浙江省生物治疗重点实验室主任，浙江省特聘专家，浙江省常见实体肿瘤综合诊治创新团队首席科学家，教育部新世纪优秀人才 1999年毕业于浙江大学医学院，在邵逸夫医院完成住院和主治医师训练后，赴德国Karlsruhe大学攻读博士学位；分别在德国耶拿分子生物技术研究所和中国香港中文大学临床肿瘤学系完成博士后工作；2007年在香港中文大学大学医学院开始PI工作；2009年，获聘浙江大学求是特聘教授后回国。 自2006年以来，在Nature、PNAS、Gastroenterology、Nature Communications等期刊发表SCI论文100余篇（H指数 38）；2009年回国以来，主持国自然项目5项，973子项目1项。

恶性肿瘤的发病机制和临床防治策略

2020 1. Zhu H, Ying S, Zhou B, Liang X, He Q, Song P, Hu X, Shi K, Xiong M, Jin H*, Pan Y*. Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor Activities. European Journal of Medicinal Chemistry 2020 2. Guo Y, Lu Y, Jin H*. Appraising the role of circulating concentrations of micro-nutrients in epithelial ovarian cancer risk: A Mendelian randomization analysis. Sci Rep. 2020 Apr 30;10(1):7356. 3. Song P, Feng L, Li, J, Dai D, Zhu L, Wang C, Li J, Ling L, Zhou Q, Shi R, Wang X* and Jin H*. β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer. Molecular Cancer 2020;19(1):129 4. Sun X, Chen D, Jin Z, Chen T, Lin A, Jin H, Zhu Y, Lai M*. Genome-wide methylation and expression profiling identify methylation-associated genes in colorectal cancer. Epigenomics. 2020 Jan;12(1):19-36. 2019 1. Zhu L, Zhu Y, Han S, Chen M, Song P, Dai D, Xu W, Feng L, Shin V, Wang X and Jin H*. Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer Cell Death & Diseases 2019 May 16;10(6):383 2. Cui Y, Groth S, Troutman S, Carlstedt A, Sperka T, Riecken LB, Kissil JL, Jin H, Morrison H*. The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling. Oncogene 2019 Sep;38(36):6370-6381 3. Yang L, Ying S, Hu S, Zhao X, Li M, Chen M, Zhu Y, Song P, Zhu L, Jiang T, An H, Yousafzai NA, Xu W, Zhang Z, Wang X, Feng L*, Jin H*. EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer. Signal Transduction and Targeted Therapy 2019;4(1):25 4. Q Li, X Fu, X Ge, F Tao, P Huang, M Ge, H Jin*. Antitumor Effects and Related Mechanisms of Ethyl Acetate Extracts of Polygonum perfoliatum L. Front Oncol. 2019; 9: 578 5. Liu M, Zhou J, Liu X, Feng Y, Yang W, Wu F, Cheung OK, Sun H, Zeng X, Tang W, Mok MTS, Wong J, Yeung PC, Lai PBS, Chen Z, Jin H, Chen J, Chan SL, Chan AWH, To KF, Sung JJY, Chen M, Cheng AS. Targeting Monocyte-intrinsic Enhancer Reprogramming Improves Immunotherapy Efficacy in Hepatocellular Carcinoma Gut 2019 6. Xu J, Shi Q, Xu W, Zhou Q, Shi R, Zhu L, Feng L, Cheng ASL, Morrison H, Wang X, Jin H*. Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance Theranostics 2019 May 9;9(10):2999-3013 7. Yousafzai AN, Zhou Q, Xu W, Shi Q, Xu J, Feng L, Chen H, Shin YV, Jin H*, Wang X*. SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer Cell Death and Disease 2019;10:363 8. Zhou Q, Li H, Li Y, Tan M, Fan S, Cao C, Meng F, Zhu L, Zhao L, Guan MX, Jin H, Sun Y*. Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. JCI Insight. 2019;4(4). pii: 121582 9. Shin VY, Chen J, Cheuk IW, Siu MT, Ho CW, Wang X, Jin H, Kwong A*. Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness. Cell Death & Diseases 2019 Mar 20;10(4):270 2018 1. Sun Jie, Zhu Y, Ding Z, He X, Dong H, Feng Y, Du J, Wu X, Zhang L, Yu X, Lin A, McDonald T, Zhao D, Wu H, Hua W, Zhang B, Feng L, Tohyama K, Oberdoerffer P, Chung YJ, Aplan PD, Boultwood J, Pellagatti A, Khaled S, Kuo YH, Carlesso N, Marcucci G, Jin H*, Li L*. Activation of SIRT1 Deacetylase Ablates Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 function. Cell Stem Cell 2018 Sep.7 2. Yu L, Cai Z, Zhang F, Guo D, Yang F, Li L, Wang X, Liang T, Wang J,* ,Jin H*. CD69 enhances immunosuppressive function of regulatory T cells and attenuates colitis by prompting IL-10 production. Cell Death & Diseases 2018 3. Xu W, Wei Q, Han M, Zhou B, Wang H, Zhang J, Wang Q, Sun J, Feng L, Wang S, Ye Y, Wang X, Zhou J, Jin H*. CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer. Int J Biol Sci. 2018 Jun 3;14(9):1054-1066 4. Xu W, Zhou B, Zhao X, Zhu L, Xu J, Jiang Z, Chen D, Wei Q, Han M, Feng L, Wang S, Wang X, Zhou J, Jin H*. KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance. Int J Biol Sci. 2018 Jun 22;14(9):1122-1132 5. Xu W, Shi Q, Qian X, Zhou B, Xu J, Zhu L, Feng L, Jin H, Wang X*. Rab5a suppresses autophagy to promote drug resistance in cancer cells. Am J Transl Res. 2018 Apr 15;10(4):1229-1236 6. Li J, Song P, Jiang T, Dai D, Wang H, Sun J, Zhu L, Xu W, Feng L, Shin VY, Morrison H, Wang X*, Jin H*. Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis. Molecular Therapy. 2018;Jul 5;26(7):1828-1839 7. Xu W, Wei Q, Han M, Zhou B, Wang H, Zhang J, Wang Q, Sun J, Feng L, Wang S, Ye Y, Wang X, Zhou J, Jin H*. CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer. International Journal of Biological Sciences 2018;14(9):1054-1066 8. Zhu Y, Lu H, Zhang D, Li M, Sun X, Wan L, Yu D, Tian Y, Jin H, Lin A, Gao F, Lai M. Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer. Clin Epigenetics. 2018 Mar 2;10:30 9. Cheng YY, Jin HC, Chan MWY, Chu WK, Grusch M. Epigenetic Biomarkers in Cancer. Dis Markers. 2018 Feb 20;2018:4987103 10. Dai D, Wang H, Zhu L, Jin H*, Wang X*. N6-methyladenosine links RNA metabolism to cancer progression. Cell Death Dis. 2018 Jan 26;9(2):124 2017 11. Liu L, Zhang L, Zhang L, Yang F, Zhu X, Lu Z, Yang Y, Lu H, Feng L, Wang Z, Chen H, Yan S, Wang L, Ju Z, Jin H*, Zhu X*. Hepatic Tmem30a deficiency causes intrahepatic cholestasis by impairing expression and localization of bile salt transporters The American Journal of Pathology 2017 Dec;187(12):2775-2787 12. Qian X, Xu W, Li J, Xu J, Yu W, Jiang Z, Feng L, Wang X, Zhou J, Jin H*. Enolase1 stimulates glycolysis to promote chemoresistance in gastric cancer Oncotarget 2017 Jul 18;8(29): 47691-47708 13. Yang L, Wang H, Shen Q, Feng L*, Jin H. Long non-coding RNAs involved in autophagy regulation. Cell Death Dis. 2017 Oct 5;8(10):e3073 14. Luo C, Chen X, Jin H*, Yao K*. The association between gout and cataract risk: A meta-analysis. PLoS One. 2017 Jun 29;12(6):e0180188 15. Han M, Dai D, Yousafzai NA, Wang F, Wang H, Zhou Q, Lu H, Xu W, Feng L, Jin H, Wang X*. CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer. Oncotarget. 2017 Oct 6;8(61):103557-103567 16. Feng L, Li J, Yang L, Zhu L, Huang X, Zhang S, Luo L, Jiang Z, Jiang T, Xu W, Wang X, Jin H*. Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia. Theranostics 2017;7(7):1890-1900 17. Li J, Song P, Zhu L, Aziz N, Zhou Q, Zhang Y, Xu W, Feng L, Chen D*, Wang X*, Jin H*. Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer Oncotarget 2017 Jun 27;8(26):42664-42672 18. Leygo C, Williams M, Jin HC, Chan MWY, Chu WK, Grusch M, Cheng YY. DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer. Dis Markers. 2017;2017:3726595 19. Han M, Xu W, Cheng P, Jin H, Wang X*. Histone demethylase lysine demethylase 5B in development and cancer. Oncotarget 2017 Jan 31;8(5):8980-8991 (Review) 2016 20. Lu H, Li G, Zhou C, Jin W, Qian X, Wang Z, Pan H, Jin H, Wang X*. Regulation and role of post-translational modifications of enhancer of zeste homologue 2 in cancer development. Am J Cancer Res. 2016 Dec 1;6(12):2737-2754. 21. Ying L, Zhang F, Pan X, Chen K, Zhang N, Jin J, Wu J, Feng J, Yu H, Jin H*, Su D*. Complement component 7 (C7), a potential tumor suppressor, is correlated with tumor progression and prognosis. Oncotarget. 2016; Dec 27;7(52):86536-86546 22. Klionsky D, Abe A…, Jin H, …et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. Autophagy 2016;12(1):1-222 23. Tang W, Han M, Ruan B, Jin W, Lou J, Yuan X, Chen D, Chen Y, Shin V, Jin H, Wang X*. Overexpression of GOLPH3 is associated with poor survival in Non-small-cell lung cancer American Journal of Translational Research 2016;8(4):1756-62 (IF: 3.6) 24. Zhang S#, Dai D#, Wang X#, Zhu H, Jin H, Zhao R, Jiang L, Lu Q, Yi F, Wan X, Cui H. Growth differentiation factor-15 predicts the prognoses of patients with acute coronary syndrome: a meta-analysis. BMC Cardiovasc Disord. 2016 May 6;16:82. 25. Wang Z, Ruan B, Jin Y, Zhang Y, Li J, Zhu L, Xu W, Feng L, Jin H, Wang X*. Identification of KLK10 as a therapeutic target to reverse trastuzumab resistance in breast cancer. Oncotarget. 2016 Nov 4. doi: 10.18632 26. Jin W.*, Jiang T., Sun J., Xu W., Feng L., Jin H., Wang X.*. Epigenetic silencing of miR137 in gastric cancer. Int J Clin Exp Med 2016 27. Lan H., Tang Z., Jin H., Sun Y. Neddylation inhibitor MLN4924 suppresses proliferation and migration of human gastric cancer cells. Scientific Reports 2016 28. Lu R, Hu X, Xu G, Zhou J, Zhu A, Gao X, Wang X, Jin H, Zhu P, Guo L. COPS5 Amplification and Overexpression Confers Endocrine Resistance in ER-positive Breast Cancer by Degradation of NCoR Protein Nature Communications 2016;7:12044