黄建教授，浙大“求是”特聘教授(医师)，主任医师，博士生导师。现任浙江大学医学院附属第二医院副院长、国家肿瘤学重点学科和教育部肿瘤学重点实验室方向负责人、省医学生物学重点实验室副主任。兼任中国抗癌协会乳腺癌专委会常委和浙江主委。入选浙江省151人才工程一层次，并获教育部中英友好奖学金和包氏中国留学生奖学金分赴英国MRC爱丁堡人类遗传所(12月)和美国密西根大学（3月）进修。 主要从事肿瘤免疫微环境及肿瘤干细胞分子机制和转化研究，主持了国家重大新药创制项目、 国家自然基金（含国际合作重大计划、面上项目）、浙江省重大科技专项和优先主题项目等；以第一作者或通讯作者在 Immunity、PNAS、 Oncoimmunology、 Cancer Lett、Carcinogenesis 等期刊发表 SCI 论文 40 余篇，其中以封面论文在 Cell 系列期刊Immunity（影响因子 21.56）发表，获2017年浙江省科学技术奖自然科学奖一等奖（排名第一），作为主要成员获国家科技进步二等奖（2005年）等。 奖励荣誉 1.浙大“求是” 特聘教授(医师） 2.浙江省科学技术奖自然科学奖，一等奖，2017 3.浙江省科技进步奖，二等奖，1998 4.教育部霍英东第七届高等院校优秀青年教师奖（科研类），二等奖，2000 5.浙江省科技进步奖，三等奖，2005 6.国家科技进步奖，二等奖，2005 7.“浙江省卫生高层次创新人才”称号，2008

免疫微环境及新型免疫细胞 肿瘤干细胞分子机制及转化研究

代表性论文 (1) Dang Wu ; Pin Wu ; Xianguo Wu ; Jun Ye; Zhen Wang; Shuai Zhao; Chao Ni; Guoming Hu; Jinghong Xu; Yuehua Han; Ting Zhang; Fuming Qiu; Jun Yan ;Jian Huang(*)Ex Vivo Expanded Human Circulating Vδ1 γδT Cells Exhibit Favorable Therapeutic Potential for Colon Cancer, OncoImmunology,2015, 4:e992749. (2) Ni, Chao ; Wu, Pin; Wu, Xianguo; Zhang, Ting; Zhang, Tao; Wang, Zhen;Zhang, Sai; Qiu, Fuming; Huang, Jian (*). Thymosin alpha1 enhanced cytotoxicity of iNKT cells against colon cancer via upregulating CD1d expression, Cancer Letters, 2015.1.28, 356(2 Pt B): 579~588. (3) Wu, Pin ; Wu, Dang ; Ni, Chao ; Ye, Jun ; Chen, Wuzhen; Hu,Guoming; Wang, Zhen; Wang, Changrong; Zhang, Zhigang; Xia, Wenjie; Chen,Zhigang; Wang, Ke; Zhang, Tao; Xu, Jinghong; Han, Yuehua; Zhang, Ting; Wu,Xianguo; Wang, Jianwei; Gong, Weihua; Zheng, Shu; Qiu, Fuming; Yan, Jun ;Huang, Jian (*). gamma delta T17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer , Immunity, 2014.5.15, 40(5): 785~800. (4) Yan, Jun ; Huang, Jian.Innate gammadeltaT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells. , OncoImmunology, 2014, 3(8): e953423~e953423. (5) Zhang, Zhigang ; Zhu, Ying ; Wang, Zhen ; Zhang, Ting; Wu, Pin;Huang, Jian (*).Yin-yang effect of tumor infiltrating B cells in breast cancer:From mechanism to immunotherapy. CANCER LETTERS, 2017.2.8, 393: 1~7. (6) Hu, Guoming ; Wu, Pin ; Cheng, Pu ; Zhang, Zhigang; Wang, Zhen; Yu, Xiuyan; Shao, Xuan; Wu, Dang; Ye, Jun; Zhang, Tao; Wang, Xiaochen; Qiu, Fuming; Yan, Jun ; Huang, Jian(*).Tumor-infiltrating CD39(+) gamma delta Tregs are novel immunosuppressive T cells in human colorectal cancer , ONCOIMMUNOLOGY, 2017, 6(2). (7) Wu, Dang ; Wu, Pin ; Qiu, Fuming; Wei, Qichun ; Huang, Jian(*).Human gamma delta T-cell subsets and their involvement in tumor immunity , CELLULAR& MOLECULAR IMMUNOLOGY, 2017.3, 14(3): 245~253. (8) Ye J, Wu X, Wu D, Wu P, Ni C, Zhang Z, Chen Z, Qiu F, Xu J, Huang J*. miRNA-27b targets vascular endothelial growth factor C to inhibit tumor progression and angiogenesis in colorectal cancer. PLoS One. 8(4):e60687,2013 (9) Chen Z, He X, Xia W, Huang Q, Zhang Z, Ye J, Ni C, Wu P, Wu D, Xu J, Qiu F, Huang J*.Prognostic Value and Clinicopathological Differences of HIFs in Colorectal Cancer: Evidence from Meta-Analysis. PLoS One. 8(12):e80337. 2013 (10) Ni C,Zhang Z, Zhu X, Liu Y, Qu D, Wu P, Huang J*, Xu A. Prognostic Value of CD166 Expression in Cancers of the Digestive System: A Systematic Review and Meta-Analysis. PLoSOne.; 8(8): e70958. 2013 (11) Ni C, Wu P, Zhu X, Ye J, Zhang Z, Chen Z, Zhang T, Zhang T, Wang K, Wu D, Qiu F, Huang J*. IFN-γselectively exerts pro-apoptotic effects on tumor-initiating label-retaining colon cancer cells. Cancer Lett.;336(1):174-84. 2013. (12) Zhang Z, Ni C, Chen W, Wu P, Wang Z, Yin J, Huang J*, Qiu F. Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis. BMC Cancer. 14:49. 2014 (13) Chen Z, He X, Jia M, Liu Y, Qu D, Wu D, Wu P, Ni C, Zhang Z, Ye J, Xu J, Huang J*.β-catenin overexpression in the nucleus predicts progress disease and unfavourable survival in colorectal cancer: a meta-analysis. PLoS One.;8(5):e63854. 2013 (14) Wang K, Liu L, Zhang T, Zhu YL, Qiu F, Wu XG, Wang XL, Hu FQ, Huang J*. Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer. International Journal of Nanomedicine; 6: 3207-3218. 2011. (15) Wang YK, Zhu YL, Qiu FM,Zhang T,Chen ZG,Zheng S,Huang J*. Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells. Carcinogenesis; 31: 1376-1380. 2010. (16) Huang J, Papadopoulos N, McKinley AJ, Farrington SM, Curtis LJ, Wyllie AH, Zheng S, Willson J, Markowitz SD, Morin P et al: APC mutations in colorectal tumors with mismatch repair deficiency. P Natl Acad Sci Usa 1996, 93(17):9049-9054. (17) Luo C, Zhong HJ, Zhu LM, Wu XG, Ying JE, Wang XH, Lu WX, Xu Q, Zhu YL, Huang J. Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. Mol Biol Rep 2011. (18) Liu JR, Fang S, Ding MP, Chen ZC, Zhou JJ, Sun F, Jiang B, Huang J.Toxic encephalopathy caused by occupational exposure to 1, 2-Dichloroethane. J Neurol Sci 2010, 292(1-2):111-113. (19) Qiu FM, Yu JK, Chen YD, Jin QF, Sui MH, Huang J. Mining Novel Biomarkers for Prognosis of Gastric Cancer with Serum Proteomics. J Exp Clin Cancer Res. 2009, 9(28): 126. (20)Zhang M, Huang J, Xie X, Holman CD.Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women. Int J Cancer 2009, 124(6):1404-1408. (21) Zhou H, Wu X, Lu X, Chen G, Ye X, Huang J. Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B. Thromb Res 2009, 123(3):537-542.