浙江大学药学院副教授，博士生导师。入选浙江省台州市“500精英计划”创新人才B类（2017年）。主要研究方向为基于化学策略的先导化合物发现与创新药物开发，作为主要完成人获得一类新药临床试验批件2项，正在开展临床I期和II期研究。作为负责人承担国家“十二五”重大新药创制专项子课题、国家自然科学基金青年基金、浙江省自然科学基金、中国博士后科学基金、企业合作项目等科研项目。以第一或通讯作者在Chem. Sci., J. Med. Chem., Green Chem.等国际知名刊物上发表SCI论文50余篇，参与编写英文专著1部，获授权美国专利1项，欧洲专利1项，香港专利1项，中国专利25项。现任浙江省药学会药物化学与抗生素专委会青年委员、浙江省抗癌协会抗癌药物专委会青年委员、浙江省科技奖评审专家，《中国现代应用药学》青年编委, Journal of Medicinal Chemistry, Organic Letters, The Journal of Organic Chemistry审稿人。 1、大学开始受教育经历 · 2008/09-2013/06，浙江大学，药学院，药物化学，研究生/医学博士，导师 俞永平 教授 · 2004/09-2008/06，厦门大学，医学院，药学专业，本科/理学学士 2、研究工作经历 · 2020/01-至今，浙江大学，药学院，药物发现与设计研究所，副教授，主要从事基于化学策略的抗病毒(流感、新冠等)创新药物开发 · 2013/07-2019/12，浙江大学，药学院，药物设计与发现研究所，助理研究员，从事抗肿瘤创新药物研发及疾病相关酶响应型分子探针开发； · 2013/07-2015/06，浙江大学，药学院，药理毒理与生化研究所，博士后（合作导师 何俏军 教授 俞永平 教授），从事针对获得性耐药的抗肿瘤药物分子的设计、合成及成药性评价。 · 2010/08-2011/09，美国Torrey Pines Institute for Molecular Studies，访问学者（合作导师 Richard A. Houghten 教授，美国著名的多肽合成专家，美国科学院发明家院士），从事多肽类药性化合物库的构建及多肽片段合成中Chemical Ligation方法学的研究； 奖励荣誉 入选教育部首届“研究生国家奖学金”（2012年），浙江省优秀毕业生（2013年），浙江省台州市“500精英计划”创新人才B类（2017年）

基于未满足临床需求的创新药物开发 基于化学发光的检测试剂盒开发 药物合成新技术的开发

现任浙江省药学会药物化学与抗生素专委会青年委员、浙江省抗癌协会抗癌药物专委会青年委员、浙江省科技奖评审专家，《中国现代应用药学》青年编委, Journal of Medicinal Chemistry, Organic Letters, The Journal of Organic Chemistry审稿人。

2024 1. Lei Zhang, # Di Ke, # Yuting Li, # Hui Zhang, Xi Zhang, Sihan Wang, Shaokai Ni, Bo Peng, Huixuan Zeng, Tingjun Hou, Yushen Du, * Peichen Pan, * Yongping Yu, * Wenteng Chen, * Design and synthesis of 7-membered lactam fused hydroxypyridinones as potent metal binding pharmacophores (MBPs) for inhibiting influenza virus PAN endonuclease. Eur. J. Med. Chem. 2024, 276, 116639. 2. Liang Tao, Xinquan Yang, Chaodong Ge, Peng Zhang, Wenjian He, Xingbo Xu, Xin Li, Wenteng Chen, Yingying Yu, Huai Zhang, Suidan Chen, Xiaoyan Pan, Yunxing Su, Chengfu Xu, Yongping Yu, Minghua Zheng, Junxia Min, Fudi Wang, Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH, Cell Metab. 2024, accepted. 3. Haiyang Wang, Yihui Zhou, Li Lu, Jie Cen, Zhenying Wu, Bo Yang, Chengliang Zhu, Ji Cao, * Yongping Yu, *Wenteng Chen, * identification of 5-thiocyanatothiazol-2-amines disrupting WDR5-MYC protein-protein interaction, ACS Med. Chem. Lett., 2024, 15, 1143-1150. 4. You Wu, Shuqi Wang, Bo Peng, Jie Cen, Yongping Yu, * Wenteng Chen, * Facile access to thieno[2,3-b]thiophenes and poly-substituted thiophenes through divergent annulation of ketene 1,3-dithietanes. Org. Chem. Front. 2024, 11, 422-426. 5. Jie Cen #, Haiying Zhu #, Chenggang Hong, Xi Zhang, Shuangrong Liu, Bo Yang, Yongping Yu, Yuanmei Wen, Ji Cao,* Wenteng Chen*, Synthesis and structure-activity optimization of hydroxypyridinones against rhabdomyolysis-induced acute kidney injury. Eur. J. Med. Chem. 2024, 263, 115933. 6. 钟秀文、张蕾、黄友纯、罗峰、陈仁尔、俞永平*、陈文腾*，塞拉菌素合成新工艺研究，中国现代应用药学杂志，2024，41,221-227. 2023 1.Shuangrong Liu,# Zhimin Ying,# Qi Zhu,# Xiuwen Zhong, Jie Cen, You Wu, Yongping Yu, Jiaan Shao,* Wenteng Chen,* Ac-L-methionine-catalyzed, nitrite-triggered cycloaddition reaction between bromide and alkyne/alkene: A step-economical reaction for modular synthesis. Org. Chem. Front. 2023, 10, 3269-3274. 2. Haiying Zhu,# Jie Cen,# Chenggang Hong, Haiyang Wang, Yuanmei Wen, Qiaojun He, Yongping Yu, Ji Cao,* Wenteng Chen,* Targeting labile iron-mediated ferroptosis provides a potential therapeutic strategy for rhabdomyolysis-induced acute kidney injury. ACS Chem. Biol. 2023, 18,1294-1304. 3.Xiuwen Zhong, Danzhi Ying, Youchun Huang, Lei Zhang, Haiyang Wang, Qi Zhu, En Chen, Yongping Yu, Wenteng Chen, * BF3·CH3CN promotes a formation of aryl α-O-glycosides from pyranoses: A facile approach to oligosaccharide EPS-G7. ChemistrySelect, 2023, 8, e202301035. 4. Yitong Chen,# Qi Zhu,# Haiyang Wang, Yongping Yu, Guolin Zhang, * Wenteng Chen,* Palladium (II)-catalyzed intramolecular tandem cyclization reaction for the assembly of unsymmetrical 2,6-disubstituted pyrazines. Synthesis, 2023, 55, 2554-2560. 5.Sihan Wang,# Zhimin Ying,# Youchun Huang, Yuting Li, Menglong Hu, Ke Kang, Haiyang Wang, Jiaan Shao, Gaoqi Wu, Yongping Yu, Yushen Du, * Wenteng Chen, * Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit. Eur. J. Med. Chem. 2023, 250, 115185. 6.Youchun Huang, Ke Kang, Xiuwen Zhong, Yongping Yu, Wenteng Chen*, Rh(III)-catalyzed C-H activation/intramolecular annulation for the synthesis of N-methoxydihydropyrimidin-2-one fused heterocycles. Tetrahedron Lett., 2023, 115, 154311. 7. Zhaoxian Cai, Xiaotian Wu, Zijun Song, Shumin Sun, Yunxing Su, Tianyi Wang, Xihao Cheng, Yingying Yu, Chao Yu, En Chen, Wenteng Chen, Yongping Yu, Andreas Linkermann, Junxia Min, * Fudi Wang, * Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis. Cell Discov. 2023, 9, 104. 2022 1. Wenteng Chen, * Jiaan Shao, Zhimin Ying, Yushen Du, Yongping Yu, * Approaches for discovery of small-molecular antivirals targeting to influenza A virus PB2 subunit. Drug Discov. Today, 2022, 27, 1545-1553. 2. Di Ke, Lei Zhang, Xiuwen Zhong, Jiaan Shao, Yongping Yu, * Wenteng Chen, * Boronic-acid-accelerated electrophilic activation of unprotected maltols to N-substituted hydroxypyridinones in water. Org. Lett. 2022, 24, 1263-1267. 3.Di Ke, You Wu, Lei Zhang, Jiaan Shao, Yongping Yu, Wenteng Chen, * Group-assisted-purification chemistry strategy for the efficient assembly of cyclic fused pyridinones, Synthesis, 2022, 54, 1765-1774. 2021 1.Zhimin Ying, Jie Cen, Feng Luo, You Wu, Shuangrong Liu, Wenteng Chen,* Jiaan Shao,* Yongping Yu,* Substrate-tuned domino annulation for selective synthesis of poly-substituted benzo[f]imidazo[2,1-a][2,7]naphthyridines and 3-azaheterocyclic substituted 2-arylquinolines. J. Org. Chem. 2021, 86, 4747-4755. 2. Jiaan Shao, *, # Ke Shu, # Shuangrong Liu, Huajiang Zhu, Jiangkang Zhang, Chong Zhang, Linhui Zeng, Wenteng Chen, * Palladium-catalyzed synthesis of polysubstituted pyrazoles via ring opening reactions of 2H-azirines with hydrazones. Synlett, 2021, 32, 316-320. 2020 1. Wenteng Chen, Xin Yuan, Zhi Li, Zidong Lu, Sisi Kong, Huidi Jiang, Houbing Du, Xiuhong Pan, Manasi Nandi, Xiaole Kong, Kathryn Brown, Zudong Liu, Guolin Zhang, Robert C. Hider, * Yongping Yu *, CN128, a new orally active hydroxypyridinone iron chelator, J. Med. Chem. 2020, 63, 4215-4226. 2. Wenteng Chen, Feng Luo, You Wu, Jie Cen, Jiaan Shao,* Yongping Yu, * Efficient access to fluorescent benzofuro[3,2-b]carbazoles via TFA-promoted cascade annulations of sulfur ylides, 2-hydroxy-β-nitrostyrenes and indoles. Org. Chem. Front. 2020, 7，873-878. 3. Shuangrong Liu, You Wu, Zhimin Ying, Feng Luo, En Chen, Wenteng Chen,* Yongping Yu * Facile and mild access to fluorescent ladder-type indolo[3,2-a]carbazoles via cascade annulation. Synthesis, 2020, accepted. 4. Jiaan Shao, *, # Ke Shu, # Shuangrong Liu, Huajiang Zhu, Jiangkang Zhang, Chong Zhang, Linhui Zeng, Wenteng Chen, * Palladium-catalyzed synthesis of polysubstituted pyrazoles via ring opening reactions of 2H-azirines with hydrazones. Synlett, 2020, 10.1055/s-0040-1707262. 5. Jiaan Shao,* ,# Shuangrong Liu, # Xingyu Liu, # Youlu Pan, Wenteng Chen,* Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M. Bioorg. Med. Chem. 2020, 28,115680.