焦保卫
研究员
个人简介
简历
2013.04—中国科学院昆明动物研究所研究员
2008.10—2013.04马萨诸塞大学医学院博士后
2007.05—2008.10香港中文大学中医学院任研究助理
2003.09—2007.03香港中文大学生化系环境科学哲学博士
2000.09—2003.07西南大学生命科学学院动物学专业理学硕士 1996.09—2000.07西南大学生命科学学院理学学士
承担科研项目
2013国家自然科学基金面上项目
2014中国科学院先导专项课题
云南省高端科技人才引进项目
2016干细胞及转化研究国家重点研发计划项目
2018国家自然科学基金-云南联合基金
研究领域
乳腺发育、乳腺癌、乳腺(癌)干细胞
学术兼职
云南省细胞生物学学会第五届理事会秘书长
近期论文
1.WangS#,KeH#,ZhangH,MaY,AoL,ZouL,YangQ,ZhuH,NieJ*,WuC*,JiaoB*.LncRNAMIR100HGpromotescellproliferationintriple-negativebreastcancerthroughtriplexformationwithp27loci.CellDeathandDisease.2018Jul24;9(8):805.
2.ChenW#,WangH#,ChengM#,NiL,ZouL,YangQ,CaiX*,JiaoB*.Isoharringtonineinhibitsbreastcancerstem-likepropertiesandSTAT3signaling.Biomedicine&Pharmacotherapy.2018Jul103:435-442.
3.KeH#,ZhaoL#,ZhangH#,FengX,XuH,HaoJ,WangS,YangQ,ZouL,SuX,WangL,WuC,WangY,NieJ,JiaoB*.LossofTDP43inhibitsprogressionoftriple-negativebreastcancerincoordinationwithSRSF3.ProceedingsoftheNationalAcademyofSciencesofUSA.http://www.pnas.org/content/early/2018/03/21/1714573115
4.ZhangH#,YangX#,FengX,XuH,YangQ,ZouL,YanM,LiuD,SuX,JiaoB*.Chromosome-widegenedosagerebalancemaybenefittumorprogression.MolecularGeneticsandGenomics.2018Mar15.https://link.springer.com/article/10.1007/s00438-018-1429-2
5.LvC,LiF,LiX,TianY,ZhangY,ShengX,SongY,MengQ,YuanS,LuanL,AndlT,FengX,JiaoB,XuM,PlikusMV,DaiX,LengnerC,CuiW,RenF,ShuaiJ,MillarSE,YuZ*.MiR-31promotesmammarystemcellexpansionandbreasttumorigenesisbysuppressingWntsignalingantagonists.NatureCommunications.2017,8(1):1036.doi:10.1038/s41467-017-01059-5.
6.YangX#,WangH*,JiaoB*.Mammaryglandstemcellsandtheirapplicationinbreastcancer.Oncotarget.2017;8(6):10675-91.
7.KeH#,ZhaoL#,FengX,XuH,ZouL,YangQ,SuX,PengL,JiaoB*.NEAT1isrequiredforsurvivalofbreastcancercellsthroughFUSandmiR-548.GeneRegulationandSystemsBiology,2016,10(Suppl1):11-7.
8.WuY#,FengX#,GaoL*,JiaoB*.Imprintedgenes:importantregulatorsindevelopment.Hereditas(Beijing).2016,38(6):508-522.
9.ShinJ,WallingfordMC,GallantJ,MarchoC,JiaoB,ByronM,BossenzM,LawrenceJB,JonesS,MagerJ,BachI*.2013.Rnf12/RLIMisdispensableforXchromosomeinactivationinthemouseembryonicepiblast.Nature,2014,511(7507):86-9.
10.JiaoB#,Taniguchi-IshigakiN#,Güng?rC#,PetersMA,ChenYW,RiethdorfS,DrungA,AhronianLG,ShinJ,PagnisR,PantelK,TachibanaT,LewisBC,JohnsenSA#*,BachI*.2013.Nucleo-cytoplasmicshuttlingregulatesfunctionalactivityofRnf12/RLIM.MolecularBiologyoftheCell,24(19):3085-96.
11.JiaoB,MaH,ShokhirevM,DrungA,YangQ,ShinJ,LuS,ByronM,KalantryS,MercurioAM,LawrenceJB,HoffmannA,BachIhttp://10.20.40.10/wcm/app/editor/editor/images/spacer.gif*.2012.http://10.20.40.10/wcm/app/editor/editor/images/spacer.gifPaternalRLIM/Rnf12isasurvivalfactorformilk-producingalveolarcells.Cell,149:630-41.
12.ShinJ,BossenzM,ChungY,MaH,ByronM,Taniguchi-IshigakiN,ZhuX,JiaoB,HallLL,GreenMR,JonesSN,Hermans-BorgmeyerI,LawrenceJB,BachI*.2010.http://10.20.40.10/wcm/app/editor/editor/images/spacer.gifMaternalRnf12/RLIMisrequiredforimprintedX-chromosomeinactivationinmice.Nature,467:977-81.
13.LinZX*,JiaoB,CheCT,ZuoZ,MokCF,ZhaoM,HoWK,TseWP,LamKY,FanRQ,YangZJ,ChengCH*.2010.EthylacetatefractionoftherootofRubiacordifoliaL.inhibitskeratinocyteproliferationinvitroandpromoteskeratinocytedifferentiationinvivo:potentialapplicationforpsoriasistreatment.PhytotherapyResearch,24:1056-64.
14.JiaoB,YeungEKC,ChanCB,ChengCHK*.2008.Establishmentofatransgenicyeastscreeningsystemforestrogenicityandidentificationoftheanti-estrogenicactivityofmalachitegreen.JournalofCellularBiochemistry,105:1399-409.
15.JiaoB,ChengCHK*.2010.DisruptingactionsofbisphenolAandmalachitegreenongrowthhormonereceptorgeneexpressionandsignaltransductioninseabream.FishPhysiologyandBiochemistry,36:251-61.
16.WangDS#*,JiaoB#,HuC,HuangX,LiuZ,ChengCHK*.2008.Discoveryofagonad-specificIGFsubtypeinteleost,BiochemicalandBiophysicalResearchCommunications,367,336-41.
17.HuangX#,JiaoB#,FungKK#,ZhangY#,ChanCB,LinH,WangDS,ChengCHK*.2007.Thepresenceoftwodistinctprolactinreceptorswithdifferentsignalpathwaysandconstructiveexpressionpatternunderthestimulationofsteroidhormonesinteleost.JournalofEndocrinology,194,373-92.
18.LiuZ#,WuF#,JiaoB#,ZhangX,HuC,HuangB,ZhouL,HuangX,WangZ,ZhangY,NagahamaY,ChengCHK*,WangDS*.2007.MolecularcloningofDmrt1,Foxl2andCyp19inSoutherncatfishandtheirpossiblerolesinsexdifferentiation.JournalofEndocrinology,194,223-41.
19.JiaoB#,HuangX#,ChanCB#,ZhangL#,WangDS#,ChengCHK*.2006.Theco-existenceoftwogrowthhormonereceptorsinteleostfishandtheirdifferentialsignaltransduction,tissuedistributionandhormonalregulationofexpressioninseabream.JournalofMolecularEndocrinology,36,23-40.