教育经历 1981.09 - 1986.07 河南医科大学医学系，医学学士学位 1990.04 - 1997.03 日本神户大学大学院，医学博士学位

工作经历 1986.09 - 1990.03 河南南阳医专附属医院，医师 1997.04 - 2003.03 日本千叶大学大学院医学研究院，研究员 2003.04 - 2005.03 日本国立国际医疗中心研究所，研究员 2005.05 - 至今 中国科学院上海药物研究所，研究员、研究组长

主要研究方向为代谢失调性疾病的新药发现与药理药效学研究，以及代谢失调性疾病发生发展分子机制和药物新靶标确认研究。选择与代谢性疾病相关(肥胖、糖尿病、高脂、高尿酸血症、脂肪肝以及皮肤色素代谢失调)的G-蛋白偶联受体、酶分子作为药物筛选的主要靶点，建立细胞或分子水平的高通量筛选模型，通过筛选和评价，从中发现具有良好开发前景的药物先导化合物。 胰岛β-细胞糖脂毒性机制研究及β-细胞保护药物发现研究。 脂肪细胞分化的分子机制研究及其干预药物的发现研究。 黑色素代谢信号通路研究及干预黑色素代谢失调药物的发现研究。基于激酶B-RafV600E的抗皮肤黑色素瘤药物发现与研究。研究组与国内外多个研究机构、大学和企业紧密合作，共同开展代谢失调性疾病新药和发病机制研究，为药物研发提供平台和新的研究思路。

上海市科技系统少数民族联合会副理事长 日本国立国际医疗中心研究所糖尿病研究中心客座研究员

1. Ting Wang, Peng Sun, Liang Chen, Qi Huang, Kaixian Chen, Qi Jia, Yiming Li,* Heyao Wang*. Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress. Journal of Agricultural and Food Chemistry. 62 (2014):5038-5045

2. Lin-Fu Liang, Ting Wang, You-Sheng Cai, Wen-Fei He, Peng Sun, Yu-Fen Li, Qi Huang, Orazio Taglialatela-Scafati*, He-Yao Wang*, Yue-Wei Guo*. Brominated polyunsaturated lipids from the Chinese sponge Xestospongia testudinaria as a new class of pancreatic lipase inhibitors. European Journal of Medicinal Chemistry. 79(2014):290-297

3. Jia Liu, Xiu-Feng He, Gai-Hong Wang, Emilio F. Merino, Sheng-Ping Yang,Rong-Xiu Zhu,Li-She Gan, Hua Zhang, Maria B. Cassera, He-Yao Wang, David G. I. Kingston, and Jian-Min Yue*. Aphadilactones A−D, Four Diterpenoid Dimers with DGAT Inhibitory and Antimalarial Activities from a Meliaceae Plant. The Journal of Organic Chemistry. 79(2014):599−607

4. Bo Li, Gaihong Wang, Zhijian Xu, Yong Zhang, Xiangui Huang, Bubing Zeng, Kaixian Chen, Jiye Shi*, Heyao Wang*, Weiliang Zhu*. Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement. European Journal of Medicinal Chemistry. 77 (2014):204-210

5. Haiyan Cai，Ting Wang, Jian-chun Zhao, Peng Sun, Gui-rui Yan, Hai-peng Ding, Ying-xia Li, He-yao Wang*,Wei-liang Zhu*, Kai-xian Chen. Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice. Acta Pharmacologica Sinica. 34(2013): 1397–1402

6. Bo Li, Gaihong Wang, Mu Yang, Zhijian Xu, Bubing Zeng,*, Heyao Wang*, Jingshan Shen, Kaixian Chen, Weiliang Zhu*.Overman rearrangement and PomeranzeFritsch reaction for the synthesis of benzoazepinoisoquinolones to discover novel antitumor agents. European Journal of Medicinal Chemistry. 70(2013):677-684

7. Guirui Yan, Jingjie Zhu, Laibin Zhang, Zhijian Xu, Gaihong Wang,Weiliang Zhu, Aijun Hou, HeyaoWang*. Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells. Planta Medica. 79(2013):933-938

8. Peng Sun, Ting Wang, Yuren Zhou, Hong Liu, Hualiang Jiang, Weiliang Zhu*, Heyao Wang*. DC260126: A Small-Molecule Antagonist of GPR40 that Protects against Pancreatic β-Cells Dysfunction in db/db Mice. PLOS ONE. 8 (6) (2013):e66744

9. Liang Chen, Peng Sun, Ting Wang, Kaixian Chen, Qi Jia,*, Heyao Wang,* and Yiming Li* Diverse Mechanisms of Antidiabetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice. Journal of Agricultural and Food Chemistry. 60(36) (2012):9144-9150

10. Zhijian Xu, Guirui Yan, Gaihong Wang, Bo Li, Jianming Zhu, Peng Sun, Xiaodong Zhang, Cheng Luo, Heyao Wang*, Weiliang Zhu*. Combining pharmacophore, docking and substructure search approaches to identify and optimize novel B-RafV600E inhibitors. Biooranic Medicinal Chemistry Letters. 22(17) (2012):5428-5437

11. Hai-yan CAI, Zhi-jian XU, Jie TANG, Ying SUN, Kai-xian CHEN, He-yao WANG*, Wei-liang ZHU*. The essential role for aromatic cluster in the β3 adrenergic receptor. Acta Pharmacologica Sinica. 33(2012):1062–1068

12. Xiaodong Zhang, Jun Ji, Gurui Yan, Jinwei Wu, Xiaoyun Sun, Jingshan Shen, Hualiang Jiang, Heyao Wang. PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells. Journal of Cellular Biochemistry. 113(2012):2738-2743

13. Jinwei Wu, Peng Sun, Xiaodong Zhang, Hong Liu, Hualiang Jiang, Weiliang Zhu, Heyao Wang*. Inhibition of GPR40 protects MIN6 β-cells from palmitate-induced ER stress and apoptosis. Journal of Cellular Biochemistry. 113(2012):1152-1158

14. Xiao Hu, Jinwei Wu, Xiaodong Zhang, Qinshi Zhao, Jianming Huang, Heyao Wang*, Aijun Hou*. Isoprenylated Flavonoids and Adipogenesis-Promoting Constituents from Morus nigra. Journal of Natural Products. 74(4) (2011):816-824

15. Liangcai Zhao, Xiaodong Zhang, Heyao Wang*, Donghai Lin*. ¹H NMR-based metabonomic analysis of metabolic changes of serum and liver in Zucker obese rats. Analytical Letters 44(2011):1579–1590

16. Xiao-dong Zhang Jian-wei Yan, Gui-rui Yan Xiao-yun Sun, Jun Ji, Yi-ming Li, You-hong Hu*, He-yao Wang*. Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice. Acta Pharmacologica Sinica. 31 (2010):1470–1477

17. Xiaodong Zhang, Guirui Yan, Yiming Li,Weiliang Zhu*, Heyao Wang*, DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomedicine & Pharmacotherapy. 64(9) (2010):647-651

18. Xiaodong Zhang, Jun Ji, Gurui Yan, Jinwei Wu, Xiaoyun Sun, Jingshan Shen, Hualiang Jiang, Heyao Wang*. Sildenafil promotes adipogenesis through a PKG pathway. Biochemical and Biophysical Research Communications. 396 (2010):1054-1059

19. Haiyan Cai, Gurui Yan, Xiaodong Zhang, Gorbenko O, Heyao Wang*, Weiliang Zhu*. Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 20(12) (2010):3675-3679

20. Hui Hu, Ling-Yan He, Zhen Gong, Ning Li, Yi-Na Lu, Qi-Wei Zhai, Hong Liu, Hua-Liang Jiang, Wei-Liang Zhu*, and He-Yao Wang*. A novel class of antagonists for the FFAs receptor GPR40. Biochemical and Biophysical Research Communications. 390(3) (2009):557-563