段树民 照片

段树民

教授

所属大学: 浙江大学

所属学院: 医学院

邮箱:
duanshumin@zju.edu.cn

个人主页:
https://person.zju.edu.cn/0006042#0

个人简介

段树民,浙江大学教授、医药学部主任。中国科学院院士,第三世界科学院院士。1991年获日本九州大学医学博士。国家基金委创新团队负责人。担任为期8年的国家基金委重大研究计划“情感和记忆的神经环路基础”项目专家组组长,对我国脑科学环路水平的研究起到了重要推动作用。牵头建立的浙江大学中国人脑库,成为国家健康和疾病人脑组织资源库。先后担任Glia等国际杂志编委,Neuroscience Bulletin主编,Neuron顾问委员会委员,中国神经科学学会理事长(2011-2019)和监事长(2019-)。 长期从事神经生物学研究,在神经元-胶质细胞相互作用、突触发育和功能、脑功能的神经环路机制解析等方面取得系列研究成果。相关研究成果分别发表在Science、Cell、Neuron、Nature Neuroscience、Nature Cell Biology等国际著名杂志,在该领域产生了重要的国际影响。研究成果入选为2003年中国医药科技十大新闻,2006年中国基础研究十大新闻。指导的学生多次获全国百篇优秀博士论文。研究成果两次获得国家自然科学二等奖(2010年第一获奖人,2017年第二获奖人)。2008年获何梁何利科学与进步奖。 奖励和荣誉 国家自然科学二等奖(第二获奖人) 2017 国家自然科学二等奖 2010 何梁何利科学与进步奖 2008

研究领域

神经元-胶质细胞相互作用 情绪及相关疾病的神经环路解析 神经信号传递机制 神经系统疾病

近期论文

Liu YJ*, Zhang T, Cheng DX, Yang JH,Chen SC, Wang XY, Li X, Duan D, Lou HF, Zhu LY, Luo JH, Ho M*, Wang XD*, Duan SM*. Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD. Science Advances. 2020 Dec 9; 6(50)eaba5783. (IF= 14.094) Li Sun*#, Rui Liu#, Fang Guo, Man-qing Wen, Xiao-lin Ma, Kai-yuan Li, Hao Sun, Ceng-lin Xu, Yuan-yuan Li, Zheng-gang Zhu, Xinjian Li, Yan-qin Yu, Zhong Chen, Xiang-Yao Li, Shumin Duan*, Parabrachial nucleus circuit governs 1 neuropathic pain-like behavior. Nature Communications. 2020 Nov 25;11(1):5974.doi: 10.1038/s41467-020-19767-w (IF 12.123) Bin Zhang#, Liyao Qiu#, Wei Xiao, Hong Ni, Lunhao Chen, Fan Wang, Weihao Mai, Jintao Wu, Aimin Bao, Hailan Hu, Hui Gong, Shumin Duan, Anan Li*, Zhihua Gao*. Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain, Neuron 2020 doi.org/10.1016/j.neuron.2020.10.032 Yulan Li#, Lixuan Li#, Jintao Wu, Zhenggang Zhu, Xiang Feng, Liming Qin, Yuwei Zhu, Li Sun, Yijun Liu, Zilong Qiu, Shumin Duan*,Yan-Qin Yu*.Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors. eLife 2020 9:e57155. DOI: https://doi.org/10.7554/eLife.57155 Duan D#, Zhang H#, Yue X#, Fan Y#, Xue Y, Shao J,Ding G, Li S, Cheng H, Zhang X, Chen D, Zou W, Zhao J, Wang L, Wang Z, Xu S, Duan S*, Kang L*. Sensory glia detect repulsive odorant and drive olfactory adaptation. Neuron, 2020 Sep 23; 108, 1–15 Xia Li, Liming Qin,Yefei Li, Hao Yu,Zhijun Zhang, Changlu Tao, Yijun Liu, Yanhong Xue, Xiaoxing Zhang, Zhenghao Xu, Yi Wang, Huifang Lou, Zhibin Tan, Paul Saftig, Zhong Chen, Tao Xu, Guoqiang Bi, Shumin Duan*, Zhihua Gao*. PresynapticEndosomalCathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles. Cell Reports. 2019 Jul 23;28(4):1015-1028. Tan Z, Liu Y, Xi W, Lou HF, Zhu L, Guo Z, Mei L, Duan S*. Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons. Nat Commun, 2017, 8: 13772. Yang H, Yang J, Xi W, Hao S, Luo B, He X, Zhu L, Lou H, Yu YQ, Xu F, Duan S*, Wang H*. Laterodorsaltegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear.[J]. Nat Neurosci, 2016, 19(2): 283-289. Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan S*. A novel size-based sorting mechanism of pinocytic luminal cargoes in microglia. J Neurosci. 2015, 35(6):2674-2688. Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng GP, Huang ZL, Duan S*, Yu YQ*, Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep wake Transitions, Curr Biol. 2014,24: 693-698 Wu HJ, Liu YJ, Li HQ, Chen C, Dou Y, Lou HF, Ho MS, Li XM, Gao Z*, Duan S. Analysis of microglial migration by a micropipette assay. Nat Protoc. 2014, 9: 491-500. Li HQ, Chen C, Dou Y, Wu HJ, Liu YJ, Lou HF, Zhang JM, Li XM, Wang H, Duan S*. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol Cell Biol. 2013, 33: 4282-93. Chen J, Tan Z, Zeng L, Zhang X, He Y, Gao W, Wu X, Li Y, Bu B, Wang W, Duan S*.Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia. 2013, 61:178-191. Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson WB, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S*, Zheng J*. CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem Cells. 2012, 30:2571-2583. Y Dou, HJ Wu, HQ Li, S Qin, HF Lou, QM Luo, Duan S*, Microglia Migration Mediated by ATP-Induced ATP Release from Lysosome, Cell Res, 2012 22:1022-1033. Song AH, Wang D, Chen G, Li Y, Luo J, Duan S*, Poo MM. A selective filter for cytoplasmic transport at the axon initial segment. Cell. 2009, 136(6):1148-1160. Tong XP, Li XY, Zhou B, Shen WH, Zhang ZJ, Xu TL, Duan S*,Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration, J Cell Biol. 2009, 186(1): 113-128. Li H, Chen G, Zhou B, Duan S*. Actin Filament Assembly by MARCKS- PI(4,5)P2 Signaling Is Critical for Dendrite Branching. MolBiol Cell. 2008, 19(1): 4804-4813. Zhang ZJ, Chen G, Zhou W, Song AH, Wang W, Xu T, Luo QM, Gu XS, Duan S*, Regulated ATP release from astrocytes via lysosome exocytosis. Nat Cell Biol.2007, 9(8): 945-953. Chen G, Li HM, Chen YR, Gu XS, Duan S*. Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C. Glia 2007; 55(15)):1509-1518. Ge WP, Yang XJ, Zhang ZJ, Wang HK, Deng QD, Duan S*. Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors. Science, 2006,312, 1533-1537. Shen W, Wu B, Zhang Z, Dou Y, Rao ZR, Chen YR, Duan S*. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron, 2006, 50(3): 401-414 (Cover article) Duan S*,Neary J, P2X7/P2Z receptors: properties and relevance to CNS functions (Invited review). Glia, 2006, 54:738-746. Li, C., Wu, CP., Duan S*, and Poo, M*. Bidirectional Modification of Presynaptic Neuronal Excitability Accompanying Spike Timing-Dependent Synaptic Plasticity. Neuron, 2004, 41(2), 257-268. Zhang J, Wang H Ye C, Ge W, Chen Y, Wu CP, Poo M, and Duan S*.ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression. Neuron,2003, 40 (5), 971-982.