汤谷平 照片

汤谷平

教授 博导

所属大学: 浙江大学

所属学院: 化学系

邮箱:
tangguping@zju.edu.cn

个人主页:
https://person.zju.edu.cn/0087491

个人简介

1984年毕业于厦门大学海洋系,获学士学位 1993年毕业于浙江医科大学药学系,获硕士学位 2001年毕业于浙江大学高分子系,获博士学位 2001.7-2004.7在新加坡材料研究和工程研究所(IMRE)进行博士后研究工作,后在新加坡生物工程和纳米技术研究所(IBN)研究员 2006.9-2008.4在香港大学化学系分子生物研究所做访问学者 2010.7-2010.10在德国Rostock大学心脏外科研究所做访问学者 2011.7-2011.10在香港城市大学等离子生物材料研究所高级访问学者 2012.7-2012.10在香港城市大学等离子生物材料研究所高级访问学者 2013.7-2013.10在香港城市大学等离子生物材料研究所高级访问学者 2014.7-2014.10在香港城市大学等离子生物材料研究所高级访问学者 2015.7-2015.10在香港城市大学等离子生物材料研究所高级访问学者 2016.7-2016.10在香港城市大学等离子生物材料研究所高级访问学者

研究领域

生物材料 药物的控制释放 基因药物输送

近期论文

Liu K, Zhou X, Xu Z, et al. Anhydrates and hemihydrate of tasimelteon: Synthesis, structure, and pharmacokinetic study[J]. Journal of pharmaceutical and biomedical analysis, 2018, 151: 235-243. Li, Yang, et al. "Reactive oxygen species (ROS)-responsive nanomedicine for RNAi-based cancer therapy." Nanoscale,2018, 10, 203-2142.gif Wu, Dan, et al. "Supramolecular Nanomedicine Constructed from Curcurbit [8] uril-Based Amphiphilic Brush Copolymer for Cancer Therapy." ACS applied materials & interfaces 2017, 9 (51), 44392–44401. Wang, Hebin, et al. "A Cooperative Dimensional Strategy for Enhanced Nucleus‐Targeted Delivery of Anticancer Drugs." Advanced Functional Materials Bai, H., Wu, M., Zhang, H., & Tang, G. (2017). Chronic polycyclic aromatic hydrocarbon exposure causes DNA damage and genomic instability in lung epithelial cells. Oncotarget, 8(45), 79034-79045 Jin, W.; Wang, Q.; Wu, M.; Li, Y.; Tang, G.; Ping, Y.; Chu, P. K., Lanthanide-integrated supramolecular polymeric nanoassembly with multiple regulation characteristics for multidrug-resistant cancer therapy. Biomaterials 2017, 129, 83-97. M, W.; X, L.; W, J.; Y, L.; Q, H.; PK, C.; G, T.; Y, P., Targeting ETS1 with RNAi-based supramolecular nanoassemblies for multidrug-resistant breast cancer therapy. J. Control. Release 2017, 253:110-121 Wang, H.; Li, Y.; Zhang, M.; Wu, D.; Shen, Y.; Tang, G.; Ping, Y., Redox-Activatable ATP-Depleting Micelles with Dual Modulation Characteristics for Multidrug-Resistant Cancer Therapy. Adv. Healthc. Mater. DOI: 10.1002/adhm.201601293 Liu, X.; Wu, M.; Hu, Q.; Bai, H.; Zhang, S.; Shen, Y.; Tang, G.; Ping, Y., Redox-Activated Light-Up Nanomicelle for Precise Imaging-Guided Cancer Therapy and Real-Time Pharmacokinetic Monitoring. ACS nano 2016,10(12): 11385-11396. Bai, H.; Zhou, J.; Zhang, H.; Tang, G., Enhanced adsorbability and photocatalytic activity of TiO2-graphene composite for polycyclic aromatic hydrocarbons removal in aqueous phase. Colloids and surfaces. B, Biointerfaces 2017, 150, 68-77. Li, Y.; Wang, H.; Wang, K.; Hu, Q.; Yao, Q.; Shen, Y.; Yu, G.; Tang, G., Targeted Co-delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer.Small 2016, DOI: 10.1002/smll.201602697. Ping, Y.; Hu, X.; Yao, Q.; Hu, Q.; Amini, S.; Miserez, A.; Tang, G., Engineering bioinspired bacteria-adhesive clay nanoparticles with a membrane-disruptive property for the treatment of Helicobacter pylori infection. Nanoscale 2016, 8 (36), 16486-98. Hu, Q.; Wang, K.; Sun, X.; Li, Y.; Fu, Q.; Liang, T.; Tang, G., A redox-sensitive, oligopeptide-guided, self-assembling, and efficiency-enhanced (ROSE) system for functional delivery of microRNA therapeutics for treatment of hepatocellular carcinoma. Biomaterials 2016, 104, 192-200. Wu, D.; Shao, L.; Li, Y.; Hu, Q.; Huang, F.; Yu, G.; Tang, G., A boron difluoride dye showing the aggregation-induced emission feature and high sensitivity to intra- and extra-cellular pH changes. Chem. Commun. 2015.541-544. Wang, K.; Hu, Q.; Zhu, W.; Zhao, M.; Ping, Y.; Tang, G., Structure-Invertible Nanoparticles for Triggered Co-Delivery of Nucleic Acids and Hydrophobic Drugs for Combination Cancer Therapy. Adv. Funct. Mater. 2015, 25 (22), 3380-3392. Hu, Q. L.; Wu, M.; Fang, C.; Cheng, C. Y.; Zhao, M. M.; Fang, W. H.; Chu, P. K.; Ping, Y.; Tang, G. P., Engineering Nanoparticle-Coated Bacteria as Oral DNA Vaccines for Cancer Immunotherapy. Nano Lett. 2015, 15 (4), 2732-2739. Wang, Q. W.; Jin, W. H.; Wu, G. S.; Zhao, Y.; Jin, X.; Hu, X. R.; Zhou, J.; Tang, G. P.; Chu, P. K., Rare-earth-incorporated polymeric vector for enhanced gene delivery. Biomaterials 2014, 35 (1), 479-488. Shen, J.; Wang, Q.; Hu, Q.; Li, Y.; Tang, G.; Chu, P. K., Restoration of chemosensitivity by multifunctional micelles mediated by P-gp siRNA to reverse MDR. Biomaterials 2014, 35 (30), 8621-34. Li, D.; Li, Y. B.; Xing, H. B.; Guo, J. L.; Ping, Y.; Tang, G. P., Synergistic Enhancement of Lung Cancer Therapy Through Nanocarrier-Mediated Sequential Delivery of Superantigen and Tyrosin Kinase Inhibitor. Adv. Funct. Mater. 2014, 24 (35), 5482-5492. Jin, X.; Hu, X.; Wang, Q.; Wang, K.; Yao, Q.; Tang, G.; Chu, P. K., Multifunctional cationic polymer decorated and drug intercalated layered silicate (NLS) for early gastric cancer prevention. Biomaterials 2014, 35 (10), 3298-308. Hu, Q. D.; Tang, G. P.; Chu, P. K., Cyclodextrin-based host-guest supramolecular nanoparticles for delivery: from design to applications. Acc. Chem. Res. 2014, 47 (7), 2017-25. Shen, J.; Zhao, D. J.; Li, W.; Hu, Q. L.; Wang, Q. W.; Xu, F. J.; Tang, G. P., A polyethylenimine-mimetic biodegradable polycation gene vector and the effect of amine composition in transfection efficiency. Biomaterials 2013, 34 (18), 4520-31. Ping, Y.; Hu, Q.; Tang, G.; Li, J., FGFR-targeted gene delivery mediated by supramolecular assembly between beta-cyclodextrin-crosslinked PEI and redox-sensitive PEG. Biomaterials 2013, 34 (27), 6482-94. Hu, Q. L.; Jiang, Q. Y.; Jin, X.; Shen, J.; Wang, K.; Li, Y. B.; Xu, F. J.; Tang, G. P.; Li, Z. H., Cationic microRNA-delivering nanovectors with bifunctional peptides for efficient treatment of PANC-1 xenograft model. Biomaterials 2013, 34 (9), 2265-76. Wang, J. L.; Tang, G. P.; Shen, J.; Hu, Q. L.; Xu, F. J.; Wang, Q. Q.; Li, Z. H.; Yang, W. T., A gene nanocomplex conjugated with monoclonal antibodies for targeted therapy of hepatocellular carcinoma. Biomaterials 2012, 33 (18), 4597-607. Liu, M.; Li, Z. H.; Xu, F. J.; Lai, L. H.; Wang, Q. Q.; Tang, G. P.; Yang, W. T., An oligopeptide ligand-mediated therapeutic gene nanocomplex for liver cancer-targeted therapy. Biomaterials 2012, 33 (7), 2240-50. Hu, Q.; Wang, J.; Shen, J.; Liu, M.; Jin, X.; Tang, G.; Chu, P. K., Intracellular pathways and nuclear localization signal peptide-mediated gene transfection by cationic polymeric nanovectors. Biomaterials 2012, 33 (4), 1135-45. Hu, Q.; Li, W.; Hu, X.; Shen, J.; Jin, X.; Zhou, J.; Tang, G.; Chu, P. K., Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly. Biomaterials 2012, 33 (27), 6580-91. Fan, H.; Hu, Q. D.; Xu, F. J.; Liang, W. Q.; Tang, G. P.; Yang, W. T., In vivo treatment of tumors using host-guest conjugated nanoparticles functionalized with doxorubicin and therapeutic gene pTRAIL. Biomaterials 2012, 33 (5), 1428-36. Lu, X.; Wang, Q. Q.; Xu, F. J.; Tang, G. P.; Yang, W. T., A cationic prodrug/therapeutic gene nanocomplex for the synergistic treatment of tumors. Biomaterials 2011, 32 (21), 4849-56. Jiang, Q. Y.; Lai, L. H.; Shen, J.; Wang, Q. Q.; Xu, F. J.; Tang, G. P., Gene delivery to tumor cells by cationic polymeric nanovectors coupled to folic acid and the cell-penetrating peptide octaarginine. Biomaterials 2011, 32 (29), 7253-62.