博士，浙江大学医学院附属第二医院主任医师，博士研究生导师。毕业于湘雅医学院，分别获学士、硕士和博士学位。哈佛大学医学院Joslin糖尿病中心留学专家。中华医学会骨质疏松和骨矿盐疾病分会社区与基层工作学组委员，浙江省转化医学会内分泌学分会会长，浙江省预防医学会甲状腺疾病防治专委会副主任委员，浙江省医学会骨质疏松和骨矿盐疾病分会常务委员，浙江省营养学会肥胖防治分会常委，浙江省营养学会慢病管理学分会常委，省医师协会专家志愿者，SCI杂志International Journal of Endocrinology的Lead Guest Editor。Diabetes、Diabetologia、British Journal of Medicine等知名SCI杂志审稿专家，国家自然科学基金一审专家，中华内分泌代谢杂志特邀审稿专家。主持国家自然科学基金4项，浙江省自然科学基金联合重大项目1项，省厅级课题多项。发表医学论文70余篇，其中SCI收录论文（Cell Rep Med、Diabetes Care、Journal of Experimental Medicine、Circ Res、Diabetes、Brain等）50余篇。 擅长糖尿病、肥胖、代谢综合征、骨质疏松、垂体、甲状腺疾病等内分泌疾病的临床诊治。参与编写2个国家级专家共识 “缓解2型糖尿病中国专家共识”、“超重或肥胖人群体重管理流程的专家共识（2021年）”；作为项目负责人主办首个国家级医学继续教育学习班“糖尿病逆转新技术”学习班。在2型糖尿病逆转、肥胖相关疾病逆转、减肥有丰富经验。 受教育经历（从大学本科开始，按时间倒排序） · 2003/9－2006/6，中南大学，湘雅医学院，博士，导师 廖二元教授 · 2000/9－2003/6，中南大学，湘雅医学院，硕士，导师 廖二元教授 · 1995/9－2000/6，中南大学，湘雅医学院，学士 工作和研究经历（按时间倒排序） · 2017/12－今，浙江大学，医学院附属第二医院，主任医师 · 2012/1－2017/11，浙江大学，医学院附属第二医院，副主任医师 · 2012/1－2016/3，浙江大学，医学院附属第二医院，副主任医师 · 2014/6－2015/6，哈佛大学，哈佛医学院Joslin糖尿病中心，访问学者 · 2006/8－2011/12，浙江大学，医学院附属第二医院，主治医师 奖励 1. 获2013年浙江省优秀专家志愿者称号（全省共10位） 2. 谷卫、单鹏飞、徐小红、余捷凯、陈益定、兰 兰、曾文衡、吴华，早期糖尿病肾病尿液标志性蛋白分析、鉴定及诊断模型的建立，浙江省卫生厅，浙江省医药卫生科技奖，二等奖，2011 3. 单鹏飞，中华医学会骨质疏松和骨矿盐疾病分会，临床研究杰出青年学者，优秀奖，2010 4. 研究生 单鹏飞，导师 廖二元；论文题目“长沙地区儿童、青少年面积骨密度横断面初步调查”，湖南省教育厅，湖南省优秀硕士论文，2005 参编的部分著作 《内分泌代谢病学》第4版，2019，人民卫生出版社，廖二元主编； 《全科医学临床住院医师指导手册》，2017，人民卫生出版社， Mori J. Morikawa 《临床甲状腺病学》，2013，人民卫生出版社，向光大主编， 《内分泌代谢病学》第3版，2012，人民卫生出版社，廖二元主编； 《内分泌学》第2版，2007，人民卫生出版社，廖二元主编； 《内分泌学手册》，2006，人民卫生出版社，廖二元主编； 《代谢性骨病学》，2003，人民卫生出版社，廖二元主编； 《激素敏感综合征和激素不敏感综合征》，2002，人民卫生出版社，廖二元主编）。

内分泌代谢病学 糖尿病 肥胖

发表的部分学术论文和著作(* 代表通讯作者) Xu Y, Wang A, Lin X, Xu J, Shan Y, Pan X, Ye J, Shan PF*. Global burden and gender disparity of vision loss associated with diabetes retinopathy. Acta Ophthalmol. 2020 Oct 29. doi: 10.1111/aos.14644. Lin X, Lou L, Miao Q, Wang Y, Jin K, Shan P, Xu Y. The pattern and gender disparity in global burden of age-related macular degeneration. Eur J Ophthalmol. 2020 Jun 4:1120672120927256. doi: 10.1177/1120672120927256. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, Song X, Ren Y, Shan PF*. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020 Sep 8;10(1):14790. doi: 10.1038/s41598-020-71908-9. Lin X, Xu Y, Xu J, Pan X, Song X, Shan L, Zhao Y, Shan PF*. Global burden of noncommunicable disease attributable to high body mass index in 195 countries and territories, 1990-2017. Endocrine. 2020 Aug;69(2):310-320. doi: 10.1007/s12020-020-02352-y. Ye L, Xu J, Zhang T, Lin X, Pan X, Zeng W, Ren Y, Shan P*. Global burden of noncommunicable diseases attributable to high fasting plasma glucose.J Diabetes. 2020 Nov;12(11):807-818. doi: 10.1111/1753-0407.13072. Ye L, Xu J, Zhang T, Lin X, Pan X, Zeng W, Ren R, Shan PF*. Global burden of noncommunicable diseases attributable to high fasting plasma glucose. Journal of Diabetes 2020;1–12. https://doi.org/10. 1111/1753-0407.13072. Cen Z, Chen Y, Chen S, Wang H, Yang D, Zhang H, Wu H, Wang L, Tang S, Ye J, Shen J, Wang H, Fu F, Chen X, Xie F, Liu P, Xu X, Cao J, Cai P, Pan Q, Li J, Yang W, Shan PF, Li Y, Liu JY, Zhang B, Luo W. Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification. Brain. 2020 Feb 1;143(2):491-502. Kang YX, Lin XL, Ding Y, Pan XW, He SX, Shan PF*. Comment on Warren et al. Diabetes and Trajectories of Estimated Glomerular Filtration Rate: A Prospective Cohort Analysis of the Atherosclerosis Risk in Communities Study. Diabetes Care 2018;41:1646-1653. Diabetes Care. 2019 Mar;42(3):e51-e52. Shen J, Zhang N, Lin YN, Xiang P, Liu XB, Shan PF, Hu XY, Zhu W, Tang YL, Webster KA, Cai R, Schally AV, Wang J, Yu H.Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and Its Agonists. Circ Res. 2018 May 11;122(10):1395-1408. Wu Y, He J, Sun X, Zhao YM, Lou HY, Ji XL, Pang XH, Shan LZ, Kang YX, Xu J, Zhang SZ, Wang YJ, Ren YZ, Shan PF*. Carotid atherosclerosis and its relationship to coronary heart disease and stroke risk in patients with type 2 diabetes mellitus, Medicine (Baltimore), 2017, 96(39):e8151. Pang XH, Han J, Ye WL, Sun X, Ding Y, Huang WJ, Zhao YM, Lou HY, Shan LZ, Kang YX, Song XX, Zhang SZ, Gu W, Shan PF*. Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China. Int J Endocrinol, 2017, 2017:9620513. Shan PF*, Li Q, Khamaisi M, Qiang GF. Type 2 Diabetes Mellitus and Macrovascular Complications. Int J Endocrinol, 2017;2017:4301461. Ding Y, Sun X, Shan PF. MicroRNAs and Cardiovascular Disease in Diabetes Mellitus. Biomed Res Int. 2017;2017:4080364. Sun X, He J, Ji XL, Zhao YM, Lou HY, Song XX, Shan LZ, Kang YX, Zeng WH, Pang XH, Zhang SZ, Ding Y, Ren YZ, Shan PF*. Association of Chronic Kidney Disease with Coronary Heart Disease and Stroke Risks in Paents with Type 2 Diabetes Mellitus: An Observational Cross-sectional Study in Hangzhou, China. Chin Med J (Engl). 2017 5th Jan 2017;130(1):57-63. (通讯作者) 1.064 Sun X, Shan PF, Ding Y, Yu H, Song ZY. Comment on Gagnum et al. Long-term Mortality and End-Stage Renal Disease in a Type 1 Diabetes Population Diagnosed at Age 15-29 Years in Norway. Diabetes Care 2017;40:38-45. Diabetes Care. 2017 Sep;40(9):e124. Yao MF, He J, Sun X, Ji XL, Ding Y, Zhao YM, Lou HY, Song XX, Shan LZ, Kang YX, Zhang SZ, Shan PF*. Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China. Int J Endocrinol. 2016;2016:8483405. (通讯作者) 2.51 Shan PF, Ji XL, Wang L, Li P, Ren YZ. Comment on Tang et al. Effects of Insulin Glargine and Liraglutide Therapy on Liver Fat as Measured by Magnetic Resonance in Patients With Type 2 Diabetes: A Randomized Trial. Diabetes Care 2015;38:1339-1346. Diabetes Care. 2015 Sep;38(9):e148–9. 8.934 Yuan LQ, Ouyang HW, Andersen TL, Jiang Y, Pantano F, Shan PF. Osteoporosis 2014. Int J Endocrinol. 2015; 2015:567593. Shan PF, Ji XL. Comment on Lin et al. Risk Factors for Decline in IQ in Youth With Type 1 Diabetes Over the 12 Years From Diagnosis/Illness Onset. Diabetes Care 2015;38:236-242. Diabetes Care. 2015 Aug;38(8):e120. 8.934 Zou QL, Wei GN, Chen JX, Ye Q, Shan PF*.Hepatitis B virus-associated nephropathy in a patient with diabetes mellitus. J Diabetes Investig 2014;5(1):87–89. 1.825 Zheng J, Shan PF, Gu W. The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials. J Endocrinol Invest 2013;36(10):797–802.（共同第一作者） Zhu X, Jiang Y, Shan PF, Shen J, Liang QH, Cui RR, Liu Y, Liu GY, Wu SS, Lu Q, Xie H, Liu YS, Yuan LQ, Liao EY. Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway. Amino Acids, 44(3):961–968, 2013. Shan PF, Xian CJ, Li M, Xiang GD, Yuan LQ. Osteoporosis. Int J Endocrinol. 2013;2013:952858. Yin JH, Song ZY, Shan PF*, Xu J, Ye ZM, Xu XH, Zhang SZ, Liang Q, Zhao Y, Ren Z, Yu YP. Age- and gender-specific prevalence of carotid atherosclerosis and its association with metabolic syndrome in Hangzhou, China. Clin Endocrinol (Oxf), 76(6):802–809, 2012 Shan PF, Lu Y, Cui RR, Jiang Y, Yuan LQ, Liao EY. Apelin Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. PLoS One 2011, 6(3):e17938. Shan PF, Wu XP, Zhang H, Cao XZ, Yuan LQ, Liao EY. Age-related bone mineral density, osteoporosis rate and risk of vertebral fracture in mainland Chinese women with type 2 diabetes mellitus. J Endocrinol Invest. 2011 Mar;34(3):190–196.