陈家东 照片

陈家东

研究员

所属大学: 浙江大学

所属学院: 医学院

邮箱:
jardongchen@zju.edu.cn

个人主页:
https://person.zju.edu.cn/0017031

个人简介

陈家东,浙江大学基础医学院研究员,博士生导师。2004年于南京大学基础学科教学强化部(现匡亚明学院)获得学士学位,2010年于中国科学院上海神经科学研究所获得神经生物学博士学位。2011年起在美国加州大学旧金山分校从事神经环路发育和神经干细胞研究。研究成果以第一作者和通讯作者发表于Science, Cell Stem Cell, Glia 等神经科学和干细胞科学领域顶级杂志。获得美国CARE & CURE 儿童癫痫研究博士后奖学金和美国癫痫研究协会青年项目基金。

研究领域

神经生物学 细胞生物学

近期论文

1. Plastic embedding immunolabeled large-volume samples for three-dimensional high-resolution imaging. Gang Y, Liu X, Wang X, Zhang Q, Zhou H, Chen R, Liu L, Jia Y, Yin F, Rao G, Chen J, Zeng S. (2017) Biomed Opt Express. 2017 Jul 10;8(8):3583-3596. PMID: 28856037 2. Fandel TM, Trivedi A, Nicholas CR, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Kriegstein AR. (2016). Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury. Cell Stem Cell. Oct 6;19(4):544-557. PMID: 27666009 (Featured Article) Subject of Previews “Human ESC-Derived Interneurons Improve Major Consequences of Spinal Cord Injury” 3. Chen J†, Kriegstein AR†. (2015) A GABAergic projection from the zona incerta to cortex promotes cortical neuron development. Science. Oct 30;350(6260):554- 8. PMID: 26429884 († Co-correspondence author) Subject of Previews “Neurotransmitter-tailored dendritic trees” 4. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu J, Oldham MC, Diaz A, Leyrat AA, West JA, Kriegstein AR. (2015) Molecular Identity of Human Outer Radial Glia During Cortical Development. Cell. Sep 24;163(1):55-67. PMID: 26406371 5. Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein A, Lim DA. (2014) The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation. J. Neurosci. Sep 10;34(37):12560-7. PMID: 25209293 6. Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, García-Verdugo JM, Kriegstein A, Alvarez-Buylla A. (2014) Axonal Control of the Adult Neural Stem Cell Niche. Cell Stem Cell. Apr 3;14(4):500-11. PMID: 24561083 (Featured Article) 7. Nicholas CR*, Chen J*, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR. (2013). Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell stem cell. May 2;12(5):573-86. PMID: 23642366. (* Co-first author) Subject of Previews “Human cortical interneurons take their time” 8. Chen J*, Tan Z*, Zeng L, Zhang X, He Y, Gao W, Wu X, Li Y, Bu B, Wang W, Duan S. (2013). Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia. Feb;61(2):178-91. PMID: 23044720 (* Co-first author) 9. Lu G, Zhou QX, Kang S, Li QL, Zhao LC, Chen J, Sun JF, Cao J, Wang YJ, Chen J, Chen XY, Zhong DF, Chi ZQ, Xu L, Liu JG. (2010). Chronic morphine treatment impaired hippocampal long-term potentiation and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. J. Neurosci. April. 30(14), 5058-70. PMID: 20371826 10. Lu W, Zheng BJ, Xu K, Schwarz W, Du L, Wong CK, Chen J, Duan S, Deubel V, Sun B. (2006). Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release. Proc Natl Acad Sci U S A. Aug.103(33), 12540-12545. PMID: 16894145