教育经历 2002-2007，北京大学，生命科学学院，博士 1998-2002，四川大学，生命科学学院，学士 工作经历 2015-今， 浙江大学，医学院基础医学系，研究员，博士生导师 2010-2015，浙江大学，生命科学研究院，副教授，副博士生导师 2009-2010，美国M.D.安德森癌症医学中心，博士后 2007-2009，美国耶鲁大学，医学院，博士后 主持或参加科研项目及人才计划项目情况 国家自然科学基金面上项目，32270769，主持 科技部重大科学研究计划，2022YFA1302800，骨干 国家自然科学基金面上项目，31970664，主持 科技部重大科学研究计划，2021YFA1101000，骨干 科技部重大科学研究计划，2018YFC1004903，骨干 国家优秀青年科学基金项目，31822031，主持 浙江省杰出青年基金，LR18C070001，主持 国家自然科学基金面上项目，31670818，主持 国家自然科学基金面上项目，31970664，主持 科技部重大科学研究计划，2018YFC1004900，骨干 科技部重大科学研究计划，2013CB945303，结题，骨干 国家自然科学基金面上项目，31171347，结题，主持 科技部重大科学研究计划，2012CB966602，结题，骨干 奖励荣誉 2017年浙江省自然科学奖一等奖 2017年浙江省杰出青年科学基金 2018年国家优秀青年科学基金 2019年浙江大学青年教师教学竞赛二等奖

DNA损伤应答 基因组不稳定性与人类疾病 肿瘤发生的分子机制研究

浙江大学医学院附属第二医院双聘教授

1. Xie, H.#, Song, L.#, Mao, G., Han, J., Pu, J., Wu, Z., Chen, J., Zhou, J, Huang, J.*, Fang, D.*, Liu, T.* (2025) Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2-RAD51. Nat Chem Biol (Online ahead of print) https://www.nature.com/articles/s41589-024-01833-9 2.Song, L.#, Xie, H.#, Fan, H.#, Zhang, Y.#, Cheng, Z.#, Chen, J., Guo, Y., Zhang, S., Zhou, X., Li, Z., Liao, H., Han, J., Huang, J., Zhou, J., Fang, D., Liu, T.* (2025) Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A. Mol Cell (Online ahead of print) https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00989-4 3. Tian, T., Chen J., Zhao, H., Li, Y., Xia, F., Huang, J., Han, J., Liu, T.* (2024) UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells. Nat Chem Biol 20(12):1650-1661 4. Chen, S., Pan, C., Huang, J.*, and Liu, T.* (2024) ATR limits Rad18-mediated PCNA monoubiquitination to preserve replication fork and telomerase-independent telomere stability. EMBO J 43(7):1301-1324 5. Chen, J.#, Wu, M.#, Yang, Y.#, Ruan, C.#, Luo, Y., Song, L., Wu, T., Huang, J., Yang, B., and Liu, T.* (2024) TFIP11 promotes replication fork reversal to preserve genome stability. Nat Commun15, 1262 6. Zhu, X.#, Su, Q.#, Xie, H., Song, L., Yang, F., Zhang, D., Wang, B., Lin, S., Huang, J., Wu, M., and Liu, T.* (2023) SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition. Nat Chem Biol 19, 585-595 7. Wang, X.#, Jiang, X.#, Li, B.#, Zheng, J., Guo, J., Gao, L., Du, M., Weng, X., Li, L., Chen, S., Zhang, J., Fang, L., Liu, T., Wang, L., Liu, W., Neculai, D., and Sun, Q*. (2023) A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy. J Cell Biol 222 8. Huang, H., Ouyang, Q., Mei, K., Liu, T., Sun, Q., Liu, W., and Liu, R*. (2023) Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion. Autophagy 19, 189-203 9. Han, J., Wan, L., Jiang, G., Cao, L., Xia, F., Tian, T., Zhu, X., Wu, M., Huen, M. S. Y., Wang, Y., Liu, T.*, and Huang, J*. (2021) ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP. Proc Natl Acad Sci U S A. 118(12):e2022600118. 10. Wang, J., He, H., Chen, B., Jiang, G., Cao, L., Jiang, H., Zhang, G., Chen, J., Huang, J., Yang, B., Zhou, C., and Liu, T.* (2020) Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation. Nat Commun 11, 786 11. Zhang, Q., Xiao, M., Gu, S., Xu, Y., Liu, T., Li, H., Yu, Y., Qin, L., Zhu, Y., Chen, F., Wang, Y., Ding, C., Wu, H., Ji, H., Chen, Z., Zu, Y., Malkoski, S., Li, Y., Liang, T., Ji, J., Qin, J., Xu, P., Zhao, B., Shen, L., Lin, X., and Feng, X. H.* (2019) ALK phosphorylates SMAD4 on tyrosine to disable TGF-beta tumour suppressor functions. Nat Cell Biol 21, 179-189 12. Cheng, X., Ma, X., Zhu, Q., Song, D., Ding, X., Li, L., Jiang, X., Wang, X., Tian, R., Su, H., Shen, Z., Chen, S., Liu, T., Gong, W., Liu, W., and Sun, Q*. (2019) Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol Cell 73, 788-802 e787 13. He, H., Wang, J., and Liu, T.* (2017) UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair. Cell Rep 20, 2010-2025 14. Han, J., Ruan, C., Huen, M. S. Y., Wang, J., Xie, A., Fu, C., Liu, T., and Huang, J.* (2017) BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability. Nat Commun 8, 1470 15. Lou, J., Chen, H., Han, J., He, H., Huen, M. S. Y., Feng, X. H., Liu, T., and Huang, J.* (2017) AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway. Nat Commun 8, 985 16. Liu, T.#*, Zhao, M.#, Liu, J., He, Z., Zhang, Y., You, H., Huang, J., Lin, X.*, and Feng, X. H*. (2017) Tumor suppressor bromodomain-containing protein 7 cooperates with Smads to promote transforming growth factor-beta responses. Oncogene 36, 362-372 17. Mu, Y., Lou, J., Srivastava, M., Zhao, B., Feng, X. H., Liu, T.*, Chen, J.*, and Huang, J.* (2016) SLFN11 inhibits checkpoint maintenance and homologous recombination repair. EMBO Rep 17, 94-109 18. Wang, G., Yu, Y., Sun, C., Liu, T., Liang, T., Zhan, L., Lin, X., and Feng, X. H. (2016) STAT3 selectively interacts with Smad3 to antagonize TGF-beta signalling. Oncogene 35, 4422 19. Liu, T.#*, and Huang, J.* (2014) Quality control of homologous recombination.Cell Mol Life Sci 71, 3779-3797 20. Dong, S., Han, J., Chen, H., Liu, T., Huen, M. S. Y., Yang, Y., Guo, C., and Huang, J.* (2014) The human SRCAP chromatin remodeling complex promotes DNA-end resection. Curr Biol 24, 2097-2110