2023/08-至今，浙江大学物理学院长聘副教授 浙江大学物理高等研究院 2017.08-2023.07，南京大学，物理学院，副研究员 2015.03-2016.09，University of British Columbia，化学系，联合培养博士 2013.09-2017.06，天津大学，精仪学院，仪器科学与技术，博士 2010.09-2013.06，天津大学，精仪学院，仪器仪表工程，硕士 2006.09-2010.06，南开大学，物理学院，光信息科学与技术，学士

单分子生物物理，软物质物理，生物力学，微纳技术与测量

Fenghou Yuan, Huitang Qi, Binghui Song, Yuntian Cui, Junsheng Zhang, Huan Liu, Bo Liu, Hai Lei* and Tian Liu*. Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues. Nat. Commun., 2025, 16, 1081. Haoyu Song, Jian Cui, Guorong Hu, Long Xiong, Yanee Wutthinitikornkit, Hai Lei* and Jingyuan Li*. Scale-free spatio-temporal correlations in conformational fluctuations of intrinsically disordered proteins. Adv. Sci., 2025, 2412989. Xiaoyu Huang, Luofei Li, Haoqi Zhu, Tiancheng Lv, Lei Tang, Zhexian Shentu, Haoyue Li, Tian Gao, Kai Zhang, Juntao Hu, Wei Wang, Bin Xue, Hai Lei*, Yi Cao*. Designing High-Damping, Optically Clear Ionogels through Competitive Binding for Flexible and Impact-Resistant Applications. ACS Appl. Mater. Interfaces, 2025, 17, 9830-9840. Feng Xu, Shuxiang Zhang, Linjie Ma, Yong Hou, Jie Li, Andrej Denisenko, Zifu Li, Joachim Spatz, Jorg Wrachtrup, Hai Lei, Yi Cao, Qiang Wei, Zhiqin Chu. Quantum-enhanced diamond molecular tension microscopy for quantifying cellular forces. Sci. Adv. 2024, 10, eadi5300. Liang Dong, Luofei Li, Huiyan Chen, Yi Cao*, Hai Lei*,. Mechanochemistry: Fundamental Principles and Applications. Adv. Sci. 2024, 2403949. Zhengyu Xu, Jiajun Lu, Di Lu, Yiran Li, Hai Lei, Bin Chen, Wenfei Li, Bin Xue*, Yi Cao*, Wei Wang*. Rapidly damping hydrogels engineered through molecular friction. Nat. Commun., 2024, 15,4895. Chen Huiyan, Li Luofei, Wang Wei, Yi Cao*, Lei Hai*. Regulation of mechanical force on cardiomyocytes beating. Acta Physica Sinica, 2024, 73(8). Huiyan Chen, Shouhan Wang, Yi Cao*, Hai Lei*. Molecular force sensors for Biological Application. Int. J. Mol. Sci., 2024, 25(11). Hai Lei, Quan Ma, Zhangxia Wang, Di Zhang, Xiaoyu Huang, Meng Qin, Haibo Ma*, Wei Wang* and Yi Cao*. Ester Bond: Chemically Labile Yet Mechanically Stable. ACS Nano, 2023, DOI: 10.1021/acsnano.3c03807. Di Zhang, Luofei Li, Yizhou Fang, Quan Ma, Yi Cao* and Hai Lei*. Ester Bonds for Modulation of the Mechanical Properties of Protein Hydrogels, Int. J. Mol. Sci. 2023, 24 (13) Weishuai Di, Kai Xue, Jun Cai, Zhenshu Zhu, Zihan Li, Hui Fu, Hai Lei, Wenbing Hu, Chun Tang*, Wei Wang* and Yi Cao*. Single-molecule force spectroscopy reveals cation-pi interactions in aqueous media are highly affected by cation dehydration. Phy. Rev. Lett. 2023, 130, 118101 Luofei Li, Hai Lei*, Yi Cao*. Fatigue-resistant hydrogels. Chem. Res. Chinese Universities. 2023, s40242-023-3250-7. Wenxu Sun, Xiang Gao, Hai Lei*, Wei Wang*, Yi Cao*. Biophysical approaches for applying and measuring biological forces. Adv. Sci. 2022, 9, 2105254. Hai Lei, Junsheng Zhang, Ying Li*, Xin Wang, Meng Qin, Wei Wang* and Yi Cao*. Histidine-specific bioconjugation for single-molecule force spectroscopy. ACS Nano, 2022, 16, 9, 15440-15449 Guangxiao He, Hai Lei, Wenxu Sun, Jie Gu, Wenting Yu, Di Zhang, Huiyan Chen, Ying Li, Meng Qin, Bin Xue*, Wei Wang* and Yi Cao*. Strong and reversible covalent double network hydrogel based on force-coupled enzymatic reactions. Angew. Chem. Int. Ed. 2022, 61, e202201765 Yueying Han, Yi Cao* and Hai Lei*. Dynamic covalent hydrogels: strong yet dynamic. Gels, 2022, 8 (9), 577 Quan Ma, Hai Lei* and Yi Cao*. Intramolecular covalent bonds in Gram-positive bacterial surface proteins. ChemBioChem, 2022, 3, e2022003 Dongdong Wu, Hai Lei, Xian Xie, Liang Zhou, Peng Zheng, Yi Cao* and Yan Zhang*. Self-sorting double network hydrogels with photodifinable biochemical cues as artificial synthetic extracellular matrix. Nano Res., 2022, 15, 4294-4301 Junsheng Zhang, Hai Lei*, Meng Qin and Yi Cao. Quantifying cation-pi interactions in marine adhesive proteins using single-molecule force spectroscopy. Supramolecular Materials, 2022, 1, 100005 Bin Wen, Weiwei Zhang, Yangyang Zhang, Hai Lei, Yi Cao, Wenfei Li* and Wei Wang*. Self-effected allosteric coupling and cooperativity in hypoxic response regulation with disordered proteins. J. Phys. Chem. Lett., 2022, 13, 39, 9201-9209 Hai Lei, Quan Ma, Wenfei Li, Jing Wen, Haibo Ma, Meng Qin, Wei Wang and Yi Cao*. An ester bond underlies the mechanical strength of a pathogen surface protein. Nat. Commun., 2021, 12, 5082 Junsheng Zhang, Siu Hong Dexter Wong, Xin Wu, Hai Lei, Meng Qin, Peng Shi, Wei Wang*, Liming Bian* and Yi Cao*. Engineering photoresponsive ligand tethers for mechanical regulation of stem cells. Adv. Mater. 2021, 33, 2105765 Tiankuo Wang, Yu Zhang, Zichen Gu, Wei Cheng, Hai Lei, Meng Qin, Bin Xue*, Wei Wang*, Yi Cao*. Regulating mechanical properties of polymer-supramolecular double-network hydrogel by supramolecular self-assembling structures. Chin. J. Chem. 2021, 39, 2711-2717 Hai Lei, Liang Dong, Ying Li, Junsheng Zhang, Huiyan Chen, Junhua Wu, Yu Zhang, Qiyang Fan, Bin Xue, Meng Qin, Bin Chen, Yi Cao and Wei Wang. Stretchable hydrogels with low hysteresis and anti-fatigue fracture based on polyprotein cross-linkers. Nat. Commun. 2020, 11, 1032 Wenmao Huang, Xin Wu, Xiang Gao, Yifei Yu, Hai Lei, Zhenshu Zhu, Yi Shi, Yulan Chen, Meng Qin, Wei Wang* and Yi Cao*. Maleimide-thiol adducts stabilized through stretching. Nat. Chem. 2019, 11, 310-319 Weishuai Di, Xiang Gao, Wenmao Huang, Yang Sun, Hai Lei, Yang Liu, Wenfei Li, Yiran Li, Xin Wang, Meng Qin, Zhenshu Zhu*, Yi Cao* and Wei Wang*. Direct measuring of length scale dependence of the hydrophobic free energy of a single collapsed polymer nanosphere. Phy. Rev. Lett. 2019, 122, 047801 Bin Xue, Lishan Zhao, Xuehua Qin, Meng Qin, Jiancheng Lai, Wenmao Huang, Hai Lei, Jianjun Wang*, Wei Wang*, Ying Li* and Yi Cao. Bioinspired ice growth inhibitors based on self-assembling peptides. ACS Macro. Lett. 2019, 8, 10, 1383-1390 Li. kou, Lei. Jin, Hai Lei*, Chunguang Hu, Hongbin Li, Xiaodong Hu, Xiaotang Hu. Real-time parallel 3D multiple particle tracking with single molecule centrifugal force microscopy. Journal of Microscopy, 2019, 273 (3), 178-188