方群 照片

方群

教授

所属大学: 浙江大学

所属学院: 化学系

邮箱:
fangqun@zju.edu.cn

个人主页:
https://person.zju.edu.cn/qunfang

个人简介

方群,浙江大学求是特聘教授,博士生导师,化学系微分析系统研究所所长,国家杰出青年基金获得者。 自1998年开始从事微流控芯片分析的研究工作。目前研究方向包括微流控液滴分析,微流控液相色谱、质谱和毛细管电泳分析,微型化分析系统研制,以及微流控系统在单细胞多组学分析、人工智能+化学、高通量筛选、微量生化分析、临床分析和现场分析中的应用。发表研究论文130余篇。在微流控分析领域申请国家发明专利40项,其中29项获得授权。曾主持承担国家自然科学基金委重大项目课题、国家杰出青年基金、国家基金重点项目、科学仪器研制专项和面上项目,以及和国家科技部973项目课题和863计划课题等科研项目。其中,2006年获得教育部新世纪优秀人才支持计划资助,2008年获得国家自然科学基金委杰出青年基金资助,2010,2012和2018年三次获得国家基金委科学仪器研制专项项目资助。2015年,获中国化学会分析化学基础研究梁树权奖。2016年获颁国务院政府特殊津贴。

研究领域

微流控液滴分析,微流控质谱、液相色谱和和毛细管电泳分析 微型化分析仪器研制 微流控系统和仪器在单细胞多组学分析、人工智能+化学、高通量筛选、生物分析、临床检验及现场分析中的应用

学术兼职

目前担任中国化学会分析化学学科委员会委员、中国化学会色谱专业委员会委员、中国微米纳米技术学会理事、中国机械工程学会生物制造工程分会委员、组织器官芯片专业委员会副主任委员。担任国际分析化学期刊 “Talanta”副主编,“Analytica Chimica Acta”、“Analyst”和“Lab on a Chip”编委。2015年3月入选英国皇家化学会会士(Fellow of the Royal Society of Chemistry, FRSC)。还担任国内分析化学期刊“分析化学”、“色谱”、“分析科学学报”、“化学传感器”、“光谱学与光谱分析”的编委。曾担任2012年全国微-纳尺度生物分离分析学术会议和第七届全国微全分析系统学术会议组委会主席;2013年第八届全国微全分析系统学术会议、第三届全国微-纳尺度生物分离分析学术会议暨第五届国际微化学与微系统学术会议(International Symposium on Microchemistry and Microsystems, ISMM)共同会议主席;2015年第19届国际微全分析系统会议(19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015)共同会议副主席;2016年首届液滴微流控学国际学术研讨会(Lab on a Chip Symposium: Droplet-based Microfluidics)主席;还将担任将于2022年在中国杭州召开的第26届国际微全分析系统会议(26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021)会议主席。

近期论文

代表性论文 1. J. Wu, Q-Q. Xu, Y-R. Jiang, J-B. Chen, W-X. Ying, Q-X. Fan, H-F. Wang, Y. Wang, S-W. Shi, J-Z. Pan, Q. Fang*, One-shot single-cell proteome and metabolome analysis strategy for the same single cell, Anal. Chem., 2024, 96, 5499-5508. 2. J-M. Lu, J-Z. Pan*, Y-M. Mo, Q. Fang*, Automated intelligent platforms for high-throughput chemical synthesis, Artificial Intelligence Chemistry, 2024, 2, 100057. 3. Y. Yang*, Q. Fang*, Prediction of glycopeptide fragment mass spectra by deep learning. Nat. Commun., 2024, 15, 2448. 4. Wang, Z-Y. Guan, S-W. Shi, Y-R. Jiang, J. Zhang, Y. Yang, Q. Wu, J. Wu, J-B. Chen, W-X. Ying, Q-Q. Xu, Q-X. Fan, H-F. Wang, L. Zhou, J. Fang J-Z. Pan, Q. Fang*, Pick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a Mammalian cell. Nat. Commun., 2024, 15, 1279. 5. Y-R. Jiang, L. Zhu, L-R. Cao, Q. Wu, J-B. Chen, Y. Wang, J. Wu, T-Y. Zhang, Z-L. Wang, Z-Y. Guan, Q-Q. Xu, Q-X. Fan, S-W. Shi, H-F. Wang, J-Z. Pan, X-D. Fu*, Y. Wang*, Q. Fang*, Simultaneous deep transcriptome and proteome profiling in a single mouse oocyte, Cell Rep., 2023, 42, 113455. 6. T-T. Lin, J-W. Wang, Q-N. Shi, H-F. Wang, J-Z. Pan*, Q. Fang*, An automated, fully-integrated nucleic acid analyzer based on microfluidic liquid handling robot technique, Anal. Chim. Acta, 2023, 1239, 340698. 7. J-Z. Pan*, C. Fan, Z-Q. Zuo, Y-X. Yuan, H-F. Wang, Z. Dong, Q. Fang*, Lab at home: a promising prospect for on-site chemical and biological analysis, Anal. Bioanal. Chem., 2023, 415, 17-25. 8. Z-Q. Zuo, J-Z. Pan*, Q. Fang*, An integrated microfluidic system for multi-target biochemical analysis of a single drop of blood, Talanta, 2022, 249, 123585. 9. M-T. Zhang, Y-M. Peng, J-Z. Pan*, X-X. Fang, H-Y. Li, X-Y. Zhang, Y-C. Liao, J-K. Yao, M-L. Wu, Y-Y. Yao, Q. Fang*, LIFGO: A modular laser-induced fluorescence detection system based on plug-in blocks, Talanta, 2022, 239, 123063. 10. J-J. Yang, C. Klinkenberg, J-Z. Pan*, H. M. Wyss*, J. M. J. den Toonder*, Q. Fang*, An integrated system for automated measurement of airborne pollen based on electrostatic enrichment and image analysis with machine vision, Talanta, 2022, 237, 12290. 11. S-W. Shi, Q. Lou, Q. Fang*, Petrel Probe: an integrated in situ sampling and injection interface for fast, high-efficiency liquid chromatography-mass spectrometry analysis, Anal. Chem., 2021, 93, 10114-10121. 12. Y. Wang, D-F. Wang, H-F. Wang, J-W. Wang, J-Z. Pan, X-G. Guo*, Qun Fang*, A microfluidic robot for rare cell sorting based on machine vision identification and multi-step sorting strategy, Talanta, 2021, 226, 122136. 13. Q. Lou, Y. Ma, S-P. Zhao, G-S. Du, Q. Fang*, A flexible and cost-effective manual droplet operation platform for miniaturized cell assays and single cell analysis, Talanta, 2021, 224, ‏121874. 14. L-H. Jin, Y. Wei, H-F. Wang, J-B. Chen, Q. Fang*, Nanoliter-scale liquid metering and droplet generation based on a capillary array for high throughput screening, Talanta, 2021, 221, 121613. 15. H-T. Li, H-F. Wang*, Y. Wang, J-Z. Pan, Q. Fang*, A minimalist approach for generating picoliter to nanoliter droplets based on an asymmetrical beveled capillary and its application in digital PCR assay, Talanta, 2020, 217, 120997 16. D-Q. Jin, S-W. Shi, Y. Ma, Q. Fang*, LC-Swan probe: An integrated in situ sampling interface for liquid chromatography separation and mass spectrometry analysis, Anal. Chem., 2020, 92, 9214-9222. 17. W-H. Sun, Y. Wei, X-L. Guo, Q. Wu, X. Di*, Q. Fang*, Nanoliter-scale droplet–droplet microfluidic microextraction coupled with MALDI-TOF mass spectrometry for metabolite analysis of cell droplets, Anal. Chem., 2020, 92, 8759-8767. 18. Y-M. Feng, T-T. Hu, P. Fang, L-L. Zhou, W-M. Li, Q. Fang*, J. Fang*, Consecutive and automatic detection of multi-gene mutations from colorectal cancer samples by coupling droplet array-based capillary electrophoresis and PCR-RFLP, Anal. Bioanal. Chem., 2020, 412, 3037-3049. 19. Z. Dong, Q. Fang*, Automated, flexible and versatile manipulation of nanoliter-topicoliter droplets based on sequential operation droplet array technique, TrAC-Trend Anal. Chem., 2020, 124, 115812 20. J-G. Xu, M-S. Huang, H-F. Wang, Q. Fang*, Forming a large-scale droplet array in a microcage array chip for high-throughput screening, Anal. Chem., 2019, 91, 10757-10763. 21. J-W. Wang, J. Gao, H.-F. Wang, Q-H. Jin, B. Rao, W. Deng, Y. Cao, M. Lei, S. Ye*, Q. Fang*, Miniaturization of the whole process of protein crystallographic analysis by a microfluidic droplet robot: from nanoliter-scale purified proteins to diffraction-quality crystals, Anal. Chem., 2019, 91, 10132-10140. 22. Y. Wei, Y. Zhu*, Q. Fang*, Nanoliter quantitative high-throughput screening with large-scale tunable gradients based on a microfluidic droplet robot under unilateral dispersion mode, Anal. Chem., 2019, 91, 4995-5003. 23. J-Z. Li, H-F. Wang, L. Lin, Q. Fang*, X-G. Peng*, Quantitative identification of basic growth channels for formation of monodisperse nanocrystals, J. Am. Chem. Soc., 2018, 140, 5474-5484. 24. X-L. Guo, Y. Wei, Q. Lou, Y. Zhu, Q. Fang*, Manipulating femtoliter to picoliter droplets by pins for single cell analysis and quantitative biological assay, Anal. Chem., 2018, 90, 5810-5817. 25. Z-Y. Li, M. Huang, X-K. Wang, Y. Zhu, J-S. Li, C. C. L. Wong*, Q. Fang*, Nanoliter-scale oil-air-droplet chip-based single cell proteomic analysis, Anal. Chem., 2018, 90, 5430-5438. 26. X-H. Du, W-M. Li, G-S. Du, H. Cho, M. Yu, Q. Fang*, L. P. Lee*, J. Fang*, Droplet array-based 3D coculture system for high-throughput tumor angiogenesis assay, Anal. Chem., 2018, 90, 3253-3261. 27. J-Z. Pan, P. Fang, X-X. Fang, T-T. Hu, J. Fang, Q. Fang*, A low-cost palmtop high-speed capillary electrophoresis bioanalyzer with laser induced fluorescence detection. Sci. Rep., 2018, 8, 1791. 28. P. Fang, J-Z. Pan, Q. Fang*, A robust and extendable sheath flow interface with minimal dead volume for coupling CE with ESI-MS, Talanta, 2018, 180, 376-382.