龚行楚，男，博导，副教授，浙江大学求是青年学者。 学习工作经历 2015.12至今 浙江大学药学院 副教授 2011.2-2015.11 浙江大学药学院 助理研究员 2013.12-2014.12 明尼苏达大学药学院 访问学者 2009.2-2011.2 浙江大学药学院 博士后 2003.9-2009.1 清华大学化学工程系 化学工程与技术 博士 1999.9-2003.7 清华大学化学工程系 化学工程与工艺 学士 研究成果及项目 承担或参与包括国家自然科学基金、发改委中药标准化项目、科技部重大专项、浙江省自然科学基金、浙江省科技厅项目、浙江省领雁项目及企业重大横向课题等。在国内外刊物发表学术论文120余篇，其中SCI收录70余篇；获国家授权发明专利13项（转让企业1项），软件著作权19项。研究成果获得天津市科技进步特等奖1项（2020年）、黑龙江省科技进步二等奖1项（2021年）、浙江省科技进步一等奖1项（2022年）。 参与编写 [1] 中药现代化二十年（1996-2015），上海科学技术出版社，上海，第一版，2016年11月 [2] 中药药效物质研究前沿——创新中药研发关键技术，人民卫生出版社，北京，第一版，2018年12月 [3] 中药制药分离工程，中国中医药出版社，北京，第一版，2021年6月 [4] 医药数理统计方法，人民卫生出版社，北京，第七版，2022年7月 [5] 2021中医药发展报告，上海科学技术出版社，上海，第一版，2022年11月 奖励 浙江省科技进步奖一等奖，浙江省人民政府，2022 黑龙江省科技进步奖二等奖，黑龙江省科技厅，2021，6/11 科技进步特等奖，天津市科技局，202011，4/12 教育教学成果奖一等奖，全国药学专业学位研究生教育指导委员会，202009，3/5 科技进步一等奖. 中国石油和化学工业联合会, 2010.10.15, 3/11 科技进步一等奖. 中国石油和化学工业协会, 2008.10.15, 10/14 荣誉 浙江大学求是青年学者 2023 浙江大学药学院百诚奖教金 2021 浙江大学药学院韩建华奖教金 三等奖 2020 浙江大学药学院石华玉青年教师奖教金 二等奖 2019 浙江大学药学院石华玉青年教师奖教金 三等奖 2018 浙江大学药学院李光华奖教金 教书育人创新奖

中药质量控制 制药工程

担任中华中医药学会中药制药工程分会副秘书长、浙江省药学会制药工程专业委员会委员、中国医药设备工程协会中药设备工程技术专委会委员、中华中医药学会中药分析分会委员、世界中医药学会联合会中药系统科学与工程专委会理事、世界中医药学会联合会中药药剂专委会理事。担任SCI源刊《Separations》编委、《ChemoSensors》客座编委、《中草药》、《针灸与草药》（英文版）、《分析测试学报》刊物的青年编委、《中国现代应用药学》特邀编委。

1. 田甜; 王欣雨; 聂复礼; 李今豪; 汪娟; 龚行楚, 基于分析质量源于设计理念的鱼腥草芩蓝合剂水提浓缩液中7种化学成分的定量研究. 分析测试学报 2024, 43 (11), 1687-1696. 2. 李今豪; 周雅青; 颉佳乐; 王元远; 龚行楚, 基于分析质量源于设计的银杏叶提取液中有机酸含量分析方法. 分析测试学报 2024, 43 (11), 1735-1744. 3. 兰婧; 颉佳乐; 曹智铭; 关建丽; 王毅; 龚行楚, 基于HPLC-CAD的元胡止痛口服液糖类成分定量指纹图谱研究. 中国现代应用药学 2024, 41 (12), 1694-1698. 4. 颉佳乐; 邰艳妮; 仇萍; 丁丰; 龙宪军; 龚行楚, 基于分析质量源于设计同时开发盐酸青藤碱制药过程3种物料的指纹图谱方法. 中草药 2024, 55 (18), 6154-6166. 5. 丁丰; 吴革林; 邢冷; 瞿海斌; 李道超; 周鹏; 龚行楚, 小柴胡胶囊中间体和制剂的色谱检测方法研究（1）——制剂的定量指纹图谱方法. 分析测试学报 2024, 43 (11), 1754-1763. 6. 丁丰; 吴革林; 钱俊回; 刘思含; 司徒倩彤; 邢冷; 瞿海斌; 谢永建; 龚平; 周鹏; 龚行楚, 小柴胡胶囊中间体和制剂的色谱检测方法研究（2）——中间体的多成分含量测定方法. 分析测试学报 2024, 43 (11), 1764-177I. 7. 陈博; 王欣雨; 艾玉廷; 蒋剑平; 龚行楚, 基于裂区设计优化适用于多批次羊栖菜的提取工艺参数. 中草药 2024, 55 (17), 5822-5831. 8. Zhao, M.; Tai, Y.; Wu, G.; Ding, F.; Qu, H.; Gong, X., Integrated Application of Risk Management Techniques in Developing an Analysis Method for Traditional Chinese Medicine: A Case Study of a Percolation Solution for Xiaochaihu Capsules. Chemosensors 2024, 12 (8). 9. Zhang, S.; Zhang, S.; Gong, X.; Qu, H., Real-time monitoring of the column chromatography process of Ginkgo biloba using near-infrared and Raman spectroscopy combined with spectral fusion strategy. Process Biochemistry 2024, 145, 50-62. 10. Zhang, S.; Gong, X.; Qu, H., An effective and comprehensive optimization strategy for preparing Ginkgo biloba leaf extract enriched in shikimic acid by macroporous resin column chromatography. Phytochem Anal 2024, 35 (6), 1428-1442. 11. Wu, L.; Gong, X.; Qu, H., An optimization strategy for charged aerosol detection to linearize the detector response in the multicomponent quantitative analysis of Qishen Yiqi dripping pills. Journal of Separation Science 2024, 47 (2). 12. Tai, Y.; Zhao, M.; Ding, F.; Wu, G.; Qu, H.; Gong, P.; Xie, Y.; Zhou, P.; Gong, X., Analytical quality by design based on knowledge organization: A case study of developing an ultrahigh-performance liquid chromatography method for the detection of phenolic compounds. Phytochemical Analysis 2024. 13. Ren, D.; Xie, J.; Chen, T.; Qu, H.; Gong, X., Design and optimization of a greener sinomenine hydrochloride preparation process considering variations among different batches of the medicinal herb. Chinese Journal of Chemical Engineering 2024, 71, 77-90. 14. Abudureheman, K.; Wang, Q.; Zhang, H.; Gong, X., Development of a QAMS Analysis Method for Industrial Lanolin Alcohol Based on the Concept of Analytical Quality by Design. Separations 2024, 11 (9). 15. 周雅青; 龚行楚, 络合法提取胆固醇的研究进展. 华西药学杂志 2023, 38 (06), 711-717. 16. 张雪灿; 孟庆芬; 关建丽; 王毅; 龚行楚, 黄芩提取物制备过程的关键工段辨识研究. 中南药学 2023, 21 (01), 123-129. 17. 颉佳乐; 兰婧; 曹智铭; 关建丽; 王毅; 龚行楚, 元胡止痛口服液药材、中间体及制剂的定量指纹图谱方法研究. 分析测试学报 2023, 42 (08), 984-991. 18. Zhou, Y.; Li, J.; Wang, Q.; Tian, T.; Gong, X., Solubility Measurement of Cholesterol in Several Solvents from 283.2 to 323.2 K. Journal of Chemical and Engineering Data 2023, 68 (5), 1237-1243. 19. Wang, W.; Ding, F.; Qu, H.; Gong, X., Mechanism modeling and application of Salvia miltiorrhiza percolation process. Scientific Reports 2023, 13 (1). 20. Teng, K.; Fu, H.; Wu, G.; Gong, P.; Xie, Y.; Zhou, P.; Gong, X.; Qu, H., QbD-Guided Traditional Chinese Medicine Manufacturing Process: Development and Optimization of Fluid-Bed Granulation and Drying Processes for Xiaochaihu Capsules. Aaps Pharmscitech 2023, 24 (7). 21. Tai, Y.; Ren, D.; Zhao, W.; Qu, H.; Xiong, H.; Gong, X., Analytical quality by design oriented development of the UPLC method for analysing multiple pharmaceutical process intermediates: A case study of Compound Danshen Dripping Pills. Microchemical Journal 2023, 187. 22. Ren, D.; Xiang, S.; Yan, Y.; Kong, R.; Gong, X., Design and optimization of purification process of sinomenine hydrochloride. Chinese Journal of Chemical Engineering 2023, 55, 63-72. 23. Qian, J.; Chen, Y.; Tai, Y.; Tang, Z.; Wang, Z.; Guo, K.; Liu, X.; Gong, X., Analysis of Pharmaceutical Processes in Chinese Medicine Based on Quantity and Measure Value Transfer: A Case of Salvia miltiorrhiza Purified Extract Preparation. Separations 2023, 10 (6). 24. Li, J.; Lan, J.; Wang, S.; Yao, J.; Wang, F.; Gong, X., Advances on analysis methods of ginkgo biloba leaf extract. Journal of Liquid Chromatography & Related Technologies 2023, 46 (6-10), 138-152. 25. Lan, J.; Wu, G.; Wu, L.; Qu, H.; Gong, P.; Xie, Y.; Zhou, P.; Gong, X., Development of a Quantitative Chromatographic Fingerprint Analysis Method for Sugar Components of Xiaochaihu Capsules Based on Quality by Design Concept. Separations 2023, 10 (1). 26. Ding, F.; Liu, S.; Wu, G.; Qu, H.; Gong, P.; Xie, Y.; Zhou, P.; Gong, X., A novel process for developing a quantitative chromatographic fingerprint analysis method based on analytical quality by design: A case study of Xiaochaihu capsules. Microchemical Journal 2023, 194. 27. Chen, X.; Guo, D.; Gong, X.; Wan, N.; Wu, Z., Optimization of Steam Distillation Process for Volatile Oils from Forsythia suspensa and Lonicera japonica according to the Concept of Quality by Design. Separations 2023, 10 (1). 28. 潘晶晶; 任丹丹; 瞿海斌; 龚行楚, 中药醇沉前浓缩液质控指标的完善及标准建立——以党参醇沉为例. 中草药 2022, 53 (19), 6012-6022. 29. 龚行楚; 汪清琳; 程翼宇, 中药制药过程质量控制方法探索——以三七总皂苷生产制造为例. 中国食品药品监管 2022, 10 (10), 54-63. 30. Xinlong, W.; Wei, L.; Chao, L.; Jiaxin, Y.; Tong, W.; Min, Z.; Limin, Z.; Hanjiang, C.; Xilian, Z.; Songtao, B.; Fangyi, L.; Xinbo, S.; Xingchu, G.; Heshui, Y.; Zheng, L., Discrimination and characterization of the volatile organic compounds of Acori tatarinowii rhizoma based on headspace-gas chromatography-ion mobility spectrometry and headspace solid phase microextraction-gas chromatography-mass spectrometry. Arabian Journal of Chemistry 2022, 15 (11). 31. Wu, L.; Gong, X.; Pan, J.; Qu, H., Establishing a chromatographic fingerprint using tandem UV/charged aerosol detection and similarity analysis for Shengmai capsule: A novel method for natural product quality control. Phytochemical analysis : PCA 2022, 33 (3), 460-472. 32. Wan, N.; Lan, J.; Wu, Z.; Chen, X.; Zheng, Q.; Gong, X., Optimization of Steam Distillation Process and Chemical Constituents of Volatile Oil from Angelicaesinensis Radix. Separations 2022, 9 (6), 137. 33. Sijie, Z.; Xingchu, G.; Haibin, Q., Near-infrared spectroscopy and HPLC combined with chemometrics for comprehensive evaluation of six organic acids in Ginkgo biloba leaf extract. The Journal of pharmacy and pharmacology 2022, 74, 1040–1050. 34. Li, W.; Luo, Y.; Wang, X.; Gong, X.; Huang, W.; Wang, G.; Qu, H., Development and Validation of a Near-Infrared Spectroscopy Method for Multicomponent Quantification during the Second Alcohol Precipitation Process of Astragali radix. Separations 2022, 9 (10). 35. Guo, S.; Lan, J.; Liu, B.; Zheng, B.; Gong, X.; Fan, X., Continuous Flow Synthesis of N-Doped Carbon Quantum Dots for Total Phenol Content Detection. Chemosensors 2022, 10 (8), 334. 36. Gu, S.; Lin, P.; Ou, R.; Guo, J.; Gong, X., Discussion on several statistical problems in establishing quality standards of standard decoctions. Chinese Herbal Medicines 2022, 14 (1), 36-47. 37. 刘子齐; 钱俊回; 龚行楚; 范骁辉, 一种用针刺压传感器检测中药材软化情况的方法. 世界中医药 2021, 16 (23), 3442-3445. 38. 郭俊林; 邵青; 吴琳琳; 杜新刚; 龚行楚, 麦冬标准汤剂的质量标准研究. 中国现代应用药学 2021, 38 (13), 1572-1576. 39. Zhang, S.; Wu, L.; Wang, X.; Gong, X.; Qu, H., Development of an HPLC-MS method for the determination of four terpene trilactones in Ginkgo biloba leaf extract via quality by design. Biomed Chromatogr 2021, 35 (10), e5170. 40. Zhang, S.; Gong, X.; Qu, H., A simple and effective method for the preparation of high-purity shikimic acid from chromatography wash effluent of Ginkgo biloba leaf extract by macroporous resin considering the effect of varying feed solution compositions. J Pharm Pharmacol 2021, 73 (4), 447-459. 41. Xu, G.; Wang, H.; Deng, Y.; Xie, K.; Zhao, W.; Gong, X., Research Progress on Quality Control Methods for Xiaochaihu Preparations. Separations 2021, 8 (11), 199. 42. Wang, W.; Zheng, B.; Wu, J.; Lv, W.; Lin, P.; Gong, X., Determination of the Dissociation Constants of 16 Active Ingredients in Medicinal Herbs Using a Liquid–Liquid Equilibrium Method. Separations 2021, 8 (4), 49. 43. Wang, C.; Liu, X.; Gong, X. J. P.; Pharmacy, The Influences of Concentrate Extract Properties and Ethanol Addition Amount on the Ethanol Precipitation Process of Salvia Miltiorrhiza. 2021, 12 (10), 191-207. 44. Tai, Y.; Qu, H.; Gong, X., Design Space Calculation and Continuous Improvement Considering a Noise Parameter: A Case Study of Ethanol Precipitation Process Optimization for Carthami Flos Extract. Separations 2021, 8 (6), 74. 45. Tai, Y.; Pan, J.; Qu, H.; Gong, X., An Index for Quantitative Evaluation of the Mixing in Ethanol Precipitation of Traditional Chinese Medicine. Separations 2021, 8 (10), 181. 46. Liu, B.; Guo, S.; Fan, X.; Gong, X., Carbon quantum dot preparation and application to detecting active ingredients in traditional Chinese medicine. Acupuncture and Herbal Medicine 2021, 1 (2), 81-89. 47. Gong, X.; Shao, J.; Guo, S.; Pan, J.; Fan, X., Determination of inhibitory activity of Salvia miltiorrhiza extracts on xanthine oxidase with a paper-based analytical device. Journal of Pharmaceutical Analysis 2021, 11 (5), 603-610. 48. Gong, X.; Guo, J.; Pan, J.; Wu, Z., The development of Fructus corni quality standard considering the effects of processing. Chinese Journal of Chemical Engineering 2021, 29, 77-84. 49. 王婉莹; 瞿海斌; 龚行楚, 中药渗漉提取工艺研究进展. 中国中药杂志 2020, 45 (5), 1039-1046. 50. Zhao, S.; Wang, C.; Wang, X.; Jin, Y.; Sun, W.; Gong, X.; Tong, S., Liquid-liquid chromatography in sample pretreatment for quantitative analysis of trace component in traditional Chinese medicines by conventional liquid chromatography. J Chromatogr A 2020, 1619, 460917. 51. Wang, X.; Zhao, S.; Wang, C.; Sun, W.; Jin, Y.; Gong, X.; Tong, S., Off-line comprehensive two-dimensional reversed-phase countercurrent chromatography with high-performance liquid chromatography: Orthogonality in separation of Polygonum cuspidatum Sieb. et Zucc. Journal of Separation Science 2020, 43 (3), 561-568. 52. Tai, Y.; Shen, J.; Luo, Y.; Qu, H.; Gong, X., Research progress on the ethanol precipitation process of traditional Chinese medicine. Chinese Medicine 2020, 15 (1), 84. 53. Sun, M.; Yang, J.; Cao, W.; Shao, J.; Wang, G.; Qu, H.; Huang, W.; Gong, X., Critical process parameter identification of manufacturing processes of Astragali Radix extract with a weighted determination coefficient method. Chinese Herbal Medicines 2020, 12 (2), 125-132. 54. Pan, J.; Tai, Y.; Qu, H.; Gong, X., Optimization of membrane dispersion ethanol precipitation process with a set of temperature control improved equipment. Scientific Reports 2020, 10 (1), 19010. 55. Pan, J.; Shao, J.; Qu, H.; Gong, X., Ethanol precipitation of Codonopsis Radix concentrate with a membrane dispersion micromixer. Journal of Cleaner Production 2020, 251, 119633. 56. Pan, J.; He, S.; Shao, J.; Li, N.; Gong, Y.; Gong, X., Critical pharmaceutical process identification considering chemical composition, biological activity, and batch-to-batch consistency: A case study of notoginseng total saponins. Chinese Herbal Medicines 2020, 12 (1), 29-35. 57. He, Y.; Chen, Z.; Qu, H.; Gong, X. J. A. i. C. E.; Science, Research Progress on the Separation of Alkaloids from Chinese Medicines by Column Chromatography. 2020, 10 (4), 358-377.