教育背景 2001-09--2005-07 中国科学院微生物研究所 博士 1998-09--2001-06 南京农业大学 硕士 1994-09--1998-06 南京农业大学 本科 工作简历 2011-04~现在, 中国科学院微生物研究所, 研究员 2006-07~2011-04,University of Wisconsin-Madison, Postdoc Research Associate

（1） 挖掘人体致病菌、益生菌、食品等重要微生物中的次级代谢潜力，获取具有特定活性的化合物，解析其作用机制和生理功能，创新健康促进和疾病诊疗的先进手段。 （2）在对微生物药物分子和高活性化合物的生物合成机理充分了解的基础上，设计合理的策略，通过合成生物学和合成衍生等手段改造药物分子，创制新的先导药物。 （3） 利用次级代谢的多样性探索生命最基本的代谢和进化问题，理解生命形式的多样性。

Li, Shuyu, Zhang, Yuwei, Zong, Jianfa, Liu, Yufeng, Tang, Yue, Lu, Jincai, Chen, Yihua. Production improvement of an antioxidant in cariogenic Streptococcus mutans UA140. JOURNAL OF APPLIED MICROBIOLOGY[J]. 2024, 第 7 作者 通讯作者 135(2): http://dx.doi.org/10.1093/jambio/lxae017. Chen, Meng, Wang, Min, Shi, Zhaoxiang, Li, Pengwei, Zhang, Yuwei, Li, Zilong, Wang, Weishan, Tang, Yue, Chen, Yihua. Reconstitution of Septacidin Biosynthesis in Escherichia coli by Redirecting an ADP-Heptose Precursor from Primary Metabolism. ACS SUSTAINABLE CHEMISTRY & ENGINEERING[J]. 2024, 第 9 作者 通讯作者 12(8): 2978-2987, http://dx.doi.org/10.1021/acssuschemeng.3c05645. Wang, Dacheng, Mao, Huijin, Zhao, Zelian, Liu, Lilu, Chen, Yihua, Li, Pengwei. Reprogramming of the Aurantinin Polyketide Assembly Line to Synthesize Auritriacids by Excising an Atypical Enoyl-CoA Hydratase Domain. ADVANCED SCIENCE[J]. 2024, 第 5 作者 通讯作者 11(35): http://dx.doi.org/10.1002/advs.202401708. Li, Xinli, Tang, Yue, Ding, Yong, Li, Pengwei, Chen, Yihua. Engineering the C3N Pathway as a Short Detour for De Novo NAD + Biosynthesis in Saccharomyces cerevisiae. FERMENTATION-BASEL[J]. 2023, 第 5 作者 通讯作者 9(10): http://dx.doi.org/10.3390/fermentation9100886. Miao, LiLi, Hou, TingTing, Ma, Lan, Wang, Min, Liu, Ying, Wu, Yao, Chen, YiHua, Wang, WenZhao, Fu, Ying, Xiang, Hua, Liu, ZhiPei. N -Hydroxylation and Hydrolysis by the DnfA/B/C Multienzyme System Involved in the Aerobic N 2 Formation Process. ACS CATALYSIS[J]. 2023, 第 7 作者13(18): 11963-11976, http://dx.doi.org/10.1021/acscatal.3c02412. 张雨薇, 刘煜峰, 陈义华. 人体微生物天然产物研究进展. 药学进展. 2023, 第 3 作者47(4): 273-286, http://lib.cqvip.com/Qikan/Article/Detail?id=7109916308. Chen, Meng, Guo, Zhengyan, Sun, Jinyuan, Tang, Wei, Wang, Min, Tang, Yue, Li, Pengwei, Wu, Bian, Chen, Yihua. Insights into the biosynthesis of septacidin L-heptosamine moiety unveils a VOC family sugar epimerase. ACTA PHARMACEUTICA SINICA B[J]. 2023, 第 9 作者 通讯作者 13(2): 765-774, http://dx.doi.org/10.1016/j.apsb.2022.05.031. 刘俐璐, 王文昭, 陈萌, 张雨薇, 毛会金, 王大成, 李鹏伟. Characterization of three succinyl-CoA acyltransferases involved in polyketide chain assembly.. Appl Microbiol Biotechnol[J]. 2023, Xinli Li, Yue Tang, Yong Ding, Pengwei Li, Yihua Chen. Engineering the C3N Pathway as a Short Detour for De Novo NAD + Biosynthesis in Saccharomyces cerevisiae. FERMENTATION[J]. 2023, 第 5 作者9(10): https://doaj.org/article/f6fc1319ce4a47fc8bf9d35ce3b74441. Zhang, Yuwei, Liao, Ge, Wang, Min, Zhang, Zhao, Liu, Liwei, Song, Yuqin, Wang, Dacheng, Hao, Tingting, Feng, Jie, Xia, Bin, Wang, Yixiang, Tang, Xiaoyu, Chen, Yihua. Human-associated bacteria adopt an unusual route for synthesizing 3-acetylated tetramates for environmental adaptation. MICROBIOME[J]. 2023, 第 13 作者 通讯作者 11(1): http://dx.doi.org/10.1186/s40168-023-01548-4. Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 11 作者 通讯作者 11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087. Zhang, Yuwei, Li, Pengwei, Ma, Yue, Wang, Jun, Chen, Yihua. Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome. CLINICAL AND TRANSLATIONAL MEDICINE[J]. 2022, 第 5 作者 通讯作者 12(8): http://dx.doi.org/10.1002/ctm2.1011. 魏维佳等, 陈义华. Construction and heterologous expression of the di-AFN A1 biosynthetic gene cluster in Streptomyces model strains.. Chinese Journal of Natural Medicines[J]. 2022, 第 2 作者 通讯作者 22: 60197-3, 陈萌, 曹贞菊等, 陈义华. Discovery of novel septacidin congeners from a high yield heterologous expression strain Streptomyces albus 1597.. Journal of Antitiotics[J]. 2022, 第 3 作者 通讯作者 Tang, Yue, Tang, Wei, Wang, Min, Zhang, Zhilong, Chen, Yihua. A conservative distribution of tridomain NDP-heptose synthetases in actinobacteria. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 第 5 作者 通讯作者 65(5): 1014-1023, http://dx.doi.org/10.1007/s11427-021-2000-2. Sun, Zhi, Wei, Weijia, Zhang, Mingyue, Shi, Wenjia, Zong, Yeqing, Chen, Yihua, Yang, Xiaojing, Yu, Bo, Tang, Chao, Lou, Chunbo. Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback. NUCLEIC ACIDS RESEARCH[J]. 2022, 第 6 作者50(4): 2377-2386, http://dx.doi.org/10.1093/nar/gkac066. Ma, Yue, Guo, Zhengyan, Xia, Binbin, Zhang, Yuwei, Liu, Xiaolin, Yu, Ying, Tang, Na, Tong, Xiaomei, Wang, Min, Ye, Xin, Feng, Jie, Chen, Yihua, Wang, Jun. Identification of antimicrobial peptides from the human gut microbiome using deep learning. NATURE BIOTECHNOLOGY. 2022, 第 12 作者 通讯作者 40(6): 921-931, http://dx.doi.org/10.1038/s41587-022-01226-0. 张志龙, 李鹏伟, 王敏, 张雁, 吴边, 陶勇, 潘国辉, 陈义华. (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine.. mLife[J]. 2022, 第 8 作者 通讯作者 张雨薇, 李鹏伟, 陈义华. Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome.. Clin. Transl. Med.[J]. 2022, 第 3 作者 通讯作者 Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 11 作者 通讯作者 11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087. Wang, Dacheng, Li, Pengwei, Yan, JiaLei, Mao, Huijin, Liu, Lilu, Wang, Min, Chen, Meng, Ye, Tao, Chen, Yihua. Assigning the stereochemical structures of aurantinin A and B with the assistance of biosynthetic investigations. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 9 作者 通讯作者 9(21): 5949-5954, http://dx.doi.org/10.1039/d2qo01251k. Li, Chao, Bao, Wuyundalai, Zhang, Haoyue, Lyu, Zhitang, Chen, Yihua, Guo, Zhengyan. Discovery of Brominated Alboflavusins With Anti-MRSA Activities. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 5 作者12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920986/. 张昊月, 郭正彦, 吕志堂, 陈义华. 应用响应面法优化发酵培养基提高达托霉素产量. 微生物学通报[J]. 2021, 第 4 作者48(1): 113-122, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21010113?st=article_issue. Guo, Zhengyan, Tang, Yue, Tang, Wei, Chen, Yihua. Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses. NATURAL PRODUCT REPORTS. 2021, 第 4 作者 通讯作者 38(10): 1887-1909, http://dx.doi.org/10.1039/d0np00075b. Ding, Yong, Wang, Min, Li, Jine, Li, Pengwei, Guo, Zhenyan, Chen, Yihua. Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 第 6 作者 通讯作者 543: 8-14, http://dx.doi.org/10.1016/j.bbrc.2021.01.042. Chen, Ying, Dou, Guili, Wang, Dandan, Yang, Jingyi, Zhang, Yixin, Garnett, James A, Chen, Yihua, Wang, Yixiang, Xia, Bin. Comparative Microbial Profiles of Caries and Black Extrinsic Tooth Stain in Primary Dentition. CARIES RESEARCH[J]. 2021, 第 7 作者 通讯作者 55(4): 310-321, http://dx.doi.org/10.1159/000517006. Ding, Yong, Li, Xinli, Horsman, Geoff P, Li, Pengwei, Wang, Min, Li, Jine, Zhang, Zhilong, Liu, Weifeng, Wu, Bian, Tao, Yong, Chen, Yihua. Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway. ADVANCED SCIENCE[J]. 2021, 第 11 作者 通讯作者 8(9): https://doaj.org/article/7c65560618944b09848626d4f5994e7e. Pengwei Li, Meng Chen, Wei Tang, Zhengyan Guo, Yuwei Zhang, Min Wang, Geoff P Horsman, Jin Zhong, Zhaoxin Lu, Yihua Chen. Initiating polyketide biosynthesis by on-line methyl esterification. NATURE COMMUNICATIONS[J]. 2021, 第 10 作者 通讯作者 12(1): http://dx.doi.org/10.1038/s41467-021-24846-7. Xueyan Yao, Zhenying Zhang, Jun Huang, Shiping Wei, Xianyun Sun, Yihua Chen, Hongwei Liu, Shaojie Li. Candicidin Isomer Production Is Essential for Biocontrol of Cucumber Rhizoctonia Rot by Streptomyces albidoflavus W68. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2021, 第 6 作者87(9): e03078-20-., http://dx.doi.org/10.1128/AEM.03078-20. 陈义华. Deciphering the Biosynthesis of TDP-β‑L‑oleandrose in Avermectin. Journal of Natural Products. 2020, 第 1 作者 通讯作者 Qiao, Shanshan, Bao, Li, Wang, Kai, Sun, Shanshan, Liao, Mingfang, Liu, Chang, Zhou, Nan, Ma, Ke, Zhang, Yuwei, Chen, Yihua, Liu, ShuangJiang, Liu, Hongwei. Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis. CELL REPORTS[J]. 2020, 第 10 作者32(6): https://doaj.org/article/3c0c6df27461447caf7c341d1077a6ea. Zhang, Qian, Ren, JinWei, Wang, Weishan, Zhai, Jian, Yang, Jing, Liu, Ning, Huang, Ying, Chen, Yihua, Pan, Guohui, Fan, Keqiang. A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters. ACS CHEMICAL BIOLOGY[J]. 2020, 第 8 作者15(9): 2551-2557, https://www.webofscience.com/wos/woscc/full-record/WOS:000574920900024. Feng, Jing, Li, Ruifeng, Zhang, Shasha, Bu, Yifan, Chen, Yanchun, Cui, Yinglu, Lin, Baixue, Chen, Yihua, Tao, Yong, Wu, Bian. Bioretrosynthesis of FunctionalizedN-Heterocycles from Glucose via One-Pot Tandem Collaborations of Designed Microbes. ADVANCED SCIENCE[J]. 2020, 第 8 作者7(17): https://doaj.org/article/9c2328f94707485287af5a2f1cbca236. Pei Du, Huiwei Zhao, Haoqian Zhang, Ruisha Wang, Jianyi Huang, Ye Tian, Xudong Luo, Xunxun Luo, Min Wang, Yanhui Xiang, Long Qian, Yihua Chen, Yong Tao, Chunbo Lou. De novo design of an intercellular signaling toolbox for multi-channel cell-cell communication and biological computation. NATURE COMMUNICATIONS[J]. 2020, 第 12 作者11(1): http://dx.doi.org/10.1038/s41467-020-17993-w. Zhang, Yuwei, Wang, Min, Tian, Jun, Liu, Jia, Guo, Zhengyan, Tang, Wei, Chen, Yihua. Activation of paulomycin production by exogenous gamma-butyrolactone signaling molecules in Streptomyces albidoflavus J1074. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2020, 第 7 作者 通讯作者 104(4): 1695-1705, https://www.webofscience.com/wos/woscc/full-record/WOS:000519153800025. Tang, Yue, Wang, Min, Qin, Hua, An, Xiangxiang, Guo, Zhengyan, Zhu, Guoliang, Zhang, Lixin, Chen, Yihua. Deciphering the Biosynthesis of TDP-beta-L-oleandrose in Avermectin. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 第 8 作者 通讯作者 83(10): 3199-3206, http://dx.doi.org/10.1021/acs.jnatprod.0c00902. Tang, Wei, Li, Pengwei, Chen, Meng, Guo, Zhengyan, Chen, Yihua. Characterization of SepE and SepF for the N-6-Glycosylated Adenine Structure Formation in Septacidin Biosynthesis. ORGANIC LETTERS[J]. 2020, 第 5 作者 通讯作者 22(13): 5251-5254, http://dx.doi.org/10.1021/acs.orglett.0c01918. 陈义华. Activation of paulomycin production by exogenous γ-butyrolactone signaling molecules in Streptomyces albidoflavus J1074.. Applied Microbiology and Biotechnology. 2020, 第 1 作者 通讯作者 Wang, Min, Xie, Zhoujie, Tang, Shoubin, Chang, Ee Ling, Tang, Yue, Guo, Zhengyan, Cui, Yinglu, Wu, Bian, Ye, Tao, Chen, Yihua. Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage. ORGANIC LETTERS[J]. 2020, 第 10 作者 通讯作者 22(3): 960-964, http://dx.doi.org/10.1021/acs.orglett.9b04501.