游剑 照片

游剑

教授 博导

所属大学: 浙江大学

所属学院: 药学院

邮箱:
youjiandoc@zju.edu.cn

个人主页:
http://www.cps.zju.edu.cn/index.php?c=index&a=jzyg_detail&id=215&web=chinese

个人简介

2013~现在,浙江大学,教授,博士生导师 2007~2013,浙江大学,副教授 2008~2011,美国University of Texas M.D. Anderson Cancer Center 2005~2007,浙江大学,师资博士后 2000~2005,沈阳药科大学,药学博士

研究领域

1)高端药物制剂基础研究:揭示药物制剂体内作用机制、生物学行为、药效评价等 纳米药物及其给药系统 缓控式制剂 长效微球制剂 2)药物制剂的临床转化应用研究 探索药物制剂从基础研究到产业化的关键核心技术,尤其是纳米药物的临床转化 3)药物靶向治疗的设计与应用 研究药物靶向治疗的合理化设计和机理机制探索 4)癌症免疫治疗研究 采用药物制剂手段实现癌症的免疫治疗优化,以及实现多重治疗的结合 5)癌症光热治疗 以金纳米材料为基础的肿瘤显影技术研究,药物传递研究和靶向肿瘤的光热治疗研究

近期论文

1. Xiaomeng Guo, Jiaxin Qu, Wei Li, Lihua Luo, Chunqi Zhu, Jie Yang, Xiaoyi Yin, Qingpo Li, Yongzhong Du, Dawei Chen, Jian You*. Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy. Drug Delivery, 2018, 25. 585-599. (IF: 6.402) 2. Lihua Luo, Chunqi Zhu, Jie Yang, XiaomengGuo, Wei Li, Xiaoyi Yin, Mengshi Jiang, Bing Qin, Xiaoling Yuan, Hang Yin, Qingpo Li, Yongzhong Du, Jian You*, Sustained Release of Anti-PD-1 Peptide for Perdurable Immunotherapy Together with Photothermal Ablation against Primary and Distant Tumors. J Control Release, 2018 In press.(IF: 7.786) 3. Chunqi Zhu, Hanbo Zhang, Wei Li, Lihua Luo, Xiaomeng Guo, Zuhua Wang, Fenfen Kong, Qingpo Li, Jie Yang, Yongzhong Du, Jian You*. Suppress orthotopic colon cancer and its metastasis through exact targeting and highly selective drug release by a smart nanomicelle. Biomaterials, 2018, 161, 144-153.(IF: 8.402) 4. Wei Li, Wanqing Hou, Xiaomeng Guo, Lihua Luo, Qingpo Li, Chunqi Zhu, Jie Yang, Jiang Zhu, Yongzhong Du, Jian You. A temperature-controlled and phase-transition ultrasound imaging-guided photothermal-chemotherapy triggered by NIR light. Theranostics, 2018, In press. (IF=8.766) 5. Qingpo Li, Wei Li, Haixiao Di, Lihua Luo, Chunqi Zhu, Jie Yang, Xiaoyi Yin, Hang yin, Jianqing Gao, Yongzhong Du, Jian You*. A photosensitive liposome with NIR light triggered doxorubicin release as a combined photodynamic-chemo therapy system. J Control Release, 2018, 277, 114-125. (IF=7.786)