教育背景 1994-09--1997-06 中国科学院上海药物研究所 博士 1991-09--1994-06 兰州大学 硕士 工作简历 2005-05~现在, 中国科学院上海药物研究所, 研究员 2001-08~2005-05,美国Vivoquest Inc., 药物化学资深研究员 2001-04~2001-07,美国Rockefeller University, 博士后 2000-08~2001-04,美国Harvard Medical School , 博士后 1998-09~2000-08,美国Georgetown University Medical Center, 博士后 1997-09~1998-07,日本名古屋大学农学院有机室, 博士后 社会兼职 2015-01-01-2019-12-31,上海市药学会药化专业委员会委员, 药化专业委员会委员 2014-01-01-2019-12-31,中国科学院藏药研究重点实验室学术委员会委员, 学术委员会委员

1.类天然产物和类药性骨架合成新方法的研究与高质量多样性小分子库的构建 2.新型活性化合物的发现与成药性优化至先导或候选药物的开发 3.小分子探针的设计合成及相关化学生物学方法探索生物机制研究

Xie, Zhicheng, Li, Lin, Guo, Yihao, Zhang, Mi, Chen, Taiwen, Li, Yongpeng, Li, Xin, Zhu, Xi, Zhang, Yu, Lou, Liguan, Hu, Youhong. Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors. ACTA PHARMACEUTICA SINICA B[J]. 2022, 12(10): 4004-4007, http://dx.doi.org/10.1016/j.apsb.2022.07.015. Ji, Xingyu, Zhu, Nanlin, Ma, Yanjie, Liu, Jia, Hu, Youhong. Protein C-Terminal Tyrosine Conjugation via Recyclable Immobilized BmTYR. ACS OMEGA[J]. 2022, 7(44): 40532-40539, http://dx.doi.org/10.1021/acsomega.2c05794. Han, Sheng, Li, Heng, Chen, Weixiong, Yang, Li, Tong, Xiankun, Zuo, Jianping, Hu, Youhong. Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 240: http://dx.doi.org/10.1016/j.ejmech.2022.114608. Chen, Jingjing, He, Huixin, Wei, Aihuan, Li, Yalei, Cheng, Gang, Qin, Hui, Zhong, Hanyue, Liu, Hongchun, Geng, Meiyu, Shen, Aijun, Hu, Youhong. Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 236: http://dx.doi.org/10.1016/j.ejmech.2022.114259. Chen, Weixiong, Feng, Bo, Han, Sheng, Wang, Peipei, Chen, Wuhong, Zang, Yi, Li, Jia, Hu, Youhong. Discovery of highly potent SARS-CoV-2 M-pro inhibitors based on benzoisothiazolone scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2022, 58: http://dx.doi.org/10.1016/j.bmcl.2022.128526. Huang, JunShang, Guo, BinBin, Lin, FeiFei, Zeng, LiMin, Wang, Ting, Dang, XiangYu, Yang, Yang, Hu, YouHong, Liu, Jia, Wang, HeYao. A novel low systemic diacylglycerol acyltransferase 1 inhibitor, Yhhu2407, improves lipid metabolism. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 2021, 158: http://dx.doi.org/10.1016/j.ejps.2020.105683. Wang, Congcong, Zhang, YuFang, Guo, Shimeng, Zhao, Quan, Zeng, Yanping, Xie, Zhicheng, Xie, Xin, Lu, Boxun, Hu, Youhong. GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(2): 941-957, https://www.webofscience.com/wos/woscc/full-record/WOS:000614306000004. Xie, Zhicheng, Xiang, Caigui, Li, Xin, Fan, Chen, Chen, Taiwen, Liu, Moting, Ma, Yanjie, Bai, Fang, Tang, Wei, Hu, Youhong. Discovery of Potent Antiallergic Agents Based on an o-Aminopyridinyl Alkynyl Scaffold. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(18): 13588-13603, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000701513400027. Che, Jinxin, Wang, Zhilong, Shen, Zheyuan, Zhuang, Weihao, Ying, Huazhou, Hu, Yongzhou, Hu, Youhong, Xie, Xin, Dong, Xiaowu. Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2021, 12(5): 836-845, http://dx.doi.org/10.1021/acsmedchemlett.1c00113. Chen, Jingjing, Li, Yalei, Zhang, Jie, Zhang, Minmin, Wei, Aihuan, Liu, Hongchun, Xie, Zhicheng, Ren, Wenming, Duan, Wenwen, Zhang, Zhuo, Shen, Aijun, Hu, Youhong. Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 209: 20-, http://dx.doi.org/10.1016/j.ejmech.2020.112868. Xie, Zhicheng, Wu, Bing, Liu, Yingqiang, Ren, Wenming, Tong, Linjiang, Xiang, Caigui, Wei, Aihuan, Gao, Yuanzhuo, Zeng, Limin, Xie, Hua, Tang, Wei, Hu, Youhong. Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(3): 1397-1414, https://www.webofscience.com/wos/woscc/full-record/WOS:000514221700031. Ma, Mengna, Guo, Shimeng, Lin, Xi, Li, Shanshan, Wu, Yiran, Zeng, Yanping, Hu, Youhong, Zhao, Suwen, Xu, Fei, Xie, Xin, Shui, Wenqing. Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52. ACS CHEMICAL BIOLOGY[J]. 2020, 15(12): 3275-3284, https://www.webofscience.com/wos/woscc/full-record/WOS:000608852300023. Huang, Junshang, Guo, Binbin, Wang, Gaihong, Zeng, Limin, Hu, Youhong, Wang, Ting, Wang, Heyao. DGAT1 inhibitors protect pancreatic beta-cells from palmitic acid-induced apoptosis. ACTA PHARMACOLOGICA SINICA[J]. 2020, 42(2): 264-271, https://www.webofscience.com/wos/woscc/full-record/WOS:000554332300001. Chen, Wuhong, Liu, Feifei, Zhao, Qiliang, Ma, Xinna, Lu, Dong, Li, Heng, Zeng, Yanping, Tong, Xiankun, Zeng, Limin, Liu, Jia, Yang, Li, Zuo, Jianping, Hu, Youhong. Discovery of Phthalazinone Derivatives as Novel Hepatitis B Virus Capsid Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(15): 8134-8145, http://dx.doi.org/10.1021/acs.jmedchem.0c00346. WenDi Duan, YuFang Zhang, Youhong Hu. NaH Promoted One-Pot Tandem Reactions of 3-(1-Alkynyl) Chromones to Form 2-Nitrogen-Substituted Xanthones. ACS OMEGA[J]. 2020, 5(22): 13454-13461, https://www.webofscience.com/wos/woscc/full-record/WOS:000541503700093. Lei, Yu, Ren, Wenming, Wang, ChengKun, Tao, RongRong, Xiang, HuaiJiang, Feng, LiLi, Gao, YinPing, Jiang, Quan, Li, Xin, Hu, Youhong, Han, Feng. Visualizing Autophagic Flux during Endothelial Injury with a Pathway-Inspired Tandem-Reaction Based Fluorogenic Probe. THERANOSTICS[J]. 2019, 9(19): 5672-5680, https://www.webofscience.com/wos/woscc/full-record/WOS:000481600100017. Zhang, YuFang, Duan, WenDi, Chen, Jingjing, Hu, Youhong. Base-Promoted Cascade Reactions of 3-(1-Alkynyl)chromones with Pyridinium Ylides to Chromeno2,3-dazepine Derivatives. JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 84(7): 4467-4472, https://www.webofscience.com/wos/woscc/full-record/WOS:000464250800071. Ren, Wenming, Xiang, Huaijiang, Peng, Chengyuan, Musha, Zulipali, Chen, Jingjing, Li, Xin, Huang, Ruimin, Hu, Youhong. Direct C-H functionalization of difluoroboron dipyrromethenes (BODIPYs) at beta-position by iodonium salts. RSC ADVANCES[J]. 2018, 8(10): 5542-5549, https://www.webofscience.com/wos/woscc/full-record/WOS:000424024200055. Yu, Xueli, Cheng, Gang, Zhang, Lei, Zhang, Yu, Wang, Qing, Zhao, Mengxue, Zeng, Limin, Hu, Youhong, Feng, Linyin. N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination. SCIENTIFIC REPORTS[J]. 2018, 8(1): https://doaj.org/article/337b6f7a5d6142579a1d38d93fa4e348. Lu, Hui, Cheng, Gang, Hong, Feng, Zhang, Lei, Hu, Youhong, Feng, Linyin. A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice. STEM CELLS[J]. 2018, 36(8): 1273-1285, https://www.webofscience.com/wos/woscc/full-record/WOS:000441443900014. Lu, Dong, Liu, Jianan, Zhang, Yunzhe, Liu, Feifei, Zeng, Limin, Peng, Runze, Yang, Li, Ying, Huazhou, Tang, Wei, Chen, Wuhong, Zuo, Jianping, Tong, Xiankun, Liu, Tao, Hu, Youhong. Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 145: 328-337, http://dx.doi.org/10.1016/j.ejmech.2018.01.008. Lu, Dong, Liu, Feifei, Xing, Weiqiang, Tong, Xiankun, Wang, Lang, Wang, Yajuan, Zeng, Limin, Feng, Chunlan, Yang, Li, Zuo, Jianping, Hu, Youhong. Optimization and Synthesis of Pyridazinone Derivatives as Novel Inhibitors of Hepatitis B Virus by Inducing Genome-free Capsid Formation. ACS INFECTIOUS DISEASES[J]. 2017, 3(3): 199-205, http://dx.doi.org/10.1021/acsinfecdis.6b00159. Liu, Yang, Peng, Xia, Guan, Xiaocong, Lu, Dong, Xi, Yong, Jin, Shiyu, Chen, Hui, Zeng, Limin, Ai, Jing, Geng, Meiyu, Hu, Youhong. Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 126: 122-132, http://dx.doi.org/10.1016/j.ejmech.2016.10.003. Li, Shan, Wan, Penghui, Ai, Jing, Sheng, Rong, Hu, Yongzhou, Hu, Youhong. Palladium-Catalyzed, Silver-Assisted Direct C-5-H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation. ADVANCED SYNTHESIS & CATALYSIS[J]. 2017, 359(5): 772-778, https://www.webofscience.com/wos/woscc/full-record/WOS:000396631700002. Yan, Jianwei, Wang, Gaihong, Dang, Xiangyu, Guo, Binbin, Chen, Wuhong, Wang, Ting, Zeng, Limin, Wang, Heyao, Hu, Youhong. Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2017, 25(17): 4701-4714, http://dx.doi.org/10.1016/j.bmc.2017.07.007. Lu, Dong, Yan, Juan, Wang, Lang, Liu, Hongchun, Zeng, Limin, Zhang, Minmin, Duan, Wenwen, Ji, Yinchun, Cao, Jingchen, Geng, Meiyu, Shen, Aijun, Hu, Youhong. Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2017, 8(8): 830-834, https://www.webofscience.com/wos/woscc/full-record/WOS:000407656800008.