教育经历 2001/03 - 2004/06，浙江大学，肿瘤学，博士，导师 郑树 1993/09 - 1996/06，武汉大学，细胞生物学，硕士，导师 利容千 1989/09 - 1993/06，华中师范大学，生物，学士 科研与学术工作经历 2010/11 - 至今，浙江大学，医学院附属邵逸夫医院，教育部恶性肿瘤预警和干预重点实验室，副研究员 2007/09 - 2010/03，美国加州大学洛杉矶分校，博士后，导师 Mo Kwan Kang 2006/01 - 2010/10，浙江大学，肿瘤研究所，教育部恶性肿瘤预警和干预重点实验室，浙江省医学分子生物学重点实验室，副研究员 1999/04 - 2005/12，浙江大学，肿瘤研究所，浙江省医学分子生物学重点实验室，助理研究员 1996/07 – 1999/03，同济医科大学，药学院，助教

肿瘤相关基因功能 小分子抗肿瘤药物

1. Xu ZY#, Zhou Z#, Zhang J, Xuan FC, Liuyang ZY, Fan MJ, Zhou DF, Ma XM, Hong YY, Wang YH, Sharma S, Dong QH*, Wang GY*. Targeting Bmi-1 -mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis. Acta Pharm Sin B. 2021 (Epub online) 2. Ma X#, Zhou Z#, Zhang X, Fan M, Hong Y, Feng Y, Dong Q*, Diao H*, Wang G*. Sodium butyrate modulates gut microbiota and immune response in colorectal cancer liver metastatic mice. Cell Bio Toxicol. 36(5):509-515, 2020 3. Fan M, Ma X, Wang F, Zhou Z, Zhang J, Zhou D, Hong Y, Wang Y, Wang G*, Dong Q*. MicroRNA-30b-5p functions as a metastasis suppressorin colorectal cancer by targeting Rap1b. Cancer Lett. 477:144-156, 2020 4. Tao J, Fan M, Zhou D, Hong Y, Zhang J, Liu H, Sharma S, Wang G*, DongQ*. MiR-200c modulates the pathogenesis of radiation-induced oral mucositis. Oxid Med Cell Longev. 2352079, 2019 5. Xu Z，Tao J, Chen P, Chen L, Sharma S, Wang G*, Dong Q*. Sodium Butyrate Inhibits Colorectal Cancer Cell Migration by downregulating Bmi-1 through enhanced miR-200c expression. Mol Nutr Food Res. 62(6):e1700844, 2018 6. Wang G，Dong F, Xu Z, Sharma S, Chen D, Hu X, Zhang L, Zhang J*, Dong Q*. MicroRNA profile in HBV-induced infection and hepatocellular carcinoma. BMC Cancer. 17(1):805, 2017 7. Liu H, Yang W, Gao H, Jiang T, Gu B, Dong Q, Xu W, Wu S, Sun X. Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair. Onco Targets Ther. 8:509-18, 2015 8. Dong Q, Chen L, Lu Q, Sharma S, Li L, Morimoto S, Wang G. Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression.Br J Pharmacol. 171:4440 - 4454, 2014. 9. Dong Q, Sharma S, Liu H, Chen L, Gu B, Sun X, Wang G. HDAC inhibitors reverse acquired radio resistance of KYSE-150R esophageal carcinoma cells by modulating Bmi-1 expression. Toxicol Lett. 224(1):121-129, 2014. 10. Dong Q, Oh JE, Yi JK, Kim RH, Shin KH, Mitsuyasu R, Park NH, Kang MK. Efavirenz induces autophagy and aberrant differentiation in normal human keratinocytes. Int J Mol Med. 31(6):1305-1312, 2013. 11. Wang GY, Zhang JW, Liu LY, Sharma S, Dong QH*.Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl. PLoS ONE. 7:e51764, 2012. 12. Wang G, Liu L, Sharma S, Liu H, Yang W, Sun X, Dong Q*.Bmi-1 confers adaptive radioresistance to KYSE-150R esophageal carcinoma cells. Biochem Biophys Res Commun. 425:309-314, 2012. 13. Liu Y, Ye F, Yamada K, Tso JL, Zhang Y, Nguyen DH, Dong Q, Soto H, Choe J, Dembo A, Wheeler H, Eskin A, Schmid I, Yong WH, Mischel PS, Cloughesy TF, Kornblum HI, Nelson SF, Liau LM, Tso CL. Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol Cancer Res. 9(12):1668-1685, 2011. 14. Kim RH, Lee RS, Williams D, Bae S, Woo J, Lieberman M, Oh JE, Dong Q, Shin KH, Kang MK, Park NH. Bisphosphonates induce senescence in normal human oral keratinocytes. J Dent Res. 90: 810-816, 2011. 15. Dong Q, Oh JE , Chen W, Kim R, Kim RH, Shin KH, McBride WH, Park NH, Kang MK. Radioprotective effects of Bmi-1 involve epigenetic silencing of its target genes and enhanced DNA repair in normal human keratinocytes. J Invest Dermatol. 131:1216-1225, 2011. 16. Chen W, Dong Q, Shin KH, Kim RH, Oh JE, Park NH, Kang MK. Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes. J. Biol Chem. 285:40852-40863, 2010. 17. Liu Q, Nguyen DH, Dong Q, Shitaku P, Chung K, Liu OY, Tso JL, Liu JY, Konkankit V, Cloughesy TF, Mischel PS, Lane TF, Liau LM, Nelson SF, Tso CL. Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors. J Neurooncol. 94:1-19, 2009. 18. Wang GY, Lv QH, Dong Q., Xu RZ, Dong QH*. Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice. J Asian Nat Prod Res. 11:219-228, 2009. 19. Wang GY, Zhang JW, Lv QH, Xu RZ, Dong QH*. Berbamine induces apoptosis in human hepatoma cell line SMMC7721 by loss in mitochondrial transmembrane potential and caspase activation. Journal of Zhejiang University Science B., 8:248-255, 2007. 20. Xu R, Dong Q#, Yu Y, Zhao X, Gan X, Wu D, Lu Q, Xu X, Yu XF.Berbamine: A novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity. Leuk Res., 30:17-23, 2006. #Co-first author 21. Dong QH, Zheng S, Hu Y, Chen GX, Ding JY. Evaluation of ST13 gene expression in colorectal cancer patients. Journal of Zhejiang University Science B., 6:1170-1175, 2005. 22. Xu R, Yu Y, Zheng S, Zhao X, Dong Q, Liang Y, Lu Q, Fang Y, Gan X, Xu X, Zhang S, Dong Q, Zhang X, Feng GS. Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.Blood, 106:3142-3149, 2005.