浙江大学求是特聘教授/国家杰出青年基金获得者 浙江大学医学院/动物科学学院/浙江大学第二附属医院 双聘教授/博士生导师 E-mail fengyj@zju.edu.cn 学习/工作经历 2022.01 — 至今 浙江大学公共卫生学院 兼聘教授 2018.05 — 2024.12 浙江大学医学院附属第二医院 双聘教授 2016.12 — 至今 浙江大学动物科学学院 兼聘教授/博士生导师 2014.03 — 至今 浙江大学医学院 微生物学系 教授/博士生导师 2013.01 — 2014.03 美国伊利诺伊大学厄巴纳-香槟分校(UIUC) Research scientist 2008.01 — 2013.01 美国伊利诺伊大学厄巴纳-香槟分校(UIUC) Post-doc 2007.09 — 2008.01 中国科学院 微生物研究所 博士后 2004.09 — 2007.09 中国科学院大学/微生物研究所 微生物学 博士 2001.09 — 2004.06 广西大学 微生物学 硕士 1997.09 — 2001.06 陕西科技大学 (原西北轻工业学院) 生物化工 本科 研究项目 2023.12 — 2026.12 在研 国家重点研发计划 子课题负责人 2023.12 — 2026.12 在研 国家重点研发计划 子课题骨干 2022.01 — 2025.12 在研 国家自然科学基金重大专项（骨干） 2022.01 — 2026.12 在研 国家自然科学基金杰出青年项目（主持） 2019.01 — 2023.12 在研 国家自然科学基金重点项目（主持） 2018.01 — 2021.12 结题 国家自然科学基金面上项目（主持） 2016.01 — 2019.12 结题 国家自然科学基金面上项目（主持） 2017.06 — 2020.06 结题 国家重点研发计划 子课题骨干 2016.06 — 2019.06 结题 国家重点研发计划 子课题骨干 学术荣誉 2021 浙江大学医学院附属第二医院 科研突出贡献奖 2021 浙江大学医学院杰出学者奖 2016 浙江大学“十大科学进展”提名奖 2016 浙江大学医学院重大科研贡献奖 2014 国家科技进步二等奖 2011 中华医学一等奖 2011 中华预防医学一等奖 文章发表 近五年来，以通讯作者身份在Sci Adv, Nat Commun, PLoS Pathog (x3)与Cell Rep等知名刊物发表70余篇研究论文 (https://www.ncbi.nlm.nih.gov/myncbi/youjun.feng.1/bibliography/public/)，发表文章累计引用11000余次 (H-index: 51)，并受邀为CELL子刊Trends in Biochemical Science (IF 2019: ~17) 撰写细菌耐药机制综述文章。 本实验室常年接受 特别研究员 (tenure-track investigator)、特别副研究员 (tenure-track associate investigator)、博士后 (Postdoc)、外校客座研究人员/研究生、本科生以及技术员的申请，欢迎国内外热爱科学的志同道合之士加盟！ 浙江大学医学院/第二附属医院 冯友军教授课题组诚聘青年才俊：1. 特别研究员/特别副研究员 (2-3名，按浙二医院政策执行，薪资范围：35-45万/年)；2. 博士后（依托深圳三院 招收2-3名，底薪42万/年， 年度考核后绩效最高12万/年；依托浙二医院招收博后2名，薪资范围：30-40万/年)；3. 科研助理/技术员 （2-3名，本科/硕士毕业，按浙二医院政策执行，薪资范围：10-20万）。

重要医学细菌ESKAPE的耐药机制、感染机理及其防控新策略

2021 -- 2024, Editor, Gut Microbes (IF: 10.245) 2021 -- 2024, Editor, mSystems (IF: 6.496) 2014 -- 至今, Editor, Virulence (IF: 5.882)

代表性论文 (Selected Publications) PI (2014--) 47. Huang H#, Wang C#, Chang S#, Cui T#, Xu Y, Huang M, Zhang H, Zhou C*, Zhang X*, Feng Y*. Structure and catalytic mechanism of exogenous fatty acid recycling by AasS, a versatile acyl-ACP synthetase. Nat Struct Mol Biol, 2025 Jan 10. doi: 10.1038/s41594-024-01464-7. *corresponding author 46. Su Z#, Zhang W#, Shi Y, Cui T, Xu Y, Yang R, Huang M, Zhou C, Zhang H, Lu T, Qu J, He Z*, Gan J*, Feng Y*. A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway. Sci Adv, 2024 Dec 20;10(51):eadp3954. doi: 10.1126/sciadv.adp3954. *corresponding author 45. Huang H#, Chang S#, Cui T#, Huang M, Qu J, Zhang H, Lu T, Zhang X*, Zhou C*, Feng Y*. An inhibitory mechanism of AasS, an exogenous fatty acid scavenger: Implications for re-sensitization of FAS II antimicrobials. PLoS Pathog, 2024 Jul 15;20(7):e1012376. doi: 10.1371/journal.ppat.1012376. *corresponding author 44. Chen H#, Shi Y#, Huang M, Lu T, Zhang H, Zhou C*, Hou T*, Feng Y*. Recognition and acquisition of FakB2-loaded exogenous fatty acid (eFA) by a streptococcal FakA kinase. Sci Bull, 2024 Nov 15;69(21):3355-3360. doi: 10.1016/j.scib.2024.05.015. *corresponding author 43. Liu L#, Lou N#, Liang Q#, Xiao W#, Teng G, Ma J, Zhang H, Huang M*, Feng Y*. Chasing the landscape for intrahospital transmission and evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae, Sci Bull, 2023, Oct 31: S2095-9273(23)00738-7.doi: 10.1016/j.scib.2023.10.038. *corresponding author 42. Shi Y#, Cao Q#, Sun J#, Hu X, Su Z, Xu Y, Zhang H, Lan L*, Feng Y*. The opportunistic pathogen Pseudomonas aeruginosa exploits bacterial biotin synthesis pathway to benefit its infectivity, PLoS Pathog, 2023 Jan 23; 19(1): e1011110. *corresponding author 41. Shi Y#, Zang N#, Lou N, Xu Y, Sun J, Huang M, Zhang H, Lu H*, Zhou C*, Feng Y*. Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging, Sci Adv, 2022 Sep 2; eabq3944. *corresponding author 40. Xu Y#, Yang J#, Li W#, Song S#, Shi Y#, Wu L, Sun J, Hou M, Wang J, Jia X, Zhang H, Huang M, Lu T, Gan J*, Feng Y*. Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an atractive anti-TB drug target, PLoS Pathog, 2022 Jul 11;18(7):e1010615. doi: 10.1371/journal.ppat.1010615. *corresponding author 39. Wang H, Feng Y*, Lu H*. Low-level cefepime exposure induces high-level resistance in environmental bacteria: Molecular mechanism and evolutionary dynamics, Environ Sci Technol, 2022 May 24. doi: 10.1021/acs.est.2c00793. *corresponding author 38. Chen Q#, Liu L#, Hu X, Jia X, Gong X, Feng Y*, Huang M*. A small KPC-2-producing plasmid in Klebsiella pneumoniae: Implications for diversified vehicles of carbapenem resistance, Microbiol Spectr, 2022 May 17: e0268821. doi: 10.1128/spectrum.02688-21. *corresponding author 37. Zhang M, Cui Z, Wang Y, Ma W, Ji Y, Ye F, Feng Y*, Liu C*. Effects of sub-lethal antimicrobial photodynamic therapy mediated by haematoporphyrin monomethyl ester on polymyxin-resistant Escherichia coli clinical isolate, Photodiagnosis Photodyn Ther, 2021 Dec; 36: 102516. doi: 10.1016/j.pdpdt.2021.102516. *corresponding author 36. Cui CY#, Chen Q#, He Q, Chen C, Zhang RM, Feng Y*, Sun J*. Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family, WIREs Mech Dis, 2022 Jan; 14(1): e1538. doi: 10.1002/wsbm.1538. *corresponding author 35. Umar Z#, Chen Q#, Tang B#, Xu Y#, Wang J, Zhang H, Ji K, Jia X, Feng Y*. The poultry pathogen Riemerella anatipestifer appears as a reservoir for Tet(X) tigecycline resistance, Environ Microbiol, 2021 Jun 7. doi: 10.1111/1462-2920.15632. *corresponding author 34. Xu Y#, Chen H#, Zhang H#, Ullah S#, Hou T*, Feng Y*. The MCR-3 inside linker appears as a facilitator of colistin resistance, Cell Rep, 2021 May 18; 35(7): 109135. doi: 10.1016/j.celrep.2021.109135. *corresponding author 33. Zhang S#, Xu Y#, Guan H#, Cui T#, Liao Y#, Wei W#, Li J, Hassan BH, Zhang H, Jia X, Ouyang S*, Feng Y*. Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway, Nat Commun, 2021 April 6, 12(1): 2056, doi: 10.1038/s41467-021-22360-4. *corresponding author 32. Xu Y, Liu L, Zhang H, Feng Y*. Co-production of Tet(X) and MCR-1, two resistance enzymes by a single plasmid, Environ Microbiol, 2021 Feb 8. doi: 10.1111/1462-2920.15425. *corresponding author 31. Li P#, Liang Q#, Liu W#, Zheng B#, Liu L#, Wang W, Xu Z, Huang M*, Feng Y*. Convergence of carbapenem resistance and hypovirulence in a highly-transmissible ST11 clone of K. pneumoniae: An epidemiological, genomic and functional study. Virulence, 2021 Dec;12(1): 377-388. doi: 10.1080/21505594.2020.1867468. *corresponding author 30. Tang B#, Yang H#, Jia X, Feng Y*. Coexistence and characterization of Tet(X5) and NDM-3 in the MDR-Acinetobacter indicus of duck origin. Microb Pathog, 2020 Dec 18: 104697. doi: 10.1016/j.micpath.2020.104697. *corresponding author 29. Ji K#, Xu Y#, Sun J, Huang M, Jia X, Jiang C*, Feng Y*. Harnessing efficient multiplex PCR methods to detect the expanding Tet(X) family of tigecycline resistance genes. Virulence, 2020 Dec; 11(1): 49-56. doi: 10.1080/21505594.2019.1706913. *corresponding author 28. Wang W, Zhou D, Jia X, Feng Y*. Influenza-like illness caused by a cluster of importer Italian COVID-19. J Med Virol, 2020 Oct; 92 (10): 1764-1766. doi: 10.1002/jmv.25869. Epub 2020 Jun 29. *corresponding author 27. Tang B, Chang J, Zhang L, Liu L, Xia X, Hassan BH, Jia X, Yang H*, Feng Y*. Carriage of distinct mcr-1-harboring plasmids by unusual serotypes of Salmonella. Adv Biosyst. 2020 Mar; 4(3): e1900219. *corresponding author 26. Ullah S#, Ji K#, Li J, Xu Y, Jiang C, Zhang H, Huang M, Feng Y*. Characterization of NMCR-2, a new non-mobile colistin resistance enzyme: Implications for an MCR-8 ancestor. Environ Microbiol, 2021 Feb; 23(2): 844-860. doi: 10.1111/1462-2920.15171. *corresponding author 25. Zhang H, Srinivas S, Xu Y, Wei W, Feng Y*. Genetic and biochemical mechanisms for bacterial lipid A modifiers associated with polymyxin resistance. Trends Biochem Sci, 2019 Nov; 44(11): 973-988. *corresponding author 24. Gao R, Wei W, Hassan BH, Li J, Deng J, Feng Y*. A single regulator NrtR maintains bacterial NAD+ homeostasis via its acetylation. eLife, 2019 Oct 9; 8: e51603. *corresponding author 23. Wei W#, Guan H#, Zhu T#, Zhang S#, Fan C, Ouyang S*, Feng Y*. Molecular basis of BioJ, a unique gatekeeper in bacterial biotin synthesis. iScience, 2019 Aug 22; 19: 796-808. *corresponding author 22. Xu Y, Liu L, Sun J, Feng Y*. Limited distribution and mechanism for the TetX4 tigecycline resistance enzyme. Sci Bull, 2019, 64(20): 1478-1481. *corresponding author 21. Zhang H#, Wei W#, Huang M, Umar Z, Feng Y*. Definition of a family of nonmobile colistin resistance (NMCR-1) determinants suggests aquatic reservoirs for MCR-4. Adv Sci, 2019, 6(11): 201900038. *corresponding author 20. Zhang H#, Zong Z#*, Lei S#, Srinivas S, Sun J, Feng Y, Huang M, Feng Y*. A genomic, evolutionary, and mechanistic study of MCR-5 action suggests functional unification across the MCR family of colistin resistance. Adv Sci, 2019, 6(11): 201900034. *corresponding author 19. Wang Q, Hassan BH, Lou N, Merritt J, Feng Y*. Functional definition of NrtR, a remnant regulator of NAD+ homeostasis in the zoonotic pathogen, Streptococcus suis. FASEB J. 2019 May; 33(5): 6055-6068. *corresponding author 18. Zhang H#, Hou M#, Xu Y#, Srinivas S, Huang M, Liu L, Feng Y*. Action and mechanism of the colistin resistance enzyme MCR-4. Commun Biol. 2019 Jan 25; 2: 36. *corresponding author 17. Xu Y#, Zhong L#, Srinivas S#, Sun J#, Paterson DL, Lei S, Lin J, Xin Li, Tang Z, Feng S, Shen C, Tian GB*, Feng Y*. Spread of MCR-3 colistin resistance in China: An epidemiological, genomic and mechanistic study. EBioMedicine, 2018, 34: 139-157. *corresponding author 16. Wei W#, Zhang Y#, Gao R#, Li J, Xu Y, Wang S, Ji Q*, Feng Y*. Crystal structure and acetylation of BioQ suggests a novel regulatory switch for biotin biosynthesis in Mycobacterium smegmatis. Mol Microbiol, 2018 Sep; 109(5): 642-662. *corresponding author 15. Wei W#, Srinivas S#, Lin J#, Tang Z#, Wang SH, Ullah S, Kota VG, Feng Y*. Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis. PLoS Genet, 2018, May14; 14(5): e1007389. *corresponding author 14. Xu Y#, Wei W#, Lei S#, Lin J, Srinivas S, Feng Y*. An evolutionarily-conserved mechanism for intrinsic and transferable polymyxin resistance. mBio, 2018 Apr 10; 9(2): e02317-17. *corresponding author 13. Sun J#, Zhang H#, Liu YH*, Feng Y*. Towards understanding MCR-like colistin resistance. Trends Microbiol, 2018 Sep; 26(9): 794-808. *corresponding author 12. Xu Y#, Lin J#, Cui T#, Srinivas S, Feng Y*. Mechanistic insights into transferable polymyxin resistance among gut bacteria. J Biol Chem, 2018 Mar 23; 293(12): 4350-4365. *corresponding author 11. Wang Q#, Sun J#, Li J#, Ding Y, Li XP, Lin J, Hassan B, Feng Y*. Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs. Microbiome. 2017, Jul 6; 5(1): 70. *corresponding author 10. Sun J#, Xu Y#, Gao R#, Lin J, Wei W, Srinivas S, Li D, Yang RS, Li XP, Liao XP, Liu YH*, Feng Y*. Deciphering MCR-2 colistin resistance. mBio. 2017 May 9; 8(3): e00625-17. *corresponding author 9. Wang Q, Sun J, Ding Y, Li XP, Liu YH, Feng Y*. Genomic insights into mcr-1-positive plasmids carried by the colistin-resistant Escherichia coli from the inpatients. AAC. 2017 Jun 27; 61(7): e00361-17. *corresponding author 8. Gao R#, Hu Y#, Li Z#, Sun J#, Wang Q, Lin J, Ye H, Liu F, Srinivas S, Li D, Zhu B, Liu Y, Tian GB, Feng Y*. Dissemination and mechanism for the MCR-1 colistin resistance. PLoS Pathog, 2016, 12(11): e1005957. *corresponding author 7. Shi X#, Ye H#, Wang J, Li Z, Wang J, Chen B, Wen R, Hu Q, Feng Y*. Loss of 89K pathogenicity island in epidemic Streptococcus suis, China. Emerg Infect Dis 2016 Jun; 22(6): 1126-1127. *corresponding author 6. Ye H#, Li Y#, Li Z, Gao R, Zhang H, Wen R, Gao GF, Hu Q, Feng Y*. Diversified mcr-1-harbouring plasmid reservoirs confer resistance to colistin in human gut microbiota. mBio, 2016 Apr 5; 7(2): e00177-16. *corresponding author 5. Zhang H, Seward C, Wu Z, Ye H, Feng Y*. Genomic insights into the ESBL and MCR-1-producing ST648 Escherichia coli with multi-drug resistance. Sci Bull 2016, 61: 875-878. *corresponding author 4. Gao R#, Lin J#, Zhang H, Feng Y*. Transcriptional repression of the VC2105 by the Vibrio FadR suggests a new auxilliary member of fad regulon. Appl Environ Microbiol. 2016 Mar 4. 82(9): 2819-2832. *corresponding author 3. Zhang H, Zheng B, Gao R, Feng Y*. Binding of Shewanella FadR to the fabA fatty acid biosynthetic gene: Implications for contraction of the fad regulon. Protein & Cell, 2015, 6(9): 667-679. *corresponding author 2. Tang Q, Li X, Zou T, Zhang H, Wang Y, Gao R, Li Z, He J*, Feng Y*. Mycobacterium smegmatis BioQ defines a new regulatory network for biotin metabolism. Mol Microbiol, 2014, 94(5): 1006-1020. *corresponding author 1. Zhang Y, Gao R, Ye H, Wang Q, Feng Y*. A new glimpse of FadR-DNA crosstalk revealed by deep dissection of the E. coli FadR regulatory protein. Protein & Cell, 2014, 5(12): 928-39. *corresponding author