2013年7月毕业于中国科学院上海生命科学院神经科学研究所，获博士学位。2013年8月至今，就职于浙江大学医学院神经生物学系，承担教学和科研工作。主要综合运用分子遗传学、分子生物学和细胞生物学手段，以小鼠和果蝇作为模式生物，主要研究神经系统各类细胞的溶酶体新功能，以及神经免疫调节机制。近年来，针对神经系统疾病及细胞极性发生和迁移过程中的机制进行系列研究，承担浙江省杰出青年基金项目、国家自然科学基金及重大项目子课题，参与多项科技部重点研发及基金委重大项目，是美国神经生物学会及中国神经生物学会会员，担任多个SCI杂志的审稿工作。

神经元及胶质细胞溶酶体 小胶质细胞与神经系统疾病 神经元形态发生与神经功能网络形成

发表论文(*: 通讯作者，#：共同第一作者) 1. Yi-Jun Liu#*, Ting Zhang#, Sicong Chen, Daxiao Cheng, Cunjin Wu, Xingyue Wang, Duo Duan, Liya Zhu, Huifang Lou, Zhefeng Gong, Xiao-Dong Wang*, Margaret S Ho*, Shumin Duan. The noncanonical role of the protease cathepsin D as a cofilin phosphatase. Cell Research, 2021, 0 (1): 1-13. 2. Yi-Jun Liu#*, Ting Zhang, Daxiao Cheng, Junhua Yang, Sicong Chen, Xingyue Wang, Xia Li, Duo Duan, Huifang Lou, Liya Zhu, Jianhong Luo, Margaret S Ho*, Xiao-Dong Wang*, Shumin Duan*. Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD. Science Advances, 2020, 6(50). 10.1126/sciadv.aba5783 3. Lunhao Chen, Daxiao Cheng, Jiachen Chu, Ting Zhang, Zhuoer Dong, Huifang Lou, Liya Zhu, Yijun Liu*. A Novel Method to Image Macropinocytosis in Vivo. Front Neurosci. 2018 May 15;12:324. 4. Ting Zhang, Daxiao Cheng, Cunjin Wu, Xingyue Wang, Qiang Ke, Huifang Lou, Liya Zhu, Xiao-Dong Wang, Shumin Duan*, Yi-Jun Liu*. Lysosomal hydrolase cathepsin D non-proteolytically modulates dendritic morphology in Drosophila. Neuroscience Bulletin, 2020, 36(10): 1147-1157. 5. Yi-jun Liu, Da-wen Guo, Li Tian, De-shu Shang, Wei-dong Zhao, Bo Li, Wen-gang Fang, Li Zhu, Yu-hua Chen. Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-a-dependent, Neurobiology of Aging, 2010, 31(2):175-188 6. Chi Wang #, Hui Liu #, Kun Li, Zhen-Zhen Wu, Chen Wu, Jing-Ying Yu, Qian Gong, Ping Fang, Xing-Xing Wang, Shu-Min Duan, Hao Wang, Yan Gu, Ji Hu, Bing-Xing Pan, Mathias Schmidt, Yi-Jun Liu, Xiao-Dong Wang*. Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis. Nature Communications, 2020, 11(1): 0-6045. 7. Yaling Hu, Weihao Mai, Lunhao Chen, Kelei Cao, Bin Zhang, Zhenjie Zhang, Yijun Liu, Huifang Lou, Shumin Duan*, Zhihua Gao*. TOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP. Glia, 2020, 68(5): 1031-1045. 8. Yulan Li#, Lixuan Li#, Jintao Wu, Zhenggang Zhu, Xiang Feng, Liming Qin, Yuwei Zhu, Li Sun, Yijun Liu, Zilong Qiu, Shumin Duan*, Yan-Qin Yu*. Activation of astrocytes in hippocampus decreases fear memory through adenosine A(1) receptors. eLife, 2020, 9. 10.7554/eLife.57155 9. Sijia Hao#, Hongbin Yang#, Xiaomeng Wang, Yang He, Haifeng Xu, Xiaotong Wu, Libiao Pan, Yijun Liu, Huifang Lou, Han Xu, Huan Ma, Wang Xi, Yudong Zhou, Shumin Duan, Hao Wang*. The Lateral Hypothalamic and BNST GABAergic Projections to the Anterior Ventrolateral Periaqueductal Gray Regulate Feeding. Cell Reports, 2019, 28(3): 616-324. 10. Hang-jun Wu, Yi-jun Liu, Hui-quan Li, Cong Chen, Ying Dou, Hui-fang Lou, Margaret S Ho, Xiao-ming Li, Zhihua Gao, Shu-min Duan, Analysis of microglial migration by a micropipette assay, Nature Protocols, 2014, 9(2): 491-500 11. Ji-Tao Li, Xiao-Meng Xie, Jing-Ying Yu, Ya-Xin Sun, Xue-Mei Liao, Xing-Xing Wang, Yun-Ai Su, Yi-Jun Liu, Mathias V. Schmidt, Xiao-Dong Wang, Tian-Mei Si, Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss, Cell Reports, 2017, 21(4):891-900 12. Cong Chen, Hui-Quan Li, Yi-Jun Liu, Zhi-Fei Guo, Hang-Jun Wu, Xia Li, Hui-Fang Lou, Liya Zhu, Di Wang, Xiao-Ming Li, Li Yu, Xue-tao Cao, Lin-rong Lu, Zhi-hua Gao, Shu-Min Duan, A novel size-based sorting mechanism of pinocytic luminal cargoes in microglia, Journal of Neuroscience, 2015, 35(6): 2674-2688 13. Hui-quan Li, Cong Chen, Ying Dou, Hang-jun Wu, Yi-jun Liu, Hui-fang Lou, Jian-min Zhang, Xiao-ming Li, Hao Wang, Shu-min Duan, P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia, Molecular and Cellular Biology, 2013, 33(21): 4282-4293 14. Xin Wang, Bo Li, Wei-dong Zhao, Yi-jun Liu, De-shu Shang, Wen-gang Fang, Yu-hua Chen, Perfluorooctane sulfonate triggers tight junction “opening” in brain endothelial cells via phosphatidylinositol 3-kinase, Biochemical and Biophysical Research Communications, 2011, 410(2): 258-263