仓晓慧
副教授
个人简介
学习经历 1994年9月 – 1998年7月 南京大学生物化学系. 学士. 2001年9月 – 2003年12月 南京大学生物化学系. 硕士. 2004年8月 – 2010年9月 美国犹他大学药物化学系. 博士. 工作经历 2011年1月 -- 2013年5月 中科院上海药物研究所. 博士后. 2013年5月 -- 2015年2月 浙江大学生命科学学院. 教师, 副教授 2015年3月-- 2023年6月 浙江大学医学院 遗传学研究所 副教授 2023年7月至今 浙江大学医学院,基础医学院生物物理系 副教授 2016年7月至今 浙江大学医学院附属儿童医院 双聘副教授 主持科研项目 6.国家自然科学基金面上项目,32171241,线粒体ADP/ATP转运蛋白高效构象转变的内在驱动机制研究,2022/01-2025/12,主持 5.横向项目,一种病毒融合蛋白序列计算机辅助设计,2021/11-2023/10,主持 4.浙江省自然科学基金面上项目,LY18C050002,ADP/ATP转运蛋白选择性机制的理论模拟和实验研究,2018/01-2020/12 3.国家自然科学基金青年项目,31400709,线粒体ADP/ATP载体蛋白转运机制的分子动力学模拟及实验研究,2015/01-2017/12,主持, 2.浙江省教育厅一般项目,Y201432207, merlin蛋白致病突变的分子动力学模拟研究 2014/10-2016/10, 主持 1.中央高校基本科研业务费专项资金资助,2014QNA6004,2014/01-2015/12,主持
研究领域
计算结构生物学 跨膜转运机制研究 重要生物模式分子功能微观机制研究
近期论文
33. Tong L, Rao J, Yang C, Xu J, Lu Y, Zhang Y, Cang X, Xie S, Mao J*, Jiang P*. (2023) Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1. iScience, 26(8):107446. doi: 10.1016/j.isci.2023.107446. 32. Tong F, Zhang Y, Chen C, Zhu L, Lu Y, Zhang Z, Chen T, Yan J, Zheng J, Zhao X, Zhou D, Yang X, Yang R, Cang X, Jiang P*, Shu Q*.(2023) Long-term prognosis of 35 patients with methionine adenosyltransferase deficiency based on newborn screening in China. Front Cell Dev Biol ,10:1059680. doi: 10.3389/fcell.2022.1059680. 31. Jia Z, Yang S*, Li M, Lei Z, Ding X, Fan M, Wang D, Xie D, Zhou H, Qiu Y, Zhuang Q, Li D, Yang W, Qi X, Cang X, Zhao JW, Wang W, Lin A*, Yan Q*. (2022) A novel NF2 splicing mutant causes neurofibromatosis type 2 via liquid-liquid phase separation with large tumor suppressor and Hippo pathway. iScience, 25(11):105275. https://doi.org/10.1016/j.isci.2022.105275 30. Yi Q, Yao S, Ma B, Cang X*. (2022) Function-related asymmetry of the interactions between matrix loops and conserved sequence motifs in the mitochondrial ADP/ATP carrier. Int. J. Mol. Sci. 23(18), 10877; https://doi.org/10.3390/ijms231810877 29. Yi Q#, Yao S#, Ma B, Cang X*. (2022) The effects of cardiolipin on the structural dynamics of the mitochondrial ADP/ATP carrier in its cytosol-open state. J lipid Res, 63(6):100227. https://doi.org/10.1016/j.jlr.2022.100227 Reported by ASBMB today (Nov.8, 2022) " How cardiolipin mediates ADP/ATP carrier modulation" https://www.asbmb.org/asbmb-today/science/110822/from-the-journals-jlr 28. Xu C, Tong L, Rao J, Ye Q, Chen Y, Zhang Y, Xu J, Mao X, Meng F, Shen H, Lu Z, Cang X, Fu H, Wang S, Gu W, Lai EY, Guan M*, Jiang P*, Mao J*. (2022) Heteroplasmic and homoplasmic m.616T>C in mitochondria tRNAPhe promote isolated chronic kidney disease and hyperuricemia. JCI Insight, Apr 26:e157418. https://doi.org/10.1172/jci.insight.157418 27. Yao S#, Yi Q#, Ma B, Mao X, Chen Y, Guan MX*, Cang X*. (2022) Mechanistic insights into multiple-step transport of mitochondrial ADP/ATP carrier. Comput Struct Biotechnol J, Apr 5;20:1829-1840. https://doi.org/10.1016/j.csbj.2022.03.032 26. Yao S#, Ma B#, Yi Q, Guan MX*, Cang X*. (2022) Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations. Molecules, Feb 5;27(3):1071. https://doi.org/10.3390/molecules27031071 25. Chen Y#, Yao H#, Fu J*, Shu Q*, Chen Z, Wu N, Ye S, Wang W, Ni Y, Shang S, Li W, Zheng J, Li S, Hong L, Zhang Q, Xu W, Chen J, Fan L, Cang X, Wang J, Lu X, Cao Q. (2021) The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study. Int J Infect Dis,111:347-353. http://doi.org/10.1016/j.ijid.2021.08.036 24. Zhang Z, Vögele J, Mráziková K, Kruse H, Cang X, Wöhnert J*, Krepl M*, Šponer J*. (2021) Phosphorothioate Substitutions in RNA Structure Studied by Molecular Dynamics Simulations, QM/MM Calculations, and NMR Experiments. J Phys Chem B,125(3):825-840. 23. Mao X, Yao S, Yi Q, Xu ZM, Cang X*.(2021)Function-related asymmetry of the specific cardiolipin binding sites on the mitochondrial ADP/ATP carrier. BBA-Biomembrane,1863(1):183466. 22. Meng F, Zhou M, Xiao Y, Mao X, Zheng J, Lin J, Lin T, Ye Z, Cang X, Fu Y, Wang M*, Guan MX*. (2020) A deafness-associated tRNA mutation caused pleiotropic effects on the m1G37 modification, processing, stability and aminoacylation of tRNAIle and mitochondrial translation. Nucleic Acids Res, 49(2):1075-1093. 21. Chen T, Tong F, Wu XY, Zhu L, Yi QZ, Zheng J, Yang RL, Zhao ZY, Cang XH, Shu Q*,Jiang PP*. (2020) Novel ACADVL variants resulting in mitochondrial defects in long-chain acyl-CoA dehydrogenase deficiency. J Zhejiang Univ Sci B, 21(11):885-896. 20. Nie H, Ju H, Fan J, Shi X, Cheng Y, Cang X, Zheng Z, Duan X, Yi W*.(2020)O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth. Nat Commun, 11(1):36. 19. Gong S, Wang X, Meng F, Cui L, Yi Q, Zhao Q, Cang X, Cai Z, Mo JQ, Liang Y, Guan MX*. (2020)Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNAHis mutation. J Biol Chem, 295(4):940-954. 18. Fan W, Zheng J, Kong W, Cui L, Aishanjiang M, Yi Q, Wang M, Cang X, Tang X, Chen Y, Mo JQ, Sondheimer N, Ge W, Guan MX*.(2019)Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation. J Biol Chem, 13;294(50):19292-19305. 17. Chen Y, Yuan X*, Cang X. (2019) Population-based incremental learning for the prediction of Homo sapiens' protein secondary structure. International Journal of biomethematics, 12(3): 1950017. 16. Huang X, Cang X, Liu J*.(2019)Molecular mechanism of Bisphenol A on androgen receptor antagonism. Toxicol In Vitro,61:104621. 15. Yi Q, Li Q, Yao S, Chen Y, Guan MX, Cang X*. (2019)Molecular dynamics simulations on apo ADP/ATP carrier shed new lights on the featured motif of the mitochondrial carriers. Mitochondrion,47:94-102. 14. Ji Y, Zhang J, Yu J, Wang Y, Lu Y, Liang M, Li Q, Jin X, Wei Y, Meng F, Gao Y, Cang X, Tong Y, Liu X, Zhang M, Jiang P, Zhu T, Mo JQ, Huang T, Jiang P, Guan MX*.(2019)Contribution of mitochondrial ND1 3394T>C mutation to the phenotypic manifestation of Leber's hereditary optic neuropathy. Hum Mol Genet,28(9):1515-29 .(封面文章) 13. Jia Z, Zhang Y, Li Q, Ye Z, Liu Y, Fu C, Cang X, Wang M*, Guan MX*.(2019)A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis. Nucleic Acids Res,47(4):2056-74. 12. Zhang LW, Cang XH, Chen Y*, Guan MX. (2019) In vitro culture of mammalian inner ear hair cells. J Zhejiang Univ Sci B, 20(2):170-179. 11. Meng F#, Cang X#, Peng Y, Li R, Zhang Z, Li F, Fan Q, Guan AS, Fischel-Ghosian N, Zhao X, Guan MX*.(2017)Biochemical Evidence for a Nuclear Modifier Allele (A10S) in TRMU (Methylaminomethyl-2-thiouridylate-methyltransferase) Related to Mitochondrial tRNA Modification in the Phenotypic Manifestation of Deafness-associated 12S rRNA Mutation. J Biol Chem,292(7):2881-92. (#: co-first authors) 10. Pan X#, Cang X#, Dan S, Li J, Cheng J, Kang B, Duan X, Shen B, Wang YJ*.(2016)Site-specific Disruption of the Oct4/Sox2 Protein Interaction Reveals Coordinated Mesendodermal Differentiation and the Epithelial-Mesenchymal Transition. J Biol Chem,291(35):18353-69. (#:co-first authors) 9. Cang X, Yang L, Yang J, Luo C, Zheng M, Yu K, Yang H*, Jiang H*.(2014)Cholesterol-beta(1)AR interaction versus cholesterol-beta(2)AR interaction. Proteins,82(5):760-70. 8. Sponer J*, Mládek A, Spačková N, Cang X, Cheatham TE 3rd, Grimme S.(2013) Relative stability of different DNA Guanine quadruplex stem topologies derived using large-scale quantum-chemical computations. J Am Chem Soc,135(26):9785-96. 7. Cang X, Du Y, Mao Y, Wang Y, Yang H*, Jiang H*.(2013)Mapping the functional binding sites of cholesterol in β2-adrenergic receptor by long-time molecular dynamics simulations. J Phys Chem B,117(4):1085-94. 6. Mao Y, Du Y, Cang X, Wang J, Chen Z, Yang H*, Jiang H*.(2013)Binding competition to the POPG lipid bilayer of Ca2+, Mg2+, Na+, and K+ in different ion mixtures and biological implication. J Phys Chem B,117(3):850-8. 5. Sponer J*, Cang X, Cheatham TE 3rd*.(2012)Molecular dynamics simulations of G-DNA and perspectives on the simulation of nucleic acid structures (Review). Methods,57(1):25-39. 4. Du Y, Yang H, Xu Y, Cang X, Luo C, Mao Y, Wang Y, Qin G, Luo X, Jiang H*.(2012)Conformational transition and energy landscape of ErbB4 activated by neuregulin1β: one microsecond molecular dynamics simulations.J Am Chem Soc, 134(15):6720-31. 3. Cang X, Sponer J, Cheatham TE 3rd*.(2011)Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis. J Am Chem Soc,133(36):14270-9. 2. Cang X, Sponer J, Cheatham TE 3rd*.(2011)Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes. Nucleic Acids Res,39(10):4499-512. 1. Cang X, Wang J*.(2004)A unique ATG triplet downstream of gene start in archaea: implications for translation initiation and evolution. Gene,327(1):75-9. [ #: co-first authors; *: corresponding author(s) ]