个人简介
刘伟,本科毕业于第四军医大学,名古屋大学获博士学位,历经名古屋大学博士后(合作导师 中岛 泉),爱知医科大学药理学系助理教授,美国国家卫生研究院博士后(合作导师 Jennifer Lippincott-Schwartz),2007年受聘浙江大学医学院教授。长期从事细胞生物学研究,目前的主要研究方向是自噬的分子细胞学机制和功能,近年来在自噬启动的信号调控和自噬与肿瘤的发生发展等领域取得系列成果,迄今在Nature, Nat Struct Mol Biol, Mol Cell, J Cell Biol, Autophagy, Hepatology等共发表论文约80篇,被引用超过8000次,先后获得国家自然科学基金重大项目、重点项目和国家重点研发计划项目的资助。目前任浙江大学求是特聘教授,浙江大学国际医学院代谢中心主任,中国细胞生物学会理事和细胞器分会副会长,中国生物物理学会膜生物学分会副会长,JMCB杂志编委和Autophagy杂志副主编。
研究领域
自噬的分子细胞学机制 自噬与代谢性疾病
近期论文
代表性论文 Pu M, Zheng W, Zhang H, Wan W, Chao P, Chen X, Liu X, Xu Z, Zhou T, Sun Q, Neculai D, Liu W. ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover. Protein Cell 202314:653-667. Wan W, Qian C, Wang Q, Li J, Zhang H, Wang L, Pu M, Huang Y, Zhou T, Shen H-M, Liu W. STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy. EMBO J 2023 Apr 17;42(8):e112387 Lu G, Wang L, Zhou J, Liu W, Shen HM. A destiny for degradation: interplay between Culin-Ring E3 ligases and autophagy. Trends Cell Biol 2021 Jun; 31(6):432-444. Shen Q, Shi Y, Liu J, Su H, Huang J, Zhang Y, Peng C, Zhou T, Sun Q, Wan W, Liu W. Acetylation of STX17 (syntaxin 17) controls autophagosome maturation. Autophagy 2021 May; 17(5):1157-1169. Wang Y, Huang Y, Liu J, Zhang J. Xu M, You Z, Peng C, Gong Z, Liu W. Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB. EMBO Rep 2020 Jan 7; 21(1):e48335. You Z, Jiang WX, Qin LY, Gong Z, Wan W, Li J, Zhang H, Peng C, Zhou T, Tang C, Liu W. Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat Commun 2019 Dec 19; 10(1):5792. Cheng X, Max, Zhu Q, Song D, Ding X, Li L, Jiang X, Wang X, Tian R, Su H, Shen Z, Chen S, Liu T, Gong W, Liu W, Sun Q. Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in the regulation of autophagosome maturation and lipid metabolism. Mol Cell 2019 Feb 21; 73(4):788-802. You Z, Xu Y, Wan W, Zhou L, Zhou T, Shi Y, Liu W. TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction. Autophagy 2019 Dec; 15(8):1309-1321. Wan W, You Z, Zhou L, Xu Y, Peng C, Zhou T, Yi C, Shi Y, Liu W. mTORC1-regulated and HUWE1-mediated WIPI2 degradation controls autophagy flux. Mol Cell 2018 Oct 18; 72:303-315. Wan W, You Z, Xu Y, Zhou L, Guan Z, Peng C, Wong CC, Su H, Zhou T, Xia H, Liu W. mTORC1 phosphorylates acetyltransferase p300 to regulate autophagy and lipogenesis. Mol Cell 2017 Oct 19; 68:323-335. Su H, Yang F, Wang T, Shen Q, Huang J, Peng C, Zhang Y, Wan W, Wong CC, Sun Q, Wang F, Zhou T, Liu W. VPS34 acetylation controls its lipid kinase activity and the initiation of canonical and non-canonical autophagy. Mol Cell 2017 Sep 21; 67:907-921. Xu Y, Wan W, Shou X, Huang R, You Z, Shou Y, Wang L Zhou T, Liu W. DOR/TP53INP2, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of polymerase I pre-initiation complex at rDNA promoter. Autophagy 2016 Jul 2; 12:1118-1128. Chang C, Su H, Zhang D, Wang Y, Shen Q, Liu B, Huang R, Zhou T, Peng C, Wong CC, Shen HM, Lippincott-Schwartz J, Liu W. AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation. Mol Cell 2015 Dec 17; 60(6):930-940. Liu B, Fang M, He Z, Cui D, Jia S, Lin X, Xu X, Zhou T, Liu W. Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation. Cell Death Dis 2015 Nov 19;6(11):e1980. Huang R, Xu Y, Qian J, Wan W, Liu B, Chang C, Zhou T, Lippincott-Schwartz J, Liu W. Deacetylation of nuclear LC3 drives autophagy initiation under starvation. Mol Cell 2015 Feb 5; 57(3):456-466.