蔡志坚 免疫学博士 浙江大学教授 博士生导师 长期致力于胞外囊泡（EVs）的研究，从EVs的生成、病理生理功能及基于EVs的新药开发三方面系统性阐述了EVs对免疫功能的调控，并已取得一系列原创性成果。 目前，以通讯作者在国际知名期刊Immunity、Cell Metabolism、J Extracell Vesicles （5篇）、Nat Commun（3篇）、Cell Reports、Cell Research 、Cell Mol Immunol（3篇）、Autophagy、J Immunol（2篇）等发表SCI论文30余篇。 以第1发明人获得国家发明专利授权8项。获国家自然科学基金委重点项目资助1项，以子课题负责人承担国家重点研发计划1项。 担任Cell Mol Immunol、EVCNA、Scientific Reports、World Journal of Gastroenterology、Discov Med杂志编委。 受邀为Nature Communications, Cell Reports, Cell Mol Immunol, Advanced Science等期刊审稿，曾获Cell Mol Immunol 杂志最佳审稿人奖。 参编专著2部。 实验室地址 浙江省杭州市西湖区余杭塘路866号 浙江大学紫金港校区 医学院科研楼A813 长期诚招博士后 欢迎咨询

胞外囊泡与肿瘤免疫；胞外囊泡与免疫耐受

1、中国研究型医学学会细胞外囊泡研究与应用专业委员会 常委 2、中国免疫学会基础免疫分会 委员 3、浙江省免疫学会肿瘤免疫与生物治疗委员会 常委 4、国际生物制品学杂志 编委

2024年度 1. Zhang B#,Chen JQ#, Chen JM#, Shen YY#, Chen YH, Wang SB, Zhang CY, He YZ*, Feng H*J, Wang JL*,Cai ZJ*.CD7-targeting pro-apoptotic extracellular vesicles: A novelapproach for T-cell haematological malignancy therapy.J Extracell Vesicles. 2024 Dec 13(12):e70025. IF: 16.00. https://pubmed.ncbi.nlm.nih.gov/39676736/ 2. Yang J#, Huang XF#, Yu Q#, Wang SB, Wen XH, Bai SJ, Cao LX, Zhang K, Zhang SF, Wang XG*, Chen ZH*, Cai ZJ*, Zhang GS*. Extracellular vesicles derived from M2-like macrophages alleviate acute lung injury in a miR-709-mediated manner. J Extracell Vesicles. 2024 Apr;13(4):e12437. (*co-corresponding author) IF: 16.00 https://pubmed.ncbi.nlm.nih.gov/38594787/ 3、 Bai SJ#, Wen XH#, Li BY#, Hu RM, Yang J, Yu Q, Zeng XC, Feng HJ*, Zhu F*, Cai ZJ*, Zhang GS*. Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis. Cell Rep. 2024 Jul 9;43(7):114453. https://pubmed.ncbi.nlm.nih.gov/38985677/ 4、 Lu, XL#; Song, ZB#; Hao, JY#; Kong, XH#; Yuan, WY; Shen, YY; Zhang, CY; Yang, J; Yu, PF; Qian, Y; Zhang, GS; Feng, HJ*; Wang, JL*; Cai, ZZ*; Cai, ZJ*. Proton pump inhibitors enhance macropinocytosis-mediated extracellular vesicle endocytosis by inducing membrane v-ATPase assembly. J Extracell Vesicles. 2024 Apr; 13(4): e12426.(IF: 20.6) https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.12426 5. Zhang C#, Nan X#, Zhang B#, Wu H#, Zeng X, Song Z, Li S, Wang J, Xie S, Zhang G, Xiu H, Wang J, Guo J, Wang P*, Cai Z*, Zhen Y*, Shen Y*. Blockade of CD93 in pleural mesothelial cells fuels anti-lung tumor immune responses. Theranostics. 2024 Jan 1;14(3):1010-1028. https://www.thno.org/v14p1010.htm 6. Wang SB#, Qiao CX#, Kong XH#, Yang J, Guo F, Chen JM, Wang WH, Zhang B, Xiu HQ, He YZ*, Wang JL*, Feng HJ*, Cai ZJ*. Adhesion between EVs and tumor cells facilitated EV-encapsulated doxorubicin delivery via ICAM1. Pharmacol Res. 2024 May 29;205:107244. https://doi.org/10.1016/j.phrs.2024.107244 2023年度 1. Lu XL#,Kong, XH#, Wu H#, Hao JY, Li SR, Gu ZC, Zeng XC, Shen YY, Wang SB,Chen JM, Fei XF, Sun Y, Li X, Jiang LL, Yang F, Wang, JL, Cai ZJ*. UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders. Cell Metab. 2023 Jun; 35, 1-16.（IF: 20.56）https://doi.org/10.1016/j.cmet.2023.05.011 2. Kong XH#, Lu XL*, Wang SB#, Hao JY, Guo DF, Wu H, Jiang Y, Sun Y, Wang JL*, Zhang GS*, Cai ZJ*. Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner. Cell Rep. 2023 Jan 18;42(1):112002. （IF: 9.99）https://doi.org/10.1016/j.celrep.2023.112002 3. Wang SD#, Li HY#, Chen T, Zhou H, Zhang WK, Lin N, Yu XH, Lou Y, Li BH, Yinwang E, Wang ZN, Wang KY, Xue YC, Qu H, Lin P, Sun HX, Teng WSY, Mou HC, Chai XP, Cai ZJ*, Ye ZM*. Human γδ T cells induce CD8+ T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK. Cancer Immunol Immunother. 2023 Jan 21. (*co-corresponding author) (IF: 6.63) https://doi.org/10.1007/s00262-023-03375-w 4. Yu L#, Zhou BL#, Zhu YR#, Li L, Zhong YM, Zhu LY, Wang HY, Chen H, Xu JX, Guo TX, Feng LF, Wang X, Cai ZJ*, Wang JL*, Jin H*. HSF1 promotes CD69+ Treg differentiation to inhibit colitis progression. Theranostics. 2023 Mar 21;13(6):1892-1905. (IF:12.106) https://doi.org/10.7150/thno.78078 5. Zhang CY#, Ma ZY#, Nan X,Wang WH, Zeng XC, Chen JM, Cai ZJ*, Wang JL*. Comprehensive analysis to identify the influences of SARS-CoV-2 infections to inflammatory bowel disease. Front Immunol. 2023 Feb 14:1024041. https://doi.org/10.3389/fimmu.2023.1024041 2022年度 1. Xiu HQ#, Nan X#, Guo DF#, Wang JL#, Li JH, Peng YM, Xiong GR, Wang SB, Wang CJ, Zhang GS*, Yang YS*, Cai ZJ*. Gp350-anchored extracellular vesicles: promising vehicles for delivering therapeutic drugs of B cell malignancies. Asian J Pharm Sci. 2022 May;17(3):462-474. （IF: 9.273） https://doi.org/10.1016/j.ajps.2022.03.004 2. Shen YY#, Lu CJ#, Song ZB#, Qiao CX#, Wang JL, Chen JM, Zhang CY, Zeng XC, Ma ZY, Chen T, Li X, Lin AF, Guo JF, Wang JL*, Cai ZJ*. Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation. Nat Commun. 2022 Jun 14;13(1):3419. （IF: 17.694） https://doi.org/10.1038/s41467-022-31141-6 3. Chen JM#, Yang J#, Wang WH#, Guo DF#, Zhang CY, Wang SB, Lu X, Huang XF, Wang PL, Zhang GS, Zhang J, Wang JL, Cai ZJ*. Tumor extracellular vesicles mediate anti-PD-L1 therapy resistance by decoying anti-PD-L1. Cell Mol Immunol. 2022 Oct 11. （IF: 22.096）https://doi.org/10.1038/s41423-022-00926-6 2021年度 1.Xiu HQ#, Peng YM#, Huang XF#, Gong JL, Yang J, Cai JC, Zhang K, Cui W, Shen Yy, Wang JL*, Zhang SF*,Cai ZJ*,Zhang GS*. Neddylation alleviates methicillin-resistant staphylococcus aureus infection by inducing macrophage reactive oxygen species production. J Immunol. 2021.Jun 28;207(1):296-307.(IF:5.426) https://doi.org/10.4049/jimmunol.2001167 2. Xiu HQ#, Gong JL#, Huang TC#, Peng YM, Bai SJ, Xiong GR, Zhang SF, Huang HQ*, Cai ZJ*, Zhang GS*. Fludarabine inhibits type I interferon-induced expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2. Cell Mol Immunol. 2021 Jul;18(7):1829-1831. (IF: 22.096) https://doi.org/10.1038/s41423-021-00698-5 3. Liu JJ#, Li SM#, Fei XF, Nan X, Shen YY, Xiu HQ, Cormier SA, Lu CJ, Guo CQ, Wang SB, Cai ZJ*, Wang PL*. Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis. Autophagy. 2021 Sep 15;1-19. (IF: 13.391) https://doi.org/10.1080/15548627.2021.1965421 4. Fei XF#, Li ZJ#, Yang DY, Kong XX, Lu X, Shen YY, Li X, Xie SF, Wang JL, Zhao YC, Sun Y, Zhang J, Ye ZM, Wang JL, Cai ZJ*. Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles. J Extracell Vesicles. 2021 Oct;10(12):e12153. （IF: 17.337） https://doi.org/10.1002/jev2.12153 2020年度 1. Chen T#, Guo JF#, Cai ZH#, Li BH, Sun LL, Shen YY, Wang SD, Wang Z, Wang ZN, Wang YC, Zhou H, Cai ZJ*, Ye ZM*. Th9 cell differentiation and its dual effects in tumor development. Front Immunol. 2020 May 20;11:1026.(IF:4.716) https://doi.org/10.3389/fimmu.2020.01026 2. Chen JM#, Fei XF#, Wang JL*, Cai ZJ*. Tumor-derived extracellular vesicles: Regulators of tumor microenvironment and the enlightenment in tumor therapy. Pharmacol Res. 2020 Sep;159:105041. doi: 10.1016/j.phrs.2020.105041. (IF: 5.893) https://doi.org/10.1016/j.phrs.2020.105041 3. Zhang GS#, Huang XF#, Xiu HQ#, Sun Y, Chen JM, Cheng GP, Song ZB, Peng YM, Shen YY, Wang JL, Cai Z*.Extracellular vesicles: natural liver-accumulating drug delivery vehicles for the treatment of liver diseases. J Extracell Vesicles. 2020 Dec;10(2):e12030. (IF: 25.841) https://doi.org/10.1002/jev2.12030