureImmunology、Immunity、NatureCommunications、ChemicalReviews、ProcNatlAcadSci、MolCellProteomics、Hypertension、JMedChem、FASEBJ、Allergy、FreeRadicBiolMed、JBC等；受邀担任JVenomRes副主编；申请发明专利70多项

获奖及荣誉

1.国家杰出青年基金获得者，2010年

2.基于生物生存策略的有毒动物中药功能成分定向挖掘技术体系，2013年，国务院，国家技术发明奖，二等，第一完成人

3.两栖动物活性多肽的结构与功能研究，2008年，云南省政府,云南省自然科学奖，一等，第一完成人

4.吸血蜱与其宿主相互作用的分子机制研究，2009年，云南省政府，云南省自然科学奖，二等，第一完成人

5.全国创新争先奖状，2017年，中国科协、科技部、人力资源和社会保障部、国有资产监督管理委员会，个人奖

6.中医药管理局突出贡献奖，2017年，中医药管理局，个人奖

7.中国青年科技奖，2011年，中国科协，个人奖

8.中国科学院王宽诚西部学者突出贡献奖，2010年，中国科学院，个人奖

9.第十届“中国科学院十大杰出青年”，2010年，中国科学院，个人奖

10.谈家桢生命科学创新奖，2010年，科技部、上海市生物医药行业协会，个人奖

11.“万人计划”科技领军人才，科技部

12.连续2年（2016、2017）指导的博士研究生获得中科院百篇博优秀论文

13.云南省“十二五”十大科技人物

14.云南省“天然活性多肽研究与利用”重点实验室主任

15.云南省“天然活性多肽”工程实验室主任

长期致力于生物生存策略及环境适应机制研究、探索有毒动物（如蜈蚣、牛虻等）捕食和防御策略，揭示生物环境适应的物质基础与分子机制、并基于天然活性物质进行新药研发

1）研究高原两栖动物环境适应机制，从臭蛙皮肤发现第三套抗氧化系统，对皮肤保护、衰老研究与药物研究应用具重要意义(MolCellProteomics2009，8:571-583)，该工作得到德国哥廷根大学BurkhardPoeggeler教授高度赞赏“这是该领域的先驱工作，近期内没有任何其他工作在同领域有类似影响”；

2）研究两栖动物微生物防御机制，从铃蟾等识别了超过400种抗菌肽，占目前世界两栖动物抗菌肽总数40%以上，揭示两栖动物环境适应机制，也为抗感染药物研发提供源头资源(ChemRev.2015;115:1760-846)，并利用抗菌肽作为工具研究动脉粥样硬化疾病机理(Immunity2015;43:1137-47）；

3）研究树蛙对捕食者的防御策略，从华西树蛙发现神经毒素，这是首次发现的两栖动物基因编码的神经毒(JBiolChem.2009，284:22079-86)，为镇痛新药研发提供了候选药物、并被美国生物化学与分子生物学联合会作为亮点工作重点报道及被ScienceDaily等二十多家国际媒体报道；

4）研究吸血节肢动物吸血策略，揭示牛虻从其宿主成功吸血分子机制，从牛虻唾液腺发现>100种抗血栓和抗感染多肽，为药物研发提供源头资源(MolCellProteomics.2008;7:582-90.MolCellProteomics.2009;8:2071-9)；探索埃及伊蚊与宿主互作机制及吸血策略，发现其唾液腺成分通过抑制宿主免疫而协助寨卡病毒传播(NatureImmunology,19(4):342-353)，并为自身免疫药物研发提供及源头资源;

5）研究蜈蚣捕食策略，首次发现钠通道NaV1.7专一抑制剂（PNAS2013;110:17534-9），被Nature、NatureMedicine进行专门评论，并被推为Faculty1000，认为是目前全世界发现的最好的治疗慢性疼痛候选药物；蜈蚣毒素成分SsTx阻断离子通道KCNQ从而实现对巨大猎物高效捕食（PNAS2018；115:1646-1651），该工作被Science、华盛顿邮报、德国新闻社等专门评论;蜈蚣通过其毒素成分激活辣椒素受体诱导捕食者产生剧烈疼痛，从而逃避捕食(NatCommun.2015;6:8297)，为镇痛药物研发提供新思路和新的工具药物；

通过这些工作，揭示有毒动物环境适应策略；以通讯作者身份在Immunity（IF25）、NatureImmunology（IF22）,PNAS(2篇)，NatureCommunications,ChemicalReviews（IF50）等著名国际刊物上发表SCI研究论文170篇（具体论文情况可通过如下链接查询：https://www.ncbi.nlm.nih.gov/pubmed/?term=lai+ren），识别了自主知识产权活性多肽1300多种，提供候选药物资源，获发明专利授权60项，奠定了我们在该领域的国际领先地位，受邀在国际顶级刊物ChemicalReviews（IF50）发表长篇综述论文（ChemRev.2015;115:1760-846）、利用毒素多肽研发药物或工具药物（如一工具药物已在全球销售RHT-3832-PI，https://www.pepnet.com/Products/Detail/3766/Rh-Tx）；利用有毒动物资源推动山区农村脱贫致富，十一五、十二五期连续两次被云南省评为“扶贫工作”先进集体。

2018

1.WangG,LongC,LiuW,XuC,ZhangM,LiQ,LuQ,MengP,LiD,RongM,SunZ,LuoX,LaiR.NovelSodiumChannelInhibitorFromLeeches.FrontPharmacol.2018Mar6;9:186.

2.JinL,GuoX,ShenC,HaoX,SunP,LiP,XuT,HuC,RoseO,ZhouH,YangM,QinCF,GuoJ,PengH,ZhuM,ChengG,QiX,LaiR.SalivaryfactorLTRINfromAedesaegyptifacilitatesthetransmissionofZikavirusbyinterferingwiththelymphotoxin-βreceptor.NatImmunol.2018Apr;19(4):342-353.

3.ZengX,LiP,ChenB,HuangJ,LaiR,LiuJ,RongM.SelectiveClosed-StateNav1.7BlockerJZTX-34ExhibitsAnalgesicEffectsagainstPain.Toxins(Basel).2018Feb2;10(2).pii:E64.

4.TuQ,HaoJ,ZhouX,YanL,DaiH,SunB,YangD,AnS,LvL,JiaoB,ChenC,LaiR,ShiP,ZhaoX.CDKN2Bdeletionisessentialforpancreaticcancerdevelopmentinsteadofunmeaningfulco-deletionduetojuxtapositiontoCDKN2A.

Oncogene.2018Jan4;37(1):128-138.

5.LuoL,LiB,WangS,WuF,WangX,LiangP,OmbatiR,ChenJ,LuX,CuiJ,LuQ,ZhangL,ZhouM,TianC,YangS,LaiR.CentipedessubduegiantpreybyblockingKCNQchannels.ProcNatlAcadSciUSA.2018Feb13;115(7):1646-1651.

6.LiY,GuoX,HuC,DuY,GuoC,DiWang,ZhaoW,HuangG,LiC,LuQ,LaiR,XuT,QiX.TypeIIFNoperatespyroptosisandnecroptosisduringmultidrug-resistantA.baumanniiinfection.CellDeathDiffer.2018Jan19.doi:10.1038/s41418-017-0041-z.

2017

1.AluthwatthaST,HarrisonRD,RanawanaKB,XuC,LaiR,ChenJ.Doesspatialvariationinpredationpressuremodulateselectionforaposematism?EcolEvol.2017Aug15;7(18):7560-7572.

2.YangS,YangF,ZhangB,LeeBH,LiB,LuoL,ZhengJ,LaiR.Abimodalactivationmechanismunderliesscorpiontoxin-inducedpain.SciAdv.2017Aug2;3(8):e1700810.

3.JinL,FangM,ChenM,ZhouC,OmbatiR,HakimMA,MoG,LaiR,YanX,WangY,YangS.AninsecticidaltoxinfromNephilaclavataspidervenom.AminoAcids.2017Jul;49(7):1237-1245.

4.FangYQ,ShenCB,LuanN,YaoHM,LongCB,LaiR,YanXW.InvivoantimalarialactivityofsynthetichepcidinagainstPlasmodiumbergheiinmice.ChinJNatMed.2017Mar;15(3):161-167.

5.LuanN,ZhouC,LiP,OmbatiR,YanX,MoG,RongM,LaiR,DuanZ,ZhengR.

Joannsin,anovelKunitz-typeFXainhibitorfromthevenomofProspirobolusjoannsi.ThrombHaemost.2017Jun2;117(6):1031-1039.

2016

1.MengP,HuangH,WangG,YangS,LuQ,LiuJ,LaiR,RongM.ANovelToxinfromHaplopelmalividumSelectivelyInhibitstheNaV1.8ChannelandPossessesPotentAnalgesicEfficacy.Toxins(Basel).2016Dec26;9(1).pii:E7.

2.HeX,ShenC,LuQ,LiJ,WeiY,HeL,BaiR,ZhengJ,LuanN,ZhangZ,RongM,LaiR.Prokineticin2PlaysaPivotalRoleinPsoriasis.EBioMedicine.2016Nov;13:248-261.

3.LuanN,ShenW,LiuJ,WenB,LinZ,YangS,LaiR,LiuS,RongM.ACombinationalStrategyuponRNASequencingandPeptidomicsUnravelsaSetofNovelToxinPeptidesinScorpionMesobuthusmartensii.Toxins(Basel).2016Oct5;8(10).

4.LiuWH,ChenY,BaiXW,YaoHM,ZhangXG,YanXW,LaiR.Identificationandcharacterizationofanovelneuropeptide(neuropeptideY-HS)fromleechsalivaryglandofHaemadipsasylvestris.ChinJNatMed.2016Sep;14(9):677-682.

5.YaoHM,WangG,LiuYP,RongMQ,ShenCB,YanXW,LuoXD,LaiR.PhenolicacidsisolatedfromthefungusSchizophyllumcommuneexertanalgesicactivitybyinhibitingvoltage-gatedsodiumchannels.ChinJNatMed.2016Sep;14(9):661-670.

6.MaH,Xiao-PengT,YangSL,LuQM,LaiR.Proteaseinhibitorinscorpion(Mesobuthuseupeus)venomprolongsthebiologicalactivitiesofthecrudevenom.ChinJNatMed.2016Aug;14(8):607-14.

7.LaiY,LiB,LiuW,WangG,DuC,OmbatiR,LaiR,LongC,LiH.PurificationandCharacterizationofaNovelKazal-TypeTrypsinInhibitorfromtheLeechofHirudinariamanillensis.Toxins(Basel).2016Jul23;8(8).

8.RongM,LiuJ,ZhangM,WangG,ZhaoG,WangG,ZhangY,HuK,LaiR.AsodiumchannelinhibitorISTX-Iwithanovelstructureprovidesanewhintattheevolutionarylinkbetweentwotoxinfolds.SciRep.2016Jul13;6:29691.

9.JinL,BaiX,LuanN,YaoH,ZhangZ,LiuW,ChenY,YanX,RongM,LaiR,LuQ.ADesignedTryptophan-andLysine/Arginine-RichAntimicrobialPeptidewithTherapeuticPotentialforClinicalAntibiotic-ResistantCandidaalbicansVaginitis.JMedChem.2016Mar10;59(5):1791-9.

10.KangD,LiB,LuoL,JiangW,LuQ,RongM,LaiR.Curcuminshowsexcellenttherapeuticeffectonpsoriasisinmousemodel.Biochimie.2016Apr;123:73-80.

11.WeiNN,LvHN,WuY,YangSL,SunXY,LaiR,JiangY,WangK.SelectiveActivationofNociceptorTRPV1ChannelandReversalofInflammatoryPaininMicebyaNovelCoumarinDerivativeMuralatinLfromMurrayaalata.JBiolChem.2016Jan8;291(2):640-51.

12.HaoX,TangX,LuoL,WangY,LaiR,LuQ.Anovelranacyclin-likepeptidewithanti-plateletactivityidentifiedfromskinsecretionsofthefrogAmolopsloloensis.Gene.2016Jan15;576(1Pt1):171-5.

2015

1.ZhangZ,MengP,HanY,ShenC,LiB,HakimMA,ZhangX,LuQ,RongM,LaiR.MitochondrialDNA-LL-37ComplexPromotesAtherosclerosisbyEscapingfromAutophagicRecognition.Immunity.2015;43(6):1137-47.

2.HakimMA,YangS,LaiR.CentipedeVenomsandTheirComponents:ResourcesforPotentialTherapeuticApplications.Toxins(Basel).2015Nov17;7(11):4832-51.

3.HaoX,TangX,LuoL,WangY,LaiR,LuQ.Anovelranacyclin-likepeptidewithanti-plateletactivityidentifiedfromskinsecretionsofthefrogAmolopsloloensis.Gene.2016Jan15;576(1Pt1):171-5.

4.YangS,YangF,WeiN,HongJ,LiB,LuoL,RongM,Yarov-YarovoyV,ZhengJ,WangK,LaiR.Apain-inducingcentipedetoxintargetstheheatactivationmachineryofnociceptorTRPV1.NatCommun.2015Sep30;6:8297..

5.HakimMA,JiangW,LuoL,LiB,YangS,SongY,LaiR.ScorpionToxin,BmP01,InducesPainbyTargetingTRPV1Channel.Toxins(Basel).2015Sep14;7(9):3671-87.

6.FangY,LongC,BaiX,LiuW,RongM,LaiR,AnS.Twonewtypesofallergensfromthecockroach,Periplanetaamericana.Allergy.201570(12):1674-8.

7.BaiX,YaoH,DuC,ChenY,LaiR,RongM.AnimmunoregulatorypeptidefromtsetseflysalivaryglandsofGlossinamorsitansmorsitans.Biochimie.2015Nov;118:123-8.

8.WangYW,TanJM,DuCW,LuanN,YanXW,LaiR,LuQM.ANovelTrypsinInhibitor-LikeCysteine-RichPeptidefromtheFrogLepidobatrachuslaevisContainingProteinase-InhibitingActivity.NatProdBioprospect.2015Aug;5(4):209-14.

9.HuK,JiangY,XieY,LiuH,LiuR,ZhaoZ,LaiR,YangL.Small-AnionSelectiveTransmembrane"Holes"InducedbyanAntimicrobialPeptideTooShorttoSpanMembranes.JPhysChemB.2015Jul9;119(27):8553-60.

10.ZhongS,WuJ,CuiY,LiR,ZhuS,RongM,LuQ,LaiR.VascularendothelialgrowthfactorfromTrimeresurusjerdoniivenomspecificallybindstoVEGFR-2.Biochimie.2015Sep;116:1-7.

11.JiangWB,HakimM,LuoL,LiBW,YangSL,SongYZ,LaiR,LuQM.PurificationandcharacterizationofcholecystokininfromtheskinofsalamanderTylototritonverrucosus.DongwuxueYanjiu.2015May18;36(3):174-7.

12.XuX,LaiR.Thechemistryandbiologicalactivitiesofpeptidesfromamphibianskinsecretions.ChemRev.2015Feb25;115(4):1760-846.

13.RongM,YangS,WenB,MoG,KangD,LiuJ,LinZ,JiangW,LiB,DuC,YangS,JiangH,FengQ,XuX,WangJ,LaiR.PeptidomicscombinedwithcDNAlibraryunravelthediversityofcentipedevenom.JProteomics.2015Jan30;114:28-37.

14.TangJ,FangY,HanY,BaiX,YanX,ZhangY,LaiR,ZhangZ.YY-39,atickanti-thrombosispeptidecontainingRGDdomain.Peptides.2015Jun;68:99-104.

2014

1.ZhuY,LiZ,LiuH,HeX,ZhangY,JinJ,CheJ,LiC,ChenW,LaiR,LiuJ.NovelanalgesicpeptidesfromthetreefrogofHylajaponica.Biochimie.2014,99:38-43.

2.ZhuY,DuanZ,MoG,ShenC,LvL,ChenW,LaiR.Anovel26RFapeptidecontainingbothanalgesicandanti-inflammatoryfunctionsfromChinesetreeshrew.Biochimie.2014,102:112-6.

3.ZhangK,DingW,SunJ,ZhangB,LuF,LaiR,ZouY,YedidG.Antioxidantandantitumoractivitiesof4-arylcoumarinsand4-aryl-3,4-dihydrocoumarins.Biochimie.2014Dec;107PtB:203-10

4.MuL,TangJ,LiuH,ShenC,RongM,ZhangZ,LaiR.Apotentialwound-healing-promotingpeptidefromsalamanderskin.FASEBJ.2014，Sep;28(9):3919-29.

5.LiuH,DuanZ,TangJ,LvQ,RongM,LaiR.Ashortpeptidefromfrogskinacceleratesdiabeticwoundhealing.FEBSJ.2014，281(20):4633-43.

6.ZhangZ,GaoL,ShenC,RongM,YanX,LaiR.Apotentanti-thrombosispeptide(vasotabTY)fromhorseflysalivaryglands.IntJBiochemCellBiol.2014，54:83-8.

7.LiuH,MuL,TangJ,ShenC,GaoC,RongM,ZhangZ,LiuJ,WuX,YuH,LaiR.Apotentialwoundhealing-promotingpeptidefromfrogskin.IntJBiochemCellBiol.2014,49:32-41.

8.ZhongY,SongB,MoG,YuanM,LiH,WangP,YuanM,LuQ.ANovelNeurotoxinfromVenomoftheSpider,Brachypelmaalbopilosum.PLoSOne.2014,9(10):e110221.

9.TangJ,LiuH,GaoC,MuL,YangS,RongM,ZhangZ,LiuJ,DingQ,LaiR.Asmallpeptidewithpotentialabilitytopromotewoundhealing.PLoSOne.2014,9(3):e92082.

10.TangJ,FangY,HanY,BaiX,YanX,ZhangY,LaiR,ZhangZ.YY-39,atickanti-thrombosispeptidecontainingRGDdomain.Peptides.2015Jun;68:99-104.

2013

1.ZhuY,LiZ,LiuH,HeX,ZhangY,JinJ,CheJ,LiC,ChenW,LaiR,LiuJ.NovelanalgesicpeptidesfromthetreefrogofHylajaponica.Biochimie.2014Apr;99:38-43..

2.YangS,XiaoY,KangD,LiuJ,LiY,UndheimEA,KlintJK,RongM,LaiR,KingGF.DiscoveryofaselectiveNaV1.7inhibitorfromcentipedevenomwithanalgesicefficacyexceedingmorphineinrodentpainmodels.ProcNatlAcadSciUSA.2013;110(43):17534-9.

3.LiuYP,LaiR,YaoYG,ZhangZK,PuET,CaiXH,LuoXD.Inducedfuroeudesmanes:adefensemechanismagainststressinLaggerapterodonta,aChineseherbalplant.OrgLett.20134;15(19):4940-3.

4.ZhangZ,MuL,TangJ,DuanZ,WangF,WeiL,RongM,LaiR.Asmallpeptidewiththerapeuticpotentialforinflammatoryacnevulgaris.PLoSOne.2013;8(8):e72923.

5.YanH,LiuY,TangJ,MoG,SongY,YanX,WeiL,LaiR.AnovelantimicrobialpeptidefromskinsecretionsofthetreefrogThelodermakwangsiensis.ZoologSci.2013;30(9):704-9.

6.LiuR,ZhangZ,LiuH,HouP,LangJ,WangS,YanH,LiP,HuangZ,WuH,RongM,HuangJ,WangH,LvL,QiuM,DingJ,LaiR.Humanβ-defensin2isanovelopenerofCa2+-activatedpotassiumchannelsandinducesvasodilationandhypotensioninmonkeys.Hypertension.2013;62(2):415-25.

7.LiuH,ZhaoB,ChenY,YouD,LiuR,RongM,JiW,ZhengP,LaiR.Multiplecoagulationfactordeficiencyprotein2containstheabilitytosupportstemcellself-renewal.FASEBJ.2013;27(8):3298-305.

8.SongY,JiS,LiuW,YuX,MengQ,LaiR.DifferentexpressionprofilesofbioactivepeptidesinPelophylaxnigromaculatusfromdistinctregions.BiosciBiotechnolBiochem.2013;77(5):1075-9.

9.WeiL,WuJ,LiuH,YangH,RongM,LiD,ZhangP,HanJ,LaiR.Amycobacteriophage-derivedtrehalose-6,6'-dimycolate-bindingpeptidecontainingbothantimycobacterialandanti-inflammatoryabilities.FASEBJ.2013;27(8):3067-77.

10.WeiL,YangJ,HeX,MoG,HongJ,YanX,LinD,LaiR.Structureandfunctionofapotentlipopolysaccharide-bindingantimicrobialandanti-inflammatorypeptide.JMedChem.2013;56(9):3546-56.

11.AnS,ChenL,LongC,LiuX,XuX,LuX,RongM,LiuZ,LaiR.Dermatophagoidesfarinaeallergensdiversityidentificationbyproteomics.MolCellProteomics.2013;12(7):1818-28.

12.FanY,HuangZY,CaoCC,ChenCS,ChenYX,FanDD,HeJ,HouHL,HuL,HuXT,JiangXT,LaiR,LangYS,LiangB,LiaoSG,MuD,MaYY,NiuYY,SunXQ,XiaJQ,XiaoJ,XiongZQ,XuL,YangL,ZhangY,ZhaoW,ZhaoXD,ZhengYT,ZhouJM,ZhuYB,ZhangGJ,WangJ,YaoYG.GenomeoftheChinesetreeshrew.NatCommun.2013;4:1426.

13.LiuD,WangY,WeiL,YeH,LiuH,WangL,LiuR,LiD,LaiR.Snakevenom-likewaprinfromthefrogofCeratophryscalcaratacontainsantimicrobialfunction.Gene.2013;514(2):99-104.

14.WangG,WangY,MaD,LiuH,LiJ,ZhangK,YangX,LaiR,LiuJ.FivenovelantimicrobialpeptidesfromtheKuhl'swartfrogskinsecretions,Limnonecteskuhlii.MolBiolRep.2013;40(2):1097-102.

15.HeX,YangS,WeiL,LiuR,LaiR,RongM.Antimicrobialpeptidediversityintheskinofthetorrentfrog,Amolopsjingdongensis.AminoAcids.2013;44(2):481-7.

2012

1.MengP,WeiL,YangS,LiuH,LiuR,LaiR.Anovelfrogskinpeptidecontainingfunctiontoinducemusclerelaxation.Biochimie.Biochimie.2012.94(12):2508-13.

2.WangY,YanH,WangY,YangH,WeiL,XiaoY,YeH,LaiR,LiuR.Proteomicsandtranscriptomeanalysiscoupledwithpharmacologicaltestrevealsthediversityofanti-thrombosisproteinsfromthemedicinalinsect,Eupolyphagasinensis.InsectBiochemMolBiol.2012,42(8):537-44.

3.YangS,LiuZ,XiaoY,LiY,RongM,LiangS,ZhangZ,YuH,KingGF,LaiR.Chemicalpunchpackedinvenomsmakescentipedesexcellentpredators.MolCellProteomics.2012;11(9):640-50

4.YanH,WeiL,HeX,LiuH,YangS,LaiR,RaoD.Anovelmyotropicpeptidefromtheskinsecretionsofthetreefrog,Polypedatespingbianensis.Biochimie.2012,94(8):1718-23.

5.AnS,ChenL,WeiJF,YangX,MaD,XuX,XuX,HeS,LuJ,LaiR.PurificationandcharacterizationoftwonewallergensfromthevenomofVespamagnifica.PLoSOne.2012;7(2):e31920.

6.XuX,FrancischettiIM,LaiR,RibeiroJM,AndersenJF.Structureofproteinhavinginhibitorydisintegrinandleukotrienescavengingfunctionscontainedinsingledomain.JBiolChem.2012,287(14):10967-76.

7.YanX,ZhongJ,LiuH,LiuC,ZhangK,LaiR.Thecathelicidin-likepeptidederivedfrompandagenomeisapotentialantimicrobialpeptide.Gene.2012,25;492(2):368-74.

8.WuH,LiJ,ZhangQ,YanX,GuoL,GaoX,QiuM,JiangX,LaiR,ChenH.AnovelsmallOdorranalectin-bearingcubosomes:preparation,braindeliveryandpharmacodynamicstudyonamyloid-β25-35-treatedratsfollowingintranasaladministration.EurJPharmBiopharm.2012,80(2):368-78.

9.HaoX,YangH,WeiL,YangS,ZhuW,MaD,YuH,LaiR.Amphibiancathelicidinfillstheevolutionarygapofcathelicidininvertebrate.AminoAcids.2012,43(2):677-85.

10.YanX,LiuH,YangX,CheQ,LiuR,YangH,LiuX,YouD,WangA,LiJ,LaiR.Bi-functionalpeptideswithbothtrypsin-inhibitoryandantimicrobialactivitiesarefrequentdefensivemoleculesinRanidaeamphibianskins.AminoAcids.2012,43(1):309-16.

2011

1.WangY,ZhangZ,ChenL,GuangH,LiZ,YangH,LiJ,YouD,YuH,LaiR.Cathelicidin-BF,asnakecathelicidin-derivedantimicrobialpeptide,couldbeanexcellenttherapeuticagentforacnevulgaris.PLoSOne.2011,6(7):e22120.

2.WuJ,LiuH,YangH,YuH,YouD,MaY,YeH,LaiR.ProteomicanalysisofskindefensivefactorsoftreefrogHylasimplex.JProteomeRes.2011,10(9):4230-40.

3.LiuR,MuL,LiuH,WeiL,YanT,ChenM,ZhangK,LiJ,YouD,LaiR.TwoantimicrobialandnematicidalpeptidesderivedfromsequencesencodedPiceasitchensis.JPeptSci.2011,17(9):627-31.

4.YangH,WangY,XiaoY,WangY,WuJ,LiuC,YeH,LiF,YuH,LaiR.Abi-functionalanti-thrombosisproteincontainingbothdirect-actingfibrin(ogen)olyticandplasminogen-activatingactivities.PLoSOne.2011,6(3):e17519.

5.MaD,XuX,AnS,LiuH,YangX,AndersenJF,WangY,TokumasuF,RibeiroJM,FrancischettiIM,LaiR.AnovelfamilyofRGD-containingdisintegrins(Tablysin-15)fromthesalivaryglandofthehorseflyTabanusyaotargetsαIIbβ3orαVβ3andinhibitsplateletaggregationandangiogenesis.ThrombHaemost.2011,105(6):1032-45.

6.WeiL,DongL,ZhaoT,YouD,LiuR,LiuH,YangH,LaiR.Analgesicandanti-inflammatoryeffectsoftheamphibianneurotoxin,anntoxin.Biochimie.2011,93(6):995-1000.

7.WenZ,YanZ,HuK,PangZ,ChengX,GuoL,ZhangQ,JiangX,FangL,LaiR.Odorranalectin-conjugatednanoparticles:preparation,braindeliveryandpharmacodynamicstudyonParkinson'sdiseasefollowingintranasaladministration.JControlRelease.2011,151(2):131-8.

8.MaD,LiY,DongJ,AnS,WangY,LiuC,YangX,YangH,XuX,LinD,LaiR.Purificationandcharacterizationoftwonewallergensfromthesalivaryglandsofthehorsefly,Tabanusyao.Allergy.2011;66:101-9.

9.AnS,MaD,WeiJF,YangX,YangHW,YangH,XuX,HeS,LaiR.AnovelallergenTaby1withinhibitoryactivityofplateletaggregationfromsalivaryglandsofhorseflies.Allergy.2011,66(11):1420-7.

10.LiuR,LiuH,MaY,WuJ,YangH,YeH,LaiR.ThereareabundantantimicrobialpeptidesinbrainsoftwokindsofBombinatoads.JProteomeRes.2011,10(4):1806-15.

11.LiuX,LiuR,WeiL,YangH,ZhangK,LiuJ,LaiR.Twonovelantimicrobialpeptidesfromskinsecretionsofthefrog,Rananigrovittata.JPeptSci.2011,17(1):68-72.

2010

1.WuJ,WangY,LiuH,YangH,MaD,LiJ,LiD,LaiR.TwoimmunoregulatorypeptideswithantioxidantactivityfromticksalivaryglandsJBiolChem.2010;285:16606-13.

2.LiuC,HongJ,YangH,WuJ,MaD,LiD,LinD,LaiR.Frogskinskeepredoxhomeostasisbyantioxidantpeptideswithrapidradical-scavengingability.FreeRadicBiolMed.2010;48:1173-81.

3.ChenM,CheQ,WangX,LiJ,YangH,LiD,ZhangK,LaiR.Cloningandcharacterizationofthefirstamphibianbradykiningene.Biochimie.2010;92:226-31.

4.LaiR.Combinedpeptidomicsandgenomicsapproachtotheisolationofamphibianantimicrobialpeptides.MethodsMolBiol.2010;615:177-90.

5.WangM,WangY,WangA,SongY,MaD,YangH,MaY,LaiR.Fivenovelantimicrobialpeptidesfromskinsecretionsofthefrog,Amolopsloloensis.CompBiochemPhysiolB.2010;155:72-6.

6.MaY,LiuC,LiuX,WuJ,YangH,WangY,LiJ,YuH,LaiR.Peptidomicsandgenomicsanalysisofnovelantimicrobialpeptidesfromthefrog,Rananigrovittata.Genomics.2010;95:66-71.

7.MaD,GaoL,AnS,SongY,WuJ,XuX,LaiR.Ahorseflysalivaantigen5-likeproteincontainingRTSmotifisanangiogenesisinhibitor.Toxicon.2010;55:45-51.

8.LuZ,WangY,ZhaiL,CheQ,WangH,DuS,WangD,FengF,LiuJ,LaiR,YuH.Novelcathelicidin-derivedantimicrobialpeptidesfromEquusasinus.FEBSJ.2010;277:2329-39.

2009

1.WangWX,WangYP,DengXJ,DangXL,TianJH,YiHY,LiYF,HeXF,CaoY,XiaQY,LaiR,WenSY,PaskowitzS.Molecularandfunctionalcharacterizationofac-typelysozymefromtheAsiancornborer,Ostriniafurnacalis.JInsectSci.2009;9:17.

2.ZhangCX,YangSY,XuMX,SunJ,LiuH,LiuJR,LiuH,KanF,SunJ,LaiR,ZhangKY.Serratianematodiphilasp.nov.,associatedsymbioticallywiththeentomopathogenicnematodeHeterorhabditidoideschongmingensis(Rhabditida:Rhabditidae).IntJSystEvolMicrobiol.2009;59:1603-8.

3.SongY,LuY,WangL,YangH,ZhangK,LaiR.Purification,characterizationandcloningoftwonoveltigerinin-likepeptidesfromskinsecretionsofFejervaryacancrivora.Peptides.2009;30:1228-32.

4.YouD,HongJ,RongM,YuH,LiangS,MaY,YangH,WuJ,LinD,LaiR.Thefirstgene-encodedamphibianneurotoxin.JBiolChem.2009;284:22079-86.

5.MaD,WangY,YangH,WuJ,AnS,GaoL,XuX,LaiR.Anti-thrombosisrepertoireofblood-feedinghorseflysalivaryglands.MolCellProteomics.2009;8:2071-9.

6.LiuH,ZhouY,LiuR,ZhangKY,LaiR.Bacillussolisalsisp.nov.,ahalotolerant,alkaliphilicbacteriumisolatedfromsoilaroundasaltlake.IntJSystEvolMicrobiol.2009;59:1460-4.

7.YangSY,LiuH,LiuR,ZhangKY,LaiR.Saccharibacilluskuerlensissp.nov.,isolatedfromadesertsoil.IntJSystEvolMicrobiol.2009;59:953-7.

8.ZhouY,WeiW,WangX,XuL,LaiR.Azospirillumpalatumsp.nov.,isolatedfromforestsoilinZhejiangprovince,China.JGenApplMicrobiol.2009;55:1-7.

9.ZhouY,WeiW,WangX,LaiR.ProposalofSinomonasflavagen.nov.,sp.nov.,anddescriptionofSinomonasatrocyaneacomb.nov.toaccommodateArthrobacteratrocyaneus.IntJSystEvolMicrobiol.2009;59:259-63.

10.YangH,WangX,LiuX,WuJ,LiuC,GongW,ZhaoZ,HongJ,LinD,WangY,LaiR.Antioxidantpeptidomicsrevealsnovelskinantioxidantsystem.MolCellProteomics.2009;8:571-83.

2008

1.ZhouY,WeiW,CheQ,XuY,WangX,HuangX,LaiR.Bacilluspallidussp.nov.,isolatedfromforestsoil.IntJSystEvolMicrobiol.2008;58:2850-4.

2.WangY,HongJ,LiuX,YangH,LiuR,WuJ,WangA,LinD,LaiR.SnakecathelicidinfromBungarusfasciatusisapotentpeptideantibiotics.PLoSOne.2008;3:e3217.

3.WeiW,ZhouY,WangX,HuangX,LaiR.Sphingobacteriumanhuiensesp.nov.,isolatedfromforestsoil.IntJSystEvolMicrobiol.2008;58:2098-101.

4.LiJ,WuH,HongJ,XuX,YangH,WuB,WangY,ZhuJ,LaiR,JiangX,LinD,PrescottMC,ReesHH.Odorranalectinisasmallpeptidelectinwithpotentialfordrugdeliveryandtargeting.PLoSOne.2008;3:e2381.

5.LiuR,LiuH,ZhangCX,YangSY,LiuXH,ZhangKY,LaiR.Sphingobacteriumsiyangensesp.nov.,isolatedfromfarmsoil.IntJSystEvolMicrobiol.2008;58:1458-62.

6.LiuR,LiuH,FengH,WangX,ZhangCX,ZhangKY,LaiR.Pseudomonasduriflavasp.nov.,isolatedfromadesertsoil.IntJSystEvolMicrobiol.2008;58:1404-8.

7.YanX,FengH,YuH,YangX,LiuJ,LaiR.Animmunoregulatorypeptidefromsalivaryglandsofthehorsefly,Hybomitraatriperoides.DevCompImmunol.2008;32:1242-7.

8.LiJ,WuJ,WangY,XuX,LiuT,LaiR,ZhuH.AsmalltrypsininhibitorfromthefrogofOdorranagrahami.Biochimie.2008;90:1356-61.

9.ZhangC,LiuJ,XuM,SunJ,YangS,AnX,GaoG,LinM,LaiR,HeZ,WuY,ZhangK.Heterorhabditidoideschongmingensisgen.nov.,sp.nov.(Rhabditida:Rhabditidae),anovelmemberoftheentomopathogenicnematodes.JInvertebrPathol.2008;98:153-68.

10.LiuH,LiuR,YangSY,GaoWK,ZhangCX,ZhangKY,LaiRFlavobacteriumanhuiensesp.nov.,isolatedfromfieldsoil.IntJSystEvolMicrobiol.2008;58:756-60.

11.LiuSB,HeYY,ZhangY,LeeWH,QianJQ,LaiR,JinY.Anovelnon-lensbetagamma-crystallinandtrefoilfactorcomplexfromamphibianskinanditsfunctionalimplications.PLoSOne.2008;3:e1770.

12.WangA,WangJ,HongJ,FengH,YangH,YuX,MaY,LaiR.AnovelfamilyofantimicrobialpeptidesfromtheskinofAmolopsloloensis.Biochimie.2008;90:863-7.

13.HanJ,YouD,XuX,HanW,LuY,LaiR,MengQ.AnanticoagulantserineproteasefromthewaspvenomofVespamagnifica.Toxicon.2008;51:914-22.

14.CheQ,ZhouY,YangH,LiJ,XuX,LaiR.AnovelantimicrobialpeptidefromamphibianskinsecretionsofOdorranagrahami.Peptides.2008;29:529-35.

15.LuX,MaY,WuJ,LaiR.Twoserineproteaseinhibitorsfromtheskinsecretionsofthetoad,Bombinamicrodeladigitora.CompBiochemPhysiolB2008;149:608-12.

16.ZhouY,ZhangYQ,ZhiXY,WangX,DongJ,ChenY,LaiR,LiWJ.DescriptionofSinobacterflavusgen.nov.,sp.nov.,andproposalofSinobacteraceaefam.nov.IntJSystEvolMicrobiol.2008;58:184-9.

17.LuJ,YangH,YuH,GaoW,LaiR,LiuJ,LiangX.AnovelserineproteaseinhibitorfromBungarusfasciatusvenom.Peptides.2008;29:369-74.

18.ZhangK,LiuH,SunJ,LiuJ,FeiK,ZhangC,XuM,SunJ,MaX,LaiR,WuY,LinM.MolecularPhylogenyofGeographicalIsolatesofBursaphelenchusxylophilus:ImplicationsontheOriginandSpreadofthisSpeciesinChinaandWorldwide.JNematol.2008;40:127-37.

2007

1.WangX,SongY,LiJ,LiuH,XuX,LaiR,ZhangK.AnewfamilyofantimicrobialpeptidesfromskinsecretionsofRanapleuraden.Peptides.2007;28:2069-74.

2.YuH,WangX,LiuJ,LaiR.AnovelalgesicpeptidederivedfromskinsecretionsofthefrogAmolopsloloensis.JPeptSci.2007;13:798-802.

3.ChenL,LiY,LiJ,XuX,LaiR,ZouQ.AnantimicrobialpeptidewithantimicrobialactivityagainstHelicobacterpylori.Peptides.2007;28:1527-31.

4.LiuX,WangY,ChengL,SongY,LaiR.IsolationandcDNAcloningofcholecystokininfromtheskinofRananigrovittata.Peptides.2007;28:1540-4.

5.ZhouY,DongJ,WangX,HuangX,ZhangKY,ZhangYQ,GuoYF,LaiR,LiWJ.Chryseobacteriumflavumsp.nov.,isolatedfrompollutedsoil.IntJSystEvolMicrobiol.2007;57:1765-9.

6.YuH,YangH,MaD,LvY,LiuT,ZhangK,LaiR,LiuJ.Vespidchemotacticpeptideprecursorfromthewasp,Vespamagnifica(Smith).Toxicon.2007;50:377-82.

7.LiJ,ZhangC,XuX,WangJ,YuH,LaiR,GongW.Trypsininhibitoryloopisanexcellentleadstructuretodesignserineproteaseinhibitorsandantimicrobialpeptides.FASEBJ.2007;21:2466-73.

8.XuC,MaD,YuH,LiZ,LiangJ,LinG,ZhangY,LaiR.AbactericidalhomodimericphospholipasesA2fromBungarusfasciatusvenom.Peptides.2007;28:969-73.

9.LiJ,XuX,XuC,ZhouW,ZhangK,YuH,ZhangY,ZhengY,ReesHH,LaiR,YangD,WuJ.Anti-infectionpeptidomicsofamphibianskin.MolCellProteomics.2007;6:882-94.

10.ZhouY,WangX,LiuH,ZhangKY,ZhangYQ,LaiR,LiWJ.Pontibacterakesuensissp.nov.,isolatedfromadesertsoilinChina.IntJSystEvolMicrobiol.2007;57:321-5.

11.LiJ,YuH,XuX,WangX,LiuD,LaiR.Multiplebombesin-likepeptideswithoppositefunctionsfromskinofOdorranagrahami.Genomics.2007;89:413-8.

2006

1.XuX,YangH,YuH,LiJ,LaiR.Themastoparanogenfromwasp.Peptides.2006;27:3053-7.

2.LiJ,LiuT,XuX,WangX,WuM,YangH,LaiR.Amphibiantachykininprecursor.BiochemBiophysResCommun.2006;350:983-6.

3.LuY,LiJ,YuH,XuX,LiangJ,TianY,MaD,LinG,HuangG,LaiR.Twofamiliesofantimicrobialpeptideswithmultiplefunctionsfromskinofrufous-spottedtorrentfrog,Amolopsloloensis.Peptides.2006;27:3085-91.

4.ZhouZ,YangH,XuX,WangX,LaiR.Thefirstreportofkininogenfrominvertebrates.BiochemBiophysResCommun.2006;347:1099-102.

5.LiangJ,HanY,LiJ,XuX,ReesHH,LaiR.Anovelbradykinin-likepeptidefromskinsecretionsofrufous-spottedtorrentfrog,Amolopsloloensis.Peptides.2006;27:2683-7.

6.YuD,LiangJ,YuH,WuH,XuC,LiuJ,LaiR.AtickB-cellinhibitoryproteinfromsalivaryglandsofthehardtick,Hyalommaasiaticumasiaticum.BiochemBiophysResCommun.2006;343:585-90.

7.XuX,LiJ,HanY,YangH,LiangJ,LuQ,LaiR.TwoantimicrobialpeptidesfromskinsecretionsofRanagrahami.Toxicon.2006;47:459-64.

8.ZhangYQ,LiWJ,ZhangKY,TianXP,JiangY,XuLH,JiangCL,LaiR.Massiliadurasp.nov.,Massiliaalbidiflavasp.nov.,Massiliaplicatasp.nov.andMassilialuteasp.nov.,isolatedfromsoilsinChina.IntJSystEvolMicrobiol.2006;56:459-63.

9.XuX,LiJ,LuQ,YangH,ZhangY,LaiR.Twofamiliesofantimicrobialpeptidesfromwasp(Vespamagnifica)venom.Toxicon.2006;47:249-53.

10.LiJ,XuX,YuH,YangH,HuangZ,LaiRDirectantimicrobialactivitiesofPR-bombesin.LifeSci.2006;78:1953-6.

11.YuD,ShengZ,XuX,LiJ,YangH,LiuZ,ReesHH,LaiR.Anovelantimicrobialpeptidefromsalivaryglandsofthehardtick,Ixodessinensis.Peptides.2006;27:31-5.

2005

1.ZhangYX,LaiR,LeeWH,ZhangY.Frogalbuminisexpressedinskinandcharacterizedasanovelpotenttrypsininhibitor.ProteinSci.2005;14:2469-77.

2.LeeWH,ZhangJ,ZhangYX,JinY,LaiR,ZhangY.Maximin9,anovelfreethiolcontainingantimicrobialpeptidewithantimycoplasmaactivityfromfrogBombinamaxima.FEBSLett.2005;579:4443-8.

3.LeeWH,LiuSB,ShenJH,JinY,LaiR,ZhangY.IdentificationandmolecularcloningofanovelneuromedinUanalogfromtheskinsecretionsoftoadBombinamaxima.RegulPept.2005;129:43-7.

4.LeeWH,LiY,LaiR,LiS,ZhangY,WangW.VarietyofantimicrobialpeptidesintheBombinamaximatoadandevidenceoftheirrapiddiversification.EurJImmunol.2005;35:1220-9.

5.LiangJG,ZhangJ,LaiR,ReesHH.Anopioidpeptidefromsyngangliaofthetick,Amblyommatestindinarium.Peptides.2005;26:603-6.

2004

1.LaiR,TakeuchiH,JonczyJ,ReesHH,TurnerPC.Athrombininhibitorfromtheixodidtick,Amblyommahebraeum.Gene.2004;342:243-9.

2.LaiR,TakeuchiH,LomasLO,JonczyJ,RigdenDJ,ReesHH,TurnerPC.Anewtypeofantimicrobialproteinwithmultiplehistidinesfromthehardtick,Amblyommahebraeum.FASEBJ.2004;18:1447-9.

3.LaiR,LomasLO,JonczyJ,TurnerPC,ReesHH.Twonovelnon-cationicdefensin-likeantimicrobialpeptidesfromhaemolymphofthefemaletick,Amblyommahebraeum.BiochemJ.2004;379:681-5.

2003

1.LaiR,LiuH,LeeWH,ZhangY.BombinakininMgeneassociatedpeptide,anovelbioactivepeptidefromskinsecretionsofthetoadBombinamaxima.Peptides.2003;24:199-204.

2.LaiR,LiuH,LeeWH,ZhangY.TwonovelBv8-likepeptidesfromskinsecretionsofthetoadBombinamaxima.CompBiochemPhysiolB2003;134:509-14.

2002

1.LaiR,YangDM,LeeWH,ZhangY.BiologicalactivitiesofskinsecretionsofthesalamanderTylototritonverrucosus.JNatToxins.2002;11:245-50.

2.LaiR,LiuH,HuiLeeW,ZhangY.AnanionicantimicrobialpeptidefromtoadBombinamaxima.BiochemBiophysResCommun.2002;295:796-9.

3.LaiR,LiuH,LeeWH,ZhangY.Anovelprolinerichbombesin-relatedpeptide(PR-bombesin)fromtoadBombinamaxima.Peptides.2002;23:437-42.

4.LaiR,ZhengYT,ShenJH,LiuGJ,LiuH,LeeWH,TangSZ,ZhangY.AntimicrobialpeptidesfromskinsecretionsofChineseredbellytoadBombinamaxima.Peptides.2002;23:427-35.

5.LaiR,LiuH,LeeWH,ZhangY.IdentificationandcloningofatrypsininhibitorfromskinsecretionsofChinesered-bellytoadBombinamaxima.CompBiochemPhysiolB2002;131:47-53.

2001

1.LaiR,LiuH,HuiLeeW,ZhangY.Anovelbradykinin-relatedpeptidefromskinsecretionsoftoadBombinamaximaanditsprecursorcontainingsixidenticalcopiesofthefinalproduct.BiochemBiophysResCommun.2001,286:259-63.