教育背景 2008-09--2014-01 中国科学院大学 博士 2004-09--2008-07 中国矿业大学（北京） 学士 工作简历 2022-01~现在, 中国科学院微生物研究所, 研究员 2019-08~2022-01,中国科学院微生物研究所, 项目研究员 2014-02~2019-08,美国斯克里普斯研究所, 博士后

微生物天然药物基因组发掘，生物合成机制解析，合成生物学

Yao Kong, Yuanning Liu, Kaibiao Wang, Tao Wang, Chen Wang, Ben Ai, Hongli Jia, Guohui Pan, Min Yin, Zhengren Xu. Confirmation of the stereochemistry of spiroviolene. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2024, 第 8 作者20(1): 852-858, https://doaj.org/article/5e54e6614cfc4d359cfdee7eba043145. Jinmin Gao, Liyuan Li, Shijie Shen, Guomin Ai, Bin Wang, Fang Guo, Tongjian Yang, Hui Han, Zhengren Xu, Guohui Pan, Keqiang Fan. Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis. Beilstein Journal of Organic Chemistry[J]. 2024, 第 10 作者 通讯作者 20: 1198-1206, https://www.beilstein-journals.org/bjoc/articles/20/102. Andrew D Steele, Hui Jiang, Guohui Pan, Si-Kyu Lim, Edward Kalkreuter, Jianhua Ju, Thomas Kwong, Scott Rajski, Ben Shen. Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis. Biochemistry[J]. 2024, 第 3 作者63(4): 563-575, https://pubs.acs.org/doi/10.1021/acs.biochem.3c00672. Haiyan Wang, Lijun Wang, Keqiang Fan, Guohui Pan. Tetracycline family natural products: discovery, biosynthesis and engineering. Chinese Journal of Natural Medicines[J]. 2022, 第 4 作者 通讯作者 20(10): 773-794, Zhang, Chaobo, Zhao, Youbao, Li, Zilong, Wang, Weishan, Huang, Ying, Pan, Guohui, Fan, Keqiang. Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 6 作者13: http://dx.doi.org/10.3389/fmicb.2022.1078293. 张志龙, 李鹏伟, 王敏, 张雁, 吴边, 陶勇, 潘国辉, 陈义华. (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine.. mLife[J]. 2022, 第 7 作者 通讯作者 Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 9 作者11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087. Yuan, Fang, Yin, Shouliang, Xu, Yang, Xiang, Lijun, Wang, Haiyan, Li, Zilong, Fan, Keqiang, Pan, Guohui. The Richness and Diversity of Catalases in Bacteria. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 8 作者 通讯作者 12: https://www.webofscience.com/wos/woscc/full-record/WOS:000635791400001. 王立军, 范可强, 王海燕, 胡会涛, 向丽军, 艾国民, 潘国辉. 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2，3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物. 微生物学通报[J]. 2021, 第 7 作者48(7): 2307-2317, http://lib.cqvip.com/Qikan/Article/Detail?id=7105380929. Meng, Song, Steele, Andrew D, Yan, Wei, Pan, Guohui, Kalkreuter, Edward, Liu, YuChen, Xu, Zhengren, Shen, Ben. Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase. NATURE COMMUNICATIONS[J]. 2021, 第 4 作者12(1): http://dx.doi.org/10.1038/s41467-021-25798-8. 王立军, 范可强, 王海燕, 胡会涛, 向丽军, 艾国民, 潘国辉. 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2，3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物（英文）. 微生物学通报[J]. 2021, 第 7 作者48(7): 2307-2317, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21072307?st=article_issue. Zhang, Qian, Ren, JinWei, Wang, Weishan, Zhai, Jian, Yang, Jing, Liu, Ning, Huang, Ying, Chen, Yihua, Pan, Guohui, Fan, Keqiang. A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters. ACS CHEMICAL BIOLOGY[J]. 2020, 第 9 作者 通讯作者 15(9): 2551-2557, https://www.webofscience.com/wos/woscc/full-record/WOS:000574920900024. Kalkreuter, Edward, Pan, Guohui, Cepeda, Alexis J, Shen, Ben. Targeting Bacterial Genomes for Natural Product Discovery. TRENDS IN PHARMACOLOGICAL SCIENCES. 2020, 第 2 作者41(1): 13-26, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938545/. McAlpine, James B, Chen, ShaoNong, Kutateladze, Andrei, MacMillan, John B, Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A, Biavatti, Maique W, Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S, Capon, Robert J, Choi, Young H, Coppage, David, Crews, Phillip, Crimmins, Michael T, Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M, Garson, Mary J, GentaJouve, Gregory, Gerwick, William H, Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M, Hunter, Luke, Jeannerat, Damien, Ji, NaiYun, Johnson, Tyler A, Kingston, David G I, Koshino, Hiroyuki, Lee, HsiauWei, Lewin, Guy, Li, Jie, Linington, Roger G, Liu, Miaomiao, McPhail, Kerry L, Molinski, Tadeusz F, Moore, Bradley S, Nam, JooWon, Neupane, Ram P, Niemitz, Matthias, Nuzillard, JeanMarc, Oberlies, Nicholas H, Ocampos, Fernanda M M, Pan, Guohui, Quinn, Ronald J, Reddy, D Sai, Renault, JeanHugues, RiveraChavez, Jose, Robien, Wolfgang, Saunders, Carla M, Schmidt, Thomas J, Seger, Christoph, Shen, Ben, Steinbeck, Christoph, Stuppner, Hermann, Sturm, Sonja, TaglialatelaScafati, Orazio, Tantillo, Dean J, Verpoorte, Robert, Wang, BinGui, Williams, Craig M, Williams, Philip G, Wist, Julien, Yue, JianMin, Zhang, Chen, Xu, Zhengren, Simmler, Charlotte, Lankin, David C, Bisson, Jonathan, Pauli, Guido F. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. NATURAL PRODUCT REPORTS. 2019, 第 47 作者36(1): 35-107, https://explore.openaire.eu/search/publication?articleId=od______1400::6c8d23a84083002a3e15bf7dd2ff8a15. Kwong, Thomas, Ma, Ming, Pan, Guohui, Hindra, Yang, Dong, Yang, Chunying, Lohman, Jeremy R, Rudolf, Jeffrey D, Cleveland, John L, Shen, Ben. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. BIOCHEMISTRY[J]. 2018, 第 3 作者57(33): 5005-5013, https://www.webofscience.com/wos/woscc/full-record/WOS:000448082300007. Xu, Zhengren, Pan, Guohui, Zhou, Hao, Shen, Ben. Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 第 2 作者140(49): 16957-16961, http://dx.doi.org/10.1021/jacs.8b11463. Li, Liyuan, Pan, Guohui, Zhu, Xifen, Fan, Keqiang, Gao, Wubin, Ai, Guomin, Ren, Jinwei, Shi, Mingxin, Olano, Carlos, Salas, Jose A, Yang, Keqian. Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2017, 第 2 作者101(13): 5291-5300, https://www.webofscience.com/wos/woscc/full-record/WOS:000404146300007. Pan, Guohui, Xu, Zhengren, Guo, Zhikai, Hindra, Ma, Ming, Yang, Dong, Zhou, Hao, Gansemans, Yannick, Zhu, Xiangcheng, Huang, Yong, Zhao, LiXing, Jiang, Yi, Cheng, Jinhua, Van Nieuwerburgh, Filip, Suh, JooWon, Duan, Yanwen, Shen, Ben. Discovery of the leinamycin family of natural products by mining actinobacterial genomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 1 作者114(52): E11131-E11140, https://www.webofscience.com/wos/woscc/full-record/WOS:000418722400009. Pan, Guohui, Gao, Xiaoqin, Fan, Keqiang, Liu, Junlin, Meng, Bing, Gao, Jinmin, Wang, Bin, Zhang, Chaobo, Han, Hui, Ai, Guomin, Chen, Yihua, Wu, Dong, Liu, ZhiJie, Yang, Keqian. Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis. ACS CHEMICAL BIOLOGY[J]. 2017, 第 1 作者12(1): 142-152, http://dx.doi.org/10.1021/acschembio.6b00621. Guo, Zhikai, Pan, Guohui, Xu, Zhengren, Yang, Dong, Hindra, Zhu, Xiangcheng, Huang, Yong, Zhao, LiXing, Jiang, Yi, Duan, Yanwen, Shen, Ben. New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp CB01883. JOURNAL OF ANTIBIOTICS[J]. 2017, 第 2 作者70(4): 414-422, https://www.webofscience.com/wos/woscc/full-record/WOS:000397547900011.