靳明亮 照片

靳明亮

研究员

所属大学: 浙江大学

所属学院: 动物科学学院

邮箱:
mljin@zju.edu.cn

个人主页:
https://person.zju.edu.cn/0019179

个人简介

靳明亮,浙江大学计划研究员,博士生导师。国家自然科学基金优秀青年基金获得者,中国畜牧兽医学会动物营养学分会副秘书长,入选全国农业科研杰出人才培养计划及全球前2%顶尖科学家年度科学影响力排行榜,获颐和青年创新奖和中国畜牧兽医学会“第四届井冈新秀”荣誉称号。主要从事肠道微生物与肠道免疫营养调控、免疫调节肽与益生菌等抗生素替代品研发等。主持国家重点研发计划项目、国家自然科学基金、国际科学基金、浙江省自然科学基金重点项目等课题二十余项;以第一或通讯作者在Science Advances、Journal of Advanced Research、Carbohydrate Polymers等期刊发表SCI论文40余篇,发表ESI高被引论文4篇,论文总被引用5700余次,H因子39。以主要参与人获神农中华农业科技一等奖及陕西省科技进步二等奖各1项。 1. 教育经历 2006.09-2011.06 博士研究生,浙江大学,动物营养与饲料科学 2002.09-2006.06 学士,南京农业大学,动物科学 2. 工作经历 2020.08-至今 计划研究员,浙江大学 2019.05-2020.07 特聘研究员,浙江大学 2014.05-2019.04 副教授,西北工业大学 2018.07-2018.08 访问学者,加拿大阿尔伯塔大学 2015.09-2017.02 访问学者,加拿大阿尔伯塔大学 2013.07-2014.04 讲师,西北工业大学 2011.07-2013.06 博士后,西北工业大学 2011.07-2011.08 访问学者,美国密苏里州立大学哥伦比亚分校 参编著作 [1]. 《现代动物分子营养学》,科学出版社,2023,参编。 [2]. 《动物科学专业导论》,中国农业出版社,2023,参编。 [3]. 《生猪养殖替抗指南》,中国农业出版社,2022,参编。 [4]. 《动物分子营养学》,浙江大学出版社,2020,参编。 [5]. 《犬行为、营养与健康》,中国农业科学技术出版社,2024,主译。 [6]. Deehan, E.C., Duar, R.M., Armet, A.M., Perez-Muñoz, M.E., Jin, M., Walter, J. Chapter 20 Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health. Bugs as Drugs Therapeutic Microbes for the Prevention and Treatment of Disease. ASM Press, 2018. [7]. 《人类极端环境生理学》,科学出版社,2017,参译。

研究领域

肠道微生物与免疫

近期论文

[1]. Wang, C., Zhang, Y., Wei, S.Y., Fu, L.L., Wang, Y.Z., & Jin, M.L.* Bioconversion of soybean meal into gut microbiota-targeting polysaccharides via fermentation by Bacillus subtilis. Journal of Cleaner Production. 2024, 142787. [2]. Zong, X., Luo, S.Q., Liu, S.Q., Deehan, E.C., Wang, Y.Z., & Jin, M.L.* Nondigestible carbohydrates and gut microbiota: A dynamic duo in host defense. Animal Nutriomics. 2024, 1, e7. [3]. Xu, B.C., Shaoyong, W.K., Wang, L., Yang, C., Chen, T.J., Jiang, X., Zhang, P., Jin, M.L.*, Wang, Y.Z.* Gut-targeted nanoparticles deliver specifically targeted antimicrobial peptides against Clostridium perfringens infections. Science Advances. 2023, 9(39), eadf8782. [4]. Zong, X., Zhang, H., Zhu, L.Y., Deehan, E.C., Fu, J., Wang, Y.Z., Jin, M.L.* Auricularia auriculapolysaccharides attenuate obesity in mice through gut commensal Papillibacter cinnamivorans. Journal of Advanced Research. 2023, 52, 203-218. [5]. Shaoyong, W.K., Jin, H.L., Jiang, X., Xu, B.C., Liu, Y.L., Wang, Y.Z., Jin, M.L.* Benzo [a] pyrene-loaded aged polystyrene microplastics promote colonic barrier injury via oxidative stress-mediated notch signalling. Journal of Hazardous Materials. 2023, 457, 131820. [6]. Wen, C.Y., Zhang, H., Guo, Q.P., Duan, Y.H., Chen, S.S., Han, M.M., Li, F.N., Jin, M.L.*, Wang, Y.Z.* Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli (ETEC) K88-infected piglet. Journal of Zhejiang University-Science B.2023, 24 (6), 496-509. [7]. He, H., Yang, M.Z., Li, W.T., Lu, Z.Q., Wang, Y.Z., Jin, M.L.* Fecal microbial and metabolic characteristics of swine from birth to market. Frontiers in Microbiology. 2023, 14, 1191392 [8]. Chen, N.N., Liu, Y.L., Zong, X., Zhou, G.L., Lu, Z.Q., Wang, F.Q., Wang, Y.Z., Jin, M.L.* Dynamic changes of inulin utilization associated with longitudinal development of gut microbiota. International Journal of Biological Macromolecules. 2023, 229, 952-963. [9]. Wei, S.Y., Wang, C., Zhang, Q.F., Yang, H., Deehan, E.C., Zong, X., Wang, Y.Z., Jin, M.L.* Dynamics of microbial communities during inulin fermentation associated with the temporal response in SCFA production. Carbohydrate Polymers. 2022, 298, 120057. [10]. Wei, S.Y., Wang, J.J., Wang, C., Wang, Y.Z., Jin, M.L.* Inulin mitigates high fructose-induced gut dysbiosis and metabolic dysfunction in mice. Journal of Functional Foods. 2022, 97, 105236. [11]. Wang, C., Wei, S.Y., Chen, N.N., Xiang, Y., Wang, Y.Z., Jin, M.L.* Characteristics of gut microbiota in pigs with different breeds, growth periods and genders. Microbial Biotechnology. 2022, 15(3), 793-804. [12]. Kai, L.X., Zong, X., Jiang, Q., Lu, Z.Q., Wang, F.Q., Wang, Y.Z., Wang, T.H.*, Jin, M.L.* Protective effects of polysaccharides from Atractylodes macrocephalae Koidz. against dextran sulfate sodium induced intestinal mucosal injury on mice. International Journal of Biological Macromolecules. 2022, 195, 142-151. [13]. Shaoyong, W.K., Liu, Y.L., Xu, B.C., Pan, B., Xianmi, X., Wang, Y.Z., Jin, M.L.* Exposure to BDE-47 causes female infertility risk and induces oxidative stress and lipotoxicity-mediated ovarian hormone secretion disruption in mice. Science of The Total Environment. 2022, 842, 156885. [14]. Su, W.F., Jiang, Z.P., Wang, C., Xu, B.C., Lu, Z.Q.*, Wang, F.Q., Zong, X., Jin, M.L.*, Wang, Y.Z.* Dynamics of defatted rice bran in physicochemical characteristics, microbiota and metabolic functions during two-stage co-fermentation. International Journal of Food Microbiology. 2022, 362, 109489. [15]. Wen, C.Y., Wei, S.Y., Zong, X., Wang, Y.Z.*, Jin, M.L.* Microbiota-gut-brain axis and nutritional strategy under heat stress. Animal Nutrition. 2021, 7, 1329-1336. [16]. Jiang, Z.P., Li, W.T., Su, W.F., Wen, C.Y., Gong, T., Zhang, Y., Wang, Y.Z.*, Jin, M.L.*, Lu, Z.Q.* Protective Effects of Bacillus amyloliquefaciens 40 against Clostridium perfringens infection in mice. Frontiers in Nutrition. 2021, 8, 733591. [17]. Wen, C.Y., Li, S.Y., Wang, J.J., Zhu, Y.M., Zong, X., Wang, Y.Z., Jin, M.L.* Heat stress alters the intestinal microbiota and metabolomic profiles in mice. Frontiers in Microbiology. 2021, 12, 706772. [18]. Zong, X., Cheng, Y.Z., Xiao, X., Fu, J., Wang, F.Q., Lu, Z.Q., Wang, Y.Z., Jin, M.L.* Protective effects of sulfated polysaccharide from Enterobacter cloacae Z0206 against DSS-induced intestinal injury via DNA methylation. International Journal of Biological Macromolecules. 2021, 183: 861-869. [19]. Zong, X., Xiao, X., Kai, L.X., Cheng, Y.Z., Fu, J., Xu, W., Wang, Y.Z., Zhao, K., Jin, M.L.* Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1. International Journal of Biological Macromolecules. 2021, 167: 76-84. [20]. Su, W., Jiang, Z.P, Hao, L.H., Li, W.T., Gong, T., Zhang, Y., Wang, C., Lu, Z.Q.*, Jin, M.L.*, Wang, Y.Z.* Variations of soybean meal and corn mixed substrates in physicochemical characteristics and microbiota during two-stage solid-state fermentation. Frontiers in Microbiology. 2021, 12: 1856. [21]. Xu, B.C., Fu, J., Qiao, Y., Cao, J.P., Deehan, E.C., Li, Z., Jin, M.L.*, Wang, X.X.*, Wang, Y.Z.* Higher intake of microbiota-accessible carbohydrates and improved cardiometabolic risk factors: a meta-analysis and umbrella review of dietary management in patients with type 2 diabetes. American Journal of Clinical Nutrition. 2021, 113(6): 1515-1530. [22]. Zong, X., Fu, J., Xu, B.C., Wang, Y.Z., Jin, M.L.* Interplay between gut microbiota and antimicrobial peptides. Animal Nutrition. 2020, 6: 389-396. [23]. Chen, N.N.#, Zhang, H. #, Zong, X., Li, S.Y., Wang, J.J., Wang, Y.Z., Jin, M.L.* Polysaccharides from Auricularia auricula: Preparation, structural features and biological activities. Carbohydrate Polymers. 2020, 247: 116750. [24]. Chen, N.N.#, Zhao, X.Y.#, Wang, F.Q., Lu, Z.Q., Wang, Y.Z., Jin, M.L.* Proteomic study of sulfated polysaccharide from Enterobacter cloacae Z0206 against H2O2-induced oxidative damage in murine macrophages. Carbohydrate Polymers. 2020, 237: 116147. [25]. Xu, B.C., Fu, J., Zhu, L.Y., Li, Z., Wang, Y.Z., Jin, M.L.* Overall assessment of antimicrobial peptides in piglets: a set of meta-analyses. Animal. 2020, 1-9.