司同博士，研究员，博士生导师，国家重点研发计划首席科学家，深圳合成生物研究重大科技基础设施总工艺师。清华大学化生基科班本科，美国伊利诺伊大学香槟分校UIUC博士。课题组关注自动化合成生物研究的理论、技术和应用。前期成果在Nature Communications, JACS, Angew Chem, Metabolic Engineering等国际著名学术期刊发表论文40余篇，“谷歌学术”引用超过2200次，H因子21。任《合成生物学》期刊编委，中国生物工程学会合成生物学分会青年工作组委员，获国家海外高层次人才（青年）、广东省珠江青拔、国家优秀自费留学生、Baxter青年科学家奖等荣誉。

Tools: Automation in Synthetic Biology Synthetic biology applies engineering principles to construct artificial biosystems with predictable functions. Lacking design rules, however, Synbio R&D remains slow, expensive and inconsistent. We aim to develop foundries that automate the design-build-test-learn cycles of engineering biology. We envision living organisms to be designed and manufactured the way humans create other artifacts.

Profiling of d-alanine production by the microbial isolates of rat gut microbiota, Cindy J. Lee#, Tian A. Qi#, Zhilai Hong#, Zhenkun Zhang, Yuhao Min, ,Linzixuan Zhang, Lei Dai, Huimin Zhao, Tong Si*, Jonathan V. Sweedler* in revision. Available on ChemRxiv Directed evolution of a cyclodipeptide synthase with new activities via label-free mass spectrometric screening, Songya Zhang#, Jing Zhu#, Shuai Fan, Wenhao Xie, Zhaoyong Yang*, Tong Si*, Chemical Science, accepted (2022) Towards one sample per second for mass spectrometric screening of engineered microbial strains, Lihao Fu#, Erpeng Guo#, Jianzhi Zhang, Keyi Li, Yongcan Chen*, Tong Si*, Current Opinion in Biotechnology, 2022, 76, 102725 Photobiocatalytic Solar Fuel and Solar Chemical Conversion: Sufficient Activity and Better Selectivity, Shulan Shi, Cuiping Zeng*, Tong Si*, Bo Wang, Po Keung Wong*, ACS ES&T Engineering, 2022, 2(6), 989–1000 Panoramic insights into semi-artificial photosynthesis: origin, development, and future perspective, Kemeng Xiao#, Jun Liang#, Xinyu Wang#, Tianfeng Hou, Xiaoning Ren, Panqing Yin, Zhiping Ma, Cuiping Zeng, Xiang Gao, Tao Yu, Tong Si, Bo Wang*, Chao Zhong*, Zhifeng Jiang*, Chun-Sing Lee, Jimmy Chai-mei Yu, Po Keung Wong, Energy & Environmental Science, 2022, 15, 529-549 Biosynthesis of Gut-Microbiota-Derived Lantibiotics Reveals a Subgroup of S8 Family Proteases for Class III Leader Removal, Yingying Zhang#, Zhilai Hong#, Liang Zhou#, Zhenkun Zhang, Ting Tang, Erpeng Guo, Jie Zheng, Ciji Wang, Lei Dai, Tong Si*, Huan Wang*, Angewandte Chemie International Edition, 2022, 61(6), e202114414 Prospective of synthetic biology database and intelligent data analysis, Ruyun Hu#, Yongcan Chen#, Jianzhi Zhang, Erpeng Guo, Lihao Fu, Yu Qiao*, Tong Si*, Chinese Bulletin of Life Sciences《生命科学》, 2021, 33(12), 1482-1492 (in Chinese) High-Throughput Mass Spectrometry Complements Protein Engineering, Tong Si#,Pu Xue#, Kisurb Choe, Huimin Zhao*, Jonathan V. Sweedler*, In Protein Engineering: Tools and Applications, (H. Zhao, S.Y. Lee, J. Nielsen, G. Stephanopoulos Ed.) pp. 57-79, WILEY‐VCH GmbH, 2021 Genome-scale screening and combinatorial optimization of gene overexpression targets to improve cadmium tolerance in Saccharomyces cerevisiae, Yongcan Chen#, Jun Liang#, Zhicong Chen, Bo Wang* and Tong Si*, Frontiers in Microbiology, 2021, 12, 1922 Genomic and Metabolomic Investigation of a Rhizosphere Isolate Streptomyces netropsis WLXQSS-4 Associated with a Traditional Chinese Medicine, Songya Zhang, Lingxiao Zhang, Jing Zhu, Hong Chen, Zhicong Chen, Tong Si*, Tao Liu*, Molecules, 2021, 26(8), 2147 Accelerating strain engineering in biofuel research via build and test automation of synthetic biology, Jianzhi Zhang, Yongcan Chen, Lihao Fu, Erpeng Guo, Bo Wang, Lei Dai, Tong Si*, Current Opinion in Biotechnology, 2021, 67, 88-98 Insight into the tannic acid-based modular-assembly strategy based on inorganic–biological hybrid systems: a material suitability, loading effect, and biocompatibility study, Xiaoning Ren, Panqing Yin, Jun Liang, Xiangjian Liu, Wugen Zhan, Jiaojiao Niu, Tong Si, Tao Yu, Dan Wu, Bo Wang*, Materials Chemistry Frontiers, 2021, 5, 3867-3976 Recent Advances in the High-throughput Engineering of Lanthipeptides, Erpeng Guo, Jianzhi Zhang*, Tong Si*, China Biotechnology (中国生物工程杂志), 2021, 41(1), 30-41 (in Chinese) Machine learning for synthetic biology: Methods and applications, Ruyun Hu#, Songya Zhang#, Hailin Meng, Han Yu, Jianzhi Zhang, Xiaozhou Luo, Tong Si*, Chenli Liu*, Yu Qiao*, Chinese Science Bulletin《科学通报》, 2020, 66(3), 284-299 (in Chinese) Automation in synthetic biology using biological foundries, Ting Tang, Lihao Fu, Erpeng Guo, Zhenkun Zhang, Zining Wang, Chenfei Ma, Zhiyu Zhang, Jianzhi Zhang, Jiandong Huang*, Tong Si*, Chinese Science Bulletin 《科学通报》, 2020, 66(3), 300-309 (in Chinese) Engineered Live Biotherapeutics: Progress and Challenges, Yang Tan, Juntao Shen, Tong Si, Chun Loong Ho, Yinqing Li, Lei Dai*, Biotechnol. J., 2020, 15(10), 2000155 Advances in RNAi-assisted strain engineering in Saccharomyces cerevisiae, Yongcan Chen, Erpeng Guo, Jianzhi Zhang, Tong Si*, Front. Bioeng. Biotechnol., 2020, 8:731 “Optically guided mass spectrometry to screen microbial colonies for directed enzyme evolution”, Pu Xue, Tong Si, Huimin Zhao*, in Methods Enzymol., 2020, 644, 255-273 Scalable enzyme mining via synthetic biology，Jianzhi Zhang, Lihao Fu, Ting Tang, Songya Zhang, Jing Zhu, Tuo Li, Zining Wang, Tong Si*, Synth. Biol. J. 《合成生物学》, 2020, 1-18 (in Chinese) A mass spectrometry-based high-throughput screening method for engineering fatty acid synthases with improved production of medium-chain fatty acids. Pu Xue, Tong Si, Shekhar Mishra, Linzixuan Zhang, Kisurb Choe, Jonathan V Sweedler, Huimin Zhao*, Biotechnol. Bioeng .,2020, 117, 2131–2138