关怡新，工学博士，教授，博士生导师。1989年7月本科毕业于清华大学化工系，1995年1月研究生毕业于浙江大学化工系，获工学博士学位。1995年3月留校在浙江大学化工系任教至今，1999年8月至2000年7月受包兆龙包玉刚中国留学生奖学金资助英国剑桥大学蛋白质工程中心访问学者，2005年12月晋升为教授，2006年9月批准为博士生导师。主要从事生物化工领域的教学和科研工作。作为项目负责人承担国家自然科学基金7项，教育部博士点基金1项，浙江省自然科学基金1项，浙江省科技计划项目1项，并参与了多项国家自然科学基金重点项目和国际合作项目。研究成果获教育部科技进步一等奖和浙江省科学技术二等奖。主要成果发表在 BIOTECHNOL BIOENG, BIORESOURCE TECHNOL, APPL MICROBIOL BIOT, BIOCHEM ENG J, CHEM ENG J, CHEM ENG SCI, IND ENG CHEM RES, J CO2 UTIL, J SUPERCRIT FLUID, J MEMBRANE SCI, J CHROMATOGR A, J NANOBIOTECHNOL, INT J PHARMACEUT, INT J BIOL MACROMOL, CARBOHYD POLYM, ACS SUSTAIN CHEM ENG 等top期刊，共发表SCI收录论文99篇，出版学术著作（教材）2本，授权国家发明专利33项。 出版著作 1、岑沛霖，关怡新，林建平 编著，生物反应工程，高等教育出版社，2005年9月 2、任其龙，邢华斌，关怡新 等编著，化工过程强化关键技术丛书--萃取过程强化技术，化学工业出版社，2020年8月 奖励荣誉 1、 浙江省高等学校第三届现代教学技能比赛优秀奖，2004 2、 浙江大学优质教学奖，2013 3、 浙江大学事业家庭兼顾型先进个人，2006 4、 浙江大学优秀研究生德育导师，2001、2004、2010、2012、2014 5、朱祖祥正大教育基金优秀教师奖，2001 6、 汤永谦、汤永年基金优秀中青年教师奖，1998、2008 7 、汤永谦、汤永年基金服务育人奖教金，2011、2013

生物制药技术 生物催化和转化 蛋白质工程

(1) Zhang Qin, Feng Yahui, Liang Xiyu, Wu Shuming, He Fang, Guan Yixin*, Wang Zhongqing*, Efficient bio-reduction of 3-nitro phthalic acid using engineered nitroreductase and V2O5, Process Biochemistry, 2025, 148, 157-167 (2) Huang Hao, Zhang Haoyu, Du Ningjie, Lyu Yidan, Xu Jiahang, Fu Haoran*, Guan Yixin*, Nan Kewang*, Drug origami: A computation-guided approach for customizable drug release kinetics of oral formulations, Matter, 2025, 8, 101878 (3) Du Ningjie, Fan Yunlong, Zhang Yunting, Huang Hao, Lyu Yidan, Cai Ruisi, Zhang Yuqi, Zhang Tianyuan, Guan Yixin*, Nan Kewang*, Wireless, programmable, and refillable hydrogel bioelectronics for enhanced diabetic wound healing, Advanced Science, 2024, 11, 2407820 (4) Du Ningjie, Fan Yunlong, Huang Hao, Guan Yixin*, Nan Kewang*, Stimuli-responsive hydrogel actuators for skin therapeutics and beyond, Soft Science, 2024, 4, 35 (5) Wang Dong, Wang Jing, Wu Yingchao, Liu Caixia, Huang Yuzhe, Chen Yan, Ding Zhifeng, Guan Yixin, Wu Qingxi, Amelioration of acute alcoholic liver injury via attenuating oxidative damage and modulating inflammation by means of ursodeoxycholic acid−zein nanoparticles, Journal of Agricultural and Food Chemistry, 2023, 71, 17080-17096 (6) Han Yinlei, Yin Huanhuan, Xiao Chao, Matthew T. Bernards, He Yi*, Guan Yixin*, Understanding the molecular mechanisms of polyphenol inhibition of amyloid β aggregation, ACS Chemical Neuroscience, 2023, 14, 4051-4061 (7) Yin Huanhuan, Han Yinlei, Yan Xiao*, Guan Yixin*, Hematoxylin modulates tau-RD protein fibrillization and ameliorates Alzheimer's disease-like symptoms in a yeast model, International Journal of Biological Macromolecules, 2023, 250, 126140 (8) Wang Zidan, Peng Huhong, Lin Dongqiang, Guan Yixin*, Exploring the effect of different linkers on self-assembly, ROS-sensitivity and anticancer efficacy of hydroxyethyl starch-curcumin prodrug, Carboyhydrate Polymer Technologies and Applications, 2023, 5, 100324 (9) Zhang Yipeng, Wang Liying, Wang Zidan, Zhou Quan, Zhou Xuefei, Zhou Tianhua, Guan Yixin, Liu Xiangrui, Surface-anchored microbial enzyme-responsive solid lipid nanoparticles enabling colonic budesonide release for ulcerative colitis treatment, Journal of Nanobiotechnology, 2023, 21, 145 (10) Yin Huanhuan, Han Yinlei, Yan Xiao*, Guan Yixin*, Proanthocyanidins prevent tau protein aggregation and disintegrate tau filaments, Chinese Journal of Chemical Engineering, 2023, 57, 63-71 (11) Rui Jinzhou, Peng Huhong, Guan Yixin*, Yao Shanjing, Preparation of ROS-responsive drug-loaded hydrogels applied in wound dressings using supercritical solvent impregnation, The Journal of Supercritical Fluids, 2022, 188, 105682 (12) Wang Zidan, Peng Huhong, Guan Yixin*, Yao Shanjing, Supercritical CO2 assisted micronization of curcumin-loaded oil-in-water emulsion promising in colon targeted delivery, Journal of CO2 Utilization, 2022, 59, 101966 (13) Peng Huhong, Wang Zidan, Guan Yixin*, Yao Shanjing, Supercritical CO2 assisted preparation of chitosan-based nano-in-microparticles with potential for efficient pulmonary drug delivery, Journal of CO2 Utilization, 2021, 46, 101486 (14) Xiao Xia, He Jingkai, Guan Yixin*, Yao Shanjing, Effect of cholinium amino acids ionic liquids as cosolvents on the bioconversion of phytosterols by Mycobacterium sp. resting cells, ACS Sustainable Chemistry & Engineering, 2020, 8, 17124-17132 (15) Wu Qingxi, Wang Zidan, Zheng Mengfei, Su Ting, Wang Xiaohui, Guan Yixin, Chen Yan, Development of metformin hydrochloride loaded dissolving tablets with novel carboxymethylcellulose/poly-L-lysine/TPP complex, International Journal of Biological Macromolecules, 2020, 155, 411-420 (16) Peng Huhong, Hong Dongxiao, Guan Yixin*, Yao Shanjing, Preparation of pH-responsive DOX-loaded chitosan nanoparticles using supercritical assisted atomization with an enhanced mixer, International Journal of Pharmaceutics, 2019, 558, 82-90 (17) Wu Qingxi, Guan Yixin, Yao Shanjing, Sodium cellulose sulfate: A promising biomaterial used for microcarriers' designing, Frontiers of Chemical Science and Engineering, 2019, 13, 46-58 (18) Guan Jintao, Han Chaofei, Guan Yixin*, Zhang Songhong, Yun Junxian*, Yao Shanjing, Optimizational production of phenyllactic acid by a Lactobacillus buchneri strain via uniform design with overlay sampling methodology, Chinese Journal of Chemical Engineering, 2019, 27, 418-425 (19) Chen Chuanxin, Peng Huhong, Guan Yixin*, Yao Shanjing, Morphological study on the pore growth profile of poly(ε-caprolactone) bi-modal porous foams using a modified supercritical CO2 foaming process, The Journal of Supercritical Fluids, 2019, 143, 72-81 (20) Hong Dongxiao, Yun Yulong, Guan Yixin*, Yao Shanjing, Preparation of micrometric powders of parathyroid hormone (PTH1-34)-loaded chitosan oligosaccharide by supercritical fluid assisted atomization, International Journal of Pharmaceutics, 2018, 545, 389-394 (21) Guan Jintao, Guan Yixin*, Yun Junxian*, Yao Shanjing, Chromatographic separation of phenyllactic acid from crude broth using cryogels with dual functional groups, Journal of Chromatography A, 2018, 1554, 92-100 (22) Xin Xin, Guan Yixin*, Yao Shanjing, Sustained release of dexamethasone from drug-loading PLGA scaffolds with specific pore structure fabricated by supercritical CO2 foaming, Journal of Applied Polymer Science, 2018, 135, 46207 (23) Xin Xin, Guan Yixin*, Yao Shanjing, Bi-/multi-modal pore formation of PLGA/hydroxyapatite composite scaffolds by heterogeneous nucleation in supercritical CO2 foaming, Chinese Journal of Chemical Engineering, 2018, 26, 207-212