陈烨，理学博士，教授、博士生导师。长期围绕“细胞与微环境组分间的相互调控”开展基础和临床转化研究工作，相关成果发表在 Journal of Clinical Investigation、BLOOD、Advanced Science、 Signal Transduction and Targeted Therapy、Protein & Cell 、Journal of Immunology 等主流学术期刊。实验室目前主要研究方向包括干细胞分化调控与组织再生、免疫细胞分化和发育、免疫稳态及调节等。 教育和工作经历 2000/09-2004/07 浙江大学 生命科学学院 生物科学专业 学士 2004/09-2009/07 浙江大学 生命科学学院 细胞生物学专业 博士 （导师 邵建忠教授） 2009/09-2013/06 美国 MD. Anderson Cancer Center, Department of Stem Cell Transplantation & Cellular Therapy/Department of Leukemia 博士后（research fellow）（导师 Michael Andreeff, M.D.,Ph.D.） 2013/07-2019/12 浙江大学 生命科学学院、医学院 研究员、博士生导师 2019/12-迄今 浙江大学 医学院 、生命科学学院 教授、博士生导师

干细胞分化调控与组织再生：细胞微环境调控，成体干细胞命运决定等 免疫稳态与免疫调节：免疫细胞发育；自免疾病、炎症、感染免疫等基础及转化研究

Ji JF, Zhang N, Hu CB, Fan DD, Huang X, Lin AF, Chen Y*, Xiang L*, Shao JZ*. Mef2d regulates mutually exclusive expression of IgZ and IgM isotypes through epigenetic modulation in a zebrafish model. Fundamental Research. 2024-05. DOI: 10.1016/j.fmre.2024.04.019 Hu CB, Zhang N, Hong Y, Tie R, Fan DD, Lin AF, Chen Y*, Xiang L*, Shao JZ*. Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity. eLife. 2024;13:RP92424. https://doi.org/10.7554/eLife.92424.1 Hu CB, Huang C, Wang J, Hong Y, Fan DD, Chen Y, Lin AF, Xiang LX, Shao JZ. PD-L1/BTLA Checkpoint Axis Exploited for Bacterial Immune Escape by Restraining CD8+ T Cell-Initiated Adaptive Immunity in Zebrafish. J Immunol. 2023 Sep 1;211(5):816-835. Zhao Q, Chang H, Zheng J, Li P, Ye L, Pan R, Li D, Shao JZ, Zhao R C, Chen Y*. A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype. Signal Transduction and Targeted Therapy. 2023; 8 (1): pp.86. Ying H, Shen C, Pan R, Li X, Chen Y*. Strategy insight: Mechanical properties of biomaterials' influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy. Front Pharmacol. 2023 Apr 19;14:1152612. Bian Q, Jiao X, Chen Y, Yu H, Ye L. Hierarchical dynamic regulation of Saccharomyces cerevisiae for enhanced lutein biosynthesis. Biotechnol Bioeng. 2023 Feb;120(2):536-552. Zhao Q, Zhang L, He Q, Chang H, Wang Z, Cao H, Zhou Y, Pan R, Chen Y*. Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways. J Zhejiang Univ Sci B. 2023 Jan 15;24(1):50-63. Shen S, Li Y, Jin M, Fan D, Pan R, Lin A, Chen Y*, Xiang L*, Zhao R C*, Shao JZ*. CD4 + CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver. Aging and Disease. 2022 Dec 1;13(6):1919-1938. Wang Z, Hu X, He Q, Lai J, Pan R, Zheng J, Chen Y*. Establishment and characterization of IPS-OGC-C1: a novel induced pluripotent stem cell line from healthy human ovarian granulosa cells. Hum Cell. 2022 Sep;35(5):1612-1620. Zhang L, Zhao Q, Wang Z, Hu X, Pan R, Yang Y, Chen Y*. Acute Myeloid Leukemia Cells Educate Mesenchymal Stromal Cells toward an Adipogenic Differentiation Propensity with Leukemia Promotion Capabilities. Advanced Science. 2022 Mar 20;9(16):2105811. Wang Z, Zheng J, Pan R, Chen Y*. Current status and future prospects of patient-derived induced pluripotent stem cells. Hum Cell. 2021 Aug 10. He Q, He X, Xiao Y, Zhao Q, Ye Z, Cui L, Chen Y*, Guan MX*. Tissue-specific expression atlas of murine mitochondrial tRNAs. J Biol Chem. 2021 Jul 13;297(2):100960. Ying H, Pan R, Chen Y* . Epigenetic Control of Mesenchymal Stromal Cell Fate Decision, Post-Translational Modifications in Cellular Functions and Diseases, Shibo Ying, IntechOpen. (April 20th 2021; Book chapter) He Q, Zhao Q, Li Q, Pan R, Li X, Chen Y*. Mtu1 defects are correlated with reduced osteogenic differentiation, Cell Death & Disease, 2021, 12(1):0-61. Ye M, Chen Y*. Zebrafish as an emerging model to study gonad development, Comput Struct Biotechnol J, 2020, 18: 2373-2380. Cui L, Zheng J, Zhao Q, Chen JR, Liu H, Peng G, Wu Y, Chen C, He Q, Shi H, Yin S, Friedman R. A, Chen Y*, Guan MX*. Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss, JCI Insight, 2020, 5(23): e136046 Zhang LW, Cang XH, Chen Y*, Guan MX. In vitro culture of mammalian inner ear hair cells. J Zhejiang Univ Sci B. 2019 Feb.;20(2):170-179. Zheng J, Meng WF, Zhang CF, Liu HQ, Yao J, Wang H, Chen Y*, Guan MX. New SNP variants of MARVELD2 (DFNB49) associated with non-syndromic hearing loss in Chinese population. J Zhejiang Univ Sci B. 2019 Feb.;20(2):164-169. Fan W, Zheng J, Kong W, Cui L, Aishanjiang M, Yi Q, Wang M, Cang X, Tang X, Chen Y, Mo JQ, Sondheimer N, Ge W, Guan MX. Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation. J Biol Chem. 2019 Dec 13;294(50):19292-19305.