l 浙江省生物治疗重点实验室副主任 l 中华医学会病理学分会分子病理学组（工作委员会）委员 l 中国抗癌协会肿瘤病理专业委员会分子病理协作组成员 l 长三角地区临床病理质量控制联合体分子病理工作组成员 l 浙江省临床病理质控中心分子病理指导组专家 l 浙江省肿瘤靶向治疗技术指导中心成员 学习简历 1. 1980年9月至1986年7月 杭州市学军中学 2. 1986年9月至1991年7月 浙江医科大学, 临床医学, 全日制普通高校本科毕业, 医学学士 3. 1991年9月至1994年7月 浙江医科大学, 组织胚胎学, 硕士研究生毕业, 医学硕士 4. 2001年9月至2002年9月 香港大学医学院玛丽医院内科系进修, 细胞分子生物学 5. 2002年12月至2006年12月 香港大学医学院, 分子病理学, 博士研究生毕业, 哲学博士 工作简历 1. 1994年8月至1997年7月 浙江大学医学院组织胚胎教研室, 助教（高校） 2. 1997年8月至2000年9月 浙江大学医学院组织胚胎教研室, 讲师（高校） 3. 2000年10月至2010年11月 浙江大学医学院附属邵逸夫医院, 生物医学研究（治疗）中心副主任，讲师（高校） 4. 2010年12月至今 浙江大学医学院附属邵逸夫医院, 浙江省生物治疗重点实验室副主任、生物医学研究（治疗）中心副主任，副研究员（自然科学） 5. 2019年5月至今 浙江大学医学院附属邵逸夫医院，病理科副主任、分子病理诊断中心主任，副研究员（自然科学） 长期从事肿瘤发生发展分子机制及早期诊断标志物研究，近5年主持和参与国家自然科学基金、省部级等课题10余项，开展表观遗传机制调控的新抑癌基因筛查,通过对受累基因的深入研究，阐明了相关分子机制，寻找到肿瘤治疗的新靶点,对预后评估的有效指标以及作为外周血肿瘤表观标志物用于早期诊断，获得发明专利。已发表SCI论文50余篇，获浙江省自然科学奖一等奖，并参与Elsevier出版社的经典表观遗传学参考书Handbook of Epigenetics的撰写，完成Epigenetic Biomarkers章节。

肿瘤学

代表性SCI论文 1. Zhai S, Lin S, Lin Z, Xu J, Ji T, Chen K, Wu K, Liu H, Ying H, Fei W, Wang J, Fu G, Wang Y, Hu X*, Cai X. eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer. Gastric Cancer. 2020 May; 23(3):483-496. 2. Xu M, Zhu J, Liu S, Wang C, Shi Q, Kuang Y, Fang X, Hu X*. FOXD3, frequently methylated in colorectal cancer, acts as a tumor suppressor and induces tumor cell apoptosis under ER stress via p53. Carcinogenesis. 2020 Sep 24; 41(9):1253-1262. 3. He L, Fan X, Li Y, Chen M, Cui B, Chen G, Dai Y, Zhou D, Hu X*, Lin H. Overexpression of zinc finger protein 384 (ZNF 384), a poor prognostic predictor, promotes cell growth by upregulating the expression of Cyclin D1 in Hepatocellular carcinoma. Cell Death Dis. 2019 Jun 5;10(6):444. 4. Chen J, Wu Y, Zhang L, Fang X, Hu X*. Evidence for calpains in cancer metastasis. J Cell Physiol. 2019 Jun;234(6):8233-8240. 5. Song Z, Chen E, Qian J, Xu J, Cao G, Zhou W, Wang F, Chen M, Xu D, Wang X, Hu X, Ju Z, Huang X, Cai X. Serum chitinase activity prognosticates metastasis of colorectal cancer. BMC Cancer. 2019 Jun 25;19(1):629. doi: 10.1186/s12885-019-5834-7. 6. Chen J, Fang X, Zhong P, Song Z, Hu X*. N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction. RNA Biol. 2019 May 26:1-10. 7. Li X, Liu S, Fang X, He C, Hu X*. The mechanisms of DIRAS family members in role of tumor suppressor. J Cell Physiol. 2019 May;234(5):5564-5577. 8. Chen J, Wang C, Fei W, Fang X, Hu X*. Epitranscriptomic m6A modification in the stem cell field and its effects on cell death and survival. Am J Cancer Res. 2019 Apr 1;9(4):752-764. 9. Chen J, Liu S, Hu X*. Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation. Cell Death Discov. 2018 Apr 27;4:50. 10. Liu S, Fei W, Shi Q, Li Q, Kuang Y, Wang C, He C, Hu X*. CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response.Cell Death Dis 2017; 8(8):e3009. 11. Hu X, Kuang Y, Li L, Tang H, Shi Q, Shu X, Zhang Y, Chan FK, Tao Q, He C. Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers. Theranostics 2017; 7(7): 2150 -2163. 12. Liu X#, Hu X#, Kuang Y, Yan P, Li L, Li C, Tao Q, Cai X. BCLB, methylated in hepatocellular carcinoma, is a starvation stress sensor that induces apoptosis and autophagy through the AMPK-mTOR signaling cascade. Cancer Lett 2017; 395:63-71. 13. Kuang Y, Liu S, Wang C, Hu X*. Low expression of 2’-5’ oligoadenylate synthetase 1 predicted poor prognosis in colorectal cancer. Int J Clin Exp Pathol 2017;10(3): 3353-3360. 14. Fei W, Liu S, Hu X*. High FOXRED1 expression predicted good prognosis of colorectal cancer. Am J Cancer Res 2016; 6(11):2722-2728. 15. Chen R, Zhu J, Dong Y, He C, Hu X*. Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells. Oncotarget 2015; 6(32):32841-55. 16. Zhu J, Chen R, Mo L, Tang H, Kuang Y, Fei W, He C, Hu X*. Expression of fibulin-1 predicted good prognosis in patients with colorectal cancer. Am J Transl Res 2015; 7(2):339-47. 17. Zhu J, Chen X, Liao Z, He C, Hu X*. TGFBI protein high expression predicts poor prognosis in colorectal cancer patients. Int J Clin Exp Pathol 2015; 8(1):702-10. 18. Hu X, Huang ZT, Liao ZC, He C, Fang X. Low CA II expression is associated with tumor aggressiveness and poor prognosis in gastric cancer patients. Int J Clin Exp Pathol 2014; 7(10):6716-24. 19. Hu X, Xuan H, Du H, Jiang H, Huang J. Down-Regulation of CD9 by Methylation Decreased Bortezomib Sensitivity in Multiple Myeloma. PLoS One 2014; 9(5):e95765. 20. Wang X, He C, Hu X*. LIM homeobox transcription factors, a novel subfamily which plays an important role in cancer (Review). Oncol Rep 2014; 31(5):1975-85. 21. Wang X, Kuang YY, Hu XT*. Advances in epigenetic biomarker research in colorectal cancer. World J Gastroenterol 2014; 20(15):4276-87. 22. Hu X, Sui X, Li L, Huang X, Rong R, Su X, Shi Q, Mo L, Shu X, Kuang Y, Tao Q, He C. Protocadherin 17 acts as a tumor suppressor inducing tumor cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers. J Pathol 2013; 229(1):62-73. 23. Hu XT, He C. Recent progress in the study of methylated tumor suppressor genes in gastric cancer. Chin J Cancer 2013; 32(1):31-41. 24. Sui X, Wng D, Geng S, Zhou G, He C, Hu X*. Methylated Promoters of Genes Encoding Protocadherins as a new cancer biomarker family.Mol Biol Rep2012; 39(2):1105-11. 25. Sui XB, Jin LJ, Huang XF, Geng SM, He C, Hu XT*. p53 Signaling and Autophagy in Cancer: A Revolutionized Strategy Could be Developed for Cancer Treatment. Autophagy 2011; 7(6):565-71. 26. Hu XT#, Chen YW#, Liang ACT, Au WY, Wong KY, Wan TSK, Wong MLY, Shen L, Chan KK, Guo T, Chu KM, Tao Q, Chim CS, Loong F, Choi WWL, Lu L, So CC, Chan LC, Kwong YL, Liang RHS, Srivastava G. CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation. Blood 2010; 115(2):2458-61. 27. Hu XT, Zhang FB, Fan YC, Shu XS, Wong AH, Zhou W, Shi QL, Tang HM, Fu L, Guan XY, Rha SY, Tao Q, He C. Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer. Oncogene 2009; 28(26):2466-75. 28. Hu XT, Chen W, Zhang FB, Shi QL, Hu JB, Geng SM, He C. Depletion of the proteasome subunit PSMA7 inhibits colorectal cancer cell tumorigenicity and migration. Oncol Rep 2009; 22(5):1247-52.