医学博士，主任医师，博士生导师，国自然二审专家。 浙江大学医学院附属妇产科医院副院长、麻醉学学科带头人。中华医学会麻醉学会委员兼产科麻醉学组副组长、中国妇幼保健协会麻醉专业委员会副主委、浙江省医学会麻醉学分会候任主任委员、浙江省医师协会分娩镇痛专委会主任委员、浙江省医师协会麻醉医师分会副会长、浙江省神经科学协会常务理事兼麻醉专业委员会副主任委员、浙江省分娩镇痛技术指导中心常务副主任、浙江省医学会疼痛医学分会常委、浙江省中西医结合学会麻醉专业委员会副主委／浙江省抗癌协会麻醉与镇痛专业委员会常委／浙江省麻醉质控中心委员、《中华麻醉学杂志》和《国际麻醉和复苏杂志》通信编委、《British Journal of Anaesthesia》/《Journal of ClinicalAnesthesia》等杂志审稿专家。 主持国家自然基金5项、主参国家自然基金1项。发表论文90余篇，其中在《JAMA Network Open》、《Anesthesiology》、《British Journal of Aanesthesia》、 《Anaesthesia》等杂志发表SCI论文60余篇。获得浙江省科技进步二等奖1项（第一完成人）。主笔《中国产科麻醉专家共识2020年版》。从事妇产科麻醉30余年，主要致力于产科临床麻醉、激素调控疼痛和情绪的机制、麻醉深度监测等。

产科麻醉和镇痛；疼痛机制；麻醉深度

2023年文章 1、 Li-Li Xu#, Chun Wang#, Chun-Mei Deng, Shao-Bing Dai, Qun Zhou, Yong-Bao Peng, Hong-Yan Shou, Yin-Qiu Han, Jing Yu, Chao-Hui Liu, Feng Xia, Su-Qin Zhang, Dong-Xin Wang*, Xin-Zhong Chen* (陈新忠，通信作者). Efficacy and Safety of Esketamine for Supplemental Analgesia During Elective Cesarean Delivery: A Randomized Clinical Trial. JAMA Netw Open 2023 Apr 3;6(4):e239321.(IF: 13.3) Q1 2、 Xie L#, Wu H#, Chen Q, Xu F, Li H, Xu Q, Jiao C, Sun L, Ullah R, Chen X* (陈新忠，通信作者）。Divergent modulation of pain and anxiety by GABAergic neurons in the ventrolateral periaqueductal gray and dorsal raphe. Neuropsychopharmacology. 2023 Sep;48(10):1509-1519. doi: 10.1038/s41386-022-01520-0. (IF: 8.30) Q1 3、 Li-Li Xu, Jia-Qian Xie, Jian-Jun Shen, Mei-Dan Ying, Xin-Zhong Chen(陈新忠，通信作者). Neuron-derived exosomes mediate sevoflurane-induced neurotoxicity in neonatal mice via transferring lncRNA Gas5 and promoting M1 polarization of microglia. Acta Pharmacol Sin 2023 Oct 6. doi: 10.1038/s41401-023-01173-9. Online ahead of print. (IF: 8.2) Q1 4、 Fei Xiao#, Han-Qing Yao#, Jing Qian, Jia-Li Deng, Zheng-Fen Xu, Lin Liu, Xin-Zhong Chen (陈新忠，通信作者). Determination of the Optimal Volume of Programmed Intermittent Epidural Bolus When Combined With the Dural Puncture Epidural Technique for Labor Analgesia: A Random-Allocation Graded Dose-Response Study. Anesth Analg 2023 Apr 3. doi: 10.1213/ANE.0000000000006451(IF: 5.7) Q2 5、 Hang Chen, Feng Jiang, Wanlin Chena, Ying Feng, Shali Chena, Jiajun Miaoa, Cuicui Jiao, and Xinzhong Chen (陈新忠，通信作者). Distinguishing preeclampsia using the falling scaled slope (FSS) --- a novel photoplethysmographic morphological parameter. Hypertens Pregnancy 2023 Dec;42(1):2225617. doi: 10.1080/10641955.2023.2225617. (IF: 1.5) Q4 6、 Xu F, Wu H, Xie L, Chen Q, Xu Q, Sun L, Li H, Xie J and Chen X(陈新忠，通信作者). Epigallocatechin-3-gallate alleviates gestational stress-induced postpartum anxiety and depression-like behaviors in mice by downregulating semaphorin3A and promoting GSK3β phosphorylation in the hippocampus. Front. Mol. Neurosci. 2023;15:1109458 (IF: 6.26) Q2 7、 Wan-Yi Rao#, Fang Xu#, Shao-Bing Dai, Zhong Mei,Xiao-Ping Chen, Chang-Cheng Lv, Chun-Lei Liu, Warwick Ngan Kee, Xin-Zhong Chen*(陈新忠，通信作者). Comparison of Dural Puncture Epidural, Epidural and Combined Spinal-Epidural Anesthesia for Cesarean Delivery: A Randomized Controlled Trial. Drug Des Devel Ther 2023 Jul 18;17:2077-2085. doi: 10.2147/DDDT.S415684.eCollection 2023. (IF: 4.8) Q3 8、 Hua Tan, Ai-Fei Lou, Jian-Er Wu, Xin-Zhong Chen*(陈新忠，共同通信作者), Xiao-Wei Qian*. Determination of the 50% and 95% Effective Dose of Remimazolam Combined with Propofol for Intravenous Sedation During Day-Surgery Hysteroscopy. Drug Des Devel Ther 2023 Jun 13;17:1753-1761. doi: 10.2147/DDDT.S406514. eCollection 2023.(IF: 4.8) Q3 2022年文章 1、 Sun LH, Xu Q, Jin L, Jin LD, Chen Q, Wu H, Chen XZ* (陈新忠，通信作者）.The Involvement of CaV1.2 in Estrogenic Modulation of Morphine Antinociception in Rats Under Uterine Cervix Pain. Pain Physician. 2022 Nov;25(8):E1239-E1248. (IF: 4.40) Q2 2、 Ya-Kai Xie, Hao Luo, Shan-Xin Zhang, Xiao-Ying Chen, Ran Guo, Xiao-Yun Qiu, Shuai Liu, Hui Wu, Wen-Bo Chen, Xing-Hua Zhen, Qiang Ma, Jin-Lan Tian, Shun Li, Xinzhong Chen （陈新忠）, Qingjian Han, Shumin Duan, Chengyong Shen, Fan Yang, Zhen-Zhong Xu V GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation. Sci Transl Med 2022 Apr 6;14(639):eabh2557.doi: 10.1126/scitranslmed.abh2557. Epub 2022 Apr 6. (IF: 17.96)Q1 3、 Zhang W, Wang JL, Fu S, Zhou JM, Zhu YJ, Cai SN, Fang J, Xie KJ, Chen XZ*(陈新忠，通信作者）. Incidence of oxygen desaturation using a high-flow nasal cannula versus a facemask during flexible bronchoscopy in patients at risk of hypoxemia: a randomised controlled trial. BMC Pulm Med. 2022 Oct 27;22(1):389. doi: 10.1186/s12890-022-02188-4. (IF: 3.32) Q3 4、 Hu LJ, Mei Z, Shen YP, Sun HT, Sheng ZM, Chen XZ, Qian XW. Comparative Dose-Response Study of Phenylephrine Bolus for the Treatment of the First Episode of Spinal Anesthesia-Induced Hypotension for Cesarean Delivery in Severe Preeclamptic versus Normotensive Parturients. Drug Des Devel Ther. 2022 Jul 8;16:2189-2198. doi: 10.2147/DDDT.S368480. eCollection 2022.(IF: 4.32) Q2 2021年 1、 Lili Xu#, Chun Wang#, Shaobing Dai, Jianjun Shen, Xiaoping Chen, Warwick D Ngan Kee, Xinzhong Chen* （陈新忠，通信作者）. Intravenous lidocaine attenuates response to cervical dilation for hysteroscopy: a randomised controlled trial. Br J Anaesth 2021 Aug 19;S0007-0912(21)00492-X. doi: 10.1016/j.bja.2021.07.020. Online ahead of print. (IF: 9.17) Q1 2、 Feihe Guo#, Cuicui Jiao#, Kaihong Xu, Chunbo Yang, Xiadi Huang, Yongchao Lu, Lili Xu, Xinzhong Chen* (陈新忠，通信作者). Optimal Dose of Pituitrin in Laparoscopic Uterine Myomectomy: A Double-Blinded, Randomized Controlled Trial. J Minim Invasive Gynecol 2021 Jun 18;S1553-4650(21)00287-9.doi: 10.1016/j.jmig.2021.06.008 (IF: 4.14) Q2 3、 Qing Chen#, Wenxin Zhang#, Neeti Sadana, Xinzhong Chen* (陈新忠，通信作者).Estrogen receptors in pain modulation: cellular signaling. Biol Sex Differ 2021 Feb 10;12(1):22. doi: 10.1186/s13293-021-00364-5. (IF: 5.03) Q4 4、 Qi Xu#, Lihong Sun#, Wenxin Zhang, Hui Wu, Cuicui Jiao, Lili Xu, Xiaowei Qian, Huaqi Yao, Qing Chen, Fang Xu, Feng Fu, Ying Feng, Luyang Wang, Xinzhong Chen (陈新忠，通信作者)。A novel visceral pain model of uterine cervix inflammation in rat. Eur J Pharmacol. 2021 Mar 31;900:174080. doi: 10.1016/j.ejphar. 2021.174080 (IF: 4.43) Q2 5、 Xiao F, Xu WP, Yao HQ, Fan JM, Chen XZ * (陈新忠，通信作者). Randomized Double-Blinded Dose-dependent Study of Metaraminol for Preventing Spinal-Induced Hypotension in Caesarean Delivery. Front. Pharmacol. 2021 May 12;12:608198.doi: 10.3389/fphar.2021.608198. (IF: 5.81) Q1 6、 Lili Xu, Qi Xu, Shaobing Dai, Cuicui Jiao, Yingying Tang, Jiaqian Xie, Hui Wu, Xinzhong Chen (陈新忠，通信作者). lncRNA Xist regulates sevoflurane-induced social and emotional impairment by modulating miR-98-5p/EDEM1 signaling axis in neonatal mice Mol Ther Nucleic Acids 2021 Apr 16;24:939-950. doi: 10.1016/j.omtn.2021.04.010.eCollection 2021 Jun 4(IF: 8.89) Q2 7、 Mei Z, Ngan Kee WD, Sheng ZM, Hu LJ, Wu ZH, Lyu CC, Chen XZ, Qian XW. Comparative dose-response study of hyperbaric ropivacaine for spinal anesthesia for cesarean delivery in singleton versus twin pregnancies. J Clin Anesth. 2020 Dec;67:110068. doi: 10.1016/j.jclinane.2020.110068. Epub 2020 Sep 24.PMID: 32980764 Clinical Trial. (IF: 9.45) 8、 Liu JP, Pan ZB, Zhu M, Zhu GW, Song DB, Chen XZ, Qian XW. Determination of the 90% Effective Dose of Phenylephrine Boluses to Treat Spinal Anesthesia-Induced Hypotension in Patients with Severe Preeclampsia during Cesarean Delivery: A Pilot Study. Drug Des Devel Ther. 2021 Sep 7;15:3765-3772. doi: 10.2147/DDDT.S323715. eCollection 2021. (IF: 4.16) 2020年 1、 Chang Na Wei # , Jia Li Deng # , Jin Hua Dong, Ze Peng Ping, Xin Zhong Chen(陈新忠，通信作者). The Median Effective Dose of Oxytocin Needed to Prevent Uterine Atony During Cesarean Delivery in Elderly Parturients. Drug Des Devel Ther 2020 Dec 8;14:5451-5458. doi:10.2147/DDDT.S258651. eCollection 2020. (IF: 4.16) 2、 Fu F, Tang YW, Chen H, Jiao CC, Ma N, Chen XZ A randomised dose-response study of prophylactic Methoxamine infusion for preventing spinal-induced hypotension during Cesarean delivery. BMC Anesthesiol. 2020 Aug 12;20(1):198. doi: 10.1186/s12871-020-01119-2 （IF：2.22） 3、 Lili Xu, Jianjun Shen, Shaobing Dai, Lihong Sun, Xinzhong Chen (陈新忠，通信作者). Tetramethylpyrazine Attenuated Sevoflurane-Induced Neurotoxicity by Enhancing Autophagy through GPR50/CREB Pathway in SH-SY5Y Cells Am J Chin Med 2020;48(4):945-966. doi:10.1142/S0192415X20500457. Epub 2020 May 30 (IF: 4.67) 4、 Lili Xu, Shaobing Dai, Jianjun Shen, Changcheng Lv, Yuwen Tang, Xinzhong Chen(陈新忠，通信作者). The predictive ability of carotid artery corrected flow time and respirophasic variation in blood flow peak velocity measured by ultrasonography for fluid responsiveness in parturients for cesarean delivery Minerva Anestesiol 2020 Oct;86(10):1039-1046, doi:10.23736/S0375-9393.20.14315-3. (IF: 3.05) 5、 Chun-Yun Huang, Shu-Xi Li, Mei-Juan Yang, Li-li Xu, Xin-Zhong Chen(陈新忠，通信作者). A Comparative Study of Three Concentrations of Intravenous Nalbuphine Combined With Hydromorphone for Post-Cesarean Delivery Analgesia. Chin Med J (Engl) 2020;Feb 24;133(5):523-529. DOI: 10.1097/CM9.0000000000000678 (IF: 2.63) 6、 Lili Xu, Qi Xu, Fang Xu, Wenxin Zhang, Qing Chen, Hui Wu, Xinzhong Chen (陈新忠，通信作者). MicroRNA-325-3p Prevents Sevoflurane-Induced Learning and Memory Impairment by Inhibiting Nupr1 and C/EBPβ/IGFBP5 Signaling in Rats. Aging 2020 Mar 19;12(6):5209 DOI: 10.18632/aging. 102942 (IF: 5.68). 7、 Hong Chen, Hua Tan, Pei-Xin Luo, Yi-Fang Shen, Chang-Cheng Lyu, Xiao-Wei Qian, Xin-Zhong Chen ((陈新忠，通信作者). Comparison of cell salvage with one and two suction devices during cesarean section in patients with placenta previa and/or accrete: a randomized controlled trial Chin Med J (Engl) 2020 Feb 24 DOI: 10.1097/CM9.0000000000000699 (IF: 2.63) 8、 Yuwen Tang, Meijuan Yang, Feng Fu, Xiaodong Huang, Ying Feng, Xinzhong Chen (陈新忠，通信作者). Comparison of the ED50 of Intrathecal Hyperbaric Ropivacaine Co-Administered With or Without Intrathecal Dexmedetomidine for Cesarean Section: A Prospective, Double-Blinded, Randomized Dose-Response Trial Using Up-Down Sequential Allocation Method J Clin Anesth, 2020;62:109725 (IF: 9.45) (他引：5) 9、 Fu F, Xiao F, Chen W, Yang M, Zhou Y, Ngan Kee WD, Chen X (陈新忠，通信作者). A randomised double-blind dose–response study of weight-adjusted infusions of norepinephrine for preventing hypotension during combined spinal–epidural anaesthesia for Caesarean delivery. Br J Anaesth. 2020 Mar;124(3):e108-e114 doi: 10.1016/j.bja.2019.12.019. [Epub ahead of print] PMID:31959386 (IF: 9.17) (他引：11) 10、 Xu L, Dai S, Sun L, Shen J, Lv C, Chen X (陈新忠，通信作者). Evaluation of 2 ultrasonic indicators as predictors of difficult laryngoscopy in pregnant women: A prospective, double blinded study. Medicine (Baltimore). 2020 Jan;99(3):e18305. doi: 10.1097/MD.0000000000018305. (IF: 1.89) 11、 Zhang W, Wu H, Xu Q, Chen S, Sun L, Jiao C, Wang L, Fu F, Feng Y, Qian X, Chen X (陈新忠，通信作者). Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats. Biol Sex Differ 2020 Jan 9;11(1):2. doi: 10.1186/s13293-019-0271-5 (IF: 5.03) 12、 Xiao F, Shen B, Xu WP, Feng Y, Ngan Kee WD, Chen XZ (陈新忠，通信作者). Dose-Response Study of Four Weight-Based Phenylephrine Infusion Regimens for Preventing Hypotension During Cesarean Delivery Under Combined Spinal-Epidural Anesthesia. Anesth Analg. 2020 Jan;130(1):187-193. doi: 10.1213/ANE.0000000000004092 (IF: 5.11) (他引：6) 13、Xiao F, Wei C, Chang X, Zhang Y, Xue L, Shen H, Ngan Kee WD, Chen X (陈新忠，通信作者). A prospective, randomized, double-blinded study of the effect of intravenous ondansetron on the ED50 of prophylactic phenylephrine infusions for preventing spinal anesthesia-induced hypotension during cesarean delivery. Anesth Analg 2020 Aug;131(2):564-569. doi: 10.1213/ANE.0000000000004534. (IF: 5.11) (他引：5) 14、Wanlin Chen, Feng Jiang, Xinzhong Chen (陈新忠), Ying Feng, Jiajun Miao, Shali Chen, Cuicui Jiao, Hang Chen Photoplethysmography-derived Approximate Entropy and Sample Entropy as Measures of Analgesia Depth During Propofol-Remifentanil Anesthesia J Clin Monit Comput 2020 Feb 5 (IF: 2.50) 15、Qian XW, Drzymalski DM, Lv CC, Guo FH, Wang LY, Chen XZ(陈新忠，通信作者). The ED50 and ED95 of Oxytocin Infusion Rate for Maintaining Uterine Tone During Elective Caesarean Delivery: A Dose-Finding Study BMC Pregnancy Childbirth 2020;20(1): 6 DOI: 10.1186/s12884-019-2692-x (IF: 2.22) 16、Wanlin Chen, Feng Jiang, Xinzhong Chen (陈新忠), Ying Feng, Jiajun Miao, Cuicui Jiao, Shali Chen, Hang Chen Photoplethysmography Response to Laryngeal Mask Airway Insertion during Propofol-Remifentanil Anethesia. Annu Int Conf IEEE Eng Med Biol Soc 2019 Jul;2019:4664-4668. doi:10.1109/EMBC.2019.8857907.