康利军博士，浙江大学医学院脑科学与脑医学学院，教授；浙江大学医学院附属第四医院，双聘教授。1996年本科毕业于华中师范大学生科院；1996-2000年武汉生物工程学院教师；2006年博士毕业于华中科技大学；随后赴德国Max-Planck生物物理与化学研究所、美国密歇根大学生命科学研究从事博士后研究；2011年作为独立PI加盟浙江大学医学院。 主要研究机体内外环境理化信号感受的生理和病理机制，以及遗传缺陷、衰老等引起的感知觉障碍的药物调控。通讯作者研究论文发表于Neuron（2024，2020，2018）、Nature Aging（2021）、Nature Communications（2018）、Progress in Neurobiology（2023）等国际学术期刊，综述/评论性论文发表于Neuron (2020 Spotlight, 2021 Preview)、Cell Metabolism（2022 Preview）等期刊，其他研究成果发表于Cell、Cell Metabolism、Neuron、Nature Neuroscience、Nature Communications、Nature Structural & Molecular Biology和EMBO J等著名杂志；研究成果被Nature Reviews Neuroscience、Neuron、Faculty of 1000等著名期刊媒体配发评论，被Cell、Nature、Science等国际著名学术期刊广泛引用。 作为课题负责人研究课题有 科技部“科技创新2030-脑科学与类脑研究“重大项目课题、国家重大科学研究计划项目课题、国家高技术研究发展计划（863计划）项目课题、国家自然科学基金面上项目、浙江省自然科学基金杰出青年基金项目和浙江省自然科学基金重点项目等。 个人简介 2020.1-至今 浙江大学医学院脑科学与脑医学系，教授、博导、研究组长（PI） 2022.1-至今 浙江大学医学院附属第四医院脑医学中心，教授（双聘） 2019.6-2021.12 浙江大学医学院附属第一医院神经外科，教授（双聘） 2011.9- 浙江大学基础医学院，研究员/教授、博导、研究组长（PI） 2007-2011 美国密歇根大学，生命科学研究所，博士后 导师 X.Z.Shawn Xu （许献忠）教授 2006-2007 德国Max-Planck生物物理与化学研究所,博士后 2001-2006 华中科技大学，生物物理学，博士 (2003-2006 中科院生物物理研究所) 1996-2000 武汉生物工程学院，助教 1992-1996 华中师范大学，生物学，学士

神经生物学

目前主要从事以下方向的研究 1. 机械敏感通道的基因筛选、分子生物物理特性和药理机制研究，为慢性痛、听觉障碍等疾病的诊断与防治提供特异性分子靶标。 2. 神经胶质细胞--神经元相互作用的分子与环路机制在体研究，及其关键基因在神经精神性疾病中的作用。 3. 环境因素和基因对寿命的调控机制，以及衰老引发神经退行性疾病的神经生物学基础。 拥有膜片钳电生理记录系统、胞内Ca2+荧光成像系统、DNA显微注射与转基因系统、神经近紫外光激光损毁系统等大型设备，并拥有全套基本分子遗传学、细胞和生物化学实验所需常规设备和仪器。

【代表性科研论文】 1) H. Cheng*, D. Che*n, X. Li*, U. Al-Sheikh, D. Duan, Y. Fan, L. Zhu, W. Zeng, Zhitao Hu, X. Tong, G. Zhao, Y. Zhang, W. Zou, S. Duan, L. Kang#. Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging. Neuron. 2024 May 1;112(9):1473-1486. 2）J. Jiang*, W. Zou* , S. Li*, X. Qiu, L. Zhu, L. Kang#, M. Ulrich#. Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities. Neuron. 2024 Jul 3:S0896-6273(24)00448-3. 3）Duo Duan*, Hu Zhang*, Xiaomin Yue*, Yuedan Fan*, Yadan Xue, Jiajie Shao, Gang Ding, Shitian Li, Hankui Cheng, Xiaoyan Zhang, Du Chen, Wenjuan Zou, Jian Zhao, Linmei Wang, Zhiping Wang, Suhong Xu, Shumin Duan#, Lijun Kang#. Sensory glia detect repulsive odorant and drive olfactory adaptation. Neuron. 2020 Nov 25;108(4):707-721. 4）Xiaomin Yue*, Jian Zhao*, Xiao Li*, Yuedan Fan, Duo Duan, Xiaoyan Zhang, Wenjuan Zou, Yi Sheng, Ting Zhang, Qian Yang, Jianhong Luo, Shumin Duan, Rui Xiao#, Lijun Kang#. TMC proteins modulate egg-laying and membrane excitability through a background leak conductance in C. elegans. Neuron. 2018 Feb 7;97(3):571-585. 5) Shujie Chen*, Luyi Chen*, Yadong Qi, Jilei Xu, Qiwei Ge, Yuedan Fan, Du Chen, Yawen Zhang, Lan Wang, Tongyao Hou, Xiaohang Yang, Yongmei Xi, Jianmin Si#, Lijun Kang#, Liangjing Wang#, Bifidobacterium adolescentis improves lifespan and healthspan by regulating catalase activity and oxidative stress-associated metabolites. Nature Aging. 2021 Nov 1; 991-1001. 6) Wenjuan Zou*, Jiajun Fu*, Haining Zhang*, Kang Du, Wenming Huang, Junwei Yu, Shitian Li, Yuedan Fan, Howard A. Baylis, Shangbang Gao, Rui Xiao, Wei Ji#, Lijun Kang# and Tao Xu#. Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron. Nature Communications. 2018 Oct 17;9(1):4311. 7) Umar Al-Sheikh#, Lijun Kang#. Kir2.1 channel: Macrophage plasticity in tumor microenvironment. Cell Metabolism. 2022 Nov 1; 34: 1673-1615. Preview. 8) Umar Al-Sheikh*, Lijun Kang#. Mechanosensation: nAChRs transduce sound signals in earless C. elegans. Neuron. 2021 Nov 17; 109(22): 3539-3541. 9) Umar Al-Sheikh*, Lijun Kang#. Molecular Crux of Hair Cell Mechanotransduction Machinery. Neuron. 2020 Aug 5;107(3):404-406. 10) Shitian Li, Umar Al-Sheikh, Yili Chen#, Lijun Kang#. Nematode homologs of the sour taste receptor Otopetrin1 are evolutionarily conserved acid-sensitive proton channels. Frontiers in Cell and Developmental Biology. 2023, 11:1133890. 11) Du Chen*, Hankui Cheng*, Siyan Liu, Umar Al-Sheikh, Yuedan Fan, Duo Duan, Wenjuan Zou, Linhui Zhu and Lijun Kang#, The Voltage-Gated Calcium Channel EGL-19 Acts on Glia to Drive Olfactory Adaptation. Frontiers in Molecular Neuroscience.2022, 15:907064. 12) Hankui Cheng*#, Umar Al-Sheikh*, Du Chen, Duo Duan, Lijun Kang#, Protocol for glial Ca 2+ imaging in C. elegans following chemical, mechanical, or optogenetic stimulation. STAR Protocols. 2022 Feb 10;3(1):101169. 13) Hankui Cheng*, Yu Liu*, Yadan Xue, Jiajie Shao, Zhibin Tan, Siyan Liu, Shumin Duan, Lijun Kang#. Molecular Strategies for Intensity-dependent Olfactory Processing in C. elegans. Frontiers in Molecular Neuroscience. 2021 Nov 4; 14:748214. 14) Yuedan Fan*, Wenjuan Zou*, Jia Liu*, Umar Al-Sheikh*, Hankui Cheng, Duo Duan, Du Chen, Siyan Liu, Luyi Chen, Jilei Xu, Lijun Kang#. Polymodal functionalities of C. elegans OLL neurons in mechanosensation and thermosensation. Neuroscience Bulletin. 2021 Feb 8. 15) Xiaomin Yue*, Yi Sheng, Lijun Kang#, Rui Xiao#. Distinct functions of TMC channels: a comparative overview. Cellular and Molecular Life Sciences, 2019 October; 1-12. 16) Jiajie Shao*, Xiaoyan Zhang*, Hankui Cheng, Xiaomin Yue, Wenjuan Zou#, Lijun Kang#. Serotonergic neuron ADF modulates avoidance behaviors by inhibiting sensory neurons in C. elegans. European Journal of Physiology ;2018 Sep 11. doi: 10.1007/s00424-018-2202-4. 17) Zhang H*, Yue X*, Cheng H*, Zhang X, Cai Y, Zou W, Huang G, Cheng L, Ye F#, Kang L#. OSM-9 and an amiloride-sensitive channel, but not PKD-2, are involved in mechanosensation in C. elegans male ray neurons. Scientific Reports. 2018 May 8;8(1):7192. 18) Mei Han*, Wenjuan Zou*, Hao Chang*, Yong Yu, Haining Zhang, Shitian Li, Hankui Cheng, Guifeng Wei, Yan Chen, Valerie Reinke, Tao Xu#, Lijun Kang#. A systematic RNAi screen reveals a novel role of a spindle assembly checkpoint protein BuGZ in synaptic transmission in C. elegans. Frontiers in Molecular Neuroscience. 2017 May 11;10:141. doi: 10.3389/fnmol.2017.00141. 19) Wenjuan Zou*, Hankui Cheng*, Shitian Li*, Xiaomin Yue, Yadan Xue, Sixi Chen#, Lijun Kang#. Polymodal Responses in C. elegans Phasmid Neurons Rely on Mulitiple Intracellular and Intercellular Signaling Pathways. Scientific Reports; 2017 Fab 14; 7:42295. 20) Zhou W, Wang J, Wang K, Huang B, Niu L, Li F, Cai F, Chen Y, Liu X, Zhang X, Cheng H, Kang L#, Meng L#, Zheng H#. Ultrasound neuro-modulation chip: activation of sensory neurons in Caenorhabditis elegans by surface acoustic waves. Lab Chip. 2017 May 16;17(10):1725-1731.