丁克峰
教授
个人简介
丁克峰,浙江大学医学院附属第二医院副院长,国家重点研发计划首席科学家,浙江省“计划”杰出人才,浙江省卫生领军人才。浙江大学医学部教授、主任医师、博士生导师。浙江大学肿瘤学学位点负责人,浙江大学求是特聘医师。浙江大学肿瘤研究所副所长、浙江省医学分子生物学重点实验室主任。主持国家重点研发计划1项,国家自然科学基金7项,浙江省重点研发计划1项及浙江省“领雁”研发攻关计划1项。现担任中国抗癌协会理事,中国抗癌协会大肠癌专业委员会候任主任委员;中国医师协会结直肠肿瘤专委会副主任委员、外科专委会主任委员;中华医学会肿瘤学分会常务委员,浙江省抗癌协会大肠癌专业委员会候任主任委员,浙江省医学会理事、精准医学分会主任委员、肿瘤外科分会候任主委。擅长大肠癌腹腔镜微创治疗和综合诊治,率先在全国提出并开展腹腔镜辅助结直肠癌快速康复综合治疗模式,是创建浙江大学大肠癌多学科诊治中心的主要骨干和负责人之一。 1. 个人经历 1988年毕业于原浙江医科大学(现浙江大学)医学系,2000年获浙江大学肿瘤学博士学位。曾分别赴日本福井医科大学外科、澳大利亚悉尼大学Concord医院结直肠外科中心、香港基督教联合医院外科以及英国利物浦大学Anitree医院外科,进行为期三月到一年的临床工作和研修。现任浙江大学医学院附属第二医院副院长、浙江大学肿瘤研究所副所长以及浙江省医学分子生物学重点实验室主任。擅长大肠癌腹腔镜微创治疗和综合诊治,率先在全国提出并开展腹腔镜辅助结直肠癌快速康复综合治疗模式,是创建浙江大学大肠癌多学科诊治中心的主要骨干和负责人之一。专注于结直肠癌早诊早治、结直肠肿瘤外科及微创手术、晚期结直肠癌综合治疗、肿瘤转移与耐药的分子机制与新疗法等临床和科研领域。2004年晋升为主任医师、2009年晋升为浙江大学教授、2010年起担任浙江大学博士生导师(科学/专业)
研究领域
结直肠癌早诊早治与早期筛查新方法 结直肠癌微创外科与晚期肠癌的综合诊治 结直肠癌专病队列研究 基于人工智能的结直肠癌诊疗新体系 结直肠癌创新药物研发与辅助治疗新技术
学术兼职
中华医学会肿瘤学分会常务委员 中国抗癌协会理事 中国抗癌协会大肠癌专业委员会候任主任委员 中国医师协会结直肠肿瘤专委会副主任委员、外科专委会主任委员 浙江省抗癌协会大肠癌专业委员会候任主任委员 浙江省医学会理事、肿瘤外科分会候任主委、精准医疗学会主任委员 浙江省医师协会肛肠科医师分会委员
近期论文
H. Yang, J. Wang, X. Zhou, D. Fu, C. Le, J. Wei, Y. Qian, Y. Fang, T. Jin, X. Kong, C. Yu, D. Song, Y. Wang, X. Zhou, T. Zhou, Q. Zhou, X. Liu, Q. Xiao, K. Ding, Impact of protein corona and PEGylation on the accumulation and efficacy of lysosome-disrupting lipid nanoparticles in KRAS-mutated cancer, Nano Today. 56 (2024) 102307. Hu, Y-T, Chen, X-F, Zhai, C-B, et al. Clinical evaluation of a multitarget fecal immunochemical test-sDNA test for colorectal cancer screening in a high-risk population: a prospective, multicenter clinical study. MedComm. 2023; 4:e345. Fang X, Zhu N, Zhong C, Wang L, Li J, Weng S, Hu H, Dong C, Li D, Song Y, Xu D, Wang J, Sun L, Wang J, Wang Z, Cao H, Liao X, Yu N, Xiao Q, Mi M, Zhang S, Ding K, Yuan Y. Sintilimab plus bevacizumab, oxaliplatin and capecitabine as first-line therapy in RAS-mutant, microsatellite stable, unresectable metastatic colorectal cancer: an open-label, single-arm, phase II trial. EClinicalMedicine. 2023 Jul 27;62:102123. Han S, Zhuang J, Pan Y, Wu W, Ding K. Different Characteristics in Gut Microbiome between Advanced Adenoma Patients and Colorectal Cancer Patients by Metagenomic Analysis. Microbiol Spectr. 2022 Dec 1;10(6):e0159322. Yang H, Zhou X, Fu D, Le C, Wang J, Zhou Q, Liu X, Yuan Y, Ding K, Xiao Q. Targeting RAS mutants in malignancies: successes, failures, and reasons for hope. Cancer Commun (Lond). 2022 Oct 31. Shuwen H, Kefeng D. Intestinal phages interact with bacteria and are involved in human diseases. Gut Microbes. 2022 Jan-Dec;14(1):2113717. Jiang K, Chen H, Ding K. ANGPTL1, Foxo3a-Sox2, and colorectal cancer metastasis. Clin Sci (Lond). 2022 Sep 30;136(18):1367-1370. Chen S#, Cui W#, Chi Z#, Xiao Q, Hu T, Ye Q, Zhu K, Yu W, Wang Z, Yu C, Pan X, Dai S, Yang Q, Jin J, Zhang J, Li M, Yang D, Yu Q, Wang Q, Yu X, Yang W, Zhang X, Qian J, Ding K*, Wang D*. Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1. Cell Metab. 2022 Sep 7:S1550-4131(22)00359-X. Li B, Tang R, Zhang G, Cheng J, Chao M, Ding K. The efficacy and safety of continuous intra-arterial infusion neoadjuvant chemotherapy with surgery for locally advanced gastric cancer: a preliminary pilot study. J Gastrointest Oncol. 2022 Jun;13(3):968-976. Liu Y#, Xiao Q#, He J, Hu H, Du J, Zhu Y, Chen J, Liu Z, Wang J, Sun L, Xu D, Li J, Liao X, Wang J, Cai Y, Cai C, Jin Z, Wang L, Yuan Y, Ding K*. Phase II study of anlotinib in combination with oxaliplatin and capecitabine for patients with RAS/BRAF wild-type metastatic colorectal adenocarcinoma as the first-line therapy. BMC Med. 2022 May 6;20(1):155. Ye Y, Lu W, Deng Q, Chen Y, Han S, Dai S, Chen Z, Li J, Song Y, Wang Z, Ding K. Tumor enhancement ratio on preoperative abdominal contrast-enhanced CT scan for predicting recurrence risk in stage II colon cancer. Abdom Radiol (NY). 2022 Apr;47(4):1265-1275. Xiong J, He J, Zhu J, Pan J, Liao W, Ye H, Wang H, Song Y, Du Y, Cui B, Xue M, Zheng W, Kong X, Jiang K, Ding K*, Lai L*, Wang Q*. Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells [J]. Molecular Cell. 2022 March 22. Zhu Y#, Hu Y#, Kong X#, Xiao Q, Pan Z, Zheng Z, Wei Y, Ziqiang W, Wang D, Chen J, Chen K, Zheng S, Wang M, Wu X, Ding K*; NCRCC Research Group. Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China. BMJ Open. 2021 Dec 13;11(12):e051397 Pan X#, Qi Y#, Du Z, He J, Yao S, Lu W, Ding K, Zhou M. Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer. J Nanobiotechnology. 2021 Nov 27;19(1):392. Zhu Y#, Huang Y#, Hu Y#, Fang Y, Kong X, Xiao Q, He J, Zhu Y, Li Q, Yang J, Dong Q, Jin M, Wang M, Chen K, Zheng S, Ding K. Long-term Risk of Colorectal Cancer after Removal of Adenomas during Screening Colonoscopies in a Large Community-based Population in China. Int J Cancer. 2021 Oct 3 Zhou X, Xiao Q, Fu D, Zhang H, Tang Y, He J, Hu Y, Kong X, Teng F, Liu X, Yuan Y, Ding K. Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer. Cancer Biol Med. 2021 Aug 4. Xu J, Dai S, Jiang K, Xiao Q, Yuan Y, Ding K. Combining single-cell sequencing to identify key immune genes and construct the prognostic evaluation model for colon cancer patients. Clin Transl Med. 2021 Jul;11(7):e465. J-J He, F-F Sun, Q Xiao, K-F Ding. Laparoscopic ileocecal-sparing right hemicolectomy (LISH) for cancers of the hepatic flexure or proximal transverse colon: a video vignette. Tech Coloproctol. 2021 Mar 8 Qian Y, Wei J, Lu W, Sun F, Hwang M, Jiang K, Fu D, Zhou X, Kong X, Zhu Y, Xiao Q, Hu Y, Ding K. Prognostic Risk Model of Immune-Related Genes in Colorectal Cancer. Frontiers in Genetics. 2021, 12(105). Wei Lu, Xiang Pan, Siqi Dai, Dongliang Fu, Maxwell Hwang, Yingshuang Zhu, Lina Zhang, Jingsun Wei, Xiangxing Kong, Jun Li, Qian Xiao, Kefeng Ding. Identifying Stage II Colorectal Cancer Recurrence Associated Genes by Microarray Meta-Analysis and Building Predictive Models with Machine Learning Algorithms, Journal of Oncology, vol. 2021 Siqi Dai, Yao Ye, Xiangxing Kong, Jun Li, Kefeng Ding, A predictive model for early recurrence of colorectal-cancer liver metastases based on clinical parameters, Gastroenterology Report, 2021 Chen, H, Chen, L, Wang, X, et al. Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium‐induced colitis in mice. J Cell Mol Med. 2021; 00: 1– 12. Wei J, Qian Y, Tang Y, et al. Establishment of a Risk Signature Based on m6A RNA Methylation Regulators That Predicts Poor Prognosis in Renal Cell Carcinoma. OncoTargets and Therapy. 14 January 2021 Volume 2021:14 Jiang, K., Chen, H., Fang, Y. et al. Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness. J Exp Clin Cancer Res. 40, 21 (2021). Dai S, Xu S, Ye Y, Ding Kefeng Identification of an Immune-Related Gene Signature to Improve Prognosis Prediction in Colorectal Cancer Patients. Front Genet. 2020 Dec 4;11:607009. Qian Xiao, Wei Lu, XiangXing Kong, et al. Alterations of circulating bacterial DNA in colorectal cancer and adenoma: A proof-of-concept study. Cancer Lett. 2020 Nov 26;S0304-3835(20)30627-3. Xu Jiasheng, Dai Siqi, et al. A Prognostic Model for Colon Cancer Patients Based on Eight Signature Autophagy Genes. Front Cell Dev Biol. 2020 Nov 26;8:602174. Han S, Ye Y, Wu J, Li B, Zhang G, Jin K, Tang R, Huang W, Chao M, Ding K . Procalcitonin Levels in Post TACE Infection. Cancer Manag Res. 2020 Nov 26;12:12197-12203 Jingsun Wei, Xiaoxu Ge, Yang Tang, et al. An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer. Journal of Oncology. 2020 Oct. Jiafeng Wang, Xuefei Zhou, Huifang Wang, Qian Xiao, Kefeng Ding*, Xue Dong, et al. Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability. Biomaterials. 2020 Oct . Maxwell Hwang, Da Wang, Xiang-Xing Kong, Zhanhuai Wang, Jun Li, Wei-Cheng Jiang, Kao-Shing Hwang, Kefeng Ding*. An automated detection system for colonoscopy images using a dual encoder-decoder model. Computerized Medical Imaging and Graphics. September 2020. Tang Yang, Huang Zhiheng, Wang Zhanhuai, et al: Increased RAB31 Expression in Cancer-Associated Fibroblasts Promotes Colon Cancer Progression Through HGF-MET Signaling. Frontiers in Oncology. 2020. Sep 23. Jicheng Wu, Shen Hu, Lihong Zhang, Jinxia Xin, Chongran Sun, Liquan Wang, Kefeng Ding*, Ben Wang. Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis. Theranostics. 2020 Mar. Lu W, Fu DL, Kong XX, et al: FOLFOX treatment response prediction in metastatic or recurrent colorectal cancer patients via machine learning algorithms. Cancer Medicine 2020 Jan 1. doi: 10.1002/cam4.2786 Tan Y, Hu Y, Xiao Q, Tang Y, Chen H, He J, Chen L, Jiang K, Wang Z, Yuan Y, Ding K. Silencing of brain-expressed X-linked 2 (BEX2) promotes colorectal cancer metastasis through the Hedgehog signaling pathway. Int J Biol Sci 2020; 16(2):228-238. doi:10.7150/ijbs.38431.