简历

研究员，博士生导师。2008年毕业于武汉大学生命科学学院获学士学位，2013年于中国科学院昆明动物研究所获得遗传学博士学位，同年8月赴约翰霍普金斯大学医学院Lieber脑发育研究所（LieberInstituteforBrainDevelopment）从事博士后研究工作，2016年5月回昆明动物研究所工作。现为转化基因组学科组负责人。近年来已在NatureMedicine，AmericanJournalofPsychiatry，MolecularPsychiatry，SchizophreniaBulletin，BritishJournalofPsychiatry，MolecularBiologyandEvolution，GenomeBiology，BMCBiology，TranslationalPsychiatry和SchizophreniaResearch等国内外著名期刊发表论文和评述40余篇。博士毕业论文获得2014年度中科院百篇优秀博士论文和云南省百篇优秀博士论文。荣获朱李月华奖学金（2011），院长优秀奖学金（2012），国家奖学金（2013），三好学生标兵称号（2011）及优秀博士毕业生（2013）等奖励。任《ScientificReports》学术主编，受邀为超过20个SCI期刊审稿。

2004.09-2008.07武汉大学生命科学学院，获学士学位

2008.09–2013.07中国科学院昆明动物研究所，获博士学位

2013.08–2016.09Lieber脑发育研究所，博士后

2016.05–至今研究员，博士生导师，中科院昆明动物研究所转化基因组学科组负责人。

实验室主要研究方向为DNA遗传变异如何通过改变易感基因的表达和功能从而影响大脑功能及精神疾病的发生；为了使我们的研究结果与临床实践紧密结合，我们还将研究精神疾病相关药物对易感基因的表达调控及作用机理，为精神疾病药物的改进及开发奠定理论基础,进而将我们的研究成果转化于临床应用。

1.ChangH,#XiaoX,#LiM.*TheSchizophreniaRiskGeneZNF804A:ClinicalAssociations,BiologicalMechanismsandNeuronalFunctions.MolecularPsychiatry2017;22:944-953.

2.ChangH,#HoshinaN,#ZhangC,#MaY,CaoH,WangY,WuDD,BergenSE,LandénM,HultmanCM,PreisigM,KutalikZ,CastelaoE,Grigoroiu-SerbanescuM,ForstnerAJ,StrohmaierJ,HeckerJ,SchulzeTG,Müller-MyhsokB,ReifA,MitchellPB,MartinNG,SchofieldPR,CichonS,N？thenMM,TheSwedishBipolarStudyGroup,MooDSBipolarConsortium,WalterH,ErkS,HeinzA,AminN,vanDuijnCM,Meyer-LindenbergA,TostH,XiaoX,YamamotoT,*RietschelM,*LiM.*TheProtocadherin17GeneAffectsCognition,Personality,AmygdalaStructureandFunction,SynapseDevelopmentandRiskofMajorMoodDisorders.MolecularPsychiatry2017January10.doi:10.1038/mp.2016.231.

3.ChangH,#LiL,#PengT,#Grigoroiu-SerbanescuM,BergenSE,LandénM,HultmanCM,ForstnerAJ,StrohmaierJ,HeckerJ,SchulzeTG,Müller-MyhsokB,ReifA,MitchellPB,MartinNG,CichonS,N？thenMM,JamainS,LeboyerM,BellivierF,EtainB,KahnJP,HenryC,RietschelM;SwedishBipolarStudyGroup;MooDSConsortium,XiaoX,*LiM.*IdentificationofaBipolarDisorderVulnerableGeneCHDHat3p21.1.MolecularNeurobiology2017;54:5166-5176.

4.XiaoX,#LuoXJ,#ChangH,#LiuZ,LiM.*EvaluationofEuropeanSchizophreniaGWASLociinAsianPopulationsviaComprehensiveMeta-Analyses.MolecularNeurobiology2017;54:4071-4080.

5.ChangH,LiL,LiM,*XiaoX.*Rareandcommonvariantsat16p11.2areassociatedwithschizophrenia.SchizophreniaResearch2017;184:105-108.

6.LiM,JaffeAE,StraubRE,TaoR,ShinJH,WangY,ChenQ,LiC,JiaY,OhiK,MaherBJ,BrandonNJ,CrossA,ChenowethJ,HoeppnerDJ,WeiH,HydeTM,McKayR,KleinmanJE,WeinbergerDR.*Ahuman-specificAS3MTisoformandBORCS7aremolecularriskfactorsinthe10q24.32schizophreniaassociatedlocus.NatureMedicine2016;22:649-656.

7.LiM,*ChangH,XiaoX.BDNFVal66MetPolymorphismandBipolarDisorderinEuropeanPopulations:ARiskAssociationinCase-Control,Family-basedandGWASStudies.NeuroscienceandBiobehavioralReviews2016;68:218-233.

8.LiM,#,*WuDD,#YaoYG,HuoYX,LiuJW,SuB,ChasmanDI,ChuAY,HuangT,QiL,ZhengY,CHARGENutritionWorkingGroup,DietGenConsortium,LuoXJ.#,*Recentpositiveselectiondrivestheexpansionofaschizophreniarisknon-synonymousvariantatSLC39A8inEuropeans.SchizophreniaBulletin2016;42:178-190.

9.LiM,#,*LuoXJ,#LandénM,BergenSE,HultmanCM,LiX,ZhangW,YaoYG,ZhangC,LiuJ,MattheisenM,CichonS.MühleisenTW,DegenhardtFA,N？thenMM,SchulzeTG,Grigoroiu-SerbanescuM,LiH,FullerCK,ChenC,DongQ,ChenC,JamainS,LeboyerM,BellivierF,EtainB,KahnJP,HenryC,PreisigM,KutalikZ,CastelaoE,WrightA,MitchellPB,FullertonJM,SchofieldPR,MontgomeryGW,MedlandSE,GordonSD,MartinNG,MooDSConsortium,TheSwedishBipolarStudyGroup,RietschelM,LiuC,KleinmanJE,HydeTM,WeinbergerDR,SuB.*Impactofacis-associatedgeneexpressionSNPonchromosome20q11.22onbipolardisordersusceptibility,hippocampalstructureandcognitiveperformance.BritishJournalofPsychiatry2016;208:128-137.

10.LiM,#,*HuangL,#Grigoroiu-SerbanescuM,*BergenSE,LandénM,HultmanCM,ForstnerAJ,StrohmaierJ,HeckerJ,SchulzeTG,Müller-MyhsokB,ReifA,MitchellPB,MartinNG,CichonS,N？thenMM,AlkelaiA,LererB,JamainS,LeboyerM,BellivierF,EtainB,KahnJP,HenryC,RietschelM;MooDSConsortium;SwedishBipolarStudyGroup.ConvergentLinesofEvidenceSupportLRP8asaSusceptibilityGeneforPsychosis.MolecularNeurobiology2016;53:6608-6619.

11.LiM,#LuoXJ,#RietschelM,LewisCM,MattheisenM,Müller-MyhsokB,JamainS,LeboyerM,LandénM,ThompsonPM,CichonS,N？thenMM,SchulzeTG,SullivanPF,BergenSE,DonohoeG,MorrisDW,HargreavesA,GillM,CorvinA,HultmanC,TogaAW,ShiL,LinQ,ShiH,GanL,Meyer-LindenbergA,CzamaraD,HenryC,EtainB,BisJC,IkramMA,FornageM,DebetteS,LaunerLJ,SeshadriS,ErkS,WalterH,HeinzA,BellivierF,SteinJL,MedlandSE,VasquezAA,HibarDP,FrankeB,MartinNG,WrightMJ,MooDSBipolarConsortium,TheSwedishBipolarStudyGroup,Alzheimer’sDiseaseNeuroimagingInitiative,ENIGMAconsortium,CHARGEconsortium,SuB.*AllelicdifferencesbetweenEuropeansandChineseforCREB1SNPsandtheirimplicationsingeneexpressionregulation,hippocampalstructureandfunction,andbipolardisordersusceptibility.MolecularPsychiatry2014;19:452-461.

12.LuoXJ,#,*LiM,#HuangL,SteinbergS,MattheisenM,LiangG,DonohoeG,ShiY,ChenC,YueW,AlkelaiA,LererB,LiZ,YiQ,RietschelM,CichonS,CollierDA,TosatoS,SuvisaariJ,RujescuD,GolimbetV,SilagadzeT,DurmishiN,MilovancevicMP,StefanssonH,SchulzeTG,N？thenMM,ChenC,LyneR,MorrisDW,GillM,CorvinA,ZhangD,DongQ,MoyzisRK,StefanssonK,SigurdssonE,HuF;MooDSSCZConsortium,SuB,GanL.*ConvergentlinesofevidencesupportCAMKK2asaschizophreniasusceptibilitygene.MolecularPsychiatry2014;19:774-783.

13.LiM,GeT,FengJ,SuB.*SLC6A15rs1545843anddepression:implicationsfrombrainimagingdata.TheAmericanJournalofPsychiatry2013;170:805.

14.LiM,SuB.*Meta-analysissupportsassociationofanon-synonymousSNPinZNF804Awithschizophrenia.SchizophreniaResearch2013;149:188-189.

15.LiM,#LuoXJ,#XiaoX,#ShiL,LiuXY,YinLD,MaXY,YangSY,PuXF,YuJ,DiaoHB,ShiH,SuB.*AnalysisofcommongeneticvariantsidentifiesRELNasariskgeneforschizophreniainChinesepopulation.TheWorldJournalofBiologicalPsychiatry2013;14:91-99.

16.LiM,#WangY,#ZhengXB,IkedaM,IwataN,LuoXJ,ChongSA,LeeJ,RietschelM,ZhangFY,Müller-MyhsokB,CichonS,WeinbergerDR,MattheisenM,SchulzeTG,MartinNG,MitchellPB,SchofieldPR,LiuJJ,SuB,*MooDSConsortium.Meta-analysisandbrainimagingdatasupporttheinvolvementofVRK2(rs2312147)inschizophreniasusceptibility.SchizophreniaResearch2012;142:200-205.

17.LiM,LuoXJ,XiaoX,ShiL,LiuXY,YinLD,DiaoHB,SuB.*AllelicdifferencesbetweenHanChineseandEuropeansforfunctionalvariantsinZNF804Aandtheirassociationwithschizophrenia.TheAmericanJournalofPsychiatry2011;168:1318-1325.

18.LiM,#LuoXJ,ZhangX,YangZH,XiangK,XiaoX,SuB,*ZhaoYL,#ShenY,XuQ,*ChenXN,ChenJC,LiuXY,YinLD,MaXY,YangSY,YuJ,DiaoHB,ShiXD.Acommonvariantofthecardiomyopathyassociated5gene(CMYA5)isassociatedwithschizophreniainChinesepopulation.SchizophreniaResearch2011;129:217-219.

19.LiM,#MoY,#LuoXJ,#XiaoX,#ShiL,PengYM,QiXB,LiuXY,YinLD,DiaoHB,SuB.*GeneticassociationandidentificationofafunctionalSNPatGSK3betaforschizophreniasusceptibility.SchizophreniaResearch2011;133:165-171.