由于工作调动，本人自2022年9月起不再在浙大招收博士生与硕士生，请有意向的同学不用发邮件咨询。 主要学术成果、奖项与学术兼职 迄今发表SCI收录论文100余篇，总引用3270余次（根据ISI数据库），H指数33；其中第一作者及通讯作者（含共同通讯作者）论文50篇。已授权美国及欧亚拉美多国猪病毒疫苗相关专利6项（排名第一或第二）；中国授权专利9项。获浙江省人民政府科学技术奖一等奖2次（分别排名第2和第3）。SCI期刊Virology、Virus Research、Veterinary Microbiology编委（Editorial Board Member）、《中国兽医学报》编委。入选国家计划科技创新领军人才、科技部中青年科技创新领军人才、国家青年人才引进计划、浙江省特聘专家、浙江省151人才工程、杭州市“钱江特聘”专家。浙江省杰出青年基金获得者、中国畜牧兽医学会生物技术学分会常务理事、中国微生物学会病毒学专业委员会委员、黑龙江省兽医免疫学重点实验室学术委员会委员。 Web of Science ResearcherID网址 https //www.webofscience.com/wos/author/record/Q-9409-2019 教育经历 2000/09—2003/03，浙江大学，生物医学工程系，工学博士； 1998/09—2000/08，浙江大学，动物科学学院，攻读预防兽医学硕士（后转硕博连读）； 1994/09—1998/07，南京大学，生物科学与技术系，理学学士 研究工作经历 2022— 岭南现代农业科学与技术广东省实验室，PI 2013/09— 浙江大学动物科学学院动物医学系，教授 2011/01—2013/08，美国弗吉尼亚理工大学兽医学院生物医学与病理生物学系，研究助理教授(Research Assistant Professor) 2008/01—2010/12，美国弗吉尼亚理工大学兽医学院，研究科学家(Research Scientist) 2003/04—2007/12，美国弗吉尼亚理工大学兽医学院，博士后 Book Chapters Meng XJ, Huang YW. 2021. Circoviridae and Anelloviridae. In: Fields Virology, 7th Edition (volume 2, chapter 7). David M. Knipe and Peter M. Howley (eds). Lippincott Williams & Wilkins, Philadelphia, PA. pp 197-211.

1.猪肠道冠状病毒（PEDV,PDCoV,SeACoV/SADS-CoV） 2.戊型肝炎病毒（HEV） 3.其它猪重要致病性病毒及新突发病毒 4.人用与兽用新型疫苗

中国畜牧兽医学会生物技术学分会常务理事、中国微生物学会病毒学专业委员会委员、黑龙江省兽医免疫学重点实验室学术委员会委员。

Publications with the First or *Corresponding author from Huang Lab listed first (nos.1-58) Zhang F, Xu LD, Wu S, Wang B, Xu P, Huang YW*. Deciphering the hepatitis E virus ORF1: Functional Domains, Protein Processing, and Patient-Derived Mutations. Virology, 2025, https://doi.org/10.1016/j.virol.2024.110350. Liang QZ, Ji CM, Wang B, Chen W, Cong F, Huang Y, Huang YW. Deltacoronavirus HKU11, HKU13, PDCoV (HKU15) and HKU17 spike pseudoviruses enter avian DF-1 cells via clathrin-mediated endocytosis in a Rab5-, Rab7- and pH-dependent manner. Veterinary Research, 2024, Accepted. Jiao Y, Zhao P, Xu LD, Yu JQ, Cai HL, Zhang C, Tong C, Yang YL, Xu P, Sun Q, Chen N*, Wang B*, Huang YW*. Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response. Autophagy, 2024, 20(8):1762-1779. Zhang L, Liu JB, Liu HZ, Lian YX, Huang YW*, Cong F*. The Emergence of Novel Variants of the Porcine Epidemic Diarrhea Virus Spike Gene from 2011 to 2023. Transboundary and Emerging Diseases, 2024, https://doi.org/10.1155/2024/2876278. Xu LD, Zhang F, Xu P, Huang YW*. Cross-species transmission and animal infection model of hepatitis E virus. Microbes and Infection, 2024 Apr 16:105338. doi: 10.1016/j.micinf.2024.105338. Yang YL, Wang B, Li W, Cai HL, Qian QY, Qin Y, Shi FS, Bosch BJ*, Huang YW*. Functional dissection of the spike glycoprotein S1 subunit and identification of cellular cofactors for regulation of swine acute diarrhea syndrome coronavirus entry. Journal of Virology, 2024, 98(4):e0013924. Shi FS, Xie YH, Yang YL, Xu LD, Li JJ, Wang X, Zhu LY, Wang WW, Shen PL, Huang YW*, Li XQ*. Fucoidan from Ascophyllum nodosum and Undaria pinnatifida attenuate SARS-CoV-2 infection in vitro and in vivo by suppressing ACE2 and alleviating inflammation. Carbohydrate Polymers, 2024, 332:121884. Li Y, Shi F, Cao L, Zheng Q, Feng Y, Wang B, Huang Y*. Identification of novel serological agents for porcine deltacoronavirus infection based on the immunogenic accessory protein NS6. Animal Diseases, 2024, 4:3. Cai HL, Huang YW*. Reverse genetics systems for SARS-CoV-2: development and applications. Virologica Sinica, 2023, 38:837-850. Zhao Z, Xu LD, Zhang F, Liang QZ, Jiao Y, Shi FS, He B, Xu P*, Huang YW*. Heat shock protein 90 facilitates SARS-CoV-2 structural protein-mediated virion assembly and promotes virus-induced pyroptosis. Journal of Biological Chemistry. 2023, 299(5):104668. Zhao Z, Zhang YQ, Xu LD, Xiao L, Feng Y, Wang B, Huang YW*. Role of heat shock protein 90 as an antiviral target for swine enteric coronaviruses. Virus Research, 2023, 329:199103. Zhao ZY, Yu D, Ji CM, Zheng Q, Huang YW* and Wang B*. Comparative analysis of newly identified rodent arteriviruses and porcine reproductive and respiratory syndrome virus to characterize their evolutionary relationships. Frontiers in Veterinary Science, 2023, 10:1174031. Yu D, Zhao ZY, Yang YL, Pan D, Yuan LX, Huang YW*, Wang B*. The origin and evolution of emerged swine acute diarrhea syndrome coronavirus with zoonotic potential. Journal of Medical Virology. 2023, 95:e28672. Liang QZ, Wang B, Ji CM, Hu F, Qin P, Feng Y, Tang YD, Huang YW*. Chicken or porcine aminopeptidase N mediates cellular entry of pseudoviruses carrying spike glycoprotein from the avian deltacoronaviruses HKU11, HKU13 and HKU17. Journal of Virology, 2023, 97:e01947-22. Zhang F, Xu LD, Zhang Q, Wang A, Yu X, Liu S, Chen C, Wu S, Jin J, Lin A, Neculai D, Zhao B, Feng XH, Liang T, Xu P, Huang YW. Targeting proteostasis of the HEV replicase to combat infection in preclinical models. Journal of Hepatology. 2023, 78: 704-716. doi: 10.1016/j.jhep.2022.12.010. Shi FS#, Yu Y#, Li YL, Cui L, Zhao Z, Wang M, Wang B, Zhang R, Huang YW*. Expression profile and localization of SARS-CoV-2 non-structural replicase proteins in infected cells. Microbiology Spectrum, 2022, 10:e00744-22. Yang QY#, Yang YL#, Tang YX, Qin P, Wang G, Xie JY, Chen SX, Ding C, Huang YW, Zhu SJ. Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids. PLoS Pathogens, 2022, 18(6): e1010620. Chen C, Li YL, Lv FL, Xu LD*, Huang YW*. Surface display of peptides corresponding to the heptad repeat 2 domain of the feline enteric coronavirus spike protein on Bacillus subtilis spores elicits protective immune responses against homologous infection in a feline aminopeptidase-N-transduced mouse model. Frontiers in Immunology, 2022, 13:925922. Mei XQ#, Qin P#*, Yang YL#, Liao M, Liang QZ, Zhao Z, Shi FS, Wang B, Huang YW*. First evidence that an emerging mammalian alphacoronavirus is able to infect an avian species. Transboundary and Emerging Diseases, 2022, 69:e2006–e2019. Xu LD#, Zhang F#, Chen C, Peng L, Luo WT, Chen R, Xu P*, Huang YW*. Revisiting the Mongolian gerbil model for hepatitis E virus by reverse genetics. Microbiology Spectrum. 2022, 10:e02193-21. Lu W, Zhao ZZ, Huang YW*, Wang B*. A systematic review of virus-like particles of coronavirus: Assembly, generation, chimerism and their application in basic research and in the clinic. International Journal of Biological Macromolecules, 2022, 200:487-497. Liu Y#, Wang B#, Liang QZ, Shi FS, Ji CM, Yang XL, Yang YL, Qin P, Chen R, Huang YW*. Roles of two major domains of the porcine deltacoronavirus S1 subunit in receptor binding and neutralization. Journal of Virology, 2021, 95:e01118-21. Liu Y#, Liang QZ#, Lu W, Yang YL, Chen R, Huang YW*, Wang B*. A comparative analysis of coronavirus nucleocapsid (N) proteins reveals the SADS-CoV N protein antagonizes IFN-β production by inducing ubiquitination of RIG-I. Frontiers in Immunology, 2021, 12:688758. Zhao P#, Xu LD#, Zhang Y, Cao H, Chen R, Wang B*, Huang YW*. Expression of the human or porcine C-type lectins DC-SIGN/L-SIGN confers susceptibility to porcine epidemic diarrhea virus entry and infection in otherwise refractory cell lines. Microbial Pathogenesis, 2021, 157:104956. Ji CM, Yang XF, Qin P, Wang B*, Huang YW*. High-throughput sequencing of the porcine antibody repertoire with or without PEDV infection: A proof-of-concept study. Journal of Virological Methods, 2021, 292:114125. Qin P#, Yang YL#, Hu ZM#, Zhang YQ, Mei XQ, Liang QZ, Lu Z, Wang B, Chen R*, Huang YW*. A novel spike subunit 1-based enzyme-linked immunosorbent assay reveals widespread porcine torovirus infection in eastern China. Transboundary and Emerging Diseases, 2022, 69:598-608. Qin P, Luo WT, Su Q, Zhao P, Zhang Y, Wang B, Yang YL, Huang YW*. The porcine deltacoronavirus accessory protein NS6 is expressed in vivo and incorporated into virions. Virology, 2021, 556:1-8. Zhao Z, Qin P, Huang YW*. Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2. Cell Calcium, 2021, 94:102360. Hao X, Wang Y, Zhu M, Zhou D, Liu R, Wang B, Huang YW*, Zhao Z*. Development of improved mumps vaccine candidates by mutating viral mRNA cap methyltransferase sites in the large polymerase protein. Virologica Sinica, 2021, 36:521-536. Xu LD, Zhang F, Peng L, Luo WT, Chen C, Xu P*, Huang YW*. Stable expression of a hepatitis E virus (HEV) RNA replicon in two mammalian cell lines to assess mechanism of innate immunity and antiviral response. Frontiers in Microbiology, 2020, 11:603699. Yang YL, Yu JQ, Huang YW*. Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): An update three years after its discovery (invited review). Virus Research, 2020, 285:198024. Yang YL, Meng, F, Qin P, Herrler G, Huang YW*, Tang Y*. Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner. Emerging Microbes & Infections, 2020, 9:457-468.