黄河
教授
个人简介
黄河,浙江大学求是特聘教授,973首席科学家,浙江省特级专家,主任医师,博士生导师。现任浙江大学血液学研究所所长,干细胞与细胞免疫治疗浙江省工程研究中心主任,良渚实验室“血液与免疫疾病方向”首席科学家,浙江大学医学院附属第一医院骨髓移植中心主任。担任国家重点研发计划“干细胞及转化研究”重点专项专家组成员 ,第三届全国医学专业学位研究生教育指导委员会委员 ,亚洲细胞治疗组织副主席,亚太国际骨髓移植组织国际学术委员会常务委员 ,欧洲骨髓移植组织国际学术委员会委员 ,中华骨髓库专家委员会副主任委员 ,中华医学会血液学分会常务委员 ,中华医学会血液学分会造血干细胞应用学组副组长等学术职务。 1984年起从事血液学、造血干细胞移植和干细胞基础与转化研究,于2003年及2015年2次荣获国家科技进步奖二等奖。作为负责人承担973,863,国家自然科学基金重点项目,国家自然科学基金国际合作与交流项目等28项。在The New England Journal of Medicine、Nature、 Cell Metab、Lancet Haematol、Blood、Leukemia等杂志发表论文300余篇(其中通讯作者论文200余篇)。获省部级以上奖项17项,授权发明专利24项。近5年在国际大型会议担任主席、特邀报告和口头报告60余次。作为大会主席分别于2005年和2014年在杭州主办亚太国际骨髓与造血干细胞移植大会。主编人民卫生出版社《CAR-T细胞免疫治疗学》,共同主编人民卫生出版社第一版至第三版全国研究生《血液内科学》教。 所获奖励 被授予“浙江省特级专家”称号,2018年4月; 被授予“圣安东尼EBMT成就奖(中国)“,2018年7月; 异基因造血干细胞移植关键技术创新与推广应用 2015年国家科学技术进步奖二等奖(排名第一) 非亲缘异基因骨髓移植临床研究 2003年国家科学技术进步奖二等奖(排名第一) 异基因造血干细胞移植重要并发症的预警与诊治新技术 2013年教育部高等学校科学技术进步奖一等奖(排名第一) 间充质干细胞与组织工程产品的研发与应用 2011浙江省科学技术奖一等奖(排名第一) 慢性粒细胞白血病分子靶向治疗及异基因造血干细胞移植最新策略的的建立与推广 2010浙江省科学技术奖一等奖(排名第一) 慢性粒细胞白血病分子靶向治疗及异基因造血干细胞移植最新策略的的建立与推广 2010浙江省医药卫生科技创新奖一等奖(排名第一) 多发性骨髓瘤危险度分层新模式的建立及应用研究 2013年浙江省科学技术奖一等奖(排名第十) 急性移植物抗宿主病防治的基础和临床研究 2008年浙江省科学技术奖三等奖(排名第三) 急性移植物抗宿主病防治的基础和临床研究 2008浙江省医药卫生科技创新奖二等奖(排名第三) 人骨髓间充质干细胞纯化建系及临床试验研究 2007年浙江省科学技术奖三等奖(排名第二) 骨髓增生异常综合征发病机理及临床研究 2006年浙江省科学技术奖二等奖(排名第三) 骨髓增生异常综合征发病机理及临床研究 2006年浙江省医药卫生科技创新奖二等奖(排名第三) 人骨髓间充质干细胞特异性单克隆抗体的制备及应用 2006年浙江省医药卫生科技创新奖三等奖(排名第一) 人端粒结合因子(TRF1)的临床与基础研究 2003年浙江省科学技术奖二等奖(排名第一) 人端粒结合因子(TRF1)的临床与基础研究 2003年浙江省医药卫生科技创新奖二等奖(排名第一) 非亲缘异基因骨髓移植临床研究 2002年浙江省科学技术奖一等奖(排名第一) 高三尖杉酯碱致白血病细胞凋亡的信号传导和基因调控的研究及其临床意义 2002年浙江省科学技术奖二等奖(排名第五) 高三尖杉酯碱致白血病细胞凋亡的信号传导和基因调控的研究及其临床意义 2002年浙江医药卫生科技创新奖一等奖(排名第五) 非亲缘异基因骨髓移植临床研究 2001年浙江省医药卫生科技创新奖一等奖(排名第一) 脐血CD34+造血干细胞纯化和体外扩增的研究 2001年浙江省医药卫生科技创新奖三等奖(排名第二) 血小板血型基础与临床综合研究 2000年浙江省科学技术进步奖三等奖(排名第四) 血小板血型基础与临床综合研究 1999年浙江省卫生厅科技奖二等奖(排名第四) 人端粒重复序列结合因子的克隆、表达纯化和多抗制备 2000年浙江省卫生厅科技奖二等奖(排名第一) 程控冻存对人单个核细胞IL-1IL-2、TNF影响的机理研究 1999年浙江省科学技术进步奖三等奖(排名第二) 程控冻存对人单个核细胞IL-1IL-2、TNF影响的机理研究 1999年浙江省卫生厅科技奖二等奖(排名第二) 出版著作 主编 《CAR-T细胞免疫治疗学》,人民卫生出版社 血液内科学,人民卫生出版社(第一版,第二版,第三版) 《CAR-T细胞免疫治疗100问》,人民卫生出版社 参编 实用造血干细胞移植 内科学新进展(第一版,第二版,第三版) 感染微生态学(第一版,第二版) 全科医学临床治疗学 临床疾病与免疫 研究与探索
研究领域
造血干细胞移植的临床和基础研究 干细胞基础及应用研究 免疫治疗临床基础及应用研究
学术兼职
任国际造血干细胞移植领域权威杂志Bone Marrow Transplantation,Biology of Blood and Marrow Transplantation和Journal of Hematology and Oncology编委。
近期论文
Hu Y, Zhang M, Yang T, Mo Z, Wei G, Jing R, Zhao H, Chen R, Zu C, Gu T, Xiao P, Hong R, Feng J, Fu S, Kong D, Xu H, Cui J, Huang S, Liang B, Yuan X, Cui Q, Guo H, Yu Y, Feng Y, Jin C, Ren J, Chang AH*, Wang D*, Huang H*. Sequential CD7 CAR T-Cell Therapy and Allogeneic HSCT without GVHD Prophylaxis. The New England journal of medicine 2024, 390(16): 1467-1480. Zhang J, Hu Y, Yang J, Li W, Zhang M, Wang Q, Zhang L, Wei G, Tian Y, Zhao K, Chen A, Tan B, Cui J, Li D, Li Y, Qi Y, Wang D, Wu Y, Li D*, Du B*, Liu M*, Huang H*. Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL. Nature. 2022 Sep;609(7926):369-374. Zeng X, Shi C, Han Y, Hu K, Li X, Wei C, Ding L, Cui J, Huang S, Xu Y, Zhang M, Shan W, Luo Q, Yu J, Zheng Z, Li X*, Qian P*, Huang H*. A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells. Nat Aging. 2024 Oct;4(10):1477-1492. Liu L, Shao M, Huang Y, Qian P*, Huang H*. Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis. J Hematol Oncol. 2024 Oct 12;17(1):95. Si X, Shao M, Teng X, Huang Y, Meng Y, Wu L, Wei J, Liu L, Gu T, Song J, Jing R, Zhai X, Guo X, Kong D, Wang X, Cai B, Shen Y, Zhang Z, Wang D, Hu Y, Qian P*, Xiao G*, Huang H*. Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation. Cell Metab. 2024 Jan 2;36(1):176-192.e10. Zhang M, Wei G, Zhou L, Zhou J, Chen S, Zhang W, Wang W, Luo X, Cui J, Huang S, Fu S, Zhou X, Tang Y, Ding X, Kuang J, He XP, Hu Y, Huang H*. GPRC5D CAR T cells (OriCAR-017) in patients with relapsed or refractory multiple myeloma (POLARIS): a first-in-human, single-centre, single-arm, phase 1 trial. Lancet Haematol 2023:10: e107–16. Hu Y, Feng J, Gu T, Wang L, Wang Y, Zhou L, Hong R, Tan Su Yin E, Zhang M, Lu P, Huang H*. CAR T-cell therapies in China: rapid evolution and a bright future. Lancet Haematol. 2022 Dec;9(12):e930-e941. Cai S, Li H, Tie R, Shan W, Luo Q, Wang S, Feng C, Chen H, Zhang M, Xu Y, Li X, Chen M, Lu J*, Qian P*, Huang H*. Nlrc3 signaling is indispensable for hematopoietic stem cell emergence via Notch signaling in vertebrates. Nat Commun. 2024 Jan 3;15(1):226. doi: 10.1038/s41467-023-44251-6. Hu Y, Zhou Y, Zhang M, Zhao H, Wei G, Ge W, Cui Q, Mu Q, Chen G, Han L, Guo T, Cui J, Jiang X, Zheng X, Yu S, Li X, Zhang X, Chen M, Li X, Gao M, Wang K, Zu C, Zhang H, He X, Wang Y, Wang D, Ren J, Huang H*. Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study. Cell Res. 2022 Nov;32(11):995-1007. Wang X, Tao X, Chen P, Jiang P, Li W, Chang H, Wei C, Lai X, Zhang H, Pan Y, Ding L, Liang Z, Cui J, Shao M, Teng X, Gu T, Wei J, Kong D, Si X, Han Y, Fu H, Lin Y, Yu J, Li X, Wang D, Hu Y, Qian P*, Huang H*. MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB. Signal Transduct Target Ther. 2024 Oct 22;9(1):293. Zeng X, Li X, Li X, Wei C, Shi C, Hu K, Kong D, Luo Q, Xu Y, Shan W, Zhang M,Shi J, Feng J, Han Y, Huang H*, Qian P*. Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation. Blood. 2023 Apr 6;141(14):1691-1707. doi:10.1182/blood.2022017514. Wang L, Wang Y, He X, Mo Z, Zhao M, Liang X, Hu K, Wang K, Yue Y, Mo G, Zhou Y, Hong R, Zhou L, Feng Y, Chen N, Shen L, Song X, Zeng W, Jia X, Shao Y, Zhang P, Xu M, Wang D*, Hu Y*, Yang L*, Huang H*. CD70-targeted iPSC-derived CAR-NK cells display potent function against tumors and alloreactive T cells. Cell Rep Med. 2024 Dec 31:101889. Ye Y, Labopin M, Chen J, Wu D, Gedde-Dahl T Sr, Blaise D, Socie G, Forcade E, Salmenniemi U, Maury S, Versluis J, Bazarbachi A, Nagler A, Brissot E, Li L, Luo Y, Shi J, Ciceri F, Huang H*, Mohty M*, Gorin NC*. Lower relapse incidence with HAPLO versus MSD or MUD HCTs for AML patients with KMT2A rearrangement: a study from the Global Committee and the ALWP of the EBMT. Blood Cancer J. 2024 May 27;14(1):85. Yang L, Zhang Z, Jiang P, Kong D, Yu Z, Shi D, Han Y, Chen E, Zheng W, Sun J, Zhao Y, Luo Y, Shi J, Yao H, Huang H*, Qian P*. Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia. Nat Cell Biol. 2024 Jun;26(6):946-961. Zhou B, Chen J, Liu T, Ye Y, Zhang Y, Ding Y, Liu H, Zhu M, Ma X, Li X, Zhao L, Lin Z, Huang H*, Xu Y*, Wu D*. Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia: a multicenter, randomized, open-label, phase 3 trial. Signal Transduct Target Ther. 2024 May 6;9(1):108. Wang K, Wang L, Wang Y, Xiao L, Wei J, Hu Y*, Wang D*, Huang H*. Reprogramming natural killer cells for cancer therapy. Mol Ther. 2024 Sep 4;32(9):2835-2855. Li X, Li C, Zhang W, Wang Y, Qian P*, Huang H*. Inflammation and aging:signaling pathways and intervention therapies. Signal Transduct Target Ther.2023 Jun 8;8(1):239. doi: 10.1038/s41392-023-01502-8. Huang Y, Shao M, Teng X, Si X, Wu L, Jiang P, Liu L, Cai B, Wang X, Han Y, Feng Y, Liu K, Zhang Z, Cui J, Zhang M, Hu Y*, Qian P*, Huang H*. Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism. Cell Rep Med. 2024 Feb 20;5(2):101400. Wang L, Lv Y, Zhou L, Wu S, Zhu Y, Fu S, Ding S, Hong R, Zhang M, Yu H, Chang AH, Wei G, Hu Y*, Huang H*. Cytokine-based models for efficient differentiation between infection and cytokine release syndrome in patients with hematological malignancies. Exp Hematol Oncol. 2024 Mar 5;13(1):28. Wang K, Wang L, Wang Y, Xiao L, Wei J, Hu Y*, Wang D*, Huang H*. Reprogramming natural killer cells for cancer therapy. Mol Ther. 2024 Jan 24:S1525-0016(24)00027-3. Epub ahead of print. Hu Y, Zu C, Zhang M, Wei G, Li W, Fu S, Hong R, Zhou L, Wu W, Cui J, Wang D, Du B, Liu M, Zhang J*, Huang H*. Safety and efficacy of CRISPR-based non-viral PD1 locus specifically integrated anti-CD19 CAR-T cells in patients with relapsed or refractory Non-Hodgkin's lymphoma: a first-in-human phase I study. EClinicalMedicine. 2023 May 18;60:102010. doi: 10.1016/j.eclinm.2023.102010. Li J, Wang Q, Han Y, Jiang L, Lu S, Wang B, Qian W, Zhu M, Huang H*, Qian P*. Development and application of nanomaterials, nanotechnology and nanomedicine for treating hematological malignancies. J Hematol Oncol. 2023 Jun 23;16(1):65. doi: 10.1186/s13045-023-01460-2. Gao F, Wu H, Wang L, Zhao Y*, Huang H*. Altered intestinal microbiome and epithelial damage aggravate intestinal graft-versus-host disease. Gut Microbes. 2023 Jan-Dec;15(1):2221821. doi: 10.1080/19490976.2023.2221821. Jiang P, Zhang Z, Hu Y, Liang Z, Han Y, Li X, Zeng X, Zhang H, Zhu M, Dong J, Huang H*, Qian P*. Single-cell ATAC-seq maps the comprehensive and dynamic chromatin accessibility landscape of CAR-T cell dysfunction. Leukemia. 2022 Nov;36(11):2656-2668. Xu Y, Zeng X, Zhang M, Wang B, Guo X, Shan W, Cai S, Luo Q, Li H, Li X, Li X, Zhang H, Wang L, Lin Y, Liu L, Li Y, Zhang M, Yu X, Qian P*, Huang H*. Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture. Protein Cell. 2022 Nov;13(11):808-824. Hu Y, Li J, Ni F, Yang Z, Gui X, Bao Z, Zhao H, Wei G, Wang Y, Zhang M, Hong R, Wang L, Wu W, Mohty M, Nagler A, Chang AH, van den Brink MRM*, Li MD*, Huang H*. CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies. Nat Commun. 2022 Sep 9;13(1):5313. Shao M, Teng X, Guo X, Zhang H, Huang Y, Cui J, Si X, Ding L, Wang X, Li X, Shi J, Zhang M, Kong D, Gu T, Hu Y, Qian P*, Huang H*. Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti-Leukemia Efficacy of CAR-T Cells via SOCE-Calcineurin-NFAT and Glycolysis Pathways. Adv Sci (Weinh). 2022 Mar;9(9):e2103508. Zhang M, Zhou L, Zhao H, Zhang Y, Wei G, Hong R, Wu W, Xu H, Wang L, Ni F, Cui J, Peng S, Huang CH, Chang AH, Hu Y*, Huang H*. Risk factors associated with durable progression-free survival in relapsed or refractory multiple myeloma patients treated with anti-BCMA CAR-T cell therapy. Clin Cancer Res. 2021 Dec 1;27(23):6384-6392. Zhang M, Xiao H, Shi J, Tan Y, Zhao Y, Yu J, Lai X, Hu Y, Zheng W, Luo Y, Huang H*. Improved survival for young acute leukemia patients following a new donor hierarchy for allogeneic hematopoietic stem cell transplantation: A phase III randomized controlled study. Am J Hematol. 2021 Nov 1;96(11):1429-1440. Wei G, Zhang Y, Zhao H, Wang Y, Liu Y, Liang B, Wang X, Xu H, Cui J, Wu W, Zhao K, Nagler A, Chang AH, Hu Y*, Huang H*. CD19/CD22 Dual-Targeted CAR T-cell Therapy for Relapsed/Refractory Aggressive B-cell Lymphoma: A Safety and Efficacy Study. Cancer Immunol Res. 2021 Sep;9(9):1061-1070. Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H*. CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia. Clin Cancer Res. 2021 May 15;27(10):2764-2772. Li X, Guo X, Zhu Y, Wei G, Zhang Y, Li X, Xu H, Cui J, Wu W, He J, Ritchie ME, Weiskittel TM, Li H, Yu H, Ding L, Shao M, Luo Q, Xu X, Teng X, Chang AH, Zhang J*, Huang H*, Hu Y*. Single-Cell Transcriptomic Analysis Reveals BCMA CAR-T Cell Dynamics in a Patient with Refractory Primary Plasma Cell Leukemia. Mol Ther. 2021 Feb 3;29(2):645-657. Zhang L, Tian L, Dai X, Yu H, Wang J, Lei A, Zhu M, Xu J, Zhao W, Zhu Y, Sun Z, Zhang H, Hu Y, Wang Y, Xu Y, Church GM, Huang H*, Weng Q*, Zhang J*. Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions. J Hematol Oncol. 2020 Nov 11;13(1):153. Zhao H, Wei J, Wei G, Luo Y, Shi J, Cui Q, Zhao M, Liang A, Zhang Q, Yang J, Li X, Chen J, Song X, Jing H, Li Y, Hao S, Wu W, Tan Y, Yu J, Zhao Y, Lai X, Yin ETS, Wei Y, Li P, Huang J, Wang T, Blaise D, Xiao L, Chang AH, Nagler A, Mohty M, Huang H*, Hu Y*. Pre-transplant MRD negativity predicts favorable outcomes of CAR-T therapy followed by haploidentical HSCT for relapsed/refractory acute lymphoblastic leukemia: a multi-center retrospective study. J Hematol Oncol. 2020 May 4;13(1):42. Zhao Y, Wu H, Shi J, Luo Y, Li X, Lan J, Ni W, Lu Y, Chen L, Tan Y, Lai X, Yu J, Huang H*. Ruxolitinib combined with etanercept induce a rapid response to corticosteroid-refractory severe acute graft vs host disease after allogeneic stem cell transplantation: Results of a multi-center prospective study. Am J Hematol. 2020 Sep;95(9):1075-1084.