男，1971.10月出生，籍贯浙江慈溪，医学博士，主任医师，博士研究生导师。1994年毕业于浙江大学医学院，2005～2006年作为访问学者赴美国爱因斯坦医学院长岛犹太医学中心。2013年及2016年分别赴意大利欧洲癌症中心及美国加州大学戴维斯医学中心进修乳腺肿瘤整形术。2011年入选浙江省151人才工程第三层次培养人员，2014年入选浙江省卫生高层次创新人才培养对象，2011年入选浙江省科技创新团队肿瘤学骨干成员。 一直从事乳腺肿瘤外科临床、教学和科研工作，擅长于乳腺良恶性疾病的诊断和治疗，在慢性复杂性乳腺炎、乳腺癌I/II期乳房重建、乳腺癌保乳根治的肿瘤整形等手术有极高的造诣。作为负责人获国家自然科学基金4项，省部级课题资助4项，作为主要参与者获省部级科技成果奖2项；作为第一发明人获国家发明专利2项，发表论文近56余篇，其中SCI收录期刊论文46篇；迄今已培养硕士研究生20名,博士生5名。 出版著作 结直肠肿瘤基础研究与临床实践 20060304 外科学学习指导 20030904

乳腺癌诊治新技术研发 乳腺癌早诊早治 乳腺癌发病机制研究 遗传性乳腺癌相关研究 液体活检技术开发与应用

中国抗癌协会乳腺癌专业委员会委员，中国抗癌协会家族遗传性肿瘤专委会常务委员，中国医促会乳腺疾病分会常务委员，浙江省抗癌协会乳腺癌专业委员会常务委员，浙江省医师协会乳腺肿瘤专业委员会副主委，浙江省医学会肿瘤外科分会及肿瘤学分会委员

Yu J, Chen Y, Zheng S, . An integrated approach utilizing Proteomics and bioinformatics to detect colorectal cancer. World J Gastroenterol, 2004, 10: 3127-3131 （SCI 2.433） Dong LF, Xu SY, Long JP, Wan F, Chen YD. Role of number of sentinel nodes in predicting non-sentinel node metastasis in breast cancer. J Int Med Res. 2018 Feb;46(2):828-835. (Corresponding author) （SCI 1.323） Kong N, Deng M, Sun XN, Chen YD, Sui XB. Polydopamine-Functionalized CA-(PCL-ran-PLA) Nanoparticles for Target Delivery of Docetaxel and Chemo-photothermal Therapy of Breast Cancer. Front Pharmacol. 2018 Feb 21;9:125. doi: 10.3389/fphar.2018.00125. eCollection 2018. (Corresponding author) （SCI 4.4） Zhang K, Zhou J, Zhu X, Luo M, Xu C, Yu J, Deng M, Zheng S, Chen Y.Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer. Breast Cancer Res Treat. 2017 Dec;166(3):865-873. (Corresponding author) （SCI 3.64） Dong LF, Xu SY, Long JP, Wan F, Chen YD. RNA-Sequence Analysis Reveals Differentially Expressed Genes (DEGs) in Patients Exhibiting Different Risks of Tumor Metastasis. Med Sci Monit. 2017 Jun 11;23:2842-2849. (Corresponding author) （SCI 1.585） Dong LF, Xu SY, Long JP, Wan F, Chen YD. Right metastatic occult breast cancer two years after surgery of left breast cancer: a case report and review of the literature. European Journal of Gynaecological Oncology. 2017,4,635-637 (Corresponding author) （SCI 0.692） Xu W, Hu Y, He X, Li J, Pan T, Liu H, Wu X, He H, Ge W, Yu J, Wei Q, Zheng S, Zhang S, Chen Y. Serum profiling by mass spectrometry combined with bioinformatics for the biomarkers discovery in diffuse large B-cell lymphoma. Tumour Biol. 2015 Mar;36(3):2193-9 (Corresponding author) （SCI 3.64） Shao Y, Wang B, Shi D, Miao S, Manivel P, Krishna R, Chen Y, Eric Shi Y. Synuclein gamma protects HER2 and renders resistance to Hsp90 disruption. Mol Oncol. 2014 Dec;8(8):1521-31 (Corresponding author) （SCI 5.935） Liang W, Miao S, Zhang B, He S, Shou C, Manivel P, Krishna R, Chen Y, Shi YE. Synuclein γ protects Akt and mTOR and renders tumor resistance to Hsp90 disruption. Oncogene. 2015 Apr 30;34(18):2398-405. (Corresponding author) （SCI 8.559） Qian X, Chen Y, Wan F. Granular cell tumor of the breast during lactation: A case report and review of the literature. Oncol Lett. 2014 Dec;8(6):2565-256 （SCI 0.987） Jun Zhou , Yiting Huang , Lili Li, Liang Zhu, Dan Zhang , Suzhan Zhang , Yiding Chen. Identification of two novel，alternatively spliced mRNA transcripts of human follicle-stimulating hormone receptor. Molecular Reproduction and Development 2013. 80(11):916–923(Corresponding author) （SCI 2.675） Jun Zhou, Yiding Chen, Yiting Huang, Jingpei Long, Fang Wan, Suzhan Zhang. Serum follicle stimulating hormone level is associated with human epidermal growth factor receptor type 2 and Ki67 expression in post menopausal females with breast cancer. Oncology Letters 2013,6: 1128-1132 （SCI 0.987） Jun Zhou, Huiyong Hu, Jingpei Long, Fang Wang, Lili Li, Suzhan Zhang, Yuenian Eric Shi, Yiding Chen. Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway. Anti-Cancer Drugs 2013, 24(9):928~936 (Corresponding author) （SCI2.013） Fan Wan, Li Dong, Feng Zhang, Yi Wang, Fang Chen, San Ni, Yi Chenand Jing Long. Clinical study of the relationship between g-synuclein and the response of neoadjuvant chemotherapy in breast cancer. Journal of International Medical Research 2013;41(3):743-53 （SCI 1.095） Lili Li, Jun Zhou, Xiajing Qian and Yiding Chen. Meta-analysis on the possible association between in vitro fertlilization and cancer risk. Int J Gynecol cancer.2013 ;23(1):16-24. （Corresponding author）（SCI1.949） Wu J, Chen YD, Yu JK, Shi XL, Gu W. Analysis of urinary proteomic patterns for type 2 diabetic nephropathy by ProteinChip. Diabetes Res Clin Pract. 2011 ;91(2):213-9. （SCI 2.536） Shi YE, Chen Y, Dackour R, Potters L, Wang Z and Liu YE. Synuclein gamma stimulates membrane initiated estrogen signaling by chaperoning ER-α36, a variant of ER-α. American J Pathology,.2010,177:964-73（Co-first Author）（SCI 5.036） Chen Y, Chen F, Xie P, Qiu P, Zhou J, Deng Y. Combined Oxidized Cellulose and Cyanoacrylate Glue in the Management of Severe Presacral Bleeding. Surgery Today. 2009，39:1016～1017（First Author）（SCI 1.208） Wang H, Ge J, Chen L, Xie P, Chen F, Chen Y. Melanocytic Malignant Peripheral Nerve Sheath Tumor of the Male Breast. Breast care. 2009,4:460-462 （Corresponding author）（SCI 0.911） Zhou Y, Liu Y, Cao J, Zeng, G, Shen C, Li Y, Zhou M, Chen Y,Pu W, Potters L, Shi E. Vitexins, Nature-Derived Lignan Compounds, Induce Apoptosis and Suppress Tumor Growth. Clinical Cancer Research. 2009,15:5161-5170 （SCI 8.193） Gu W, Zhou L, Shan P, Chen Y. Analysis of Urinary Proteomic Patterns for Diabetic Nephropathy by ProteinChip. Proteomics. 2008, 2, 744–750 （Corresponding author）（SCI 2.683） Wu K, Quan Z, Weng Z, Li F, Zhang Y, Yao X, Chen Y, Budman D, Goldberg ID, Shi YE. Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis Breast Cancer Research and Treatment. 2007;101:259-67 （SCI 4.198） Guo J, Shou C, Meng L, Jiang B, Dong B, Yao L, Xie Y, Zhang J, Chen Y, Budman DR, Shi YE. Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. International Journal of Cancer. 2007;121:1296-305 （SCI 5.007） Chen Y, Zheng S, Yu J，Hu X. Artificial Neural Networks Analysis of SELDI Mass Spectra of Serum Protein Pattern Distinguishes Colorectal Cancer from Healthy Population. Clinical Cancer Research 2004.10: 8380-8385（First Author）（SCI 8.193） Chen Y, Zheng S, Yu J, Hu X. Development of serum biomarker model and its application in colorectal cancer diagnosis. Journal of Tumor Marker Oncology 2004,19: 251-258 （First Author）