教育背景 2003-09--2008-07 中科院上海药物所 博士 1999-09--2003-07 复旦大学 学士 工作简历 2012-09~现在, 中国科学院上海药物研究所, 研究员、课题组长、博士生导师 2008-10~2012-08,芝加哥大学, 博士后 2008-08~2008-09,德克萨斯大学达拉斯西南医学中心, 博士后

研究工作围绕基于蛋白组学技术的蛋白修饰调控和药物精准干预开展研究。研究工作揭发现了蛋白翻译后修饰在表观遗传和细胞代谢调控中的新机制，揭示了靶向干预蛋白修饰在疾病治疗中的重要性和普遍性，为相关肿瘤和代谢性疾病的机理和精准治疗新策略研究奠定重要基础

Baijun Dong, Jun-Yu Xu, Yuqi Huang, Jiacheng Guo, Qun Dong, Yanqing Wang, Ni Li, Qiuli Liu, Mingya Zhang, Linhui Zhai, Jing Li*, Wei Xue*, Tan M*, Jun Qin*. (2024) Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers Nature Cancer 5:1427-1447 Lu Y, Xu J, Li Y, Wang R, Dai C, Zhang B, Zhang X, Xu L, Tao Y, Han M, Guo R,Wu Q, Wu L*, Meng Z*, Tan M*, Li J*. DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser56 to diminish pancreatic β cell function upon overnutrition. Sci Transl Med. 2024,16:eade8647 Hu H, Hu W, Guo AD, Zhai L, Ma S, Nie HJ, Zhou BS, Liu T, Jia X, Liu X, Yao X, Tan M*, Chen X*. Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells. Nat Commun. 2024, 15:1465. 3. Guo A, Yan K, Hu, H, Zhai L, Hu T, Su,H, Chi Y, Zha,J, Xu Y, Zhao,Y Lu X, Xu Y, Zhang J, Tan M*, Chen X*. Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors. Nat Chem 2023, 15:803-814 Jiang L, Liu S, Jia X, Gong Q, Wen X, Lu W, Yang J, Wu X, Wang X, Suo Y, Li Y, Uesugi M, Qu ZB, Tan M,* Lu X,* Zhou L.* (2023) ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA- Encoded Libraries. J Am Chem Soc. 2023,145, 46, 25283–25292 Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH*, Tan M*, Zhao B*. Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha. Mol Cell. 2022, 82:4700-4711 Liu P#, Cong X#, Liao S#, Jia X#, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, Liu B*, Tan M*. (2022) Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. Cell Death Differ 29(1):1-13. Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M*, and Tan M*. A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell, 2021, 81: 4076-4090 Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M*, Tan M*, Li J*. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab. 2021 33: 2004–2020. Xu J, Zhang C, Wang X, Zhai L, Ma Y, Mao Y, Qian K, Sun C, Liu Z, Jiang S, Wang M, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang X, Zhao L, Chang Y, Jia J, Wang X, Zhang Y, Wang Y, Yang Y, Wu Z, Yang L, Liu B, Zhao T, Ren S, Sun A, Zhao Y, Ying W, Wang F, Wang G, Zhang Y, Cheng S, Qin J, Qian X, Wang Y*, Li J*, He F*, Xiao T*, Tan M*. Integrative proteomic characterization of human lung adenocarcinoma. 2020 Cell 182: 245-261 Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M*, Ding J*, Geng M*. Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Cell 2018，175:186-199. Liu B, Jiang S, Li M, Xiong X, Zhu M, Li D, Zhao L, Qian L, Zhai L, Li J, Lu H, Sun S, Lin J, Lu Y *, Li X*, Tan M*. Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis. Nat Commun 2018, 9: 4770 Tan, M.#, Peng, C.#, Anderson, K.A.#, Chhoy, P., Xie, Z., Dai, L., Park, J.S., Chen, Y., Huang, H., Zhang, Y., Ro, J., Wagner, G.R., Green, M.F., Madsen, A.S., Schmiesing, J., Peterson, B.S., Xu, G., Ilkayeva, O.R., Muehlbauer, M.J., Braulke, T., Mühlhausen, C., Backos, D.S., Olsen, C.A., McGuire, P.J., Pletcher, S.D., Lombard, D.B., Hirschey, M.D.*, Zhao, Y*. Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5. Cell Metab 2014,19: 605-617 Tan M.#, Luo H.#, Lee S.#, Jin F., Yang J.S., Montellier E., Buchou T., Cheng Z., Rousseaux S., Rajagopal N., Lu Z., Ye Z., Zhu Q., Wysocka J., Ye Y., Khochbin S., Ren B., Zhao Y*. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011, 146, 1016-1028 Zhang, Z.#, Tan, M.#, Xie, Z., Dai, L., Chen, Y., Zhao, Y.*. Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol 2011, 7, 58-63