李新，浙江大学药学院教授，博士生导师，长三角智慧绿洲创新中心双聘学者，入选中组部“万人计划”青年拔尖人才，浙江省杰出青年基金获得者，浙江大学求是青年学者，担任中国微循环学会微循环药物研究专业委员会常务委员、中国神经科学学会脑血管功能与疾病分会委员、中国医药生物技术协会药物分析技术分会委员等学术职务。讲授本科生课程《药物波谱解析》《药物化学》《药学化学实验》，曾获“全国高等学校药学类专业青年教师微课教学大赛”二等奖，“第十九届中国药学会-施维雅青年药物化学奖”，“江苏医学科技奖（一等奖）”等奖励。迄今，已在Nature Communications, Journal of the American Chemical Society等期刊发表文章50余篇，授权专利10余项，2项技术正市场推广。

荧光成像技术具有高时空分辨的优势，是揭示生物分子及生化事件动态变化规律必不可少的手段，同时也是药物靶标发现、新药筛选研究中的重要方法。如何实现生物分子的高特异、高灵敏、高对比度成像检测是该领域的重要科学问题。本实验室致力于实时成像分子探针构建及基于分子成像的药物发现研究工作。我们立足基础化学反应性，综合利用药物设计原理、光物理调控理论、光谱分析原理，发展高特异、高灵敏、高对比度光学探针，在多种生命维度中实时成像靶分子的时空变化规律，助力新型疾病诊疗靶标的发现及“点（靶点）线（通路）结合式”药物筛选模型的开发。

2024 A Firm-push-to-open and Light-push-to-lock Strategy for a General Chemical Platform to Develop Activatable Dual-modality NIR-II Probes Lili Shen, Jian Li, Chenglong Wen, Hao Wang, Nian Liu, Xinhui Su, Jianzhong Chen, Xin Li* Science Advances, 2024, 10, eado2037 Deconvoluting Nitric Oxide–protein Interactions with Spatially Resolved Multiplex Imaging Yi Li, Kaijun Pan, Yanan Gao, Jia Li, Yi Zang*, Xin Li* Chemical Science, 2024,15, 6562-6571 An Allysine-Conjugatable Probe for Fluorogenically Imaging Fibrosis Yilian Zhuang, Tao Yin, Jia Li, Yi Zang*, Xin Li* Analytical Chemistry, 2024, 96, 9034–9042 Aldehyde Dehydrogenases as Promising Targets for Treating Toxic Aldehyde-related Diseases Yu Chen, Xin Li* Current Medicinal Chemistry, 2024, 31, 970-994 Photoinduced electron transfer endows fluorogenicity in tetrazine-based near-infrared Labels Tianruo Shen, Xin Li and Xiaogang Liu* Materials Chemistry Frontiers, 2024, 8, 2135–2141 Invited manuscript for the themed collection on "Fluorescence Bioimaging" Organelle-resolved imaging of formaldehyde reveals its spatiotemporal dynamics Lei Zhou, Yuan Pan, Xiaozhuan Li, Tingmin Fan, Xingguang Liang,* and Xin Li* Journal of Material Chemistry B, 2024, in press 2023 1,2,4,5-Tetrazine-tethered Probes for Fluorogenically Imaging Superoxide in Live Cells with Ultrahigh Specificity Xuefeng Jiang, Min Li, YuleWang, ChaoWang, Yingchao Wang,Tianruo Shen, Lili Shen, Xiaogang Liu, Yi Wang*, Xin Li* Nature Communications, 2023, 14, 1401 Multiscale Imaging of Peroxynitrite in Gliomas with a Blood-brain Barrier Permeable Probe Reveals its Potential as a Biomarker and Target for Glioma Treatment Xinyan Wu, Yikai Shen, Shuyu Tan, Xuefeng Jiang, Zihang Chen, Qian Yu, Huaijun Chen, Yilian Zhuang, Hanhai Zeng, Xiongjie Fu, Hang Zhou, Zhangqi Dou, Gao Chen* and Xin Li* Biosensors & Bioelectronics, 2023, 236, 115415 2022 High-fidelity imaging of amyloid-beta deposits with an ultrasensitive fluorescent probe facilitates the early diagnosis and treatment of Alzheimer’s Disease Rongrong Tao, Ning Wang, Tianruo Shen, Yuhang Tan, Yong Ren, Wenjing Wei, Meihua Liao, Davin Tan, Chunzhi Tang, Nenggui Xu, Huan Wang*, Xiaogang Liu*, Xin Li* Theranostics, 2022, 12, 2549-2559 In Situ Imaging of Formaldehyde in Live Mice with High Spatiotemporal Resolution Reveals Aldehyde Dehydrogenase‑2 as a Potential Target for Alzheimer’s Disease Treatment Rongrong Tao, Meihua Liao, Yuxiang Wang, Huan Wang, Yuhang Tan, Siyao Qin, Wenjing Wei, Chunzhi Tang, Xingguang Liang, Yifeng Han, and Xin Li* Analytical Chemistry, 2022, 94, 1308−1317 A Tandemly Activated Fluorescence Probe for Detecting Senescent Cells with Improved Selectivity by Targeting a Biomarker Combination Lei Zhou, Xuan Zhang, Ying Dong, Yuan Pan, Jia Li, Yi Zang*, Xin Li* ACS Sensors, 2022, 7, 1958-1966 Invited manuscript for the special collection on "Responsive Probes and Molecular Bioimaging" Small-Molecule Fluorescent Probes for Detecting HDAC Activity Shuyu Tan and Xin Li* Chemistry - An Asian Journal, 2022, 17, e202200835 Development and Application of Activity-based Fluorescent Probes for High-Throughput Screening Juan Cheng, Xin Li* Current Medicinal Chemistry, 2022, 29, 1739-1756 image.png Unified Total Synthesis of the Limonoid Alkaloids: Strategies for the De Novo Synthesis of Highly Substituted Pyridine Scaffolds Alexander W. Schuppe, Yannan Liu, Elsie Gonzalez-Hurtado, Yizhou Zhao, Xuefeng Jiang, Sebastian Ibarraran, David Huang, Xiaoyuan Wang, Jaehoo Lee, J. Patrick Loria, Vishwa Deep Dixit, Xin Li, Timothy R. Newhouse* Chem, 2022, 8, 2856–2887 image.png A General Method to Develop Highly Environmentally Sensitive Fluorescent Probes and AIEgens Rong Miao, Jing Li, Chao Wang, Xuefeng Jiang, Ying Gao, Xiaoling Liu, Dan Wang, Xin Li, Xiaogang Liu,* and Yu Fang* Advanced Science, 2022, 9, 2104609 image.png Invited contribution Cathepsin B as a target in cancer therapy and imaging Yikai Shen, Xin Li* New Journal of Chemistry, 2022, 46, 19593 image.png Invited manuscript for a Special Issue on “Molecular Sensors and Molecular Logic Gates” Recent Advances of Small-molecule Fluorescent Probes for Detecting Biological Hydrogen Sulfide Lei Zhou, Yu Chen, Baihao Shao, Juan Cheng , Xin Li* Frontiers of Chemical Science and Engineering, 2022, 16, 34–63 image.png 2021 An Inherently Kidney-targeting Near-infrared Fluorophore Based Probe for Early Detection of Acute Kidney Injury Fangqin Wang, Xuefeng Jiang, Huaijiang Xiang, Ning Wang, Yunjing Zhang, Xi Yao, Ping Wang, Hao Pan, Lifang Yu, Yunfeng Cheng, Yongzhou Hu, Weiqiang Lin*, Xin Li* Biosensors & Bioelectronics, 2021, 172, 112756 image.png Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells Rui-Ying Guo, Yu-Tian Zhang, Supphachok Chanmungkalakul, Hao-Ran Guo, Yongzhou Hu, Jia Li, Xiaogang Liu, Yi Zang*, and Xin Li* CCS Chemistry, 2021, 3, 116–128 image.png Invited manuscript for the forum "Biospecies Sensors" Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study Rui-Ying Guo, Han-Min Wang, Xiaowu Dong, Yongzhou Hu, Jia Li, Yi Zang,* and Xin Li* ACS Applied Bio Materials, 2021, 4, 2058−2065 image.png A strategy of de novo design towards first-in-class imaging agents for simultaneously differentiating glioma boundary and grade Feng Yan, Jianfeng Zhuang, Qian Yu, Zhangqi Dou, Xuefeng Jiang, Shuyu Tan, Yifeng Han, Xinyan Wu, Yi Zang, Cong Li, Jia Li, Huaijun Chen, Libin Hu, Xin Li *, and Gao Chen* ACS Sensors, 2021, 6, 3330−3339 image.png Invited manuscript for the topic "Organic Theranostic Agents: Design, Development, and Biomedical Applications" Red-Shift (2-Hydroxyphenyl)-Benzothiazole Emission by Mimicking the Excited-State Intramolecular Proton Transfer Effect Yong Ren, Lei Zhou and Xin Li* Frontiers in Chemistry, 2021, 9, 807433 image.png 2020 Physicochemical-property Guided Design of a Highly Sensitive Probe to Image Nitrosative Stress in the Pathology of Stroke Juan Cheng, Dan Li, Meiling Sun, Yi Wang, Qiao-Qin Xu, Xing-Guang Liang, Yun-Bi Lu, Yongzhou Hu, Feng Han,* Xin Li* Chemical Science, 2020, 11, 281-289 image.png Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection Ying Dong, Xiao-Rong Li, Qi Chen, Rui-Ying Guo, Bi-Xi Tang, Wei-Juan Kan, Wei Zhang, Yongzhou Hu, Jia Li, Yi Zang*, Xin Li* Analytical Chemistry, 2020, 92, 699-702 image.png Sequentially Activated Probe Design Strategy for Analyzing Metabolite Crosstalk in a Biochemical Cascade Juan Cheng, Yong Ren, Yujie Huang, Xiaozhuan Li, Mingzhu Huang, Feng Han, Xingguang Liang,* Xin Li* Analytical Chemistry, 2020, 92, 1, 1409-1415 image.png A fluorogenic Probe for Tracking GSH Flux in Developing Neurons Haichao Zong, Jiayi Peng, Xiao-Rong Li, Meng Liu, Yongzhou Hu, Jia Li, Yi Zang,* Xin Li,* Tony D. James Chemical Communications, 2020, 56, 515 image.png Invited manuscript for the topic "Analysis of Drug or Drug Targets by Molecular Imaging" Selective and Sensitive Fluorescence Imaging Reveals Microenvironment-dependent Behavior of NO Modulators in the Endothelial System Ying Dong, Xiao-Rong Li, Jia Li, Yi Zang*, Xin Li* Journal of Pharmaceutical Analysis, 2020, 10, 466e472 image.png Microenvironment‑triggered Dual‑activation of a Photosensitizer‑fluorophore Conjugate for Tumor Specific Imaging and Photodynamic Therapy Chang Wang, Shengdan Wang, Yuan Wang, Honghai Wu, Kun Bao, Rong Sheng,* Xin Li* Scientific Reports, 2020, 10, 12127 2019 Visualizing Autophagic Flux During Endothelial Injury with a Pathway-Inspired Tandem-Reaction Based Fluorogenic Probe Yu Lei, Wenming Ren, Cheng-Kun Wang, Rong-Rong Tao, Huai-Jiang Xiang, Li-Li Feng, Yin-Ping Gao, Quan Jiang, Xin Li,* Youhong Hu,* Feng Han* Theranostics, 2019, 9, 5672-5680 State-of-the-art: Functional Fluorescent Probes for Bioimaging and Pharmacological Research Lu Lu, Zhou-yue Wu, Xin Li* and Feng Han* Acta Pharmacologica Sinica, 2019, 40, 717-723 GSH Activated Biotin-tagged Near-Infrared Probe for Efficient Cancer Imaging Ruiying Guo, Feng Huang, Bo Zhang, Youyou Yan, Jinxin Che, Yizhen Jin, Yuxin Zhuang, Rong Dong, Yangling Li, Biqin Tan, Rui Song, Yongzhou Hu, Xiaowu Dong,* Xin Li,* Theranostics, 2019, 9, 3515-3525 Rational Design of the Benzothiazole-based Fluorescent Scaffold for Tunable Emission Yong Ren, Dong Fan, Huazhou Ying, Xin Li* Tetrahedron Letters, 2019, 60, 1060-1065 2018 Bis-reaction-trigger as a Strategy to Improve the Selectivity of Fluorescent Probes Dan Li, Juan Cheng, Cheng-Kun Wang, Huazhou Ying, Yongzhou Hu, Feng Han* and Xin Li* Chemical Communications, 2018, 54, 8170-8173 A Fluorescent Peptidyl Substrate for Visualizing Peptidyl-prolyl Cis/trans Isomerase Activity in Live Cells Quan Jiang, Xiao-Rong Li, Cheng-Kun Wang, Juan Cheng, Chao Tan, Tian-Tian Cui, Nan-Nan Lu, Tony D. James, Feng Han* and Xin Li* Chemical Communications, 2018, 54, 1857-1860 Conformational Restraint as a Strategy for Navigating towards Lysosomes Xing-Guang Liang, Juan Cheng, Siyao Qin, Ling-Xiao Shao, Ming-Zhu Huang, Gang Wang, Yifeng Han, Feng Han* and Xin Li * Chemical Communications, 2018, 54, 12010-12013 2017 An Ultrasensitive Fluorogenic Probe for Revealing the Role of Glutathione in Chemotherapy Resistance Yuejing Jiang, Juan Cheng, Chengyu Yang, Yongzhou Hu, Jia Li, Yifeng Han, Yi Zang* and Xin Li* Chemical Science, 2017, 8, 8012-8018 A H2O2-Responsive Theranostic Probe for Endothelial Injury Imaging and Protection Cheng-Kun Wang, Juan Cheng, Xing-Guang Liang, Chao Tan, Quan Jiang, Yong-Zhou Hu, Ying-Mei Lu, Kohji Fukunaga, Feng Han* and Xin Li* Theranostics, 2017, 7, 3803-3813 A Fluorogenic Probe for Ultrafast and Reversible Detection of Formaldehyde in Neurovascular Tissues Xing-Guang Liang, Bo Chen, Ling-Xiao Shao, Juan Cheng, Ming-Zhu Huang, Yu Chen, Yong-Zhou Hu, Yi-Feng Han, Feng Han* and Xin Li* Theranostics, 2017, 7, 2305-2313 A Fluorogenic Probe for Imaging Protein S-nitrosylation in Live Cells Shiyi Shao, Bo Chen, Juan Cheng, Chengkun Wang, Yanli Zhang, Lingxiao Shao, Yongzhou Hu, Yifeng Han, Feng Han,* Xin Li* Biosensors & Bioelectronics, 2017, 94, 162 _ 2016 Discovery of a Novel Fluorescent Probe for the Sensitive Detection of β-amyloid Deposits Wenming Ren, Mingming Xu, Steven H. Liang, Huaijiang Xiang, Li Tang, Minkui Zhang, Dejun Ding, Xin Li,* HaiyanZhang,* YouhongHu* Biosensors & Bioelectronics, 2016, 75, 136 Development of a Novel H2S and GSH Detection Cocktail for Fluorescence Imaging Juan Cheng, Meng Liu, Baihao Shao, Shuai Zhang, Jia Li, Yongzhou Hu, Xin Li* and Yi Zang* RSC Advances, 2016, 6, 59882 2015 Visualizing Peroxynitrite Fluxes in Endothelial Cells Reveals the Dynamic Progression of Brain Vascular Injury Xin Li, Rong-Rong Tao, Ling-Juan Hong, Juan Cheng, Quan Jiang, Ying-Mei Lu, Mei-Hua Liao, Wei-Feng Ye, Nan-Nan Lu, Feng Han,* Yong-Zhou Hu,* and You-Hong Hu* Journal of the American Chemical Society, 2015, 137, 12296 ONOO.png Mapping Hydrogen Sulfide in Rats with a Novel Azo-based Fluorescent Probe Xin Li,* Juan Cheng, Yanling Gong, Bo Yang, Yongzhou Hu Biosensors & Bioelectronics, 2015, 65, 302 Selective and Sensitive Detection of Hydrogen Sulfide in Live Cells Juan Cheng, Baihao Shao, Shuai Zhang, Yongzhou Hu, Xin Li* RSC Advances, 2015, 5, 65203 2014 A Highly Specific Probe for Sensing Hydrogen Sulfide in Live Cells Based on Copper-Initiated Fluorogen with Aggregation-Induced Emission Characteristics Xin Li, Chengyu Yang, Kai Wu, Yongzhou Hu, Yifeng Han**and Steven H. Liang* Theranostics, 2014, 4, 1233 A Highly Sensitive and Water Soluble Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Living Cells Xin Li,* Yanling Gong, Kai Wu, Steven H. Liang, Ji Cao, Bo Yang, Yongzhou Hu and Yifeng Han* RSC Advances, 2014, 4, 36106 2013-2010 An ICT-based Fluorescent Switch-on Probe for Hydrogen Sulfide in Living Cells Xin Li,* Shuai Zhang, Ji Cao, Nan Xie, Tao Liu, Bo Yang, Qiaojun He and Yongzhou Hu* Chemical Communications, 2013, 49, 8656 A Mechanism-based Fluorescent Probe for Labeling O6-methylguanine-DNA Methyltransferase in Live Cells Xin Li, Shijing Qian, Lin Zheng, Bo Yang, Qiaojun He and Yongzhou Hu* Organic & Biomolecular Chemistry, 2012, 10, 3189 Diversity-oriented Derivatization of BODIPY Based on Regioselective Bromination Xin Li, Shufang Huang and Yongzhou Hu* Organic & Biomolecular Chemistry, 2012, 10, 2369 Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells Xin Li, Shijing Qian, Qiaojun He, Bo Yang, Jia Li, Yongzhou Hu* Organic & Biomolecular Chemistry, 2010, 8, 3627 Identifying the Cellular Targets of Bioactive Small Molecules with Activity-Based Probes Xin Li and Yongzhou Hu* Current Medicinal Chemistry, 2010, 17, 3030 Dependent Work A Tetradentate Ligand for the Enantioselective Ti(IV)-Promoted Oxidation of Sulfides to Sulfoxides: Origin of Enantioselectivity Timothy R. Newhouse, Xin Li, Megan M. Blewett, Clare M. C. Whitehead, and E. J. Corey* Journal of the American Chemical Society, 2012, 134, 17357 An Activity-based Probe Reveals Dynamic Protein-protein Interactions Mediating IGF-1R Transactivation by the GABAB Receptor Xin Lin, Xin Li, Ming Jiang, Linhai Chen, Chanjuan Xu, Wenhua Zhang, Han Zhao, Bing Sun, Xiaoli Xu, Fajun Nan* and Jianfeng Liu* Biochemical Journal, 2012, 443, 627 Design and Synthesis of Biotinylated Troglitazone as an Active Affinity Probe Li Xin, Li Xiaoqi, Tang Hong, Nan Fajun* Chinese Journal of Chemistry, 2010, 28, 2240 Activity-Based Probe for Specific Photoaffinity Labeling γ-Aminobutyric Acid B (GABAB) Receptors on Living Cells: Design, Synthesis, and Biological Evaluation Xin Li, JianHua Cao, Ying Li, Philippe Rondard, Yang Zhang, Ping Yi, JianFeng Liu* and Fajun Nan* Journal of Medicinal Chemistry, 2008, 51, 3057 Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor Xiaoqi Li, Xuanming Yang, Youli Xu, Xuejun Jiang, Xin Li, Fajun Nan, Hong Tang* Cell Research, 2009, 19, 720 New Sesquiterpenes from Erigeron annuus Xin Li, Min Yang, Yi-Feng Han, Kun Gao* Planta Medica, 2005, 71, 268 γ-Pyranone derivatives and other constituents from Erigeron annuus Xin Li, Jing Pan, Kun Gao* Pharmazie, 2006, 61, 474 New Eudesmenes from Erigeron annuus Xin Li, Qiu Hong Wu, Kun Gao* Chinese Chemistry Letters, 2005, 16, 61