2000年浙江大学医学院传染病学博士毕业，后浙江大学医学院附属第一医院工作。2002年晋升副研究员。多年来一直致力于乙型肝炎重症化发病机制、早期预警预测等研究，作为学术骨干参加十五攻关、国家十一五专项、十二五专项和十三五专项，主持国家自然基金1项；作为主要参加者曾获得浙江省科学技术进步一等奖，发表学术论文20篇。 科研 近年来作为第一作者或者通讯作者发表的SCI收录论文 1、 F. Chen, J. L. He, M. Zheng, H. H. Zhu, S. P. Li, K. Wang, X. X. Zhang, Y. R. Zhao, S. S. Wu, Z. Chen,* Complementary laboratory indices for predicting the disease status of patients with hepatitis B virus infection, JVH，2013,20，566-574 2、 Feng Chen, Lin-Fu Zhou, Shan-Shan Wu, Zhi Chen* ，Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method, Analytical & Bioanalytical Chemistry，2011 Oct;401(6) 1899-904， 3、 Ji-hua XUE, Min ZHENG, Xiao-wei XU, Shan-shan WU, Zhi CHEN, Feng CHEN*. Involvement of REST corepressor 3 in the development of hepatitis B in human Acta Pharmacologica Sinica.,2011,8月，32( 8) 1019-1024。 4、 X. F. TAN, S. S. WU, S. P. LI, Z. CHEN, F. CHEN（通讯作者）.Alpha-1 antitrypsin is a potential biomarker for hepatitis B, Virol J. 2011;8(1) 274. 5、 Qi Xia , LinFu Zhou, Dongcheng Liu , Zhi Chen , Feng Chen（通讯作者）. Relationship between TNF- Gene Promoter Polymorphisms and Outcomes of Hepatitis B Virus Infections A Meta-analysis，Plos One, 2011;6(5) e19606. 6、 Feng Chen, Lin-Fu Zhou, Shan-Shan Wu, Zhi Chen* IQGAP1 is overexpressed in hepatocellular carcinoma and promotes proliferation by Akt activation, Exp Mol Med. 2010 Jun 7. 42(7) 477-83.， 7、 Feng Chen, Haihong Zhu, Linfu Zhou, Shanshan Wu, Jing Wang, Zhi Chen* Inhibition of c-FLIP expression by miR-512-3p contributes to Taxol-induced apoptosis in hepatocellular carcinoma cells ，Oncology Report，2010，23（5） 1457-1462。 8、 Feng Chen, Hai-Hong Zhu, Lin-Fu Zhou, Jie Li, Li-Ying Zhao, Shan-Shan Wu, Jing Wang, and Zhi Chen.Genes related to the very early stage of ConA-induced fulminant hepatitis a gene-chip-based study in a mouse model， BMC genomics，2010;11 240. 主持或参加科研项目 1.十二五传染病重大专项，2012ZX10002007，病毒性肝炎转归预警预测的研究，2012.1-2015.12，项目总经费 6592.02万。在研，参加。 2.国家自然科学基金青年基金项目，项目批准号81301418。2013-2016，经费23万。在研，参加。 3. 国家自然科学基金，TRAF2促进肝脏炎症癌变过程的作用机制研究，201301-201612，70万；在研，参加。 4. 国家科技重大专项“丙型肝炎病毒优势表位筛选分析技术平台及中和抗体保护效应评价”子课题2009ZX10004-715，2008年10月-2010年12月，30万，结题，负责。 5. 十一五传染病重大专项，影响乙型病毒性肝炎重症化转归的机制研究，项目批准号 2008ZX10002-007 ，总经费 1001.517 万元，起止年限 2008年10月-2010年12月，结题，参加。 6. 973项目“乙型肝炎重症化早期预警和动态监测指标和方法的基础研究2007CB512905”，总经费143万元，结题，参加。 7. 国家自然基金（30571664），Smad3相关蛋白（SAP）抑制胶原合成分子机制的研究， 2006.1~2008.12，25万元，结题，负责。

内科学(传染病学)慢性乙型肝炎发病机制研究

1. F. Chen, J. L. He, M. Zheng, H. H. Zhu, S. P. Li, K. Wang, X. X. Zhang, Y. R. Zhao, S. S. Wu, Z. Chen,* Complementary laboratory indices for predicting the disease status of patients with hepatitis B virus infection, JVH，2013,20，566-574 2. Feng Chen, Lin-Fu Zhou, Shan-Shan Wu, Zhi Chen* ，Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method, Analytical & Bioanalytical Chemistry，2011 Oct;401(6):1899-904， 3. Ji-hua XUE, Min ZHENG, Xiao-wei XU, Shan-shan WU, Zhi CHEN, Feng CHEN*. Involvement of REST corepressor 3 in the development of hepatitis B in human Acta Pharmacologica Sinica.,2011,8月，32( 8): 1019-1024。1.909 4. X. F. TAN, S. S. WU, S. P. LI, Z. CHEN, F. CHEN*.Alpha-1 antitrypsin is a potential biomarker for hepatitis B, Virol J. 2011;8(1):274. 2.55 5. Qi Xia , LinFu Zhou, Dongcheng Liu , Zhi Chen , Feng Chen*. Relationship between TNF- Gene Promoter Polymorphisms and Outcomes of Hepatitis B Virus Infections: A Meta-analysis，Plos One, 2011;6(5):e19606. 4.411 6. Feng Chen, Lin-Fu Zhou, Shan-Shan Wu, Zhi Chen* IQGAP1 is overexpressed in hepatocellular carcinoma and promotes proliferation by Akt activation, Exp Mol Med. 2010 Jun 7. 42(7):477-83.，2.453 7. Feng Chen, Haihong Zhu, Linfu Zhou, Shanshan Wu, Jing Wang, Zhi Chen* Inhibition of c-FLIP expression by miR-512-3p contributes to Taxol-induced apoptosis in hepatocellular carcinoma cells，Oncology Report，2010，23（5）：1457-1462。1.686 8. Feng Chen, Hai-Hong Zhu, Lin-Fu Zhou, Jie Li, Li-Ying Zhao, Shan-Shan Wu, Jing Wang, and Zhi Chen.Genes related to the very early stage of ConA-induced fulminant hepatitis: a gene-chip-based study in a mouse model， BMC genomics，2010;11:240.4.206。 9. Chen Feng，Chen Xiangming, Chen Zhi, Jiang HL, Pan XP, Hu ZR, Liu RH, Chen XM. Construction and application of a yeast expression system for thymosin α1, BioCell, 2005,29（3）：253－259。 10. CHEN Feng, CAI Weimin, CHEN Zhi, et al. Dynamic changes in the collagen metabolism of liver fibrosis at the transcription level in rabbits with schistosomiasis japonica. Chinese Medical Journal. 2002,115(11):1637-1640 11. CHEN Feng, CAI Weimin, CHEN Zhi, et al. Studies on synthesis and degradation of collagen at transcription level in liver fibrosis of rabbits with schistosomiasis japonica. Chinese Joural of Parasitology and Parasitic Diseases. 2001,19(2):76-79 12. CHEN Feng, CAI Weimin, CHEN Zhi, et al. Expression of transforming growth factorβ1, interferon γ and tumor necrosis factor α during the rabbits with schistosomiasis japonica. Chinese Medicine Journal. 2000,80(2):154－155 13. CHEN Feng, CAI Weimin, CHEN Zhi, et al. Changes in transforming growth factor β1 mRNA and its clinical value in patients with schistosomal liver fibrosis. Chinese Joural of Parasitology and Parasitic Diseases.1999;17(3):140-142 14. CHEN Feng, CAI Weimin, CHEN Zhi, et al. Establishment of Method for Detecting transforming growth factor α1 mRNA. Chinese Joural of Parasitology and Parasitic Diseases.1998,16(3):219-222 15. CHEN Feng, CAI Weimin, et al. The improvement of anti liver fibrosis by IFN- γ. Journal of Integrated Traditional Chinese and Western Medicine. 1998,8(2):122-124 16. CHEN Feng, CAI Weimin, et al. The progress of diagnosis and therapy of liver fibrosis during the latest three years. Chinese Journal of New Gastroenterology. 1997,5(2):69-71 17. TAN Xu-fei, CHEN-Feng, WU Shan-shan, Shi Yu, LIU Dong-cheng, CHEN Zhi. Proteomic Analysis in the Liver Injuried Mice Inducible by Concanavalin A, JZUS-B ，2010，11（3）：221-226 18. Qing-yi CAO, Feng CHEN, Jie LI, Shan-shan WU, Jing WANG, Zhi CHEN. A microarray analysis of early activated pathways in concanavalin A-induced hepatitis. JZUS-B ，2010，11（5）：366-377。 19. Li Jie, Feng chen, Min Zheng, Haihong Zhu, Dongjiu Zhao, Weixia Liu, Wei Liu , Zhi Chen. Inhibition of STAT1 methylation is involved in the resistance of Hepatitis B Virus to Interferon alpha，Antiviral Research，2010,85(3): 463-469 20. Sui M, Chen F, Chen Z, Fan W.Glucocorticoids interfere with therapeutic efficacy of paclitaxel against human breast and ovarian xenograft tumors. Int J Cancer. 2006 Aug 1;119(3):712-7