刁宏燕，浙江大学医学院传染病诊治国家重点实验室，教授，博导，教育部新世纪优秀人才。 研究方向1. 感染性疾病的免疫发病机制研究；2. 肠道菌群与免疫细胞活化。 以第一或通讯作者在Immunity、PNAS等国际著名期刊发表论文70余篇。，累计影响因子超过300，总他引次数超过2000次。相继主持国家自然科学基金面上项目、国家重大专项课题、国家重点研发计划课题、浙江省重点研发计划、钱江人才等基金项目十余项。作为第一发明人获国内发明专利授权10项。作为主要成员获国家科技进步特等奖1项、国家科技进步一等奖1项，中华医学科技一等奖1项,担任《Scientific Reports》、《浙江大学学报》、《npj infection diseases》等期刊编委；《中华现代临床医学杂志》常务编委；浙江省感染免疫学会主任委员，浙江省医学微生态学会副主任委员，中华预防医学会委员会委员；浙江省女性科学工作者协会委员等学术兼职。 获奖 作为主要骨干获得国家科技进步特等奖1项、国家科技进步一等奖1项、中华医学科技一等奖1项。

肝脏疾病的免疫发病机制 肠道菌群与免疫细胞活化

1、《Scientific Reports》编委（Editorial Board Member） 2、《浙江大学学报》编委 3、《中华现代临床医学杂志》常务编委 4、《npj infection diseases》编委（Editorial Board Member） 5、浙江省免疫学会理事 6、浙江省免疫学会感染免疫分会主任委员 7、中华预防医学会微生态分会常务委员 8、浙江省女性科学工作者协会理事

代表性论文(作为通讯作者发表论文） 1. Chen J, Zeng P, Gong L, Zhang X, Ling Z , Bi K, Shi F, Wang K, Zhang Q, Jiang J, Uede T, El-Omar EM, Diao H*. Osteopontin Exacerbates High-Fat Diet-Induced Metabolic Disorders in a Microbiome-Dependent Manner. mBio. 2022 Accepted (IF:7.786, 一区) 2. Li X, Zhang Y, Wang J, Li Y, Wang Y, Shi F, Hong L, Li L, Diao H* zVAD alleviates experimental autoimmune hepatitis in mice by increasing the sensitivity of macrophage to TNFR1-dependent necroptosis. Journal of Autoimmunity.2022, 13;133:102904. (IF:14.511，一区) 3. Li Y, Wang Y, Shi F, Zhang X, Zhang Y, Bi K, Chen X, Li L*, Diao H*.Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent γδ T cells. Gut Microbes. 2022;14(1):2096994. （IF：9.434，一区） 4. Zheng W，Zhang Z，Li Y，Wang L, Fu F, Diao H*, Liu X*. A novel pullulan oxidation approach to preparing a shape memory sponge with rapid reaction capability for massive hemorrhage. Chemical Engineering Journal. 2022 Nov, 447,1374822. （IF:16.744,一区） 5. Jiang J, Li Y, Sun Z, Gong L, Li X, Shi F, Yao J, Meng Y, Meng X, Zhang Q, Wang Y, Su X, Diao H. LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination. iScience. 2022 Jun 15;25(7):104607.5.(IF:6.107） 6. Jia H, Chen J, Zhang X, Bi K, Zhou H, Liu T, Xu J, Diao H*.IL-17A produced by invariant natural killer T cells and CD3+ CD56+ αGalcer-CD1d tetramer- T cells promote liver fibrosis in patients with primary biliary cholangitis. J Leukoc Biol. 2022 Jun 22. doi: 10.1002/JLB.2A0622-586RRRR. Online ahead of print. （IF：6.011） 7. Chen J, Li X, Zeng P, Zhang X, Bi K, Lin C, Jiang J, Diao H*. Lamina propria interleukin 17 A aggravates natural killer T-cell activation in autoimmune hepatitis. FASEB J. 2022 Jun;36(6):e22346.（IF：5.834） 8. Zhang Q, Zhang X, Lei X, Wang H, Jiang J, Wang Y, Bi K, Diao H*. Influenza A virus NS1 protein hijacks YAP/TAZ to suppress TLR3-mediated innate immune response. PLoS Pathog. 2022 May 3;18(5):e1010505.（IF：7.464, 一区） 9. Zeng P, Zhang X, Xiang T, Ling Z, Lin C, Diao H*. Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers. Bioengineered. 2022 Feb;13(2):3221-3239.（IF：6.832） 10. Zhang Y, Shi F, Wang Y, Meng Y, Zhang Q, Wang K, Zeng P, Diao H*. Comparative Analysis of Long Non-Coding RNA Expression and Immune Response in Mild and Severe COVID-19. Frontiers in Molecular Biosciences. 2022 (IF:6.113) 11. Qiang Z，Xiao Y，Zhang X，Li Q, Wang L, Fu F, Diao H*, Liu X*.Bio-based epoxy resins derived from diphenolic acid via amidation showing enhanced performance and unexpected autocatalytic effect on curing. Chemical Engineering Journal. 2022 May, 435, 135022（IF:16.744, 一区） 12. Wang J#, Li X#, Wang Y, Li Y, Shi F, Diao H*. Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis. Cell Death Discov. 2022 Mar 4;8(1):97. (IF:7.109) 13. Zhang X, Bi K, Tu X, Zhang Q, Cao Q, Liang Y, Zeng P, Wang L, Liu T, Fang W*, Diao H*. Interleukin-33 as an early predictor of cetuximab treatment efficacy in patients with colorectal cancer. Cancer Med. 2021 Dec;10(23):8338-8351. 14. Wang L, Wen X, Zhang X, Yuan S, Xu Q, Fu F, Diao H*, Liu X*. Durable antimicrobial cotton fabric fabricated by carboxymethyl chitosan and quaternary ammonium salts. Cellulose 2021, 28, 5867-5879(IF:6.123) 15. Yang J, Wen X, Zhang X, Hu X, Fan L, Jia D, Xu Q, Fu F, Diao H*, Liu X*. A lipid coating on cotton fibers with enhanced adsorption capability for fabric functionalization. Cellulose 2021, 28, 5957-5971. (IF:6.123) 16. Zheng W, Chen C, Zhang X, Wen X, Xiao Y, Li L, Xu Q, Fu F, Diao H*, Liu X*. Layer-by-layer coating of carboxymethyl chitosan-gelatin-alginate on cotton gauze for hemostasis and wound healing. Surf. Coat. Technol. 2021, 406. 17. Meng Y, Zhang Q, Wang K, Zhang X, Yang R, Bi K, Chen W, Diao H*. RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes. Cell Death Disease. 2021 Jul 23;12(8):732. （IF:9.685，一区） 18. Wang Y, Zhang X, Bi K, Diao H*.Critical role of microRNAs in host and influenza A (H1N1) virus interactions.life Sci. 2021 Jul 15;277:119484 (IF:6.78) 19. Yao J#, Lin C#, Jiang J, Zhang X, Li F, Liu T, Diao H*. lncRNA-HEIM Facilitated Liver Fibrosis by Up-Regulating TGF-β Expression in Long-Term Outcome of Chronic Hepatitis B. Front Immunol. 2021 Jun 8;12:666370. （IF：8.785） 20. Qiong Zhang, Yuting Meng, Kaihang Wang, Xujun Zhang, Wenbiao Chen, Jifang Sheng, Yunqing Qiu*, Hongyan Diao*, Lanjuan Li* Inflammation and Antiviral Immune Response Associated with Severe Progression of COVID-19. Front Immunol. 2021 Feb 18;12:631226. （IF:8.785） 21. Chen W#, Jiang J#, Gong L, Shu Z, Xiang D, Zhang X, Bi K, Diao H*. Hepatitis B virus P protein initiates glycolytic bypass in HBV-related hepatocellular carcinoma via a FOXO3/miRNA-30b-5p/MINPP1 axis. J Exp Clin Cancer Res. 2021 Jan 4; 40(1):1. （IF:12.658，一区） 22. Xu, Q, Jing Y, Zhang X, Wen X, Yamada M, Fu F, Diao H, Liu X*. A “grafting through” strategy for constructing Janus cotton fabric by mist polymerization, Journal of Materials Chemistry A, 2020, 8: 24553-24562. (IF:14.511) 23. Hou X, Chen W, Zhang X, Wang G, Chen J, Zeng P, Fu X, Zhang Q, Liu X, Diao H*. Pre-selection TCR repertoire predicts CD4+ and CD8+ T cell differentiation state. Immunology. 2020 Dec;161(4):354-363. (IF：7.215） 24. Duan, P, Xu, Q, Zhang, X, Chen, J, Zheng, W, Li, L, Yang, J, Fu, F, Diao H*.; Liu, X*. Naturally occurring betaine grafted on cotton fabric for achieving antibacterial and anti-protein adsorption functions. Cellulose 2020, 27 (11), 6603-6615. (IF:6.123) 25. Bi K, Zhang X, Chen W, Diao H*.MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review.Genes (Basel). 2020 Sep 12;11(9):E1075. 26. Chen W, Zhang X, Bi K, Zhou H, Xu J, Dai Y, Diao H. Comprehensive Study of Tumor Immune Microenvironment and Relevant Genes in Hepatocellular Carcinoma Identifies Potential Prognostic Significance. Frontiers in oncology 2020 Sep 24, 10: 554165. (IF： 5.738） 27. Ma X, Zhou Z, Zhang X, Fan M, Hong Y, Feng Y, Dong Q, Diao H*, Wang G*. Sodium butyrate modulates gut microbiota and immune response in colorectal cancer liver metastatic mice. Cell Biol Toxicol. 2020 Oct;36(5):509-515.（IF：6.819） 28. Chen W, Zhuang J, Wang PP, Jiang J, Lin C, Zeng P, Liang Y, Zhang X, Dai Y*, Diao H*.DNA methylation-based classification and identification of renal cell carcinoma prognosis-subgroups.Cancer Cell Int. 2019 Jul 16;19:185. (IF: 6.429) 29. Dong F#, Chen J#, Li C*, Ma X, Jiang J, Lin Q, Lin C, Diao H*.Evidence-based analysis on the toxicity of disinfection byproducts in vivo and in vitro for disinfection selection.Water Res. 2019 Nov 15;165:114976.（IF：13.40，一区） 30. Xu Q, Zheng W, Duan P, Chen J, Zhang Y Fu F, Diao H*, Liu X*. One-pot fabrication of durable antibacterial cotton fabric coated with silver nanoparticles via carboxymethyl chitosan as a binder and stabilizer. Carbohyd Polym. JAN 15 2019 204,42-49. (IF:10.723) 31. Xianliang Hou, Ping Zeng, Jianing Chen, Hongyan Diao*. No difference in TCRβ repertoire of CD4+ naive T cell between patients with primary biliary cholangitis and healthy control subjects. Mol Immunol. 2019 Dec;116:167-173. 32. Hou X, Yang Y, Chen J, Jia H, Zeng P, Lv L, Lu Y, Liu X, Diao H*: TCRbeta Repertoire of Memory T cell Reveals Potential Role for E.coli in the Pathogenesis of Primary Biliary Cholangitis. Liver Int. 2019 May;39(5):956-966. (IF:8.754) 33. Hou X, Zeng P, Zhang X, Chen J, Liang Y, Yang J, Yang Y, Liu X, Diao H*. Shorter TCR β-chains are highly enriched during thymic selection and antigen-driven selection. Front Immunol. 2019 Feb 26;10:299. （IF：8.785） 34. Chen W, Tang D, Dai Y*, Diao H*. Establishment of microRNA, transcript and protein regulatory networks in Alport syndrome induced pluripotent stem cells. Mol Med Rep. 2019 Jan;19(1):238-250. 35. Cui G#, Chen J#, Wu Z, Huang H, Wang L, Liang Y, Zeng P, Yang J, Uede T, Diao H*.Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis. J Cell Physiol. 2019, 234(6): 8988-8997.（IF： 6.513） 36. Zhou J， Xu, QB , Zhang YY, Fu FY, Diao HY*,Liu, XD*. Excellent binding effect of L-methionine for immobilizing silver nanoparticles onto cotton fabrics to improve the antibacterial durability against washing. RSC Advances 2018, 8(43):24458-24463. 37. Lu C, Hou X, Li M, Wang L, Zeng P, Jia H, Chen J, Wei Y, He H, Liu X, Diao H*. Detection of AMA-M2 in human saliva: Potentials in diagnosis and monitoring of primary biliary cholangitis. Sci Rep. 2017 Apr 11;7(1):796. 38. Diao H*, Iwabuchi K, Li L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T. Osteopontin regulates development and function of invariant natural killer T cells. Proc Natl Acad Sci U S A. 2008 Oct 14.105;41:15884-15889.（IF：12.779，一区） 39. Diao H * and Kohanawa M. Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of production of a tumor necrosis factor-alpha. Infect Immun., 73(6):3745-8. 40. Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, Ito D, Segawa T, Maeda M, Hamuro J, Nakayama T, Taniguchi M, Yagita H, Van Kaer L, Onóe K, Denhardt D, Rittling S, Uede T. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity, 21(4):539-50, 2004. （IF：43.474，一区）